☆ 4.4 Article

An efficient intermolecular BINAM-copper(I) catalyzed Ullmann-type coupling of aryl iodides/bromides with aliphatic alcohols

TETRAHEDRON LETTERS (2008)

Journal

TETRAHEDRON LETTERS

Volume 49, Issue 19, Pages 3147-3151

Publisher

PERGAMON-ELSEVIER SCIENCE LTD

DOI: 10.1016/j.tetlet.2008.03.015

Keywords

copper catalyst; coupling reaction; alkyl aryl ether; diamine ligands; Ullmann coupling

Categories

Chemistry, Organic

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Abstract

A wide range of alkyl aryl ethers are synthesized from the corresponding aryl iodides and aliphatic alcohols through Ullmann-type intermolecular coupling reactions in the presence of a catalytic amount of easily available BINAM-Cul complex. Less reactive aryl bromides have also been shown to react with aliphatic alcohols under identical reaction conditions to give good yields of the alkyl aryl ethers without increasing the reaction temperature and time. (C) 2008 Published by Elsevier Ltd.

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