Article
Biochemistry & Molecular Biology
Panpan Wu, Borong Tu, Jinfeng Liang, Shengzhu Guo, Nana Cao, Silin Chen, Zhujun Luo, Jiahao Li, Wende Zheng, Xiaowen Tang, Dongli Li, Xuetao Xu, Wenfeng Liu, Xi Zheng, Zhaojun Sheng, Adam P. Roberts, Kun Zhang, Weiqian David Hong
Summary: A series of triterpenoid derivatives, including ursolic acid (UA), oleanolic acid (OA), and 18β-glycyrrhetinic acid (GA), were synthesized with various substituted aromatic side chains at the C-2 position. Among them, the GA derivative with aromatic side chains showed potent antibacterial activity against drug sensitive and resistant S. aureus, indicating potential for development of a new type of triterpenoid antibacterial agent.
BIOORGANIC CHEMISTRY
(2021)
Article
Plant Sciences
Luis Francisco Salome-Abarca, Thomas van der Toorn, Rogier van Vugt, Peter G. L. Klinkhamer, Young Hae Choi
Summary: The study investigated the chemical composition of latex and its antiherbivory activity, finding that latexes from different species had similar chemical profiles but higher mortality rates against thrips. The main metabolites correlated with antiherbivory activity were triterpenoids and steroids.
Review
Biochemistry & Molecular Biology
Marius Mioc, Alexandra Prodea, Roxana Racoviceanu, Alexandra Mioc, Roxana Ghiulai, Andreea Milan, Mirela Voicu, Gabriel Mardale, Codruta Soica
Summary: This paper summarizes the recent studies on the mechanism of action of several triterpenic acids, which have various biological activities and are important for drug development and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Elwira Chrobak, Ewa Bebenek, Krzysztof Marciniec, Monika Kadela-Tomanek, Szymon Siudak, Malgorzata Latocha, Stanislaw Boryczka
Summary: A series of betulin derivatives were synthesized and evaluated for anticancer activity, with one compound showing high cytotoxicity. Molecular docking and ADME studies were also conducted for further analysis.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Multidisciplinary
Dominic F. Cairns-Gibson, Scott L. Cockroft
Summary: Nanopore technology, a powerful tool for single-molecule studies, has been widely used in sensing applications. The boundaries between synthetic, solid-state, and biological nanopores have become blurred with the emergence of hybrid functionalized pores. The convergence of chemically functionalized biological pores and bio-inspired functionalization of solid-state pores has led to enhanced functionality in systems.
Review
Biotechnology & Applied Microbiology
Nathchar Naowarojna, Ronghai Cheng, Juan Lopez, Christina Wong, Lu Qiao, Pinghua Liu
Summary: Protein chemical modifications play a key role in understanding the chemical and biological functions of proteins. Various strategies, including enzymatic tailoring reactions and unnatural amino acid incorporation, have been developed to implement these modifications. These technologies have been applied in metalloenzyme studies to unravel their mechanisms, enhance enzymatic activities, and create artificial enzymes with non-natural activities.
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY
(2021)
Review
Chemistry, Medicinal
Rodrigo de Souza Miranda, Barbara da Silva Mascarenhas de Jesus, Sandra Regina da Silva Luiz, Cristina Borges Viana, Camila Rodrigues Adao Malafaia, Fabiana de Souza Figueiredo, Tatiane dos Santos Conceicao Carvalho, Matheus Lopes Silva, Vinicius Silva Londero, Thais Alves da Costa-Silva, Joao Henrique Ghilardi Lago, Roberto Carlos Campos Martins
Summary: This review provides an overview of the anti-inflammatory effects of various triterpenes and their presumed mechanisms of action, based on articles published in the last 15 years. The findings suggest that triterpenes could be valuable natural products with potential pharmaceutical applications.
PHYTOTHERAPY RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Sandra Gorska, Anna Maksymiuk, Jadwiga Turlo
Summary: Selenosugars are a diverse group of sugar derivatives with potential biological and pharmacological activities, including antitumor, immune-enhancement, and antioxidant effects. The synergy between selenium and polysaccharides in Se-polysaccharides may lead to enhanced pharmacological properties for applications in various health-related benefits.
APPLIED SCIENCES-BASEL
(2021)
Review
Biochemistry & Molecular Biology
Maria Celeste Dias, Diana C. G. A. Pinto, Artur M. S. Silva
Summary: Flavonoids are natural antioxidants synthesized in plants, playing a crucial role in plant stress tolerance and human health with anti-inflammatory and antimicrobial properties. They also have various applications in the food industry, cosmetics, and pharmaceuticals. Developing extraction methods for flavonoids with high purity and yield is essential for their industrial use.
Article
Chemistry, Multidisciplinary
Abdullah A. Elgazar, Ramadan A. El-Domany, Wagdy M. Eldehna, Farid A. Badria
Summary: In this study, new compounds based on AKBA were developed for managing drug-induced liver injury. These compounds exhibited superior anti-inflammatory activity and hepatoprotective potential, and their action mechanisms were explored through molecular docking and network pharmacology analysis.
Article
Food Science & Technology
Xinyu Yu, Xinyue Tu, Lingchen Tao, Jayasimha Daddam, Shanshan Li, Fuliang Hu
Summary: This review summarizes the current knowledge on the chemical composition, extraction methods, and biological activities of royal jelly fatty acids, providing a theoretical basis for expanding prospective applications of royal jelly in human health.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Hippolyt L. Greve, Marcel Kaiser, Pascal Maeser, Thomas J. Schmidt
Summary: In the search for leads from medicinal plants against protozoal pathogens, antileishmanial activity was found in polar fractions of a dichloromethane extract from Boswellia serrata resin. Among the tested compounds, 3-O-acetyl-11-keto-beta-boswellic acid (AKBA) showed the strongest activity against Leishmania donovani axenic amastigotes.
Article
Biochemistry & Molecular Biology
Elwira Sieniawska, Lukasz Swiatek, Kouadio Ibrahime Sinan, Gokhan Zengin, Anastazja Boguszewska, Malgorzata Polz-Dacewicz, Nabeelah Bibi Sadeer, Ouattara Katinan Etienne, Mohamad Fawzi Mahomoodally
Summary: This study evaluated the biological and chemical properties of Ficus sur Forssk. extracts, revealing their antioxidant, enzyme inhibitory, anticancer, and antiviral activities. The findings provide valuable scientific data for the development of innovative phytopharmaceuticals.
Article
Pharmacology & Pharmacy
Allisson Jhonatan Gomes Castro, Luisa Helena Cazarolli, Marisa Jadna Silva Frederico, Betina Fernanda Dambros, Francieli Kanumfre de Carvalho, Veronica Aiceles de Medeiros Pinto, Cristiane da Fonte Ramos, Fabiola Branco Filippin Monteiro, Moacir Geraldo Pizzolatti, Fatima Regina Mena Barreto Silva
Summary: THO reduces hyperglycemia by increasing serum insulin and hepatic glycogen content. The mechanism of action in adipose tissue for glucose uptake is suggested to be via GLUT4 translocation stimulation mediated by a p38-dependent mechanism.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hasna Abdullah Alali, Osama Saber, Mahmoud Mohamed Berekaa, Doaa Osama, Mohamed Farouk Ezzeldin, Nagih M. Shaalan, Abdulaziz Abdulrahman AlMulla
Summary: Novel nanomaterials with antimicrobial properties are being developed to prevent infectious diseases caused by antibiotic-resistant bacteria commonly found in wastewater and the environment. Nanohybrids based on carbon nanotubes and fatty acids were found to be effective against E. coli, while nanolayered structures prepared using ultrasonic waves showed inhibitory effects on S. aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa. These nanomaterials, which can be modified at low cost with high productivity and simple operations, have great potential for preventing infectious diseases and inhibiting the spread of bacteria.
Article
Microbiology
Jeremy J. Hoffman, Reena Yadav, Sandip Das Sanyam, Pankaj Chaudhary, Abhishek Roshan, Sanjay Kumar Singh, Simon Arunga, Victor H. Hu, David Macleod, Astrid Leck, Matthew J. Burton
Summary: This study investigated the clinical and epidemiological features of microbial keratitis in Nepal and developed a predictor score to determine the microbial aetiology. Fungal infection was found to be the main cause of keratitis, with dematiaceous fungi being particularly prevalent. Serrated infiltrate margins, patent nasolacrimal duct, raised corneal slough, and organic trauma were identified as independent predictors of fungal keratitis.
Article
Nanoscience & Nanotechnology
Swaroop Chakraborty, Prabhat Prakash, Juhi Shah, Chaithra Mayya, Sanjay Singh, Raghavan Ranganathan, Virupakshi Soppina, Eugenia Valsami Jones, Superb K. Misra
Summary: This study investigates the enhanced generation of intracellular oxidative stress through the use of CuO nanoparticles as a reservoir for slow and sustained release of Cu (II) ions to bind with Elesclomol. The results show promising potential for Elesclomol-based anticancer therapy.
ACS APPLIED NANO MATERIALS
(2022)
Article
Physics, Condensed Matter
Shakeel Ahmad Sofi, Thamraa Alshahrani, Manal Morsi, Dinesh C. Gupta
Summary: This study investigates the physical properties of two Cobalt-based Heusler materials using density functional theory calculations and Boltzmann transport simulations. The results show that these materials exhibit half-metallic behavior, ferromagnetic half-metallic character, good mechanical stability, and directional-dependent thermal conductivity.
PHYSICA STATUS SOLIDI B-BASIC SOLID STATE PHYSICS
(2022)
Article
Biotechnology & Applied Microbiology
Vishal Unadkat, Shishir Rohit, Paranjay Parikh, Kaushal Patel, Vinod Sanna, Sanjay Singh
Summary: This study investigated heterocyclic derivatives with 1,2,4 oxadiazole scaffold as mimics of tyrosine kinase inhibitors through molecular dynamics simulations and in vitro experiments. The results showed that some of these compounds exhibited activity against EGFRWT and mutant EGFRT790M, holding promise for developing oral drug delivery formulations.
ONCOTARGETS AND THERAPY
(2022)
Article
Management
Ranya Saeed Alhumoudi, Sanjay Kumar Singh, Syed Zamberi Ahmad
Summary: Perceived corporate social responsibility has a positive impact on passionate attitudes towards work and mediates the relationship between perceived CSR and innovative work behavior. The study suggests mixed-method investigations for future research and emphasizes the importance of engaging in CSR activities for organizations. Passionate Gen Y nurses play a valuable role in improving patient care services through innovative work behavior.
INTERNATIONAL JOURNAL OF ORGANIZATIONAL ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Sanjeev Meena, Radheshyam Sharma, Sanjay Kumar Singh, Ashish Kumar, R. Shiv Ramakrishnan, Stuti Sharma, G. K. Koutu, Lokesh Gaur
Summary: This study characterized the genetic diversity of farmers' varieties in central India using SSR markers and blast-linked markers. The results showed clear geographical discrimination among the varieties and the presence of multiple blast resistance genes, which could be utilized in future breeding programs.
JOURNAL OF PLANT BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Computer Science, Information Systems
Durgesh Singh, Sanjay K. Singh, Sandeep Sambhaji Udmale
Summary: In this paper, a self-embedding block-wise fragile image watermarking scheme is proposed for authentication, localization, and recovery with enhanced accuracy. The scheme splits the cover image into non-overlapping blocks and calculates restoration and authentication bits from the MSBs planes. The proposed scheme achieves high-quality restoration and significant authentication possibilities for each block, with high Peak Signal to Noise Ratio and Normalized Correlation Coefficient up to 50% tampering rate.
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Article
Mycology
P. W. Crous, J. Boers, D. Holdom, E. R. Osieck, T. Steinrucken, Y. P. Tan, J. S. Vitelli, R. G. Shivas, M. Barrett, A-G Boxshall, J. Broadbridge, E. Larsson, T. Lebel, U. Pinruan, S. Sommai, P. Alvarado, G. Bonito, C. A. Decock, S. De la Pena-Lastra, G. Delgado, J. Houbraken, J. G. Macia-Vicente, H. A. Raja, A. Rigueiro-Rodriguez, A. Rodriguez, M. J. Wingfield, S. J. Adams, A. Akulov, T. AL-Hidmi, V Antonin, S. Arauzo, F. Arenas, F. Armada, J. Aylward, J-M Bellanger, A. Berraf-Tebbal, A. Bidaud, F. Boccardo, J. Cabero, F. Calledda, G. Corriol, J. L. Crane, J. D. W. Dearnaley, B. Dima, F. Dovana, A. Eichmeier, F. Esteve-Raventos, M. Fine, L. Ganzert, D. Garcia, D. Torres-Garcia, J. Gene, A. Gutierrez, P. Iglesias, L. Istel, P. Jangsantear, G. M. Jansen, M. Jeppson, N. C. Karun, A. Karich, P. Khamsuntorn, K. Kokkonen, M. Kolarik, A. Kubatova, R. Labuda, A. C. Lagashetti, N. Lifshitz, C. Linde, M. Loizides, J. J. Luangsa-ard, P. Lueangjaroenkit, S. Mahadevakumar, A. E. Mahamedi, D. W. Malloch, S. Marincowitz, A. Mateos, P-A Moreau, A. N. Miller, A. Molia, A. Morte, A. Navarro-Rodenas, J. Nebesarova, E. Nigrone, B. R. Nuthan, N. H. Oberlies, A. L. Pepori, T. Rama, D. Rapley, K. Reschke, B. M. Robicheau, F. Roets, J. Roux, M. Saavedra, B. Sakolrak, A. Santini, H. Sevcikova, P. N. Singh, S. K. Singh, S. Somrithipol, M. Spetik, K. R. Sridhar, M. Starink-Willemse, V. A. Taylor, A. L. van Iperen, J. Vauras, A. K. Walker, B. D. Wingfield, O. Yarden, A. W. Cooke, A. G. Manners, K. G. Pegg, J. Z. Groenewald
Summary: This study describes novel species of fungi from various countries, including Australia, Canada, Czech Republic, France, India, Israel, Italy, Netherlands, Norway, Portugal, South Africa, Spain, Sweden, Thailand, Ukraine, and USA. The morphological and culture characteristics of these fungi are supported by DNA barcodes.
Article
Engineering, Mechanical
Chaitanya Sharma, Vijay Verma, Basanthkumar, Sumit Kumar Sharma, Ajay Tripathi, Sanjay Kumar Singh, Pankaj Sonia
Summary: The present research aims to study the fatigue crack propagation and fracture toughness behavior of different zones of friction stir welds of AA7039 alloy. The study found that the welding process significantly altered the grain structure of the material, resulting in changes in grain size and structure in the weld zone and heat-affected zone. Despite higher hardness, the weld zone had slightly inferior tensile properties compared to the base metal. The fatigue life was determined by the cycles consumed in crack propagation rather than crack initiation. The heat-affected zone exhibited higher fracture toughness and resistance to crack growth.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART E-JOURNAL OF PROCESS MECHANICAL ENGINEERING
(2022)
Article
Business
Mehmet A. Orhan, Insaf Khelladi, Sylvaine Castellano, Sanjay Singh
Summary: The widespread use of digital labor platforms has transformed global work, but also brought many challenges. This paper examines the impact of turking on workers' overall well-being by studying microtask platforms. The study finds that task characteristics, excessive working, and financial pressure have direct and indirect effects on workers' quality of life.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2022)
Article
Thermodynamics
Sanjay Kumar Singh, Ruchin Kacker, Prem Kumar Chaurasiya, Satyam Shivam Gautam
Summary: This study investigates the effects of swirl flow, primary and secondary vortex flow, v-cut, and teeth on a toothed v-cut twisted tape insert on heat transfer rate, friction factor, and performance evaluation criterion. The experiments were conducted on a double pipe heat exchanger and the results show that including teeth on the v-cut enhances the secondary vortex flow and increases the heat transfer rate.
INTERNATIONAL COMMUNICATIONS IN HEAT AND MASS TRANSFER
(2022)
Article
Biochemistry & Molecular Biology
Priti Talwar, Pratibha Singh, Palaniyandi Ravanan
Summary: Recently, a new signaling complex involving DAPK1 and NR2B was discovered to play a role in neuronal death cascade, where NMDA receptors interact with DAPK1 through NR2B subunit after stroke injury, leading to excitotoxicity. Using the ZINC-12 database, potential inhibitors of DAPK1 were identified, particularly natural compounds showing strong binding affinity with both ATP-binding site residues and substrate-recognition motifs. These findings suggest that these ligands have the potential to be inhibitors of DAPK1.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Ashish Malik, Sanjay Kumar Singh
Summary: An experimental program was conducted to determine the dynamic properties of pond ash and the effects of additives such as crumb rubber and coir fiber. The results showed that crumb rubber improved the liquefaction resistance of pond ash, while coir fiber had no significant effect on it. The dynamic shear modulus of pond ash decreased when mixed with crumb rubber, but increased significantly when mixed with coir fiber.
JOURNAL OF RENEWABLE MATERIALS
(2023)
Article
Food Science & Technology
Nusrat Jan, H. R. Naik, Gousia Gani, Omar Bashir, Tawheed Amin, Sajad Mohd Wani, Shakeel Ahmad Sofi
Summary: This study examined the impact of rice flour incorporation on various quality attributes of low-gluten wheat-based pretzels. The results showed that the addition of rice flour increased the swelling power and bulk density, while decreasing the oil absorption capacity, solubility index, foaming capacity, and foaming stability. The study also found that the incorporation of rice flour affected the elastic modulus, starch digestion characteristics, and texture of the flour blend. Furthermore, the developed low-gluten pretzels with rice flour had higher mineral profile and lightness, and better overall acceptability.
FOOD PRODUCTION PROCESSING AND NUTRITION
(2022)
Article
Entomology
Gurmeet Kour Bali, Sanjay K. Singh, Deepak Kumar Maurya, Fehim Jeelani Wani, Radhakrishnan Sitaram Pandit
Summary: The entomopathogenic fungus Purpureocillium lilacinum has been found to be pathogenic to the tomato leafminer and can be potentially used as a biocontrol agent in the field.
EGYPTIAN JOURNAL OF BIOLOGICAL PEST CONTROL
(2022)
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
