Article
Chemistry, Organic
Guillaume Reynard, Helene Lebel
Summary: A new alkylation reaction of monosubstituted tetrazoles via the diazotization of aliphatic amines was reported in this study, allowing for preferential formation of 2,5-disubstituted tetrazoles. Additionally, a one-pot 1,3-dipolar cycloaddition/diazotization sequence starting from widely available nitriles was described. The quenching of azide residues with nitrite reagent in the second step limited the intrinsic risk associated with trimethylsilyl azide and the reaction conditions were compatible with several functional groups.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Guillaume Reynard, Julien Moisan-Labelle, Etienne Parent, Helene Lebel
Summary: This study describes a method for the synthesis of disubstituted tetrazoles from 1H-5-monosubstituted tetrazoles via the aliphatic amine diazotization reaction. The transient alkyl diazonium intermediate acts as an alkylating agent. Although the 2,5-disubstituted tetrazole is preferentially formed, the minor 1,5-disubstituted tetrazole can also be isolated in some cases. The regioselectivities are highly variable and cannot be solely attributed to steric hindrance.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Organic
Andres Alexis Ramirez-Coronel, Ramaswamy Sivaraman, Yehya Mohammed Ahmed, Russul Reidh Abass, Hawraa Abd Kareem
Summary: This research reports the high-yielding and simple synthesis of 5-substituted 1H-tetrazoles derivatives through a one-pot three-component reaction catalyzed by MNPs-Picolylamine-Cu(OAc)(2) nanocomposite in water under microwave irradiation. The MNPs-Picolylamine-Cu(OAc)(2) catalyst, synthesized by immobilizing copper (II) acetate on magnetic Fe3O4 nanoparticles modified with Picolylamine, was extensively characterized using various techniques. The catalyst showed easy recyclability and reusability, and the obtained products exhibited high efficiency and purity.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Biochemistry & Molecular Biology
Mohaddeseh Sajjadi, Mahmoud Nasrollahzadeh, Hossein Ghafuri, Talat Baran, Yasin Orooji, Nuray Yilmaz Baran, Mohammadreza Shokouhimehr
Summary: A novel heterogeneous catalyst PdNPs@CS-Zeo has been developed for the efficient synthesis of 5-substituted-1H-tetrazoles, with high reaction yields and easy work-up procedure. The synthesized PdNPs@CS-Zeo nanocatalyst showed excellent catalytic activity and could be reused multiple times.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Mohammad Ghadermazi, Somayeh Molaei, Nahid Ghadermazi
Summary: Novel recyclable mesoporous-supported iron particles with and without ligands were developed for the synthesis of 5-substituted H-1-tetrazoles from aryl nitriles in water. Fe3+ species were identified as active sites, with the ligand-supported catalyst displaying better catalytic activity due to improved interaction with the support. The catalysts can be easily separated, recovered, and reused multiple times with consistent activity.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Chemistry, Inorganic & Nuclear
Mohammad Ghadermazi, Somayeh Molaei
Summary: Samarium (III) complex immobilized in MCM-41 was synthesized and characterized. The catalysts showed the attachment of 3,4,5-tri hydroxyphenyl acetic acid ligand and Sm ions to the MCM-41 host. These catalysts exhibited good performance in the synthesis of 5-substituted 1H-tetrazoles through [3 + 2] cycloaddition with NaN3. The catalyst also showed excellent recyclability without significant loss of activity for up to six cycles.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Polymer Science
Mohammad Ghadermazi, Somayeh Molaei, Seyed Mohsen Mousavipour
Summary: A series of bimetallic Fe/Cu mesostructured samples were synthesized using post-functionalization modification of MCM-41, resulting in MCM-41@Cu-Fe and MCM-41@Gln@Cu-Fe samples. A bimetallic mesostructured Fe-Cu/MCM-41 catalyst was also synthesized using the co-condensation method (Cu-Fe/MCM-41). The catalysts were characterized and their properties were investigated. The Cu-Fe/MCM-41 catalyst exhibited better catalytic activity in the synthesis of 5-substituted 1H-tetrazoles compared to other catalysts.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2023)
Article
Green & Sustainable Science & Technology
P. Movaheditabar, M. Javaherian, V Nobakht
Summary: This work reports a successful and versatile water preparation of 5-substituted-1H-tetrazoles via click reaction using steelmaking slag as a catalyst. The method offers advantages such as simplicity, reliability, and environmental friendliness, and holds potential for further applications in organic synthesis and industrial requirements.
JOURNAL OF SUSTAINABLE METALLURGY
(2022)
Article
Chemistry, Multidisciplinary
Padmakar A. Kulkarni, Ashis Kumar Satpati, Maiyalagan Thandavarayan, Suresh S. Shendage
Summary: The Cu-Amd-RGO catalyst prepared in this study showed excellent catalytic activity and recyclability for the synthesis of tetrazole derivatives, with an average particle size of Cu at 7.6 nm. Characterization of the catalyst was done using FE-SEM, TEM, FTIR, and XRD analyses.
Article
Chemistry, Applied
Mohammad Ghadermazi, Somayeh Molaei, Shida Khorami
Summary: Cu-functionalized mesoporous MCM-41 materials were successfully synthesized using two different methods, and their structural properties were characterized using various techniques. These catalysts exhibited efficient catalytic performance for the synthesis of 5-substituted 1H-tetrazoles in water, with high catalytic activity at low-temperature.
JOURNAL OF POROUS MATERIALS
(2023)
Article
Green & Sustainable Science & Technology
Rohit Rai, Rahul Ranjan, Chandra Kant, Udita Uday Ghosh, Prodyut Dhar
Summary: This study presents a simple method for preparing mechanically robust, water-stable, and biodegradable straws using partially delignified and microwave-treated bamboo. These straws show water stability for up to 16 hours, low wettability, and long-term stability. They also exhibit improved mechanical properties and high biodegradability. Life cycle analysis reveals that the microwave-irradiated bamboo straws have significantly reduced global warming potential and human health damage impact compared to plastic straws. Therefore, microwave-treated bamboo drinking straws can be a low-cost, eco-friendly, biodegradable, and sustainable alternative to paper and plastic straws.
ADVANCED SUSTAINABLE SYSTEMS
(2023)
Article
Chemistry, Applied
Mostafa Koolivand, Mohsen Nikoorazm, Arash Ghorbani-Choghamarani, Masoud Mohammadi
Summary: A highly stable and efficient heterogeneous catalyst was prepared successfully, which demonstrated excellent catalytic performance in the synthesis of specific molecules and showed good reusability and stability.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Chieh-Kai Chan, Chien-Yu Lai, Cheng-Chung Wang
Summary: A facile synthetic methodology for the preparation of 2,3-dialkylquinolines from anilines and propionaldehydes using environmentally friendly Nafion(R) NR50 as an acidic catalyst and microwave irradiation as the heating source is reported. The protocol allowed for the preparation of substituted 2-ethyl-3-methylquinolines with good to excellent yields. Some new chemical structures were confirmed by X-ray single-crystal diffraction analysis, and possible reaction mechanisms were discussed.
Article
Chemistry, Multidisciplinary
Jung-Ah Shin, Sejin Lee
Summary: A simple, environmentally friendly, and reusable method was developed for the synthesis of substituted tetrazoles. Nitriles were treated with sodium azide in a deep eutectic solvent to achieve high yields of products, easy workup procedure without harmful organic solvents, and recyclability of the solvent, making it environmentally benign.
Article
Chemistry, Multidisciplinary
DaPeng Xu, Meilu Xiong, Milad Kazemnejadi
Summary: A new green methodology has been developed for efficient reduction of nitroarenes and preparation of 1-substituted-1H-1,2,3,4-tetrazoles using Pd(ii)-polysalophen coated magnetite NPs as a recyclable nanocatalyst. The catalyst possesses dual-functionality for nitroarene reduction and tetrazole ring construction in one step. Characterization of the catalyst was conducted through various analytical methods, and insight into the mechanism was provided through XPS and DLS studies.
Article
Chemistry, Applied
Mahmoud Abd El Aleem Ali Ali El-Remaily, Ahmed M. M. Soliman, Mohamed E. Khalifa, Nashwa M. El-Metwaly, Amerah Alsoliemy, Tarek El-Dabea, Ahmed M. Abu-Dief
Summary: New thiazole complexes were synthesized from Cu (II), Fe (III), and Pd (II) ions, with a focus on the beneficial catalytic activity of ARPTPd in mild conditions for the synthesis of dihydrotetrazolo[1,5-a]pyrimidine derivatives. The advantages of using green solvent, shorter reaction time, and high product yield were highlighted, along with the superior performance of ARPTPd compared to other catalysts.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Ahmed M. Elsayed, Mahmoud Abd El Aleem Ali Ali El-Remaily, Kaoud S. M. Salama, Antar A. Abdelhamid
Summary: A one-pot synthetic method for [(3-cyano-5-phenyl-1H-pyrrol-2-yl)sulfanyl]acetic acids with excellent yield was developed using TBAB catalyzed reaction under phase transfer catalysis conditions. The synthesized compounds showed good in vitro antibacterial and antifungal activities, especially exhibiting strong inhibitory effects against the E. coli MurB enzyme.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Antar A. Abdelhamid, Kaoud S. M. Salama, Ahmed M. Elsayed, Mohamed A. Gad, Mahmoud Abd El Aleem Ali Ali El-Remaily
Summary: In this study, a series of biologically active pyrrole derivatives were synthesized and tested for their toxicological characteristics against Spodoptera littoralis and cotton leafworm. Compounds 6a, 7a, 8c, and 3c showed the highest insecticidal bioefficacy.
Article
Biochemistry & Molecular Biology
Moumen S. Kamel, Amany Belal, Moustafa O. Aboelez, E. Kh Shokr, H. Abdel-Ghany, Hany S. Mansour, Ahmed M. Shawky, Mahmoud Abd El Aleem Ali Ali El-Remaily
Summary: Novel pyrrolo [2,3-b] pyrrole derivatives with hypolipidemic and antimicrobial activities were synthesized and evaluated. Compounds 5 and 6 exhibited significant hypolipidemic effects, making them promising candidates for anti-atherosclerotic and hypolipidemic properties. Compound 2 showed moderate activity against Pseudomonas aeruginosa, while compound 3 demonstrated good antimicrobial activity against Staphylococcus aureus. These derivatives also displayed good anticancer activity against three tested cell lines.
Article
Biochemistry & Molecular Biology
Moustafa O. Aboelez, Moumen S. Kamel, Amany Belal, Ahmed El Badry Abdel-Aziz, Mohammed A. S. Abourehab, H. Abdel-Ghany, Mohamed A. El Hamd, Mahmoud Abd El Aleem Ali El-Remaily
Summary: In this study, new compounds were successfully synthesized and evaluated for their antimicrobial and anticancer activities. Compound 3 exhibited the most potent anticancer and anti-EGFR activities, while compound 2 showed the highest antioxidant activity. Moreover, compounds 2, 6, 7, and 8 were found to be the safest compounds.
MOLECULAR DIVERSITY
(2023)
Article
Materials Science, Multidisciplinary
Mahmoud Abd El Aleem Ali Ali El-Remaily, Moumen S. Kamel, Shimaa Abdel Halim, E. Kh Shokr, H. Abdel-Ghany, Hesham Hamad
Summary: A new characteristic with inexpensive preparation tools and best application performance has been achieved by using novel heterocyclic dyes. These compounds, synthesized through catalyzed condensation reaction and azo coupling, exhibit good adhesive properties and uniform thin films. The optical spectra reveal large direct band gaps, indicating potential applications in energy conversion.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Moumen S. Kamel, Moustafa O. Aboelez, Mohamed R. Elnagar, Elders Kh Shokr, Heba Mohammed Refat M. Selim, Hossam Eldin Abdel-Ghany, Ali M. Drar, Amany Belal, Mohamed A. El Hamd, Mahmoud Abd El Aleem Ali Ali El-Remaily
Summary: Green synthesis of novel pyrrole derivatives with insecticidal bioefficacy has been achieved. These compounds showed significant insecticide effects against cotton aphids and also exhibited antibacterial and antifungal activities. Computational tools were used to study their potential protein targets.
Article
Chemistry, Physical
Hany M. Abd El-Lateef, Mahmoud A. A. A. El-Remaily, A. Khodairy, Marwa M. Sayed, Nasr Yehia, Mai M. Khalaf, Kamal Aly
Summary: Novel unsaturated polyesters based on indazole moiety in the main chain were synthesized by interfacial poly-condensation. The copolyesters were characterized and analyzed by different techniques, including FTIR, 1H-NMR, XRD, TGA, and SEM. The synthesized copolyesters exhibited good thermal stability and morphology. They were also utilized as catalysts in the preparation of polysubstituted imidazoles and showed remarkable inhibition properties against mild steel corrosion in hydrochloric acid.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Sanaa A. Ahmed, Moumen S. Kamel, Moustafa O. Aboelez, Xiang Ma, Ahmed A. Al-Karmalawy, Sayed A. S. Mousa, Elders Kh. Shokr, H. Abdel-Ghany, Amany Belal, Mohamed A. El Hamd, Zafer S. Al Shehri, Mahmoud Abd El Aleem Ali Ali El-Remaily
Summary: In this study, novel derivatives of 3,4-diaminothieno[2,3-b]thiophene-2,5-dicarbonitrile were synthesized and analyzed. The compounds showed high cytotoxicity against MCF-7 and A549 cell lines, outperforming the reference standards erlotinib. Compound 2 exhibited the strongest activity against both forms of EGFR and also had the best antioxidant property. Molecular docking research was conducted to study the mechanism of action, and in silico tests were performed to explain the physicochemical features.
Article
Chemistry, Applied
Ahmed M. Abu-Dief, Musa A. Said, Omar Elhady, Hessah A. Al-Abdulkarim, Seraj Alzahrani, Thomas Nady A. Eskander, Mahmoud Abd El Aleem Ali Ali El-Remaily
Summary: A simple and highly tunable BSI ligand was synthesized, along with three new coordinating substances. The structures of these compounds were clarified using various spectroscopic and analytical methods. The thermal degradation behavior of the BSI complexes was investigated, and their antibacterial and anticancer properties were evaluated.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Ahmed M. Abu-Dief, Musa A. Said, O. Elhady, Nadiyah Alahmadi, Seraj Alzahrani, Thomas Nady A. Eskander, Mahmoud Abd El Aleem Ali Ali El-Remaily
Summary: A new class of bio-active Pd(II), Ni(II) and Fe(III) complexes were synthesized using the guanidine-based ligand (BSG). The structural characteristics were validated by various analytical techniques and the complexes were evaluated for their anticancer, antioxidant, antibacterial, and antifungal activities. Among them, the Pd(II) complex showed significant anticancer activity in MCF-7 breast carcinoma cells.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Applied
Mahmoud Abd El Aleem Ali Ali El-Remaily, Tarek El-Dabea, Rafat M. El-Khatib, Aly Abdou, Mohamed A. El Hamd, Ahmed M. Abu-Dief
Summary: Three GUBZCu, GUBZVO, and GUBZPd chelates were synthesized and characterized in terms of their molecular formula, stability constant, and catalytic performance. The results confirmed the promising catalytic activity and selectivity of these chelates in environmentally friendly synthesis reactions.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Ahmed M. Abu-Dief, Rafat M. El-Khatib, Tarek El-Dabea, Aly Abdou, Faizah S. Aljohani, Eida S. Al-Farraj, Ibrahim Omar Barnawi, Mahmoud Abd El Aleem Ali Ali El-Remaily
Summary: New medicinally active chelates were synthesized from Cu(II), VO(II), Ag(I), and Pd(II) ions using the N-(1H-Benzoimidazol-2-yl)-guanidine (BIG) ligand. The compounds were characterized using various techniques and theoretical studies were conducted to identify important features. The chelates exhibited good stability in solution and showed promising biological activities, including antimicrobial, antioxidant, and anticancer properties. These results suggest that the studied chelates have the potential to be used as bioactive agents.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Mahmoud Abd El Aleem Ali Ali El-Remaily, O. Elhady, Aly Abdou, Dalal Alhashmialameer, Thomas Nady A. Eskander, Ahmed M. Abu-Dief
Summary: We established new imidazole complexes using Pd2+, Fe3+, and Ni2+ ions, with the exception of the Pd (II) chelate (BIL-Pd) which has a square-planer configuration, the octahedral geometry was recommended for the other examined complexes. The condensation reaction of three components resulted in the synthesis of 5-amino-2-oxo-3,7-dihydro2H-pyrano[2,3-d]thiazole-6-carbonitrile derivatives under controlled and environmentally friendly conditions. The BIL-Pd complex showed effectiveness as a recyclable and promising heterogeneous solid catalyst.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Organic
Eman A. Ahmed, Ahmed Khodairy, Mahmoud Abd El Aleem Ali Ali El-Remaily, Abdelraheem M. Ahmed
Summary: New compounds were synthesized through Claisen-Schmidt condensation reaction and multistep reaction or one-pot three-component condensation reaction. The use of environmentally friendly solvents and optimized reaction conditions resulted in high yields and high efficiency.
CURRENT ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
