4.1 Article

Sulphur Mineral Water and SPA Therapy in Osteoarthritis

Journal

THERAPIE
Volume 67, Issue 1, Pages 43-48

Publisher

ELSEVIER SCIENCE BV
DOI: 10.2515/therapie/2012002

Keywords

SPA therapy; quality of life; osteoarthritis; depression

Ask authors/readers for more resources

Sulphur Mineral Water and SPA Therapy in Osteoarthritis. Objective. Osteoarthritis (OA), the most common degenerative osteoarticular disease, is cause of pain and limitations in physical function with high disability that can conduct to a state of psycological stress, not always considered adequately, with negative impact on the quality of life. The mud and bath therapy can improve this aspect. However, these studies are insufficient. The objective of our research was to evaluate the impact of SPA therapy cycle on safety, efficacy and psychosocial disability in osteoarthritis. Materials and methods. The study was carried out on 99 subjects suffering from OA. The patients has treated for 12 days with applications of sulphurous mud-bath therapy from Terme di Telese (Benevento, Italy). At the beginning and at the end of the SPA therapy considered has assessed: 1) the adverse reactions; 2) the efficacy on the pain and functional limitations; c) the impact on the psychosocial function using the VAS scale, the SF-36 questionnaire, the WOMAC index and the SDS-Zung test. Statistical analysis of the data was performed by determining the mean +/- SD. The results were compared with the Student t test or Wilcoxon test. A p value <0.05 was considered significant. Results. In comparison to the basal values, this investigation has demonstrated that sulphurous mud and bath therapy has induced a significant (p < 0.01) improvement of overall quality of life with reduction of pain at rest (2.1 +/- 1.5 -> 1.2 +/- 1.3) and during daily activities (2.3 +/- 1.3 -> 1.4 +/- 1.3). This has facilitated the physical function and psychosocial disability as shown by the questionnaires SF-36, WOMAC and SDS Zung. Conclusions. In conclusion our data suggest that mud-bath therapy with sulphurous mineral water can be considered as an important phase of the therapeutic strategy in OA.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.1
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Nutrition & Dietetics

Antioxidant Supplementation Hinders the Role of Exercise Training as a Natural Activator of SIRT1

Carmine Sellitto, Graziamaria Corbi, Berenice Stefanelli, Valentina Manzo, Marta Trucillo, Bruno Charlier, Francesca Mensitieri, Viviana Izzo, Angela Lucariello, Angelica Perna, Germano Guerra, Antonio De Luca, Amelia Filippelli, Valeria Conti

Summary: The research showed that exercise training can increase SIRT1 levels, while antioxidant supplements may interfere with this effect by reducing SIRT1 activity.

NUTRIENTS (2022)

Article Medicine, General & Internal

Adverse Events Associated with BNT162b2 and AZD1222 Vaccines in the Real World: Surveillance Report in a Single Italian Vaccine Center

Maria Costantino, Carmine Sellitto, Valeria Conti, Graziamaria Corbi, Francesco Marongiu, Giovanni Genovese, Giuseppina Moccia, Mario Capunzo, Anna Borrelli, Pasquale Pagliano, Mario Farroni, Grazia Maria Lombardi, Maria Giovanna Elberti, Amelia Filippelli, Francesco De Caro

Summary: This observational study reports potential adverse events following immunization with two different COVID-19 vaccines, AZD1222 and BNT162b2. The study found a higher incidence of adverse events in the AZD-vac group compared to the BNT-vac group. Fever was the most frequent adverse event associated with AZD1222, while pain at the injection site was most frequent with BNT162b2. The study also found a higher incidence of adverse events in women after receiving the BNT162b2 vaccine.

JOURNAL OF CLINICAL MEDICINE (2022)

Article Health Care Sciences & Services

Gender Differences in the Impact of COVID-19 Pandemic on Mental Health of Italian Academic Workers

Valentina Giudice, Teresa Iannaccone, Filomena Faiella, Filomena Ferrara, Giusi Aversano, Silvia Coppola, Elisa De Chiara, Maria Grazia Romano, Valeria Conti, Amelia Filippelli

Summary: According to an online survey conducted at the University of Salerno, Italy, there are gender differences in mental health status and teleworking after the first wave of the pandemic. Females tend to feel sadder, lonelier, more fearful, and more insecure than males. They also experience more sleep disorders and have a higher likelihood of sanitizing surfaces.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Article Medicine, General & Internal

Relationship between COVID-19 Mortality, Hospital Beds, and Primary Care by Italian Regions: A Lesson for the Future

Nicola Ferrara, Carlo Pietro Campobasso, Sergio Cocozza, Valeria Conti, Sergio Davinelli, Maria Costantino, Alessandro Cannavo, Giuseppe Rengo, Amelia Filippelli, Graziamaria Corbi

Summary: One of the characteristics of SARS-CoV-2 infection in Italy is the significant regional differences in lethality and mortality. This study analyzed the correlation between regional differences in COVID-19 mortality and different regional care models. The findings suggest that regions with more hospital beds and fewer general practitioners had higher death rates, indicating the need for a change in the current healthcare system organization.

JOURNAL OF CLINICAL MEDICINE (2022)

Article Medicine, General & Internal

Impact and Value of Hospital Antibiotic Stewardship: Retrospective Pre-COVID-19-Pandemic Analysis

Maria Costantino, Valeria Conti, Graziamaria Corbi, Alessandra Anna Iannelli, Francesco Marongiu, Martina Torsiello, Antonio Della Vecchia, Carmine Sellitto, Armando Genovese, Giuseppina Moccia, Amelia Filippelli, Francesco De Caro

Summary: This study aimed to evaluate the impact of antimicrobial stewardship (AMS) on antibiotic consumption trends. The results showed a decreasing trend in antibiotic consumption at the University Hospital, but an overall increase in total antibiotic consumption. AMS also led to a reduction in antibiotic therapy costs.

JOURNAL OF CLINICAL MEDICINE (2022)

Article Health Care Sciences & Services

Gender Differences Associated with the Prognostic Value of BPIFB4 in COVID-19 Patients: A Single-Center Preliminary Study

Valentina Lopardo, Valeria Conti, Francesco Montella, Teresa Iannaccone, Roberta Maria Esposito, Carmine Sellitto, Valentina Manzo, Anna Maciag, Rosaria Ricciardi, Pasquale Pagliano, Annibale Alessandro Puca, Amelia Filippelli, Elena Ciaglia

Summary: In the ongoing global COVID-19 pandemic, male sex is a risk factor for severe disease and death. While there are significant differences in inflammatory markers between males and females, no significant differences were found in inflammatory cytokine concentrations. The biomarker BPIFB4 is inversely related to disease severity in males but not in females. These findings provide insights into the gender-related susceptibility to COVID-19.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Article Biochemistry & Molecular Biology

Development and Validation of a UHPLC-MS/MS-Based Method to Quantify Cenobamate in Human Plasma Samples

Bruno Charlier, Albino Coglianese, Francesca Felicia Operto, Giangennaro Coppola, Ugo de Grazia, Pierantonio Menna, Amelia Filippelli, Fabrizio Dal Piaz, Viviana Izzo

Summary: Cenobamate is a new antiseizure medication used to reduce uncontrolled partial-onset seizures in adult patients. Its mechanism of action involves inhibiting sodium channels and modulating the GABA ion channel. A reliable analytical method using UHPLC-MS/MS was developed to determine the dosage of Cenobamate in plasma samples, and the pharmacokinetic parameters were evaluated in two non-adult patients.

MOLECULES (2022)

Article Virology

Antiviral Activity of Ficus rubiginosa Leaf Extracts against HSV-1, HCoV-229E and PV-1

Federica Dell'Annunziata, Carmine Sellitto, Gianluigi Franci, Maria Carla Marcotullio, Anna Piovan, Roberta Della Marca, Veronica Folliero, Massimiliano Galdiero, Amelia Filippelli, Valeria Conti, Domenico Vittorio Delfino

Summary: The extract of Ficus rubiginosa leaves showed antiviral activity against Herpes simplex virus-1 and Human coronavirus-229E, but not against Poliovirus-1. It may act by disrupting the viral lipid membrane or directly blocking the enriched proteins on the viral surface.

VIRUSES-BASEL (2022)

Review Infectious Diseases

Epidemiology, Mechanisms of Resistance and Treatment Algorithm for Infections Due to Carbapenem-Resistant Gram-Negative Bacteria: An Expert Panel Opinion

Nicola Coppola, Alberto Enrico Maraolo, Lorenzo Onorato, Riccardo Scotto, Federica Calo, Luigi Atripaldi, Anna Borrelli, Antonio Corcione, Maria Giovanna De Cristofaro, Emanuele Durante-Mangoni, Amelia Filippelli, Gianluigi Franci, Maria Galdo, Gaspare Guglielmi, Pasquale Pagliano, Alessandro Perrella, Ornella Piazza, Marco Picardi, Rodolfo Punzi, Ugo Trama, Ivan Gentile

Summary: Antimicrobial resistance is a serious threat to global health, requiring urgent development of new treatment strategies. Several drugs and combinations have been introduced in recent years to treat multi-drug-resistant bacteria, but their efficacy must be preserved through proper use. This paper provides an overview of the epidemiology and mechanisms of resistance of the most common MDR Gram-negative bacteria, proposing a treatment algorithm based on the latest clinical evidence for infections caused by carbapenem-resistant bacteria.

ANTIBIOTICS-BASEL (2022)

Article Medicine, General & Internal

Sex-Related Differences in Outpatient Healthcare of Acute Coronary Syndrome: Evidence from an Italian Real-World Investigation

Raffaella Ronco, Federico Rea, Amelia Filippelli, Aldo Pietro Maggioni, Giovanni Corrao

Summary: At the time of ACS hospital admission, women are older with more comorbidities than men, leading to differences in short-term prognosis. However, little research has focused on the differences in out-of-hospital management between men and women. This study found that women received fewer treatments, had fewer outpatient services, and had a lower risk of long-term clinical events compared to men. Both men and women benefited from improved adherence to clinical recommendations.

JOURNAL OF CLINICAL MEDICINE (2023)

Review Health Care Sciences & Services

Long COVID: Clinical Framing, Biomarkers, and Therapeutic Approaches

Valeria Conti, Graziamaria Corbi, Francesco Sabbatino, Domenico De Pascale, Carmine Sellitto, Berenice Stefanelli, Nicola Bertini, Matteo De Simone, Luigi Liguori, Ilenia Di Paola, Maddalena De Bernardo, Angela Tesse, Nicola Rosa, Pasquale Pagliano, Amelia Filippelli

Summary: Long COVID or post-COVID-19 syndrome (PCS) refers to the development of persistent symptoms and/or complications in patients diagnosed with COVID-19. The pathogenesis and course of this syndrome are influenced by factors such as age, sex/gender, and pre-existing conditions. The lack of precise diagnostic and prognostic biomarkers complicates the clinical management of patients. This review aims to summarize recent evidence on the factors influencing PCS, possible biomarkers, and therapeutic approaches.

JOURNAL OF PERSONALIZED MEDICINE (2023)

Article Chemistry, Medicinal

SIRT1 Signaling Is Involved in the Vascular Improvement Induced by Moringa Oleifera Seeds during Aging

Valeria Conti, Joseph Iharinjaka Randriamboavonjy, Herintsoa Rafatro, Valentina Manzo, Jessica Dal Col, Amelia Filippelli, Graziamaria Corbi, Angela Tesse

Summary: Vascular aging is associated with various factors such as reduced NO bioavailability, endothelial dysfunction, oxidative stress, and inflammation. This study investigated the effect of MOI on vascular improvement in middle-aged rats and its involvement of SIRT1. The results showed that MOI treatment enhanced SIRT1 expression and activity, reduced oxidative stress, and reversed FOXO1 expression in the aorta, suggesting its protective role against cardiovascular dysfunction due to aging.

PHARMACEUTICALS (2023)

Article Medicine, General & Internal

Marked Reduction of Oxidant Species after Sulfureous Crenotherapy in Females with Joint Diseases and Psoriasis: A Retrospective Real-Life Study

Maria Costantino, Valeria Conti, Graziamaria Corbi, Valentina Giudice, Francesco De Caro, Amelia Filippelli

Summary: Oxidative stress, induced by excessive free radicals, shows gender-related differences in cellular redox state and antioxidant responses. A study investigated the efficacy of sulfurous crenotherapy in decreasing oxidant species in patients with osteoarthritis or degenerative joint disease and Vulgar psoriasis. After 2 weeks of treatment, significant clinical improvement and reduction of oxidant species were observed in both sexes, with females showing greater improvement and reduction than males.

JOURNAL OF CLINICAL MEDICINE (2023)

Review Pharmacology & Pharmacy

Pharmacological Treatments and Therapeutic Drug Monitoring in Patients with Chronic Pain

Federica De Rosa, Bruno Giannatiempo, Bruno Charlier, Albino Coglianese, Francesca Mensitieri, Giulia Gaudino, Armando Cozzolino, Amelia Filippelli, Ornella Piazza, Fabrizio Dal Piaz, Viviana Izzo

Summary: This article aims to describe the pharmacological approaches currently used for the management of chronic pain. It covers several aspects, from the pain-scale-based methods to the commonly administered drugs. The article also discusses strategies to reduce problems related to opioid use, with a focus on therapeutic drug monitoring (TDM) and its potential for optimizing and personalizing opioid-based pain treatments based on recent scientific reports.

PHARMACEUTICS (2023)

Article Health Care Sciences & Services

Sulphurous Crenotherapy Is Effective at Reducing Pain and Disability in Overweight/Obese Patients Affected by Chronic Low Back Pain from Spine Osteoarthritis

Maria Costantino, Valeria Conti, Graziamaria Corbi, Irene Ciancarelli, Giovanni Morone, Amelia Filippelli

Summary: This study evaluates the efficacy of sulphurous crenotherapy in overweight/obese patients with chronic low back pain. The results show that sulphurous crenotherapy significantly improves pain and disability in these patients.

HEALTHCARE (2022)

No Data Available