Article
Chemistry, Multidisciplinary
Takashi Yamamoto, Tsuyoshi Saitoh, Yasuaki Einaga, Shigeru Nishiyama
Summary: Natural products have played a significant role in drug discovery and organic chemistry development, with electrochemical reactions being investigated as a key step for natural product synthesis. Electro-organic synthesis allows for control of substrate reactivity by tuning electrolysis conditions, leading to the formation of important frameworks like diaryl ether, spirodienone, and spiroisoxazoline through anodic oxidation of phenol compounds.
Article
Environmental Sciences
Wendy Calzadilla, L. Carolina Espinoza, M. Silvia Diaz-Cruz, Adria Sunyer, Mario Aranda, Carlos Pena-Farfal, Ricardo Salazar
Summary: The study investigates the anodic oxidation of 30 pharmaceuticals in various electrolytic media, showing high mineralization rates and formation of intermediates and ions. The treatment process effectively removed pharmaceuticals in real effluent and proposed a degradation scheme for emerging contaminants, indicating the potential of anodic oxidation in wastewater treatment.
Article
Engineering, Environmental
Hiba ZIND, Leslie MONDAMERT, Quentin B. L. A. N. C. A. R. T. REMAURY, Alexis CLEON, Nathalie K. A. R. P. E. L. V. E. L. LEITNER, Jerome LABANOWSKI
Summary: This study investigated the contamination of pharmaceutical metabolites and transformation products in ten sites along three French rivers, revealing their presence in various compartments at different concentrations. QSAR models were used to predict the ecotoxicity of the studied compounds, showing that some metabolites and TPs may be more toxic than others.
Review
Environmental Sciences
Ivan Lozano, Carlos J. Perez-Guzman, Abrahan Mora, Jurgen Mahlknecht, Claudia Lopez Aguilar, Pabel Cervantes-Aviles
Summary: Pharmaceutical and personal care products (PPCPs) are emerging contaminants with adverse effects on organisms and human health. Electrochemical Advanced Oxidation Processes (EAOPs) are effective in removing PPCPs. Antibiotics, anti-inflammatory, and antifungal compounds are the main categories of PPCPs detected. Further research is needed to understand the removal of PPCPs under realistic conditions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Organic
Nicholas R. Deprez, Dane J. Clausen, Jia-Xuan Yan, Feng Peng, Shaoguang Zhang, Jongrock Kong, Yanguang Bai
Summary: This study presents an effective method for the selective oxidation of pyrrolidines to pyrrolidinones, showing high selectivity and functional group compatibility. It demonstrates the use of an operationally simple ElectraSyn 2.0 and cost-effective stainless-steel electrode for this electrochemical oxidation process.
Article
Chemistry, Multidisciplinary
Md Shamim Hossain, Md Abdul Khaleque, Md Romzan Ali, Md Sadek Bacchu, Md Ikram Hossain, Mohamed Aly Saad Aly, Md Zaved Hossain Khan
Summary: A glassy carbon working electrode modified with poly(3,4-ethylenedioxythiophene):polystyrene sulfonate was developed to detect furosemide with high sensitivity and precise selectivity. The modified electrode was characterized and an efficient and cost and time-efficient technique to study the furosemide mechanism of reaction in an acidic liquid medium was presented.
Article
Chemistry, Analytical
Pankaj Gupta, Connor E. Rahm, Benjamin Griesmer, Noe T. Alvarez
Summary: The study introduced an ultrasensitive electrochemical microelectrode set with highly densified carbon nanotube fiber electrodes, demonstrating excellent detection performance and stability for various analytes with wide linear ranges and low detection limits. The direct metallic connection to CNTs enabled access to the exceptional properties of highly ordered open-ended CNTs as electrochemical sensors, showing fast electron transfer kinetics and exceptional detection capabilities.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Disni Gunasekera, Jyoti P. Mahajan, Yanick Wanzi, Sachini Rodrigo, Wei Liu, Ting Tan, Long Luo
Summary: Here, a unique electrosynthetic method is reported, which selectively oxidizes tertiary amines to generate alpha-amino radical intermediates instead of iminium cations, providing arylation products. An electrochemical descriptor obtained from cyclic voltammetry studies predicts the optimal alternating current (AC) frequency for various amine substrates, avoiding time-consuming trial-and-error methods for optimizing reaction conditions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Engineering, Environmental
Lin-Feng Zhai, He-You Guo, Yue-Yue Chen, Min Sun, Shaobin Wang
Summary: The study demonstrates the potential of electrocatalytic wet air oxidation technology for the treatment of pharmaceuticals and personal care products in water environment. The system shows higher rate constants and lower specific energy consumption compared to conventional electro-oxidation systems, promising cost-effective and safe elimination of PPCPs pollution.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Environmental
Hao Jiang, Lizhang Wang, Bai Gao, Yiran Li, Yadan Guo, Mengning Zhuo, Kaixuan Sun, Binyu Lu, Meiyu Jia, Xiaoxia Yu, Huidong Wang, Yongge Li
Summary: Utilizing OH- oxidation as a counter reaction to CO2 electroreduction can increase formate production rate and faradic efficiency. Alkaline anolyte helps stabilize catholyte pH, avoiding competitive hydrogen evolution reaction, and has the lowest power consumption compared to other anolytes.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Shannon Heinrich, Hila Benhaim, Maxwell Mattejat, Daniel Pan, Sydney Dimarco, Guang Wu, Gabriel Menard
Summary: This article reports the synthesis and characterization of a series of new, tunable phosphine oxide ligands, derivatives of a previously reported uranyl capture agent. The effects of electron-withdrawing and electron-donating groups on the properties of the ligands were studied using electrochemical methods, and their extraction and back-extraction abilities for uranyl were investigated. The results showed that the substituents on the ligands significantly influenced their coordination properties.
INORGANIC CHEMISTRY
(2023)
Article
Engineering, Environmental
Ivan Lozano, Pabel Cervantes-Aviles, Arturo Keller, Claudia Lopez Aguilar
Summary: This review presents the current opinion on the application of electrochemical advance oxidation processes (EAOPs) for the degradation of pharmaceutical and personal care products (PPCPs) in water streams. It discusses the advances in anodic oxidation (AO)- and electro-Fenton (EF)-based processes, including operational conditions, electrode performance, and removal efficiency. The review also examines the techno-economic aspects of EAOPs, such as electrode selection, operational costs, cotreatments, and synergistic effects. The article concludes with perspectives on the emerging topics and challenges in the research and practice of EAOPs for PPCPs degradation.
WATER SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jing Xiao, Siyuan Tian, Hang Zhou, Aijun Gao, Lianghua Xu
Summary: In this study, anodic oxidation with acidic electrolyte was used to treat high-modulus carbon fibers. The influence of a graphitized structure on the anodizing reaction of the carbon fiber surface was investigated. The results showed that with sulfuric acid as an electrolyte, the oxidation mainly occurred on the graphite boundary defects, and the surface energy and interfacial properties of high-modulus carbon fibers were effectively improved without decreasing their mechanical properties.
Article
Engineering, Environmental
Xiaolong Yu, Xu Jin, Meng Li, Yuanyuan Yu, Minghan Zhu, Shaoyu Tang, Haijun Zhou, Kaifeng Wang, Rongni Dou, Jianteng Sun
Summary: The study explored the degradation of tetracycline hydrochloride (TC-H) using sulfide-modified nanoscale zerovalent iron (S-nZVI) activated peroxymonosulfate (PMS). Results showed that S-nZVI efficiently activated PMS to degrade TC-H, with the degradation process influenced by various factors such as humic acids (HA), Cl-, HPO42-, and NO3-. Additionally, sulfate radicals (SO4·-) and hydroxyl radicals (·OH) played significant roles in TC-H degradation, with SO4·- identified as the predominant species. XPS analysis revealed that changes in sulfide species contributed to enhancing electron transfer rates, thus improving TC-H degradation.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Physical
Yi Xu, Shijie Liu, Jonathan P. Edwards, Yurou Celine Xiao, Yong Zhao, Rui Kai Miao, Mengyang Fan, Yuanjun Chen, Jianan Erick Huang, Edward H. Sargent, David Sinton
Summary: Direct air capture (DAC) is a potential method for mitigating and offsetting carbon emissions, but current regeneration techniques have energy consumption and emissions issues. This study presents a low-temperature electrochemical process to regenerate capture liquids using alternating electrocatalysis, reducing energy consumption and emissions.
Meeting Abstract
Oncology
Charles Skarbek, Didier Desmaele, Alain Deroussent, Lea Lesueur, Estelle Daudigeos-Dubus, Ludivine Le Dret, Michael Rivard, Thierry Martens, Gilles Vassal, Patrick Couvreur, Angelo Paci
Article
Environmental Sciences
Hugo Olvera-Vargas, Sebastien Leroy, Michael Rivard, Nihal Oturan, Mehmet Oturan, Didier Buisson
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2016)
Article
Chemistry, Medicinal
Aniket Nikam, Anthony Ollivier, Michael Rivard, Jayne Louise Wilson, Kevin Mebarki, Thierry Martens, Jean-Luc Dubois-Rande, Roberto Motterlini, Roberta Foresti
JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Chemistry, Organic
Narimane Zeghbib, Paul Thelliere, Michael Rivard, Thierry Martens
JOURNAL OF ORGANIC CHEMISTRY
(2016)
Article
Pharmacology & Pharmacy
Charles Skarbek, Julia Delahousse, Catherine Pioche-Durieu, Sonia Baconnais, Alain Deroussent, Patrice Renevret, Michael Rivard, Didier Desmaele, Thierry Martens, Eric Le Cam, Patrick Couvreur, Angelo Paci
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2017)
Article
Biochemistry & Molecular Biology
Roberto Motterlini, Aniket Nikam, Sylvie Manin, Anthony Olivier, Jayne Louise Wilson, Sabrina Djouadi, Lucie Muchova, Thierry Martens, Michael Rivard, Roberta Foresti
Article
Pharmacology & Pharmacy
Celine Laurence, Narimane Zeghbib, Michael Rivard, Sonia Lehri-Boufala, Isabelle Lachaise, Caroline Barau, Philippe Le Corvoisier, Thierry Martens, Laure Garrigue-Antar, Christophe Morin
BIOCHEMICAL PHARMACOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Isabelle Lachaise, Narimane Zeghbib, Ghada Asskar, Michael Rivard, Thierry Martens
Article
Chemistry, Medicinal
Anthony Ollivier, Roberta Foresti, Zeina El Ali, Thierry Martens, Hiroaki Kitagishi, Roberto Motterlini, Michael Rivard
Article
Chemistry, Organic
Ghada Asskar, Michael Rivard, Thierry Martens
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Polymer Science
Pauline Sautrot-Ba, Steffen Jockusch, Jean-Pierre Malval, Vlasta Brezova, Michael Rivard, Samir Abbad-Andaloussi, Agata Blacha-Grzechnik, Davy-Louis Versace
Article
Biochemistry & Molecular Biology
Zeina El Ali, Anthony Ollivier, Sylvie Manin, Michael Rivard, Roberto Motterlini, Roberta Foresti
Article
Environmental Sciences
Fidji Sandre, Nina Huynh, Emilie Caupos, Lamyae El-Mrabet, Chandirane Partibane, Isabelle Lachaise, Christophe Pommier, Michael Rivard, Christophe Morin, Julien Le Roux, Laure Garrigue-Antar
Summary: Conventional wastewater treatment systems are ineffective in removing pharmaceutical compounds, which can degrade into unstudied transformation products. This study focuses on the occurrence and degradation of furosemide and its degradation products in different types of wastewater. The results show that furosemide was well degraded in the wastewater treatment plant, but its main degradation products were not detected at increased concentrations. Chlorination and ozonation processes effectively removed furosemide and its degradation products in water from care homes, but resulted in the production of saluamine. This study is the first to identify saluamine and pyridinium of furosemide in real water samples.
Article
Pharmacology & Pharmacy
Shruti Mohan, Louis -Antoine Barel, Djamal Eddine Benrahla, Bernard Do, Qiyue Mao, Hiroaki Kitagishi, Michael Rivard, Roberto Motterlini, Roberta Foresti
Summary: It has been discovered that metal carbonyls can be grafted onto polysaccharides to efficiently deliver carbon monoxide to cells, especially adipocytes. Oral administration of two functionalized CO-RMs glyco-CORMs (5b and 6b) can lead to CO accumulation in multiple organs, including adipose tissue. Furthermore, glyco-CORM 6b administered for eight weeks in mice fed a high-fat diet can result in anti-obesity and positive metabolic effects.
PHARMACOLOGICAL RESEARCH
(2023)
Meeting Abstract
Oncology
Julia Delahousse, Charles Skarbek, Valentine Gauthier, M. Desbois, Emilie Roger, C. Pioche-Durieu, M. Rivard, D. Desmaele, T. Martens, E. LeCam, Jean-Pierre Benoit, P. Couvreur, Nathalie Chaput-Gras, Angelo Paci
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
