Journal
ANTIBIOTICS-BASEL
Volume 11, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/antibiotics11091263
Keywords
carbapenem-resistant organisms; antimicrobial resistance; Enterobacterales; Acinetobacter baumannii; Pseudomonas aeruginosa; Stenotrophomonas maltophilia
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Antimicrobial resistance is a serious threat to global health, requiring urgent development of new treatment strategies. Several drugs and combinations have been introduced in recent years to treat multi-drug-resistant bacteria, but their efficacy must be preserved through proper use. This paper provides an overview of the epidemiology and mechanisms of resistance of the most common MDR Gram-negative bacteria, proposing a treatment algorithm based on the latest clinical evidence for infections caused by carbapenem-resistant bacteria.
Antimicrobial resistance represents a serious threat for global health, causing an unacceptable burden in terms of morbidity, mortality and healthcare costs. In particular, in 2017, carbapenem-resistant organisms were listed by the WHO among the group of pathogens for which novel treatment strategies are urgently needed. Fortunately, several drugs and combinations have been introduced in recent years to treat multi-drug-resistant (MDR) bacteria. However, a correct use of these molecules is needed to preserve their efficacy. In the present paper, we will provide an overview on the epidemiology and mechanisms of resistance of the most common MDR Gram-negative bacteria, proposing a treatment algorithm for the management of infections due to carbapenem-resistant bacteria based on the most recent clinical evidence.
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