Oncolytic viruses: From bench to bedside with a focus on safety

Evaluation of homogeneity and genetic stability of REOLYSIN® (pelareorep) by complete genome sequencing of reovirus after large scale production

(2014) Romit Chakrabarty et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Intravenously injected Newcastle disease virus in non-human primates is safe to use for oncolytic virotherapy

(2014) P R A Buijs et al.   CANCER GENE THERAPY

Different responses of human pancreatic adenocarcinoma cell lines to oncolytic Newcastle disease virus infection

(2014) P R A Buijs et al.   CANCER GENE THERAPY

Genome Scale Patterns of Recombination between Coinfecting Vaccinia Viruses

(2014) L. Qin et al.   JOURNAL OF VIROLOGY

A Systematic Comparison of the Anti-Tumoural Activity and Toxicity of the Three Adv-TKs

(2014) Qinglei Gao et al.   PLoS One

Localized Oncolytic Virotherapy Overcomes Systemic Tumor Resistance to Immune Checkpoint Blockade Immunotherapy

(2014) D. Zamarin et al.   Science Translational Medicine

A phase I clinical trial of Ad5/3-Δ24, a novel serotype-chimeric, infectivity-enhanced, conditionally-replicative adenovirus (CRAd), in patients with recurrent ovarian cancer

(2013) Kenneth H. Kim et al.   GYNECOLOGIC ONCOLOGY

Hand, foot, and mouth disease: Current scenario and Indian perspective

(2013) Nilendu Sarma   Indian Journal of Dermatology Venereology & Leprology

Selective Tropism of Seneca Valley Virus for Variant Subtype Small Cell Lung Cancer

(2013) J. T. Poirier et al.   JNCI-Journal of the National Cancer Institute

YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells

(2013) Klaus Mantwill et al.   Journal of Translational Medicine

Homologous Recombination in E3 Genes of Human Adenovirus Species D

(2013) G. Singh et al.   JOURNAL OF VIROLOGY

Intravenous injection of oncolytic picornavirus SVV-001 prolongs animal survival in a panel of primary tumor–based orthotopic xenograft mouse models of pediatric glioma

(2013) Zhigang Liu et al.   NEURO-ONCOLOGY

Safety Studies on Intravenous Administration of Oncolytic Recombinant Vesicular Stomatitis Virus in Purpose-Bred Beagle Dogs

(2013) Amy K. LeBlanc et al.   Human Gene Therapy Clinical Development

Attenuated Oncolytic Measles Virus Strains as Cancer Therapeutics

(2012) P. Msaouel et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Vesicular stomatitis virus as a flexible platform for oncolytic virotherapy against cancer

(2012) E. Hastie et al.   JOURNAL OF GENERAL VIROLOGY

A First in Human Phase 1 Study of CG0070, a GM-CSF Expressing Oncolytic Adenovirus, for the Treatment of Nonmuscle Invasive Bladder Cancer

(2012) James M. Burke et al.   JOURNAL OF UROLOGY

Second-Site Mutations Selected in Transcriptional Regulatory Sequences Compensate for Engineered Mutations in the Vesicular Stomatitis Virus Nucleocapsid Protein

(2012) D. Harouaka et al.   JOURNAL OF VIROLOGY

Reovirus: A Targeted Therapeutic--Progress And Potential

(2012) R. Maitra et al.   MOLECULAR CANCER RESEARCH

Design and Selection of Toca 511 for Clinical Use: Modified Retroviral Replicating Vector With Improved Stability and Gene Expression

(2012) Omar D Perez et al.   MOLECULAR THERAPY

Ad3-hTERT-E1A, a Fully Serotype 3 Oncolytic Adenovirus, in Patients With Chemotherapy Refractory Cancer

(2012) Otto Hemminki et al.   MOLECULAR THERAPY

Infectivity-selective Oncolytic Adenovirus Developed by High-throughput Screening of Adenovirus-formatted Library

(2012) Yoshiaki Miura et al.   MOLECULAR THERAPY

Isolation of Reovirus T3D Mutants Capable of Infecting Human Tumor Cells Independent of Junction Adhesion Molecule-A

(2012) Diana J. M. van den Wollenberg et al.   PLoS One

A single amino acid change resulting in loss of fluorescence of eGFP in a viral fusion protein confers fitness and growth advantage to the recombinant vesicular stomatitis virus

(2012) Phat X. Dinh et al.   VIROLOGY

Replication-competent retrovirus vector-mediated prodrug activator gene therapy in experimental models of human malignant mesothelioma

(2011) Y Kawasaki et al.   CANCER GENE THERAPY

Phase I Clinical Study of Seneca Valley Virus (SVV-001),a Replication-Competent Picornavirus, in Advanced Solid Tumors with Neuroendocrine Features

(2011) C. M. Rudin et al.   CLINICAL CANCER RESEARCH

Integrin targeted oncolytic adenoviruses Ad5-D24-RGD and Ad5-RGD-D24-GMCSF for treatment of patients with advanced chemotherapy refractory solid tumors

(2011) Sari Pesonen et al.   INTERNATIONAL JOURNAL OF CANCER

Switching the fiber knob of oncolytic adenoviruses to avoid neutralizing antibodies in human cancer patients

(2011) Mari Raki et al.   JOURNAL OF GENE MEDICINE

A Host-Specific, Temperature-Sensitive Translation Defect Determines the Attenuation Phenotype of a Human Rhinovirus/Poliovirus Chimera, PV1(RIPO)

(2011) N. Jahan et al.   JOURNAL OF VIROLOGY

A Recombinant Vesicular Stomatitis Virus Bearing a Lethal Mutation in the Glycoprotein Gene Uncovers a Second Site Suppressor That Restores Fusion

(2011) M. L. Stanifer et al.   JOURNAL OF VIROLOGY

Attenuation of Neurovirulence, Biodistribution, and Shedding of a Poliovirus:Rhinovirus Chimera after Intrathalamic Inoculation in Macaca fascicularis

(2011) E. Y. Dobrikova et al.   JOURNAL OF VIROLOGY

Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans

(2011) Caroline J. Breitbach et al.   NATURE

Rethinking herpes simplex virus: the way to oncolytic agents

(2011) Gabriella Campadelli-Fiume et al.   REVIEWS IN MEDICAL VIROLOGY

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

(2010) R. Alba et al.   BLOOD

Targeting HSV-1 virions for specific binding to epidermal growth factor receptor-vIII-bearing tumor cells

(2010) P Grandi et al.   CANCER GENE THERAPY

Phase I Trial of Intraperitoneal Administration of an Oncolytic Measles Virus Strain Engineered to Express Carcinoembryonic Antigen for Recurrent Ovarian Cancer

(2010) E. Galanis et al.   CANCER RESEARCH

A Phase I Study of a Tropism-Modified Conditionally Replicative Adenovirus for Recurrent Malignant Gynecologic Diseases

(2010) K. J. Kimball et al.   CLINICAL CANCER RESEARCH

Phase I/II Study of Oncolytic HSVGM-CSF in Combination with Radiotherapy and Cisplatin in Untreated Stage III/IV Squamous Cell Cancer of the Head and Neck

(2010) K. J. Harrington et al.   CLINICAL CANCER RESEARCH

Clinical trials with oncolytic reovirus: Moving beyond phase I into combinations with standard therapeutics

(2010) K.J. Harrington et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Oncolytic vaccinia virus: a silver bullet?

(2010) Monika Lusky et al.   Expert Review of Vaccines

Prolonged systemic circulation of chimeric oncolytic adenovirus Ad5/3-Cox2L-D24 in patients with metastatic and refractory solid tumors

(2010) S Pesonen et al.   GENE THERAPY

Therapeutic effects of a fusogenic newcastle disease virus in treating head and neck cancer

(2010) Pingdong Li et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Phase I/II Study of Oncolytic Herpes Simplex Virus NV1020 in Patients with Extensively Pretreated Refractory Colorectal Cancer Metastatic to the Liver

(2010) Sunil K. Geevarghese et al.   HUMAN GENE THERAPY

Comparative evaluation of preclinical in vivo models for the assessment of replicating retroviral vectors for the treatment of glioblastoma

(2010) Juraj Hlavaty et al.   JOURNAL OF NEURO-ONCOLOGY

Development of a Targeted Gene Vector Platform Based on Simian Adenovirus Serotype 24

(2010) N. Belousova et al.   JOURNAL OF VIROLOGY

Potent anti-tumor effects of a dual specific oncolytic adenovirus expressing apoptin in vitro and in vivo

(2010) Li Xiao et al.   Molecular Cancer

Substitution of Adenovirus Serotype 3 Hexon onto a Serotype 5 Oncolytic Adenovirus Reduces Factor X Binding, Decreases Liver Tropism, and Improves Antitumor Efficacy

(2010) J. J. Short et al.   MOLECULAR CANCER THERAPEUTICS

Genetically Engineered Oncolytic Newcastle Disease Virus Effectively Induces Sustained Remission of Malignant Pleural Mesothelioma

(2010) G. R. Silberhumer et al.   MOLECULAR CANCER THERAPEUTICS

Oncolytic Adenoviruses for the Treatment of Human Cancer: Focus on Translational and Clinical Data

(2010) Sari Pesonen et al.   MOLECULAR PHARMACEUTICS

MAPK Signal-integrating Kinase Controls Cap-independent Translation and Cell Type-specific Cytotoxicity of an Oncolytic Poliovirus

(2010) Christian Goetz et al.   MOLECULAR THERAPY

Treatment of Cancer Patients With a Serotype 5/3 Chimeric Oncolytic Adenovirus Expressing GMCSF

(2010) Anniina Koski et al.   MOLECULAR THERAPY

A single intravenous injection of oncolytic picornavirus SVV-001 eliminates medulloblastomas in primary tumor-based orthotopic xenograft mouse models

(2010) L. Yu et al.   NEURO-ONCOLOGY

Initial testing of the replication competent Seneca Valley virus (NTX-010) by the pediatric preclinical testing program

(2010) Christopher L. Morton et al.   PEDIATRIC BLOOD & CANCER

Tropism-Modification Strategies for Targeted Gene Delivery Using Adenoviral Vectors

(2010) Lynda Coughlan et al.   Viruses-Basel

Multiple hepatic arterial injections of recombinant adenovirus p53 and 5-fluorouracil after transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma: a pilot phase II trial

(2009) Geng Tian et al.   ANTI-CANCER DRUGS

Phase I and biodistribution study of recombinant adenovirus vector-mediated herpes simplex virus thymidine kinase gene and ganciclovir administration in patients with head and neck cancer and other malignant tumors

(2009) F Xu et al.   CANCER GENE THERAPY

Genetically engineered Newcastle disease virus for malignant melanoma therapy

(2009) D Zamarin et al.   GENE THERAPY

Safety Studies on Intrahepatic or Intratumoral Injection of Oncolytic Vesicular Stomatitis Virus Expressing Interferon-β in Rodents and Nonhuman Primates

(2009) Nathan Jenks et al.   HUMAN GENE THERAPY

Phase II Clinical Trial of a Granulocyte-Macrophage Colony-Stimulating Factor–Encoding, Second-Generation Oncolytic Herpesvirus in Patients With Unresectable Metastatic Melanoma

(2009) Neil N. Senzer et al.   JOURNAL OF CLINICAL ONCOLOGY

Computational Analysis of Human Adenovirus Type 22 Provides Evidence for Recombination among Species D Human Adenoviruses in the Penton Base Gene

(2009) C. M. Robinson et al.   JOURNAL OF VIROLOGY

Enhancement of Oncolytic Properties of Recombinant Newcastle Disease Virus Through Antagonism of Cellular Innate Immune Responses

(2009) Dmitriy Zamarin et al.   MOLECULAR THERAPY

Engineered Newcastle Disease Virus as an Improved Oncolytic Agent Against Hepatocellular Carcinoma

(2009) Jennifer Altomonte et al.   MOLECULAR THERAPY

A Phase I Study of Telomerase-specific Replication Competent Oncolytic Adenovirus (Telomelysin) for Various Solid Tumors

(2009) John Nemunaitis et al.   MOLECULAR THERAPY

Evidence of Molecular Evolution Driven by Recombination Events Influencing Tropism in a Novel Human Adenovirus that Causes Epidemic Keratoconjunctivitis

(2009) Michael P. Walsh et al.   PLoS One

Comparative analysis of vector biodistribution, persistence and gene expression following intravenous delivery of bovine, porcine and human adenoviral vectors in a mouse model

(2009) Anurag Sharma et al.   VIROLOGY

Transient infection of freshly isolated human colorectal tumor cells by reovirus T3D intermediate subviral particles

(2008) W J van Houdt et al.   CANCER GENE THERAPY

Enhancing Poxvirus Oncolytic Effects through Increased Spread and Immune Evasion

(2008) D. H. Kirn et al.   CANCER RESEARCH

Measles Virus as An Oncolytic Vector Platform

(2008) Boris Blechacz et al.   CURRENT GENE THERAPY

Human Effector and Memory CD8+ T Cell Responses to Smallpox and Yellow Fever Vaccines

(2008) Joseph D. Miller et al.   IMMUNITY

Phase I Study of Adenovirus p53 Administered by Bronchoalveolar Lavage in Patients With Bronchioloalveolar Cell Lung Carcinoma: ECOG 6597

(2008) Vicki Keedy et al.   JOURNAL OF CLINICAL ONCOLOGY

Construction of a Fully Retargeted Herpes Simplex Virus 1 Recombinant Capable of Entering Cells Solely via Human Epidermal Growth Factor Receptor 2

(2008) L. Menotti et al.   JOURNAL OF VIROLOGY

Vesicular Stomatitis Virus Oncolysis of T Lymphocytes Requires Cell Cycle Entry and Translation Initiation

(2008) S. Oliere et al.   JOURNAL OF VIROLOGY

Recombinant Oncolytic Poliovirus Eliminates Glioma In Vivo Without Genetic Adaptation to a Pathogenic Phenotype

(2008) Elena Y Dobrikova et al.   MOLECULAR THERAPY

A Phase I Trial of Ad.hIFN-β Gene Therapy for Glioma

(2008) E Antonio Chiocca et al.   MOLECULAR THERAPY

Phase Ib Trial of Mutant Herpes Simplex Virus G207 Inoculated Pre-and Post-tumor Resection for Recurrent GBM

(2008) James M Markert et al.   MOLECULAR THERAPY

Directed Evolution Generates a Novel Oncolytic Virus for the Treatment of Colon Cancer

(2008) Irene Kuhn et al.   PLoS One

Clinical features and treatment of adenovirus infections

(2008) Liesbeth Lenaerts et al.   REVIEWS IN MEDICAL VIROLOGY