Article
Chemistry, Organic
Harshit Joshi, Debobrata Paul, Shyam Sathyamoorthi
Summary: We have developed protocols for the oxidation of alcohols and aldehydes as well as the oxidative cyclization of diols using a combination of Selectfluor and NaBr. The optimal solvent system is a 1:1 mixture of CH3CN/H2O for most substrates, but biphasic 1:1 mixtures of EtOAc/H2O or CH2Cl2/H2O are superior in select cases. This procedure is simple to perform, utilizes inexpensive and easily obtainable reagents, and can tolerate various functional groups. Mechanistic studies indicate that the active oxidant is hypobromous acid, which is generated by the rapid oxidation of Br- by Selectfluor in an aqueous environment.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Zhitong Zheng, Xu Ma, Xinpeng Cheng, Ke Zhao, Kaylaa Gutman, Tianyou Li, Liming Zhang
Summary: Homogeneous gold catalysis has seen significant development since the turn of the millennium, with oxidative gold catalysis being a vibrant subfield delivering valuable synthetic methods. This comprehensive review covers the mechanistic aspects, oxidants, and synthetic applications of oxidative gold catalysis.
Article
Chemistry, Applied
Yi-En Liang, Balaji D. Barve, Yao-Haur Kuo, Hsu-Wei Fang, Ting-Shen Kuo, Wen-Tai Li
Summary: A base-mediated, green, microwave-assisted efficient method for the synthesis of a diverse benzoxanthone library from readily accessible gamma-alkynyl 1,3-diketones was reported in this study. The synthesis involves tandem reactions including intramolecular cyclization, propargyl-allenyl isomerization, and electrocyclization in one pot, resulting in the formation of new C-C and C-O bonds.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Multidisciplinary Sciences
Yuta Matsukawa, Atsuya Muranaka, Tomotaka Murayama, Masanobu Uchiyama, Hikaru Takaya, Yoichi M. A. Yamada
Summary: This study demonstrated the microwave-assisted photooxidation of sulfoxides to sulfones using ethynylbenzene as a photosensitizer. The efficiency of the reaction was higher under microwave irradiation compared to conventional thermal heating, with ethynylbenzene promoting oxidation more efficiently than traditional photosensitizers. Ethynylbenzene's resistance to intersystem crossing and elongation of the T-1 state's lifetime by microwave make it suitable for this non-thermal effect reaction, marking the first use of ethynylbenzene as a photosensitizer in a microwave-assisted photoreaction.
SCIENTIFIC REPORTS
(2021)
Review
Chemistry, Applied
Jaleel Fairoosa, Salahudeen Shamna, Mohan Neetha, Gopinathan Anilkumar
Summary: Cyano compounds are versatile intermediates in organic synthesis with immense applications in various sectors, and microwave heating has improved synthetic chemistry by providing high product yield, shorter reaction time, less byproduct formation, selectivity, reproducibility, and high product purity. This review focuses on microwave assisted cyanation reactions, covering literature from 2000 to 2020.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Review
Chemistry, Organic
Qingqing You, Mingjie Liao, Huangdi Feng, Junhai Huang
Summary: The decarboxylation or decarboxylative coupling reactions of carboxylic acids and their derivatives are essential tools for organic synthesis. Microwave-assisted technology, recognized by both industry and academia, has been employed for sustainable organic synthesis. This review focuses on the recent developments in microwave-assisted decarboxylative reactions, including transition-metal-catalyzed and metal-free approaches.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Zhiliang Huang, Renpeng Guan, Elliot L. Bennett, Jianliang Xiao
Summary: This study discovered a photo-promoted catalytic system that efficiently oxidizes 1,2-diols to produce valuable compounds, while tolerating a wide range of functional groups.
Article
Environmental Sciences
Ken Sun, Fan Cheng, Yuxuan Liu, Yufeng Hua, Yifeng Zhang
Summary: The adsorption of tetracycline from wastewater using iron oxide under microwave oxidation condition was explored in this study. The results showed that microwave oxidation could promote the removal of antibiotics by iron oxide in livestock and poultry breeding wastewater.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Chemistry, Organic
Zhichao Wang, Shoko Yamazaki, Yuji Mikata, Miho Oba, Hiroshi Takashima, Tsumoru Morimoto, Akiya Ogawa
Summary: Intramolecular cycloaddition reactions of α-bromostyr-ene-functionalized amides have been investigated, resulting in the formation of 1,4-dihydronaphthalenes and naphthalene derivatives under suitable reaction conditions. The mechanisms of these reactions may involve the intervention of molecular oxygen and subsequent radical reactions.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Zainab Almansaf, Jiyun Hu, Federica Zanca, Hamid R. Shahsavari, Benjamin Kampmeyer, Miu Tsuji, Kartik Maity, Valerie Lomonte, Yumi Ha, Piero Mastrorilli, Stefano Todisco, Mourad Benamara, Rama Oktavian, Arsalan Mirjafari, Peyman Z. Moghadam, Ahmad R. Khosropour, Hudson Beyzavi
Summary: A new COF based on imine bonds with dual-pore structure and high crystallinity was successfully synthesized, and selectively metallated with Pt on the N donor in the larger pores. The metallated COF showed excellent performance as a recyclable heterogeneous photocatalyst for decarboxylative difluoroalkylation and oxidative cyclization reactions.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Jenna L. Miller, Jean-Marc I. A. Lawrence, Freddy O. Rodriguez del Rey, Paul E. Floreancig
Summary: This review primarily focuses on the application of carbon-hydrogen bond functionalizations in organic synthesis, with a particular emphasis on the mechanism, reaction development, natural product synthesis applications, approaches to catalysis, and use in enantioselective processes for hydride abstractions by quinone, oxoammonium ion, and carbocation oxidants. In addition to the commonly used quinone, oxoammonium ion, and carbocation hydride-abstracting agents, the potential of weaker ketone and triaryl borane oxidants has also been studied.
CHEMICAL SOCIETY REVIEWS
(2022)
Review
Chemistry, Multidisciplinary
Yuan-Zheng Cheng, Zuolijun Feng, Xiao Zhang, Shu-Li You
Summary: This article presents an overview of visible-light-induced dearomatization reactions and their applications. These reactions provide a rapid and efficient way to synthesize complex molecules from simple aromatic compounds and have significant implications in the synthesis of natural products, medicinal chemistry, and materials science.
CHEMICAL SOCIETY REVIEWS
(2022)
Review
Chemistry, Applied
Neha Rani, Rinku Soni, Monika Sihag, Mayank Kinger, Deepak K. Aneja
Summary: This review outlines the recent progress in reactions involving the combined approach of hypervalent iodine reagents and transition metals such as palladium, nickel, iridium, gold, rhodium, copper, iron, ruthenium, platinum, silver, zinc, rhenium, and cobalt. This approach enables organic transformations that are complementary to traditional reactions.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Review
Chemistry, Multidisciplinary
Yu Gao, Yuzhi Liu, Donglei Zou
Summary: This article reviews the application of microwave irradiation in synthesis and catalytic oxidation, including microwave irradiation alone, microwave with catalysts, microwave-Fenton, microwave-peralcohol, microwave-photochemistry, microwave-electrochemistry, and microwave-sonochemistry. Engineering for upscaling microwave irradiation is also presented.
ENVIRONMENTAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Organic
Bruce A. L. Sacchelli, Bianca C. Rocha, Leandro H. Andrade
Summary: An ultrafast methodology utilizing microwave irradiation was employed for the first time to construct novel highly functionalized 2-quinolinones from N-(o-ethynylaryl)-acrylamides (1,7-enynes). The method involved six key consecutive reactions, including a diastereoselective step, to achieve good overall yield of 2-quinolinone-fused gamma-lactones (up to 46%; 10 s).
Article
Pharmacology & Pharmacy
Mark L. Bannister, Anita Alvarez-Laviada, N. Lowri Thomas, Sammy A. Mason, Sharon Coleman, Christo L. du Plessis, Abbygail T. Moran, David Neill-Hall, Hasnah Osman, Mark C. Bagley, Kenneth T. MacLeod, Christopher H. George, Alan J. Williams
BRITISH JOURNAL OF PHARMACOLOGY
(2016)
Article
Chemistry, Multidisciplinary
Z. S. Al-Garawi, B. A. McIntosh, D. Neill-Hall, A. A. Hatimy, S. M. Sweet, M. C. Bagley, L. C. Serpell
Review
Chemistry, Multidisciplinary
Hatem M. Gaber, Mark C. Bagley, Zeinab A. Muhammad, Sobhi M. Gomha
Review
Chemistry, Organic
Hatem M. Gaber, Sobhi M. Gomha, Thoraya A. Farghaly, Zeinab A. Muhammad, Mark C. Bagley
CURRENT ORGANIC CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Sandra Roehm, Martin Schroeder, Jessica E. Dwyer, Caroline S. Widdowson, Apirat Chaikuad, Benedict-Tilman Berger, Andreas C. Joerger, Andreas Kraemer, Jule Harbig, Daniel Dauch, Mark Kudolo, Stefan Laufer, Mark C. Bagley, Stefan Knapp
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Chemistry, Organic
Arathy Jose, Raysa Khan Tareque, Martin Mortensen, Remi Legay, Simon J. Coles, Graham J. Tizzard, Barnaby W. Greenland, Trevor G. Smart, Mark C. Bagley, John Spencer
Summary: The study investigated the bioisosteric replacement of the chlorogroup in benzodiazepine with the SF5 group, leading to a decrease in potency for potentiating GABA(A) receptor activation after the replacement. This demonstrates the potential for further modification to form more complex scaffolds with highly fluorinated benzodiazepines.
Article
Biochemistry & Molecular Biology
Claudio Luparello, Ilenia Cruciata, Andreas C. Joerger, Cory A. Ocasio, Rhiannon Jones, Raysa Khan Tareque, Mark C. Bagley, John Spencer, Martin Walker, Carol Austin, Tiziana Ferrara, Pietro D' Oca, Rossella Bellina, Rossella Branni, Fabio Caradonna
Summary: Carbazole compounds PK9320 and PK9323, as second-generation analogues of PK083, have been shown to restore p53 signaling in cancer cells by binding to mutation-induced surface crevices. The study demonstrates that small modifications in carbazole substitution patterns can significantly impact their genotoxic and epigenetic properties, with PK9320 and PK9323 being potential candidates for anticancer and epi-compounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Mathematics, Applied
Omar Lakkis, Amireh Mousavi
Summary: In this article, we propose a least-squares method for recovering the gradient and possibly the Hessian of an elliptic equation in nondivergence form. By incorporating the curl-free constraint into the target functional, inf-sup stabilization is not required for the discrete spaces. We demonstrate the a priori and a posteriori convergence results using standard conforming finite elements, and validate our findings with numerical experiments involving uniform or adaptive mesh refinement.
IMA JOURNAL OF NUMERICAL ANALYSIS
(2022)
Article
Chemistry, Medicinal
Arathy Jose, Daniel Guest, Remi LeGay, Graham J. Tizzard, Simon J. Coles, Mariliza Derveni, Edward Wright, Lester Marrison, Alpha A. Lee, Aaron Morris, Matt Robinson, Frank von Delft, Daren Fearon, Lizbe Koekemoer, Tetiana Matviuk, Anthony Aimon, Christopher J. Schofield, Tika R. Malla, Nir London, Barnaby W. Greenland, Mark C. Bagley, John Spencer
Summary: The pentafluorosulfanyl (-SF5) group is gaining increasing interest as a bioisostere in medicinal chemistry. A library of SF5-containing compounds was synthesized using various methods and tested against different targets. The results demonstrate the utility of the SF5 group in medicinal chemistry.
Review
Pharmacology & Pharmacy
Yifeng Cao, Yifeng Ma, Yi Tao, Weifeng Lin, Ping Wang
Summary: OA is a common joint disease, and current clinical treatments are limited to pain relief and anti-inflammation, emphasizing the need to develop disease-modifying drugs for more efficient treatment. Intra-articular injection delivers drugs directly to the joints, increasing drug concentration and reducing side effects, calling for proper design of drug delivery systems to prolong retention time and improve targeting.
Article
Chemistry, Multidisciplinary
Lydia A. Panther, Daniel P. Guest, Andrew McGown, Hugo Emerit, Raysa Khan Tareque, Arathy Jose, Chris M. Dadswell, Simon J. Coles, Graham J. Tizzard, Ramon Gonzalez-Mendez, Charles A. Goodall, Mark C. Bagley, John Spencer, Barnaby W. Greenland
Summary: Solvent-free synthesis using a vibratory ball mill enables new chemical reactions with reduced solvent waste and shorter reaction times. This study reports the functionalization of Br-2-NDI through Suzuki, Sonogashira, and Buchwald-Hartwig coupling reactions, producing important building blocks for organic electronics.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Andrew McGown, Anthony K. Edmonds, Daniel Guest, Verity L. Holmes, Chris Dadswell, Ramon Gonzalez-Mendez, Charles A. Goodall, Mark C. Bagley, Barnaby W. Greenland, John Spencer
Summary: The study demonstrates that a cheap and conventional sealed heating reactor can be a valuable alternative to a microwave reactor for synthesizing a large-scale MIDA boronate library, with shorter reaction times and energy and solvent savings.
Article
Polymer Science
Wing T. Lam, Tahkur S. Babra, Julian H. D. Smith, Mark C. Bagley, John Spencer, Edward Wright, Barnaby W. Greenland
Summary: In this study, a polyurethane-based composite was designed and synthesized to reduce the amount of viable SARS-CoV-2 virus in contact with the polymeric film surface without manual cleaning. The composite, loaded with silver nanoparticles, showed a significant reduction in viable virus load compared to the pristine polyurethane, suggesting its potential application as a retrofit surface for common touchpoints.
Review
Biochemistry & Molecular Biology
James R. Hanson, Tyler Nichols, Yousef Mukhrish, Mark C. Bagley
NATURAL PRODUCT REPORTS
(2019)
Article
Chemistry, Medicinal
Terence Davis, Amy J. C. Brook, Michal J. Rokicki, Mark C. Bagley, David Kipling
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
