Development of carbon monoxide-releasing molecules conjugated to polysaccharides (glyco-CORMs) for delivering CO during obesity

Advances in oral absorption of polysaccharides: Mechanism, affecting factors, and improvement strategies

(2022) Ziming Zheng et al.   CARBOHYDRATE POLYMERS

The piperazine scaffold for novel drug discovery efforts: the evidence to date

(2022) Maria Novella Romanelli et al.   Expert Opinion on Drug Discovery

Delivery of therapeutic carbon monoxide by gas-entrapping materials

(2022) James D. Byrne et al.   Science Translational Medicine

Sensitive quantification of carbon monoxide in vivo reveals a protective role of circulating hemoglobin in CO intoxication

(2021) Qiyue Mao et al.   Communications Biology

Therapeutic effects of CO-releaser/Nrf2 activator hybrids (HYCOs) in the treatment of skin wound, psoriasis and multiple sclerosis

(2020) Zeina El Ali et al.   Redox Biology

Cyclodextrins in Parenteral Formulations

(2020) Thorsteinn Loftsson   JOURNAL OF PHARMACEUTICAL SCIENCES

HO-1 overexpression and underexpression: Clinical implications

(2019) George S. Drummond et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Solubility of Cyclodextrins and Drug/Cyclodextrin Complexes

(2018) Phennapha Saokham et al.   MOLECULES

Modulation of cellular bioenergetics by CO-releasing molecules and NO-donors inhibits the interaction of cancer cells with human lung microvascular endothelial cells

(2018) Marta Stojak et al.   PHARMACOLOGICAL RESEARCH

HYCO-3, a dual CO-releaser/Nrf2 activator, reduces tissue inflammation in mice challenged with lipopolysaccharide

(2018) Roberto Motterlini et al.   Redox Biology

Carbon monoxide reverses the metabolic adaptation of microglia cells to an inflammatory stimulus

(2017) Jayne Louise Wilson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Detection and Removal of Endogenous Carbon Monoxide by Selective and Cell-Permeable Hemoprotein Model Complexes

(2017) Saika Minegishi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Targeting of Adipose Tissue Macrophages in Obesity with Polysaccharide Nanocarriers

(2016) Liang Ma et al.   ACS Nano

Vascular and angiogenic activities of CORM-401, an oxidant-sensitive CO-releasing molecule

(2016) Sarah Fayad-Kobeissi et al.   BIOCHEMICAL PHARMACOLOGY

Heme Oxygenase-1 and Carbon Monoxide in the Heart

(2016) Leo E. Otterbein et al.   CIRCULATION RESEARCH

Liver and Kidney on Chips: Microphysiological Models to Understand Transporter Function

(2016) SY Chang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Targeting adipose tissue in the treatment of obesity-associated diabetes

(2016) Christine M. Kusminski et al.   NATURE REVIEWS DRUG DISCOVERY

Polyethylene glycols in oral and parenteral formulations—A critical review

(2015) Rampurna P. Gullapalli et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Heme Oxygenase-1 Gene Therapy Provides Cardioprotection Via Control of Post-Ischemic Inflammation

(2015) Rabea Hinkel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Chronic treatment with a carbon monoxide releasing molecule reverses dietary induced obesity in mice

(2015) Peter A Hosick et al.   Adipocyte

Macrophages sense and kill bacteria through carbon monoxide–dependent inflammasome activation

(2014) Barbara Wegiel et al.   JOURNAL OF CLINICAL INVESTIGATION

Isothiocyanate–cysteine conjugates protect renal tissue against cisplatin-induced apoptosis via induction of heme oxygenase-1

(2014) Yasin Tayem et al.   PHARMACOLOGICAL RESEARCH

Heme Oxygenase-1 As a Target for Drug Discovery

(2013) Roberto Motterlini et al.   ANTIOXIDANTS & REDOX SIGNALING

Protective effects of inhaled carbon monoxide in endotoxin-induced cholestasis is dependent on its kinetics

(2013) K. Vanova et al.   BIOCHIMIE

The Immune System as a Sensor of the Metabolic State

(2013) Justin I. Odegaard et al.   IMMUNITY

Chronic carbon monoxide treatment attenuates development of obesity and remodels adipocytes in mice fed a high-fat diet

(2013) P A Hosick et al.   INTERNATIONAL JOURNAL OF OBESITY

Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells

(2013) Roberta Foresti et al.   PHARMACOLOGICAL RESEARCH

Interaction of Carbon Monoxide with Transition Metals: Evolutionary Insights into Drug Target Discovery

(2012) Roberta Foresti et al.   CURRENT DRUG TARGETS

Heme Oxygenase Gene Targeting to Adipocytes Attenuates Adiposity and Vascular Dysfunction in Mice Fed a High-Fat Diet

(2012) Jian Cao et al.   HYPERTENSION

Vasorelaxing effects and inhibition of nitric oxide in macrophages by new iron-containing carbon monoxide-releasing molecules (CO-RMs)

(2012) Roberto Motterlini et al.   PHARMACOLOGICAL RESEARCH

[Mn(CO)4{S2CNMe(CH2CO2H)}], a new water-soluble CO-releasing molecule

(2011) Sian H. Crook et al.   DALTON TRANSACTIONS

Mitochondrial proton and electron leaks

(2010) Martin Jastroch et al.   Essays in Biochemistry

The therapeutic potential of carbon monoxide

(2010) Roberto Motterlini et al.   NATURE REVIEWS DRUG DISCOVERY

Multimetallic arrays: Symmetrical bi-, tri- and tetrametallic complexes based on the group 10 metals and the functionalisation of gold nanoparticles with nickel-phosphine surface units

(2009) Edward R. Knight et al.   DALTON TRANSACTIONS

Heme Oxygenase-1 Induction Remodels Adipose Tissue and Improves Insulin Sensitivity in Obesity-Induced Diabetic Rats

(2009) Angelique Nicolai et al.   HYPERTENSION

Treatment of Obese Diabetic Mice With a Heme Oxygenase Inducer Reduces Visceral and Subcutaneous Adiposity, Increases Adiponectin Levels, and Improves Insulin Sensitivity and Glucose Tolerance

(2008) M. Li et al.   DIABETES