Article
Environmental Sciences
Weilai Wang, Kaixuan Wang, Lei Xu, Yang Li, Junfeng Niu
Summary: Raney nickel coupled with nascent hydrogen (Nas-H-2) can efficiently catalyze the reduction of nitrate and nitrite (NOX-). The micro/nano-sized Nas-H-2 bubbles with fine dispersion of hydrogen molecules exhibit increased reactivity, and the alkaline environment positively maintains the activity of R-Ni. By introducing fine hydrogen resources, an efficient catalytic hydrogenation technique without noble metals can be developed.
Article
Chemistry, Analytical
Megan X. Y. Ravindran, N. Asikin-Mijan, H. C. Ong, Darfizi Derawi, M. R. Yusof, M. S. Mastuli, H. Lee, W. N. A. S. Wan Mahmood, M. S. Razali, G. Abdulkareem Al-Sultan, Y. H. Taufiq-Yap
Summary: This study investigated the catalytic reduction of oxygen-containing compounds in palm kernel oil using a microwave system approach. The use of Raney nickel and magnetite activated carbon-based catalysts significantly increased the yield and selectivity of bio-jet fuel. The study also revealed the important role of the catalyst's porous structure and active oxygen-containing groups in enhancing the deoxygenation reaction and improving the catalyst's reusability.
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
(2022)
Article
Chemistry, Multidisciplinary
Fang Lin, Ho-Yin Tse, Hanno C. Erythropel, Predrag Petrovic, Mahlet Garedew, Jinshan Chen, Jason Chun-Ho Lam, Paul T. Anastas
Summary: This study reports a highly selective electrochemical method for the cleavage of benzylic C-O bond in lignin model compounds at room temperature and ambient pressure. Using nickel ions as catalysts in the presence of water molecules, benzyl phenyl ether (BPE) can be converted to toluene and phenol in methanol with high yields.
Article
Energy & Fuels
Zheng Cui, Feng Cheng, Jacqueline M. Jarvis, Umakanta Jena, Catherine E. Brewer
Summary: Co-hydrothermal liquefaction of wastewater algae and crude glycerol can produce more biocrude oil at lower costs, but the oil has high oxygen content and low energy content. Solvent extraction and catalyst selection can help upgrade the biocrude oil to higher quality and higher energy content.
Article
Chemistry, Multidisciplinary
Zhen Fang, Michael G. Flynn, James E. Jackson, Eric L. Hegg
Summary: This study introduces a thio-assisted electrocatalytic reductive approach to cleave specific linkages in lignin at room temperature, significantly increasing the cleavage yield. By applying electric current and disulfide under certain conditions, soluble fragments in lignin can be rapidly and efficiently released.
Article
Chemistry, Multidisciplinary
Beatriz Garcia, Ana Orozco-Saumell, Manuel Lopez Granados, Jovita Moreno, Jose Iglesias
Summary: The catalytic transfer hydrogenation of glucose to sorbitol using biomass-derived alcohols and diols as hydrogen donors was studied. Sacrificial diols showed superior performance compared to short-chain alcohols, with terminal diols providing high selectivity in the conversion. Molybdenum promotion enhanced catalytic activity of sponge nickel catalysts, allowing high selectivity in continuous-flow operation for at least 550 hours.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Bogdan Shumeiko, David Kubicka
Summary: Lignin can be converted into useful precursors of fuels and fine chemicals through mild hydrogenation, which is affected by the complexity of the reactant and the position of the functional group. Different solvents also have an impact on the conversion of phenols.
Article
Chemistry, Multidisciplinary
Xin Yuan, Kwanpyung Lee, Michael T. Bender, J. R. Schmidt, Kyoung-Shin Choi
Summary: This study elucidates the key mechanistic differences between hydrogenation and hydrogenolysis reactions and demonstrates that lowering the pH can promote the hydrogenolysis of aldehydes and alcohols.
Article
Chemistry, Physical
Lucas G. Moura, Grazielle Emanuella S. dos Santos, Higor O. Alves, Juliane Z. Marinho, Marcos A. S. Barrozo, Antonio Otavio T. Patrocinio, Fabio B. Noronha, Carla E. Hori
Summary: The catalytic performance of nickel-based catalysts in the gas-phase hydrogenation reaction was investigated, showing good catalytic activity and selectivity. Additionally, the concentration of the catalyst and the type of biomass used also had a significant influence on the product distribution.
Article
Chemistry, Applied
Aracelis J. Pamphile-Adrian, Fabio B. Passos, Pedro P. Florez-Rodriguez
Summary: A systematic study was conducted to determine the maximum amount of nickel incorporated into the gamma-Al2O3 structure to form NiAl2O4. The behavior of this catalyst precursor for glycerol hydrogenolysis and cyclohexane conversion was investigated. Various characterization techniques were used to study the prepared catalysts with different nickel content. The results showed that Ni could be reversibly inserted into the gamma-Al2O3 structure, and the maximum amount of Ni incorporated into NiAl2O4 was approximately 20 wt%Ni. Different forms of Ni0 particles were observed depending on the Ni content, and their nature affected the catalytic activity. The formation of gridshell structures was found to be a determining factor for the catalytic activity in liquid-phase reactions.
Article
Chemistry, Physical
Patrick M. Barboun, Luke L. Daemen, Craig Waitt, Zili Wu, William F. Schneider, Jason C. Hicks
Summary: The study reports INS observations of alumina-supported Ni particles after treatment with N-2 and H-2 plasmas, revealing the presence of NHx species and hydrides, generated through plasma-facilitated surface reactions. Experimental assignments of surface intermediates through INS spectra support the direct implication of plasma stimulation of dinitrogen in generation of surface-bound reactions. The results suggest that these reactions can be driven thermally or with H(2) plasma.
ACS ENERGY LETTERS
(2021)
Article
Chemistry, Applied
Young Hwa Yun, Kwangsoo Kim, Changsoo Lee, Byeong-Seon An, Ji Hee Kwon, Sechan Lee, Minjoong Kim, Jongsu Seo, Jong Hyeok Park, Byung-Hyun Kim, Hyun-Seok Cho
Summary: In this study, Ni-based porous electrocatalysts with excellent hydrogen evolution activity were prepared by controlling the chemical state of Ni using plasma vapor deposition (PVD) and subsequent heat treatment, selective Al leaching, and electrochemical reduction. The presence of NiAl intermetallic compound at the interfaces facilitated the partial reduction of Ni(OH)2 and enhanced the efficiency of hydrogen evolution. This research is of great importance for improving the hydrogen production reaction in alkaline water electrolysis.
JOURNAL OF ENERGY CHEMISTRY
(2023)
Article
Chemistry, Physical
Nokwanda Tsaulwayo, Robert. T. Kumah, Stephen. O. Ojwach
Summary: Five imino-pyridine Ni(II) complexes were synthesized and evaluated as catalysts in the transfer hydrogenation of ketones, showing moderate catalytic activities. The structure of the complexes and nature of ketone substrate influenced their catalytic activities, with both Ni(0) nanoparticles and Ni(II) homogeneous species identified as active species.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Multidisciplinary Sciences
Shuai Qin, Yu Duan, Xiao-Long Zhang, Li-Rong Zheng, Fei-Yue Gao, Peng-Peng Yang, Zhuang-Zhuang Niu, Ren Liu, Yu Yang, Xu-Sheng Zheng, Jun-Fa Zhu, Min-Rui Gao
Summary: This study describes a ternary nickel-tungsten-copper nanoalloy with significant HOR activity in alkaline electrolyte, showcasing high anode potential and operational stability, as well as excellent CO-tolerant ability, rivaling the benchmark platinum catalyst.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Organic
Quan Lin, Weiqi Tong, Yunrong Chen, Xing-Zhong Shu
Summary: This study reports a Ti-catalyzed direct dehydroxylation of tertiary aliphatic alcohols under mild reaction conditions, resulting in the formation of Barton-type deoxygenation products. The method is tolerant to a wide range of functional groups, including primary alkyl chloride and carbonyl groups. It allows for selective dehydroxylation of tertiary alcohols in diols and the formation of deuterated products with moderate deuterium incorporation. The efficient modification of several drugs and natural products highlights the synthetic utility of this method.
Article
Genetics & Heredity
Katherine J. Wert, Susanne F. Koch, Gabriel Velez, Chun-Wei Hsu, MaryAnn Mahajan, Alexander G. Bassuk, Stephen H. Tsang, Vinit B. Mahajan
Article
Medicine, General & Internal
Katherine J. Wert, Gabriel Velez, Vijaya L. Kanchustambham, Vishnu Shankar, Lucy P. Evans, Jesse D. Sengillo, Richard N. Zare, Alexander G. Bassuk, Stephen H. Tsang, Vinit B. Mahajan
Article
Endocrinology & Metabolism
Elham Mosleh, Kristy Ou, Matthew W. Haemmerle, Teguru Tembo, Andrew Yuhas, Bethany A. Carboneau, Shannon E. Townsend, Karin J. Bosma, Maureen Gannon, Richard M. O'Brien, Doris A. Stoffers, Maria L. Golson
Article
Endocrinology & Metabolism
Karin J. Bosma, Mohsin Rahim, Kritika Singh, Slavina B. Goleva, Martha L. Wall, Jing Xia, Kristen E. Syring, James K. Oeser, Greg Poffenberger, Owen P. McGuinness, Anna L. Means, Alvin C. Powers, Wen-Hong Li, Lea K. Davis, Jamey D. Young, Richard M. O'Brien
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Kristen E. Syring, Karin J. Bosma, Slavina B. Goleva, Kritika Singh, James K. Oeser, Christopher A. Lopez, Eric P. Skaar, Owen P. McGuinness, Lea K. Davis, David R. Powell, Richard M. O'Brien
JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Medicine, Research & Experimental
Ashley A. Rowe, Pinkal D. Patel, Ruth Gordillo, Katherine J. Wert
Summary: The study found that reducing TCA cycle intermediates in RP disease led to cell degeneration, but promoting citrate production protected photoreceptor cells and prolonged visual function. This therapeutic effect was not specific to certain genetic mutations, showing broad applicability for RP and other retinal degenerative diseases. Targeting TCA cycle activity in the neural retina promoted photoreceptor survival and visual function during neurodegenerative disease.
Article
Biochemistry & Molecular Biology
Mohsin Rahim, Arya Y. Nakhe, Deveena R. Banerjee, Emily M. Overway, Karin J. Bosma, Jonah C. Rosch, James K. Oeser, Bo Wang, Ethan S. Lippmann, David A. Jacobson, Richard M. O. ' Brien, Jamey D. Young
Summary: Previous studies have shown a link between the G6PC2 gene and blood glucose control. In this study, the researchers further investigated the role of G6PC2 in beta-cell metabolism. The results demonstrated that deletion of G6PC2 increased glycolytic and citric acid cycle fluxes, enhanced insulin secretion, and increased cytosolic redox potential and reductive carboxylation flux.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Emily M. Overway, Karin J. Bosma, Derek P. Claxton, James K. Oeser, Kritika Singh, Lindsay B. Breidenbach, Hassane S. Mchaourab, Lea K. Davis, Richard M. O'Brien
Summary: This study investigated the impact of 22 non synonymous G6PC2 SNPs on G6PC2 protein expression and enzyme activity, finding that 16 SNPs significantly impaired G6PC2 protein expression while 4 SNPs affected G6PC2 enzyme activity. High-impact SNPs were associated with FBG, but no associations were found with other diseases or metabolites.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Karin J. Bosma, Spencer R. Andrei, Liora S. Katz, Ashley A. Smith, Jennifer C. Dunn, Valerie F. Ricciardi, Marisol A. Ramirez, Sharon Baumel-Alterzon, William A. Pace, Darian T. Carroll, Emily M. Overway, Elysa M. Wolf, Michelle E. Kimple, Quanhu Sheng, Donald K. Scott, Richard M. Breyer, Maureen Gannon
Summary: EP3 blockade promotes an increase in beta cell mass in db/db mice with type 2 diabetes, without affecting alpha cell proliferation. This effect may be mediated through the regulation of Nrf2, which plays a key role in protection against oxidative damage.
MOLECULAR METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Karin J. Bosma, Cecilia E. Kaiser, Michelle E. Kimple, Maureen Gannon
Summary: Arachidonic acid is a polyunsaturated fatty acid that plays roles in inflammation, pain, and immune function. Its metabolism through various pathways produces eicosanoids, which are associated with inflammatory, renal, cardiovascular diseases, and diabetes. Targeting the metabolism of arachidonic acid may provide new therapies for diabetes.
Article
Physiology
Karin J. Bosma, Monica Ghosh, Spencer R. Andrei, Lin Zhong, Jennifer C. Dunn, Valerie F. Ricciardi, Juliann B. Burkett, Antonis K. Hatzopoulos, Derek S. Damron, Maureen Gannon
Summary: This study found that systemic treatment with an EP3 antagonist improved cardiac function in a mouse model of diabetes. Additionally, blocking EP3 or activating EP4 enhanced contractility and calcium cycling in isolated cardiomyocytes. These findings suggest that modulation of EP3 and EP4 activity has beneficial effects on heart function.
PHYSIOLOGICAL REPORTS
(2022)
Article
Multidisciplinary Sciences
Katherine A. Bussan, Whitney L. Stuard, Natalia Mussi, Won Lee, Jess T. Whitson, Yacine Issioui, Ashley A. Rowe, Katherine J. Wert, Danielle M. Robertson
Summary: This study found that OSA does not have a significant effect on corneal nerves, but is associated with thinning of the retinal nerve fiber layer. Individuals with glaucomatous optic nerve changes and risk factors for OSA should be further examined, as uncontrolled OSA may exacerbate glaucoma progression.
Review
Biochemistry & Molecular Biology
Tiffany Yee, Katherine J. Wert
Summary: Inherited retinal diseases (IRDs) are a group of diseases that cause vision loss and currently have no effective treatment. However, the development of gene editing technologies, such as CRISPR-Cas9, has provided new hope for treating these diseases and preserving visual function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Ashley A. Rowe, Xin Chen, Emily R. Nettesheim, Yacine Issioui, Thomas Dong, Yuhui Hu, Souad Messahel, Saima N. Kayani, Steven J. Gray, Katherine J. Wert
Summary: The study highlights the rapid degeneration of retina in CLN7 Batten disease patients. By investigating a preclinical model, the researchers identified early signs of photoreceptor damage and gained a better understanding of the mechanism behind retinal degeneration. These findings contribute to the development of therapeutic strategies for patients and provide insights for future clinical trials.
Article
Endocrinology & Metabolism
Karin J. Bosma, Mohsin Rahim, James K. Oeser, Owen P. McGuinness, Jamey D. Young, Richard M. O'Brien
MOLECULAR METABOLISM
(2020)
Article
Chemistry, Organic
Dilek Isik Tasgin, Irem Bayraktar
Summary: We present a synthetic method for pyrrolizine-3-one derivatives and investigate their photophysical properties. These compounds are prepared through a series of reactions involving substituted pyrroles in one-pot, two-step oxidation, and intramolecular cyclization processes. The photophysical properties of the synthesized compounds are studied using UV-Vis and fluorescence spectroscopy in various solvents. The introduction of pyrrolyl substituents has a significant impact on Stokes shifts and quantum yield values.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Satish Kumar Burra, Vaikunta Rao Lakinani, Raghunadh Akula, Chiranjeevi Yankkanti
Summary: A novel and green strategy for the construction of biologically relevant substituted indolyl-4H-chromenes scaffolds is reported, using L-proline as a catalyst and water as a promoter solvent. This catalytic system offers wider applicability, shorter reaction times, and high yields, making it an ideal condition for green chemistry.
SYNTHETIC COMMUNICATIONS
(2024)
Review
Chemistry, Organic
Abouelhaoul El Alami, Amine El Maraghi, Fatima Youssoufi, Assiya Atif, Hamid Sdassi
Summary: Nitrobenzimidazoles have become increasingly important in the design of new compounds in medicinal, therapeutic and chemical fields. This review provides an overview of the synthesis strategies and biological activities of nitrobenzimidazole derivatives.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Nilesh Raghunath Khedkar, Alex Joseph, Milind Sindkhedkar
Summary: In this study, a new library of 3-(2-(pyrimidin-5-yl)thiazol-4-yl)-1,2,4-oxadiazole compounds was designed and synthesized as potential anticancer agents using in silico fragment-based drug design. The compounds were tested for their anticancer activity in vitro, and one compound exhibited excellent activity against multiple cancer cell lines.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Terungwa H. Iorkula, Bryce A. Tolman, Scott R. Burt, Matt A. Peterson
Summary: A new method for synthesizing C-6 substituted products has been discovered in this study, which utilizes lower doses of fluoride and CsF as a catalyst, with high reaction yields and cost-effectiveness under suitable conditions.
SYNTHETIC COMMUNICATIONS
(2024)
Review
Chemistry, Organic
Ranjana Aggarwal, Swati Sharma
Summary: This review article mainly focuses on the synthesis of 3(5)-trifluoromethylpyrazoles via condensation reaction of trifluoromethyl-beta-diketones with hydrazines. It emphasizes the importance of fluorine-containing compounds and pyrazoles in the field of biology. The literature reported condensation reactions of trifluoromethyl-beta-diketones with hydrazines are covered.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
F. M. Alshareef, Sami A. Al-Harbi, Esam S. Allehyani, Omeima Abdullah, Magdy A. Ibrahim
Summary: This study aimed to construct a novel category of linear annulated chromeno[3',2':5,6]pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidines. The chemical reactivity of the synthesized compounds was investigated, and they showed significant antimicrobial activity against various strains.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Preethi Dhanapal, S. L. Manju
Summary: Thiazole based Schiff base scaffolds have become an integral part of drug development in recent years, playing a versatile role as building blocks for lead drug molecules. This study presents a facile one pot synthetic method for producing novel 4-aryl thiazoles with high yield, shorter reaction time, and milder conditions, without the need for catalysts or purification techniques.
SYNTHETIC COMMUNICATIONS
(2024)
