AKT Kinase Pathway: A Leading Target in Cancer Research

Computational Investigation of Cancer-Associated Molecular Mechanism in Aurora A (S155R) Mutation

(2013) Ambuj Kumar et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Computational SNP Analysis: Current Approaches and Future Prospects

(2013) Ambuj Kumar et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Investigation of Binding Phenomenon of NSP3 and p130Cas Mutants and Their Effect on Cell Signalling

(2013) Balu K. et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Relationship between a point mutation S97C in CK1δ protein and its affect on ATP-binding affinity

(2013) Ambuj Kumar et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Drug resistance mechanism of PncA inMycobacterium tuberculosis

(2013) Vidya Rajendran et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Role of ELA region in auto-activation of mutant KIT receptor: a molecular dynamics simulation insight

(2013) Rituraj Purohit   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Mutational analysis of TYR gene and its structural consequences in OCA1A

(2012) Balu K et al.   GENE

MicroRNA-7 Inhibits the Growth of Human Non-Small Cell Lung Cancer A549 Cells through Targeting BCL-2

(2012) Shudao Xiong et al.   International Journal of Biological Sciences

In silico prediction of a disease-associated STIL mutant and its affect on the recruitment of centromere protein J (CENPJ)

(2012) Ambuj Kumar et al.   FEBS Open Bio

In silico investigation of molecular mechanism of laminopathy caused by a point mutation (R482W) in lamin A/C protein

(2011) Vidya Rajendran et al.   AMINO ACIDS

Combining EGFR and mTOR Blockade for the Treatment of Epithelioid Sarcoma

(2011) Xianbiao Xie et al.   CLINICAL CANCER RESEARCH

Targeting the Akt/mTOR pathway in Brca1-deficient cancers

(2011) T Xiang et al.   ONCOGENE

GILZ inhibits the mTORC2/AKT pathway in BCR-ABL+ cells

(2011) S Joha et al.   ONCOGENE

Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin

(2011) D Huertas et al.   ONCOGENE

Identification of stromally expressed molecules in the prostate by tag-profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate

(2011) B Orr et al.   ONCOGENE

Absent in Melanoma 2 (AIM2) is an important mediator of interferon-dependent and -independent HLA-DRA and HLA-DRB gene expression in colorectal cancers

(2011) J Lee et al.   ONCOGENE

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

(2011) M V Astle et al.   ONCOGENE

TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP

(2011) K Horiguchi et al.   ONCOGENE

Regulation of miR-19 to Breast Cancer Chemoresistance Through Targeting PTEN

(2011) Zhongxing Liang et al.   PHARMACEUTICAL RESEARCH

RNA and transcriptional modulation of gene expression

(2010) Peter G. Hawkins et al.   CELL CYCLE

Foxo3a Regulates Apoptosis by Negatively Targeting miR-21

(2010) Kun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relationship between mutation of serine residue at 315th position in M. tuberculosis catalase-peroxidase enzyme and Isoniazid susceptibility: An in silico analysis

(2010) Rituraj Purohit et al.   JOURNAL OF MOLECULAR MODELING

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

(2010) Laura Poliseno et al.   NATURE

miR-22 Forms a Regulatory Loop in PTEN/AKT Pathway and Modulates Signaling Kinetics

(2010) Nadav Bar et al.   PLoS One

Transcriptional inhibition of Hoxd4 expression by noncoding RNAs in human breast cancer cells

(2009) Yuliang Tan et al.   BMC MOLECULAR BIOLOGY

The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo

(2009) J. T. Huse et al.   GENES & DEVELOPMENT

Regulation of Akt(ser473) phosphorylation by Choline kinase in breast carcinoma cells

(2009) Boon Chua et al.   Molecular Cancer

Structural basis for the resilience of Darunavir (TMC114) resistance major flap mutations of HIV-1 protease

(2009) Rituraj Purohit et al.   Interdisciplinary Sciences-Computational Life Sciences

Differential Expression of PTEN-Targeting MicroRNAs miR-19a and miR-21 in Cowden Syndrome

(2008) Marcus G. Pezzolesi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The PTEN/PI3K/AKT Signalling Pathway in Cancer, Therapeutic Implications

(2008) Amancio Carnero et al.   CURRENT CANCER DRUG TARGETS

Identification and Characterization of Neuronal Mitogen-activated Protein Kinase Substrates Using a Specific Phosphomotif Antibody

(2008) Dieter Edbauer et al.   MOLECULAR & CELLULAR PROTEOMICS

Molecular architecture of a miRNA-regulated 3' UTR

(2008) D. Didiano et al.   RNA