Effects of the fusion design and immunization route on the immunogenicity of Ag85A-Mtb32 in adenoviral vectored tuberculosis vaccine

Vaccine against tuberculosis: what’s new?

(2014) Carlotta Montagnani et al.   BMC INFECTIOUS DISEASES

Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection

(2014) Fanny Tzelepis et al.   JOURNAL OF CLINICAL INVESTIGATION

Multifunctional, High-Level Cytokine-Producing Th1 Cells in the Lung, but Not Spleen, Correlate with Protection against Mycobacterium tuberculosis Aerosol Challenge in Mice

(2014) E. K. Forbes et al.   JOURNAL OF IMMUNOLOGY

Intranasal vaccination with recombinant receptor-binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than subcutaneous immunization: Implication for designing novel mucosal MERS vaccines

(2014) Cuiqing Ma et al.   VACCINE

Functional Signatures of Human CD4 and CD8 T Cell Responses to Mycobacterium tuberculosis

(2014) Teresa Prezzemolo et al.   Frontiers in Immunology

Airway Delivery of an Adenovirus-Based Ebola Virus Vaccine Bypasses Existing Immunity to Homologous Adenovirus in Nonhuman Primates

(2013) J. S. Richardson et al.   JOURNAL OF VIROLOGY

Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial

(2013) Michele D Tameris et al.   LANCET

Dendritic cells of the oral mucosa

(2013) A-H Hovav   Mucosal Immunology

Harnessing local and systemic immunity for vaccines against tuberculosis

(2013) P C L Beverley et al.   Mucosal Immunology

A Multi-Antigenic Adenoviral-Vectored Vaccine Improves BCG-Induced Protection of Goats against Pulmonary Tuberculosis Infection and Prevents Disease Progression

(2013) Bernat Pérez de Val et al.   PLoS One

A Human Type 5 Adenovirus-Based Tuberculosis Vaccine Induces Robust T Cell Responses in Humans Despite Preexisting Anti-Adenovirus Immunity

(2013) F. Smaill et al.   Science Translational Medicine

Nonlytic Fc-fused IL-7 synergizes with Mtb32 DNA vaccine to enhance antigen-specific T cell responses in a therapeutic model of tuberculosis

(2013) So-Shin Ahn et al.   VACCINE

Fusion protein linkers: Property, design and functionality

(2012) Xiaoying Chen et al.   ADVANCED DRUG DELIVERY REVIEWS

Immunogenicity comparison of the intradermal or endobronchial boosting of BCG vaccinates with Ad5-85A

(2012) Adam Whelan et al.   VACCINE

Signal peptide replacements enhance expression and secretion of hepatitis C virus envelope glycoproteins

(2011) B. Wen et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Enhancement of Gag-Specific But Reduction of Env- and Pol-Specific CD8+ T Cell Responses by Simian Immunodeficiency Virus Nonstructural Proteins In Mice

(2011) Yinfeng Zhang et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Mtb32 is a promising tuberculosis antigen for DNA vaccination in pre- and post-exposure mouse models

(2011) S-S Ahn et al.   GENE THERAPY

Role of innate cytokines in mycobacterial infection

(2011) A M Cooper et al.   Mucosal Immunology

Safety and Immunogenicity of an HIV Adenoviral Vector Boost after DNA Plasmid Vaccine Prime by Route of Administration: A Randomized Clinical Trial

(2011) Beryl A. Koblin et al.   PLoS One

Vaccine-induced anti-tuberculosis protective immunity in mice correlates with the magnitude and quality of multifunctional CD4 T cells

(2011) Steven C. Derrick et al.   VACCINE

Immunogenicity and protective efficacy of a tuberculosis DNA vaccine expressing a fusion protein of Ag85B-Esat6-HspX in mice

(2011) Wei Yuan et al.   VACCINE

The Novel Tuberculosis Vaccine, AERAS-402, Induces Robust and Polyfunctional CD4+and CD8+T Cells in Adults

(2010) Brian Abel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Sublingual Administration of an Adenovirus Serotype 5 (Ad5)-Based Vaccine Confirms Toll-Like Receptor Agonist Activity in the Oral Cavity and Elicits Improved Mucosal and Systemic Cell-Mediated Responses against HIV Antigens despite Preexisting Ad5 Immunity

(2010) Daniel M. Appledorn et al.   Clinical and Vaccine Immunology

Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung

(2010) Paul S. Redford et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Multifunctional CD4+ T cells correlate with active Mycobacterium tuberculosis infection

(2010) Nadia Caccamo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The immunogenicity of DNA constructs co-expressing GP5 and M proteins of porcine reproductive and respiratory syndrome virus conjugated by GPGP linker in pigs

(2010) Min-Yuan Chia et al.   VETERINARY MICROBIOLOGY

Inhibition of 2A-mediated ‘cleavage’ of certain artificial polyproteins bearing N-terminal signal sequences

(2009) Pablo de Felipe et al.   Biotechnology Journal

A Multicistronic DNA Vaccine Induces Significant Protection against Tuberculosis in Mice and Offers Flexibility in the Expressed Antigen Repertoire

(2009) F.-A. Mir et al.   Clinical and Vaccine Immunology

Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells

(2009) Thomas J. Scriba et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Viral Booster Vaccines Improve Mycobacterium bovis BCG-Induced Protection against Bovine Tuberculosis

(2009) H. M. Vordermeier et al.   INFECTION AND IMMUNITY

Immunization With a Bivalent Adenovirus-vectored Tuberculosis Vaccine Provides Markedly Improved Protection Over Its Monovalent Counterpart Against Pulmonary Tuberculosis

(2009) Jingyu Mu et al.   MOLECULAR THERAPY

Intranasal Mucosal Boosting with an Adenovirus-Vectored Vaccine Markedly Enhances the Protection of BCG-Primed Guinea Pigs against Pulmonary Tuberculosis

(2009) Zhou Xing et al.   PLoS One

Analysis of Mycobacterium tuberculosis-Specific CD8 T-Cells in Patients with Active Tuberculosis and in Individuals with Latent Infection

(2009) Nadia Caccamo et al.   PLoS One

A Critical Role for CD8 T Cells in a Nonhuman Primate Model of Tuberculosis

(2009) Crystal Y. Chen et al.   PLoS Pathogens