Review
Biochemistry & Molecular Biology
Lichao Huang, Yijing Liu, Xiaqin Wang, Cheng Jiang, Yanqiu Zhao, Mengzhu Lu, Jin Zhang
Summary: This article summarizes the generation and scavenging pathways of peroxisomal ROS and explains how peroxisome-derived ROS participate in cellular PCD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ming-Feng Tsai, Shih-Ming Chen, Ann-Zhi Ong, Yi-Hsuan Chung, Pei-Ni Chen, Yi-Hsien Hsieh, Yu-Ting Kang, Li-Sung Hsu
Summary: The study found that shikonin induced programmed cell death in renal cancer cells by increasing ROS levels and p38 activity, while also promoting autophagy. N-acetyl cysteine can alleviate shikonin-induced cell death and ROS generation.
Article
Biochemistry & Molecular Biology
Raghbendra Kumar Dutta, Yunash Maharjan, Joon No Lee, Channy Park, Ye-Shih Ho, Raekil Park
Summary: The study demonstrates that prolonged fasting in catalase-knockout mice significantly increases ROS production, leading to liver-specific pexophagy and cell death. The use of antioxidants and autophagy inhibitors can suppress the inflammatory response and disease progression.
Review
Biochemistry & Molecular Biology
Sheikh Mansoor, Owais Ali Wani, Jafar K. Lone, Sweeta Manhas, Navneet Kour, Pravej Alam, Ajaz Ahmad, Parvaiz Ahmad
Summary: Reactive oxygen species (ROS) are highly reactive and dangerous by-products that can cause oxidative cell death, but they also play a beneficial role in regulating biological processes. ROS are generated in various cell compartments of plants and require the action of antioxidants to scavenge them. This review provides a comprehensive overview of the fate of ROS in plants, their role in stress response, and their interaction with other signaling molecules/pathways.
Article
Biochemistry & Molecular Biology
Senzhen Wang, Xiaojuan Xu, Delu Che, Ronghui Fan, Mengke Gao, Yue Cao, Chaochao Ge, Yongli Feng, Jinghua Li, Songqiang Xie, Chaojie Wang, Fujun Dai, Lei Gao, Yuxia Wang
Summary: The study confirmed that mitochondria are the main source of ROS induced by 6c, leading to mitochondrial dysfunction and lysosomal destabilization. Moreover, ROS regulated the expression of 6c-mediated proteins, promoted the formation of autophagosomes, and caused DNA damage, ultimately resulting in cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Massimo Malerba, Raffaella Cerana
Summary: Programmed cell death (PCD) is a genetically controlled suicide process present in all living beings, playing a crucial role in plant development and stress responses. Studying PCD in whole plants or complex tissues is challenging due to its occurrence in a small group of inaccessible cells. Cultured cells provide a useful tool with their uniformity, accessibility, and reproducibility for investigating various aspects of plant PCD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jianfeng Guo, Zhuo Yu, Dandan Sun, Yifang Zou, Yun Liu, Leaf Huang
Summary: This study demonstrates the concept of successful FOLFOX-associated CRC and HCC therapies through the combination of two nano delivery systems. Further optimization in dosing and timing has the potential to enhance the clinical efficacy of this combination strategy.
Article
Oncology
Mohd Farhan, Asim Rizvi, Ferasat Ali, Aamir Ahmad, Mohammad Aatif, Arshi Malik, Mir Waqas Alam, Ghazala Muteeb, Saheem Ahmad, Awal Noor, Farhan Asif Siddiqui
Summary: Anthocyanidins can induce DNA damage and inhibit cell proliferation in cancer cells by reacting with intracellular copper. Copper supplementation increases the sensitivity of normal cells to anthocyanidins and decreases cell proliferation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Plant Sciences
Yinghui Li, Rajib Roychowdhury, Liubov Govta, Samidha Jaiwar, Zhen-Zhen Wei, Imad Shams, Tzion Fahima
Summary: Reactive oxygen species (ROS) and hypersensitive response (HR) play important roles in plant immunity against pathogens. In this study, we quantitatively analyzed the accumulation of apoplastic ROS (apoROS) and intracellular ROS (intraROS) in wheat cells infected with Blumeria graminis f. sp. tritici (Bgt). We found that apoROS accumulation accounted for 70 to 80% of infected wheat cells in both compatible and incompatible host-pathogen interactions. IntraROS accumulation and localized cell death responses were mainly observed in wheat lines carrying nucleotide-binding leucine-rich repeat R genes. Our results provide new insights into the immune responses against wheat powdery mildew.
Article
Biochemistry & Molecular Biology
Kenji Mizumura, Yasuhiro Gon
Summary: The pathogenesis of Chronic obstructive pulmonary disease (COPD) involves the reduction of alveolar surface area and airway inflammation mainly due to exposure to cigarette smoke. Iron metabolism plays a key role in producing reactive oxygen species and regulating cell death processes.
Article
Multidisciplinary Sciences
Abhinav Kaushik, Diane Dunham, Xiaorui Han, Evan Do, Sandra Andorf, Sheena Gupta, Andrea Fernandes, Laurie Elizabeth Kost, Sayantani B. Sindher, Wong Yu, Mindy Tsai, Robert Tibshirani, Scott D. Boyd, Manisha Desai, Holden T. Maecker, Stephen J. Galli, R. Sharon Chinthrajah, Rosemarie H. DeKruyff, Monali Manohar, Kari C. Nadeau
Summary: This study analyzed immune cells from participants in a peanut oral immunotherapy (OIT) trial and found that the differentiation status of CD8(+) T cells at baseline may predict the likelihood of achieving sustained unresponsiveness (SU). The study also found that lower frequencies of naïve CD8(+) T cells and terminally differentiated CD57(+)CD8(+) T cell subsets at baseline were associated with SU, while higher frequencies of IL-4(+) and IFN gamma(+) CD4(+) T cells post-OIT were correlated with a lower likelihood of SU.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Iratxe Uranga-Murillo, Elena Tapia, Marcela Garzon-Tituana, Ariel Ramirez-Labrada, Llipsy Santiago, Cecilia Pesini, Patricia Esteban, Francisco J. Roig, Eva M. Galvez, Phillip Bird, Julian Pardo, Maykel Arias
Summary: The study found that while both GzmA and GzmK do not control bacterial infection, inhibiting GzmA can reduce inflammation and improve survival, especially in E. coli-induced sepsis.
Review
Immunology
Thais Teixeira Oliveira, Leonam Gomes Coutinho, Laysa Ohana Alves de Oliveira, Ana Rafaela de Souza Timoteo, Guilherme Cavalcanti Farias, Lucymara Fassarella Agnez-Lima
Summary: APE1 is a multifunctional enzyme that is essential for maintaining cellular homeostasis and regulating immune response. It plays important roles in cell signaling, senescence, and inflammatory pathways, and is involved in the pathogenesis of various diseases, including cancer and neurological disorders. APE1 inhibitors have potential therapeutic uses, particularly in infectious and immune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Andras Szarka, Orsolya Kapuy, Tamas Lorincz, Gabor Banhegyi
Summary: Oxidative stress caused by ascorbate can be a significant strategy to eliminate cancer cells selectively, with different concentrations inducing various cell death pathways. Understanding the mechanisms underlying high-dose ascorbate-induced cancer cell death may provide insights for synergistic cancer therapies in the future.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Materials Science, Multidisciplinary
Shichen Zhang, Zhengqiang Li, Zhimin Xu, Yixin Tang, Congcong Duan, Huanyan Dai, Xinyu Dai, Xin Wei, Yan Liu, Caina Xu, Bing Han
Summary: Head and neck squamous cell carcinoma (HNSCC) is a common type of head and neck cancer. Traditional treatments can have negative effects on physiological functions and appearance. This article discusses the use of reactive oxygen species (ROS)-based cancer therapy and summarizes various nanotherapeutics for HNSCC, including photodynamic therapy, sonodynamic therapy, radiation therapy, and chemodynamic therapy. The challenges and future directions for these treatments are also discussed.
MATERIALS & DESIGN
(2022)
Article
Computer Science, Artificial Intelligence
Yuming Guo
Summary: The variant design node configuration is an effective method for balancing product diversification with cost and delivery time. To control design change propagations, this study proposes an evaluation method based on network nodes importance and employs a discrete particle swarm algorithm for node configuration. Experimental results demonstrate that this method outperforms the greedy algorithm in terms of optimization performance.
JOURNAL OF INTELLIGENT MANUFACTURING
(2023)
Article
Thermodynamics
Yuming Guo, Liang-Liang Fan, Liang Zhao
Summary: In the past few decades, there has been significant development in electronic technology, leading to a pressing need for high-performance cooling schemes. A new hybrid cooling scheme, involving enhanced flow boiling of open micro-channel and jet impingement with separated liquid-vapor pathways, has been proposed with a critical heat flux of 546 W/cm². However, the introduction of jet impingement forces bubbles generated in the channel to migrate to the top of the fins, resulting in a new series of bubble behavior and flow patterns. Visualization experiments were conducted to better understand these flow patterns and the transition mechanism. The findings include the observation of bubbles with varying critical motion diameters in different flow regions, and the proposal of a prediction model for critical motion diameter based on the force balance of a bubble on the fin tops, with a maximum error of 20%. These findings have implications for the further development of efficient cooling technology.
HEAT TRANSFER ENGINEERING
(2023)
Article
Chemistry, Physical
Pengfei Yang, Yi Chang, Jie Zhang, Fangli Gao, Xinhe Liu, Qingcong Wei, Xiaoming Ma, Yuming Guo
Summary: Photodynamic therapy (PDT) is a promising modality for clinical cancer treatment, but its effectiveness against hypoxic tumors is limited due to its oxygen-dependent nature. In this study, a self-supply strategy of oxygen based on calcium peroxide (CaO2) was proposed to enhance PDT. By encapsulating the CaO2 core with a ZIF-8 shell, premature decomposition of CaO2 was prevented and the loading efficiency of porphyrin was increased. The in situ self-supply of oxygen contributed to the enhanced PDT effect, while the decomposition of CaO2 also released free calcium ions that showed ion-interference effect and inhibited tumor growth. This work presents a synergistic strategy for the construction of a photodynamic promotion/ion-interference combined nano-platform and provides inspiration for the future design of effective nanocomposites in tumor treatment.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Qihang Hou, Jingxi Huang, Lihua Zhao, Xianjie Pan, Chaoyong Liao, Qiuyu Jiang, Jiaqi Lei, Fangshen Guo, Jian Cui, Yuming Guo, Bingkun Zhang
Summary: Age-related gastrointestinal decline contributes to whole-organism frailty and mortality. Dietary genistein promotes a healthier and longer life in aging mice by decreasing systemic inflammatory cytokines levels and ameliorating gut dysfunctions. Genistein-associated alteration in gut microbiota increases Lachnospira abundance and short-chain fatty acid production, rejuvenating the aging gut and extending the lifespan of progeroid mice.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Geography, Physical
Hengxu Huang, Fang Xiang, Deyan Zhang, Yuming Guo, Qi Yang, Li Ding
Summary: In the Three Gorges and adjacent areas, the evolution history of the upper Yangtze River was reconstructed using diagnostic heavy minerals, U-Pb geochronology, and trace elements of detrital zircons. Before the disintegration of the lowest planation surface, there were two paleorivers, the paleo-Chuan River and the paleo-Yangtze River, separated by the Huangling Dome. The paleo-Yangtze River captured the paleo-Chuan River and progressively captured the paleo-Jinsha River, forming the modern upper Yangtze River.
QUATERNARY RESEARCH
(2023)
Article
Thermodynamics
Yuming Guo, Liang-Liang Fan, Liang Zhao
Summary: With the rapid development of high-power electronics, the thermal management of these devices is challenging due to the danger of high heat flux and uneven temperature distribution. This paper investigates the differences in flow and thermal characteristics between micro-channel and micro-jet cooling technologies, and proposes a novel transition scheme that allows interchangeability between the two. The effect of vortices and various parameters on the cooling performance is also analyzed.
APPLIED THERMAL ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Guanglei Ma, Fang Li, Xin Wang, Qing Li, Youyou Hong, Qingcong Wei, Fangli Gao, Weiwei Zhang, Yuming Guo, Xiaoming Ma, Zhiguo Hu
Summary: The researchers constructed bionic yeast carriers (BYCs) by utilizing the loading capacity of mesoporous silica nanoparticles within the yeast capsules. BYCs can mimic the yeast infection pathway and can carry multiple substances. The coloading of BYCs demonstrated positive therapeutic effects in both transplantation tumor models and metastasis tumor models, and in some cases, complete cure of tumors can be achieved.
Article
Ecology
Ziyue Shi, Fang Xiang, Yuming Guo
Summary: This study assessed ecological risk in the Upper Yellow River region in China, highlighting the importance of Luqu County as an ecological barrier and susceptible area to geohazards. The results showed a correlation between ecological risk and geohazards, with a gradual decline in risk from northeast to southwest. It is recommended that high-risk areas be prioritized for effective risk management.
ECOLOGICAL INFORMATICS
(2023)
Article
Environmental Sciences
Massimo Stafoggia, Paola Michelozzi, Alexandra Schneider, Ben Armstrong, Matteo Scortichini, Masna Rai, Souzana Achilleos, Barrak Alahmad, Antonis Analitis, Christofer Astrom, Michelle L. Bell, Neville Calleja, Hanne Krage Carlsen, Gabriel Carrasco, John Paul Cauchi, Micheline D. S. Z. S. Coelho, Patricia M. Correa, Magali H. Diaz, Alireza Entezari, Bertil Forsberg, Rebecca M. Garland, Yue Leon Guo, Yuming Guo, Masahiro Hashizume, Iulian H. Holobaca, Carmen Iniguez, Jouni J. K. Jaakkola, Haidong Kan, Klea Katsouyanni, Ho Kim, Jan Kysely, Eric Lavigne, Whanhee Lee, Shanshan Li, Marek Maasikmets, Joana Madureira, Fatemeh Mayvaneh, Chris Fook Sheng Ng, Baltazar Nunes, Hans Orru, Nicolas Ortega, Samuel Osorio, Alfonso D. L. Palomares, Shih-Chun Pan, Mathilde Pascal, Martina S. Ragettli, Shilpa Rao, Raanan Raz, Dominic Roye, Niilo Ryti, Paulo H. N. Saldiva, Evangelia Samoli, Joel Schwartz, Noah Scovronick, Francesco Sera, Aurelio Tobias, Shilu Tong, Cesar D. L. C. Valencia, Ana Maria Vicedo-Cabrera, Ales Urban, Antonio Gasparrini, Susanne Breitner, Francesca K. de Donato
Summary: Suggestive evidence of effect modification between air temperature and air pollutants on mortality during the warm period was found in a global dataset of 620 cities.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Samuel Luthi, Christopher Fairless, Erich M. Fischer, Noah Scovronick, Micheline De Sousa Zanotti Stagliorio Coelho, Yue Leon Guo, Yuming Guo, Yasushi Honda, Veronika Huber, Jan Kysely, Eric Lavigne, Dominic Roye, Niilo Ryti, Susana Silva, Ales Urban, Antonio Gasparrini, David N. Bresch, Ana M. Vicedo-Cabrera
Summary: Current research focuses on the impact of rising temperatures on heat-related mortality, but it is unclear how climate change will exacerbate the effects of extreme summer seasons on human health. This study combines empirical heat-mortality relationships with climate model data to predict future highly impactful summer seasons. The findings emphasize the urgent need for mitigation and adaptation measures to reduce the impact on human lives.
NATURE COMMUNICATIONS
(2023)
Article
Environmental Sciences
Zhen Cao, Guohui Chen, Song Zhang, Shangshu Huang, Yan Wu, Fangjin Dong, Yuming Guo, Jianhao Wang, Fahui Jiang
Summary: Soil erosion is a global threat, especially in China. No-tillage (NT) and mulching (NTS) are effective soil management techniques for reducing erosion, but their utilization is limited. This study evaluated the impact of NT and NTS on water erosion in China's croplands from 2000 to 2018 and found that they significantly reduced soil loss, especially in southern regions. However, considering economic losses and ecosystem benefits, NT and NTS should be primarily implemented in northern parts of China.
Article
Biotechnology & Applied Microbiology
Xinyue Yang, Meihong Zhang, Yan Liu, Fuxiao Wei, Xin Li, Yuqing Feng, Xiaolu Jin, Dan Liu, Yuming Guo, Yongfei Hu
Summary: Accumulated evidence supports the beneficial role of inulin in alleviating metabolic dysfunction-associated fatty liver disease by modulating gut microbiota. The study found that the inulin-enriched Megamonas genus was inversely correlated with hepatic steatosis-related parameters. The newly isolated commensal bacterium M. funiformis CML154 was able to ameliorate fatty liver disease by activating the APN-AMPK-PPAR alpha signaling pathway.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Article
Chemistry, Physical
Chang-Xun Dou, Xu-Ke Tian, Ying-Jun Chen, Pei-Pei Yin, Jia-Hui Guo, Xiao-Gang Yang, Yu-Ming Guo, Lu-Fang Ma
Summary: In this study, an ionic porphyrin MOF was synthesized and exhibited efficient visible photocatalytic activity, surpassing other materials in the degradation of organic pollutants.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Environmental Sciences
Yuming Guo, Jixiong Zhang, Meng Li, Lihua Wang, Zejun Li
Summary: The backfilling mining method using coal gangue can prevent water inrush hazards and protect groundwater resources and the ecological environment of the mining area. The study shows that the particle size and stress have significant influences on the permeability of gangue. During the backfilling process, optimizing particle size distribution and considering stress and water pressure conditions are essential. The variation of seepage channels in gangue backfill materials can be divided into four stages, eventually achieving an impervious state.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Fangli Gao, Liting Jiang, Jie Zhang, Yi Chang, Weihua Gao, Lina Ding, Guanglei Ma, Xiaoming Ma, Yuming Guo
Summary: Researchers have developed a near-infrared light-triggered delivery system that enhances the penetration and accumulation of nanomedicines, leading to improved tumor therapeutic efficacy. The system combines thermosensitive liposomes, photosensitizers, and ultrasmall copper sulfide nanoparticles, and has shown promising results in vitro and in vivo using photodynamic therapy and photothermal therapy.
ACS MATERIALS LETTERS
(2023)
