Article
Hematology
Amber Afzal, Brian F. Gage, Luo Suhong, Martin W. Schoen, Kevin Korenblat, Kristen M. Sanfilippo
Summary: The relationship between INR and risk of hemorrhage is different in chronic liver disease (CLD) patients compared to warfarin users. INR has a positive correlation with hemorrhage risk in CLD patients, while in warfarin users, the risk is low in subtherapeutic and therapeutic ranges, and exponentially increases in the supratherapeutic range.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Orthopedics
Nicholas R. Arnold, Linsen T. Samuel, Jaret M. Karnuta, Alexander J. Acuna, Atul F. Kamath
Summary: The preoperative INR values are related to the outcomes of joint arthroplasty, including surgical site complications, medical complications, bleeding, readmissions, and mortality. Higher INR values are associated with poorer outcomes, suggesting a need to re-evaluate the current INR guideline targets.
Article
Orthopedics
Kevin L. Mekkawy, Yash P. Chaudhry, John G. Mawn, Aoife MacMahon, Julius K. Oni, Robert S. Sterling, Rachel B. Sotsky, Harpal S. Khanuja
Summary: The purpose of this study was to evaluate the relationship between preoperative INR and postoperative complication rates in patients with a hip fracture and determine a threshold below which the risk of complications is comparable to those with a normal INR. Using retrospective data from a surgical quality improvement program, 35,910 cases were analyzed and stratified based on preoperative INR levels. The study found that an INR of <1.6 is a safe value for hip fracture surgery, as it avoids the increased risk of transfusion and 30-day mortality associated with higher INR values. These findings can potentially improve the outcome of surgery for hip fracture patients by guiding preoperative protocols.
Article
Medicine, General & Internal
Ailbhe C. McAlister, Kwok M. Ho
Summary: This study aimed to validate a prediction equation embedded in a smartphone application to guide dosing of Prothrombinex-VF in critically ill patients. The results showed that the app was reasonably accurate at predicting normalisation of elevated INRs after administration of Prothrombinex-VF, especially among patients without liver disease. The app's dosing recommendations were similar to or possibly better than preexisting warfarin reversal guidelines in over 85% of the situations analysed.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Substance Abuse
Valentina Lorenzetti, Chandni Hindocha, Kat Petrilli, Paul Griffiths, Jamie Brown, Alvaro Castillo-Carniglia, Jonathan P. Caulkins, Amir Englund, Mahmoud A. ElSohly, Suzanne H. Gage, Teodora Groshkova, Antoni Gual, David Hammond, Will Lawn, Hugo Lopez-Pelayo, Jakob Manthey, Claire Mokrysz, Rosalie Liccardo Pacula, Margriet van Laar, Ryan Vandrey, Elle Wadsworth, Adam Winstock, Wayne Hall, H. Valerie Curran, Tom P. Freeman
Summary: The lack of an agreed international minimum approach to measuring cannabis use has hindered the integration of multidisciplinary evidence on the consequences of cannabis use. A group of 25 international expert cannabis researchers convened to discuss a framework for minimum standards to measure cannabis use globally. The expert consensus agreed upon a three-layered hierarchical framework, reflecting different research priorities and standards.
Article
Surgery
X. W. Ling, K. Lin, X. Q. Jiang, Q. Wu, Z. J. Liu, S. Li, S. Zhao, C. Lin
Summary: This study found that INR is a significant independent predictor of mortality in sepsis patients diagnosed with necrotising fasciitis. Patients with higher INR values had significantly higher mortality rates, even after adjusting for other risk factors.
ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
(2021)
Article
Surgery
Maria Conticchio, Antonella Delvecchio, Valentina Ferraro, Matteo Stasi, Annachiara Casella, Rosalinda Filippo, Michele Tedeschi, Riccardo Memeo
Summary: Since its introduction, robotics has been increasingly used for liver lesion resection, providing the benefits of minimally invasive approach and overcoming laparoscopy limitations. We present a standardized technique of robotic right liver mobilisation, which offers all the advantages of minimally invasive approaches and more ergonomic conditions for surgeons. This technique can reduce the conversion rate and improve the learning curve in young surgeons.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2023)
Review
Cardiac & Cardiovascular Systems
Neilenuo Nelly Rentta, Julie Bennett, William Leung, Rachel Webb, Susan Jack, Matire Harwood, Michael G. Baker, Mayanna Lund, Nigel Wilson
Summary: Acute rheumatic fever and rheumatic heart disease have a disproportionate impact on Indigenous and Pacific Peoples in New Zealand. Research suggests that improved anticoagulation management and the establishment of a national RHD register could improve outcomes for patients with RHD. Additionally, involving pharmacists in anticoagulation control has been found to be cost-effective.
HEART LUNG AND CIRCULATION
(2022)
Article
Hematology
Carmen B. Smith, Erin K. Hennessey, Caroline D. Crossey, Andrew J. Crannage
Summary: Limited studies have assessed the efficacy of vitamin K administration in patients with chronic liver disease (CLD). However, the results of this retrospective, single-center cohort study suggest that the administration of vitamin K in hospitalized patients with CLD may not have the intended benefit of reducing bleeding risk, as the change in international normalized ratio (INR) following vitamin K administration was minimal.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2023)
Review
Health Care Sciences & Services
Andreas M. Matthaiou, Ioannis Tomos, Sofia Chaniotaki, Dimitrios Liakopoulos, Katerina Sakellaropoulou, Sofia Koukidou, Loredana-Mariana Gheorghe, Stefanos Eskioglou, Angeliki Paspalli, Georgios Hillas, Katerina Dimakou
Summary: This study examines the association between antibiotic therapy and vitamin E supplementation with vitamin K deficiency. It found that these treatments can lead to decreased levels of vitamin K, causing coagulation issues. Patients receiving antibiotic therapy, especially those with malnutritive or malabsorptive conditions, should be closely monitored for coagulation parameters. The use of specific antibiotics or vitamin E supplementation should be avoided unless absolutely necessary.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Gastroenterology & Hepatology
F. Magro, J. Sabino, F. Rosini, M. Tripathi, P. Borralho, P. Baldin, S. Danese, A. Driessen, I. O. Gordon, M. Iacucci, N. Noor, M. Svrcek, L. Peyrin-Biroulet, R. Feakins
Summary: Inflammatory bowel disease (IBD) relies on mucosal healing as a significant therapeutic target and predictor of clinical course. In Crohn's disease (CD), there are limited studies on the importance of histological remission as a therapeutic target. Standardization of evaluating CD histological activity procedures is desirable. A consensus group by the European Crohn's and Colitis Organisation (ECCO) has developed position statements on CD histology to address these needs.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Materials Science, Multidisciplinary
Piers Turner, Keith R. Paton, Elizabeth J. Legge, Andres de Luna Bugallo, A. K. S. Rocha-Robledo, Ahmed-Azmi Zahab, Alba Centeno, Alessio Sacco, Amaia Pesquera, Amaia Zurutuza, Andrea Mario Rossi, Diana N. H. Tran, Diego Silva, Dusan Losic, Farzaneh Farivar, Hugo Kerdoncuff, Hyuksang Kwon, Jerome Pirart, Joao Luiz E. Campos, Kiran M. Subhedar, Li-Lin Tay, Lingling Ren, Luiz Gustavo Cancado, Matthieu Paillet, Paul Finnie, Pei Lay Yap, Raul Arenal, Sanjay R. Dhakate, Sebastian Wood, Sergio Jimenez-Sandoval, Tim Batten, Vaiva Nagyte, Yaxuan Yao, Angela R. Hight Walker, Erlon H. Martins Ferreira, Cinzia Casiraghi, Andrew J. Pollard
Summary: This study presents an international interlaboratory comparison (ILC) on Raman spectroscopy measurements of chemical vapor deposition (CVD) grown graphene, focusing on the comparability of measurements and addressing measurement uncertainty contributions and solutions for improved accuracy and precision.
Article
Gastroenterology & Hepatology
Mercedes Martinez, Emily R. Perito, Pamela Valentino, Cara L. Mack, Madeleine Aumar, Annemarie Broderick, Laura G. Draijer, Eleonora D. T. Fagundes, Katryn N. Furuya, Nitika Gupta, Simon Horslen, Maureen M. Jonas, Binita M. Kamath, Nanda Kerkar, Kyung Mo Kim, Kaija-Leena Kolho, Bart G. P. Koot, Trevor J. Laborda, Christine K. Lee, Kathleen M. Loomes, Tamir Miloh, Douglas Mogul, Saeed Mohammed, Nadia Ovchinsky, Girish Rao, Amanda Ricciuto, Alexandre Rodrigues Ferreira, Kathleen B. Schwarz, Vratislav Smolka, Atsushi Tanaka, Mary E. M. Tessier, Venna L. Venkat, Bernadette E. Vitola, Marek Woynarowski, Melissa Zerofsky, Mark R. Deneau
Summary: This retrospective study evaluated risk factors for rPSC in 140 children and found that patients with rPSC were younger at LT, had faster progression from PSC diagnosis to LT, and had a higher prevalence of inflammatory bowel disease. rPSC subjects experienced more episodes of acute rejection, complications of portal hypertension, and higher mortality rates post-LT.
Article
Endocrinology & Metabolism
Yanhua Zhao, Junxiang Xia, He He, Shanshan Liang, He Zhang, Wei Gan
Summary: This study explored the predictive ability of novel inflammatory biomarkers for NAFLD and found that MHR was superior to NLR, PLR, and LMR in predicting NAFLD. Combining the MHR with relevant laboratory parameters could improve the clinical noninvasive diagnosis of NAFLD with high accuracy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tsuyoshi Ishikawa, Maho Egusa, Tsuyoshi Fujioka, Natsuko Nishiyama, Daiki Kawamoto, Ryo Sasaki, Tatsuro Nishimura, Norikazu Tanabe, Takashi Oono, Issei Saeki, Taro Takami
Summary: This study found that lower LS levels and higher INR can predict the improvement of MELD-Na score and prognosis following PSS occlusion in patients with portal hypertension who underwent BRTO surgery.
JOURNAL OF GASTROENTEROLOGY
(2023)