Article
Biophysics
Athira Mani, R. Suriya, T. S. Anirudhan
Summary: A highly sensitive and selective electrochemical sensor was developed for the detection of L-Tyrosine using a surface modified glassy carbon electrode. The sensor exhibited a wide linear range, low detection limit, excellent selectivity, and potential clinical applicability.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Athira Mani, M. R. Rajeev, T. S. Anirudhan
Summary: L-Tryptophan (TRP) is a crucial precursor for various neurotransmitters and hormones, but its toxic effects can lead to serious neurological disorders and cancer. A silver decorated silanized graphene oxide sensor was developed for the selective detection of TRP, with a detection limit of 3.23 x 10-10 M. The sensor was successfully applied to detect TRP in a blood serum sample, suggesting its potential clinical application.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Nanoscience & Nanotechnology
Menglin Song, Huanhuan Sun, Jing Yu, Yu Wang, Mingfang Li, Meichuan Liu, Guohua Zhao
Summary: A label-free nonenzymatic PEC sensor for detecting microcystin-LR has been developed based on visible-light-responsive Ti-Fe-O nanotubes and reduced graphene oxide. The sensor shows high sensitivity with a low detection limit of 10 pM, and demonstrates high selectivity towards MC-LR.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
K. Prabakaran, P. J. Jandas, Jingting Luo, Chen Fu, Qiuping Wei
Summary: In this study, a molecularly imprinted polymer (MIP) for L-tryptophan was synthesized and applied in a highly selective and sensitive biosensor, showing excellent recoveries and high selectivity in real sample analysis. The biosensor demonstrated a detection limit of 0.73 ng/mL and specificity towards L-tryptophan analogues such as D-tryptophan and ascorbic acid. The MIP modified QCM biosensor exhibited high selectivity coefficients towards L-tryptophan, making it a promising tool for practical applications.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Review
Chemistry, Analytical
Xianzhi Huang, Ling Xia, Gongke Li
Summary: Molecularly imprinted polymers (MIPs) have been widely used in sensing due to their specific and high affinity for target molecules. MIP optical sensors, combining the preconcentration capability of MIPs and the quantification merit of optical techniques, have been applied to analyze various samples and gained considerable attention. This review provides an overview of the progress of MIP sensors combined with optical detection methods, including fluorescence, surface plasmon resonance, Raman scattering, and chemiluminescence. The construction, characterization, working principle, and application of four types of MIP optical sensors are discussed in detail. Finally, the opportunities and challenges faced by MIP optical sensors are summarized.
Article
Chemistry, Analytical
Fatemeh Rezaei, Narges Ashraf, Gholam Hossein Zohuri
Summary: The research presents a sol-gel approach for synthesizing hydrophilic core-shell L-tryptophan imprinted polysilicate. The nanocomposite was characterized using various techniques and used to construct an electrochemical sensor for Trp detection. The sensor showed a linear calibration plot and low LOD and LOQ values. The applicability of the sensor was demonstrated in the analysis of real samples.
MICROCHEMICAL JOURNAL
(2023)
Article
Agriculture, Dairy & Animal Science
Yinchuan Pan, Xu Liu, Jing Liu, Jianping Wang, Juxiang Liu, Yanxia Gao, Ning Ma
Summary: In this study, a chemiluminescence sensor was developed using a molecularly imprinted polymer (MIP) for specific detection of organophosphorus residues in milk samples. The sensor showed high sensitivity and reusability, and can be used as a routine tool for detecting OP residues.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Chemistry, Analytical
Vilma Ratautaite, Ernestas Brazys, Almira Ramanaviciene, Arunas Ramanavicius
Summary: The aim of this study was to compare the application of two different conducting polymers, polypyrrole and polyaniline, in the design of molecularly imprinted polymers (MIPs). The results showed that polypyrrole had a higher affinity for L-tryptophan and was more suitable for the design of MIP-based sensors for the detection of L-tryptophan.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Sheeba Alexander, Divya Rajan Panikar, Anirudhan Thayyath Sreenivasan
Summary: A novel electrochemical sensing platform based on composite material, MIP-GO, was prepared for the selective and sensitive analysis of amoxicillin (AMOX). The preparation involved the modification of graphite powder into GO, the surface modification of GO with allyl bromide, and the polymerization process using methacrylic acid (MAA) as the monomer and ethylene glycol (EGDMA) as cross-linker. The GO-MIP based sensor exhibited high selectivity and linear response to AMOX concentrations, with a detection limit of 10 -10 M.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Sahel Sani Khaneghah, Negin Sohrabi, Reza Mohammadi
Summary: In this study, a magnetic molecularly imprinted polymer based on magnetic graphene oxide and polydopamine was synthesized and used in a drug delivery system for rivastigmine. The prepared polymers were characterized using various techniques, and the drug loading and release mechanisms were investigated. The results showed that the polymer had efficient drug loading and controlled drug release properties.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Analytical
Ibrar Alam, Benchaporn Lertanantawong, Thana Sutthibutpong, Primana Punnakitikashem, Piyapong Asanithi
Summary: A tryptophan (Trp) sensor based on molecularly imprinted polymer was developed for sensitive and selective determination of Trp using electrochemical impedance spectroscopy. The sensor exhibited a wide linear range and low detection limit, and was successfully applied for Trp determination in complex samples such as milk and cancer cell media.
Article
Biophysics
Yixuan Li, Liuxiong Luo, Mengyan Nie, Andrew Davenport, Ying Li, Bing Li, Kwang-Leong Choy
Summary: In this study, a graphene nanoplatelet/polydopamine-molecularly imprinted polymer biosensor was developed for the ultra-trace detection of creatinine in various body fluids. The biosensor exhibited high sensitivity and a wide dynamic detection range, and the results obtained from practical applications correlated well with those obtained from standard clinical laboratory methods.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Applied
Luiz Felipe Pompeu Prado Moreira, Edervaldo Buffon, Acelino Cardoso de Sa, Nelson Ramos Stradiotto
Summary: This study introduces a novel electrochemical sensor for selective detection of fructose, achieving accurate quantification in various fruit juices.
Article
Chemistry, Analytical
Huan Lu, Yan Huang, Hanyue Cui, Li Li, Yaping Ding
Summary: The study presents a molecularly imprinted electrochemical aptasensor that utilizes the specificity of molecularly imprinted technology and the affinity of aptamers for the selective recognition of amoxicillin.
Article
Chemistry, Applied
Arash Mohammadinejad, Ebrahim Abouzari-Lotf, Ghazaleh Aleyaghoob, Majid Rezayi, Reza Kazemi Oskuee
Summary: An electrochemical sensor was developed for detecting curcumin, a functional herbal food. The sensor was fabricated using a molecularly imprinted polymer and a highly conductive transition metal oxide/carbon-based nano composite, which demonstrated good detection performance. The proposed method showed potential for detecting curcumin in biological samples.
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).