Journal
TETRAHEDRON LETTERS
Volume 55, Issue 40, Pages 5539-5543Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.08.041
Keywords
Suzuki cross-coupling; Phosphine-free; Pd nanoparticles; Polyphenols; Sustainable synthesis
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Funding
- CSIR, New Delhi [CSC-107]
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A mild and selective protocol has been developed for the palladium-catalyzed phosphine-free Suzuki cross-coupling reaction of aryl bromides with arylboronic acids in aqueous tea extract at room temperature. It is noteworthy that the aqueous tea extract plays an important role in the reaction, and various functional groups are tolerated under the optimized conditions. The reactions proceeded with very good chemoselectivity in favor of the bromo instead of the chloro group even at higher temperatures. Furthermore, this protocol could be applied to the cross-coupling of 4-bromoindole without protecting the base sensitive amine group with arylboronic acids in moderate to excellent yields. (C) 2014 Elsevier Ltd. All rights reserved.
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