Review
Chemistry, Multidisciplinary
Kai Dong, Chen Xu, Jinsong Ren, Xiaogang Qu
Summary: Nanozymes, which combine enzymatic activity and nanomaterials, have gained significant attention. However, substrate selectivity is often overlooked in the development of nanozymes. This Mini-review provides an overview of recent advances in synthesizing chiral nanozymes and their enantioselective biological catalysis, along with current challenges, potential solutions, and future trends.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Da Xu, Yu Chang, Yidong Liu, Wenling Qin, Hailong Yan
Summary: This study achieved the enantioselective construction of stable VQM intermediates through organocatalyzed bromination, and revealed the mechanistic details of the two sequential events in VQM-involved reactions. The high potential of VQM as axially chiral synthetic reagents in organic chemistry was demonstrated.
Article
Chemistry, Multidisciplinary
Yang Sun, Kais Dhbaibi, Hortense Lauwick, Claudia Lalli, Gregory Taupier, Yann Molard, Rafael Gramage-Doria, Sylvie Derien, Jeanne Crassous, Mathieu Achard
Summary: A novel enantiopure pi-allylruthenium(IV) precatalyst was used for the enantioselective and stereospecific allylations of indoles, resulting in the synthesis of indolin-3-ones with vicinal stereogenic centers. The separation of diastereoisomers that exhibited opposite circularly polarized luminescence (CPL) activities in various solvents, including water, highlighted the potential of these sustainable transformations and the newly synthesized molecules.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Yuefei Wang, Qing Li, Jiaxing Zhang, Wei Qi, Shengping You, Rongxin Su, Zhimin He
Summary: This study reports the self-templated assembly of amyloid-like dipeptides into long-range-ordered hierarchical helical arrays through spontaneous fibrillization and hierarchical helical assembly within a confined film. By changing the chirality and enantioselective interactions, researchers can precisely control the phase behavior, handedness, and chiroptics of the self-assembled HHAs. The redox activity of HHAs allows for the in situ decoration of nanoparticles with high catalytic activity.
Article
Chemistry, Multidisciplinary
Masashi Uno, Tatsuhiro Kojima, Naoto Kuwamura, Nobuto Yoshinari, Takumi Konno
Summary: Spontaneous resolution of chiral compounds interacting with specific metal complexes in water is reported in this study, leading to the formation of ionic crystals capable of undergoing spontaneous resolution. This finding offers significant insight into optical resolution of chemical species, spontaneous resolution, and the origin of homochirality in nature.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Physical
Bingxue Liu, Qiang Liu
Summary: Cobalt-catalyzed hydroalkylation of alkenes and alkynes is an efficient method for selective formation of C-C bonds. Significant progress has been made in the past five years, covering different reaction mechanisms.
Article
Chemistry, Multidisciplinary
Junjun Liu, Lin Yang, Ping Qin, Shiqing Zhang, Ken Kin Lam Yung, Zhifeng Huang
Summary: Inorganic nanoparticles are a versatile platform for biomedical applications, particularly in the study and application of chiral effects. Recent research focuses on characterizing 3D stereochirality, bionic fabrication of hierarchical chirality, studying optical activities, and experimental demonstration in biomedical applications. These studies pave the way for fully understanding and utilizing chiral effects in the design and fabrication of inorganic chiral nanoparticles for practical problem-solving in environment and public health.
ADVANCED MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Ana Sofia Almeida, Barbara Silva, Paula Guedes de Pinho, Fernando Remiao, Carla Fernandes
Summary: New psychoactive substances, such as synthetic cathinones, pose a public health threat as they are easily accessible online and often sold as legal alternatives to illicit drugs. Synthetic cathinones are widely abused due to their stimulating and hallucinogenic effects. However, their chemical and toxicological properties remain unknown, as new derivatives continue to emerge on the drug market. This review focuses on the recent developments in synthetic cathinones, including over 50 derivatives since 2014, and highlights the importance of enantioselectivity studies and enantioseparation analysis in understanding their biological and toxicological activities.
Review
Chemistry, Applied
Xing Wang, Xuling Chen, Wei Lin, Pengfei Li, Wenjun Li
Summary: Axially chiral allenes are important natural products and synthetic molecules with significant biological activity. The catalytic enantioselective synthesis of these compounds has been widely studied, and many simple and efficient methods have been developed, thanks to the advancements in asymmetric organocatalysis.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Johannes Grosskopf, Alexandra A. Heidecker, Thorsten Bach
Summary: Racemic 3-substituted oxindoles can be converted into enantiomerically pure or enriched material through photochemical deracemization process. Light energy compensates for the loss of entropy and enables predictable editing of the stereogenic center. The obtained oxindoles are valuable intermediates for further transformations with complete retention at the stereogenic center.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Ben Teichmann, Ana-Maria Krause, Mei-Jin Lin, Frank Wuerthner
Summary: This study introduces the concept of tailored chiral pi-surfaces and demonstrates enantioselective binding through pure van-der-Waals interactions. The BPTI receptor with a contorted pi-scaffold achieved significant enantiodifferentiation with (P)- and (M)-[6]helicene. The enantioselective recognition is observable by the naked eye.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Salih Okur, Peng Qin, Abhinav Chandresh, Chun Li, Zejun Zhang, Ulrich Lemmer, Lars Heinke
Summary: Chirality plays a crucial role in nature, especially in biological information transfer through odor messenger molecules. A sensor array coated with metal-organic framework (MOF) films of different homochiral and achiral structures has been developed to selectively identify and discriminate chiral odor molecules, demonstrating the potential of chiral-MOF e-nose for advanced odor sensing.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Qing-Qing Hang, Shu-Fang Wu, Shuang Yang, Xue Wang, Zhen Zhong, Yu-Chen Zhang, Feng Shi
Summary: The catalytic atroposelective synthesis of axially chiral isochromenone-indoles has been achieved using homophthalic anhydride-based indole derivatives as a new platform molecule for dynamic kinetic resolution. A wide range of axially chiral isochromenone-indoles were synthesized in high yields and excellent enantioselectivities using chiral quaternary ammonium salt as a phase-transfer catalyst in the catalytic asymmetric sulfonylation reaction.
SCIENCE CHINA-CHEMISTRY
(2022)
Review
Chemistry, Physical
Judith Muench, Pascal Puellmann, Wuyuan Zhang, Martin J. Weissenborn
Summary: The enzymatic hydroxylation of activated and nonactivated sp(3)-carbons is challenging in organic synthesis, but nature provides a variety of enzymes with catalytic versatility to tackle this task. Different enzymes have distinct specificity in substrate scope, selectivity, activity, stability, and catalytic cycle, and factors such as heterologous production, crystal structure availability, enzyme engineering potential, and substrate promiscuity play crucial roles in the applicability of these biocatalysts.
Review
Chemistry, Multidisciplinary
Lichao Sun, Yunlong Tao, Guizeng Yang, Chuang Liu, Xuehao Sun, Qingfeng Zhang
Summary: Intrinsically chiral plasmonic nanomaterials, which combine plasmonic features with geometric chirality, exhibit intriguing geometry-dependent chiroptical properties. These nanomaterials have become promising candidates for applications in biosensing, asymmetric catalysis, biomedicine, and photonics. Recent advances in geometric control and optical tuning have further expanded the potential applications of these nanomaterials in various emerging technological areas. This review focuses on the recent developments in the geometric control of chiral plasmonic nanomaterials and the quantitative understanding of the structure-property relationship. It also discusses important optical spectroscopic tools for characterizing the optical chirality of these nanomaterials and highlights three emerging applications in enantioselective sensing, enantioselective catalysis, and biomedicine. These advanced studies in chiral plasmonic nanomaterials are expected to pave the way for the rational design of chiral nanomaterials with desired optical properties for diverse emerging technological applications.
ADVANCED MATERIALS
(2023)
