Article
Chemistry, Physical
Da Xu, Yu Chang, Yidong Liu, Wenling Qin, Hailong Yan
Summary: This study achieved the enantioselective construction of stable VQM intermediates through organocatalyzed bromination, and revealed the mechanistic details of the two sequential events in VQM-involved reactions. The high potential of VQM as axially chiral synthetic reagents in organic chemistry was demonstrated.
Article
Chemistry, Multidisciplinary
Qing-Qing Hang, Shu-Fang Wu, Shuang Yang, Xue Wang, Zhen Zhong, Yu-Chen Zhang, Feng Shi
Summary: The catalytic atroposelective synthesis of axially chiral isochromenone-indoles has been achieved using homophthalic anhydride-based indole derivatives as a new platform molecule for dynamic kinetic resolution. A wide range of axially chiral isochromenone-indoles were synthesized in high yields and excellent enantioselectivities using chiral quaternary ammonium salt as a phase-transfer catalyst in the catalytic asymmetric sulfonylation reaction.
SCIENCE CHINA-CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ke-Wei Chen, Zhi-Han Chen, Shuang Yang, Shu-Fang Wu, Yu-Chen Zhang, Feng Shi
Summary: A new strategy has been developed for the highly atroposelective synthesis of N-N axially chiral indole scaffolds and bispyrroles, which can be used as chiral organocatalysts and exhibit potent anticancer activity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Feng-Tao Sheng, Shuang Yang, Shu-Fang Wu, Yu-Chen Zhang, Feng Shi
Summary: A new strategy for the enantioselective synthesis of axially chiral 3,3'-bisindoles was developed by directly coupling two indole rings using the C3-umpolung reactivity of 2-indolylmethanols. The synthesized compounds can be further modified to create axially chiral 3,3'-bisindole-based organocatalysts for asymmetric catalysis.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Si-Jia Liu, Zhi-Han Chen, Jia-Yi Chen, Shao-Fei Ni, Yu-Chen Zhang, Feng Shi
Summary: A new class of axially chiral styrene-based thiourea tertiary amine catalysts with efficient synthetic route, multiple chiral elements, and multiple activating groups has been designed. These catalysts have proven to be efficient in enabling the cyclization reaction of 2-benzothiazolimines and homophthalic anhydrides with high yields and excellent stereoselectivities. The role of axially chiral styrene moiety in controlling reactivity and enantioselectivity has been elucidated through theoretical calculations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Seitaro Koshino, Tohru Taniguchi, Kenji Monde, Eunsang Kwon, Yujiro Hayashi
Summary: A one-pot synthesis of biaryls was developed using a catalytic amount of a single chiral source, allowing for an enantiodivergent chirality conversion from central-to-axial chirality with excellent enantioselectivity. Both enantiomers of biaryls were obtained in a single reaction vessel, with a proposed plausible reaction mechanism for the enantiodivergence.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Applied
Michela Lupi, Omar Salmi, Caterina Viglianisi, Stefano Menichetti
Summary: This article reports the conversion of N-thiophthalimido-arylphenothiazines 2 and triarylamines 3 to dithiabridged triarylamine hetero[4]helicenes 1 using catalytic amounts of chalcogen substituted Lewis Bases and hexafluoro isopropanol as hydrogen bond donor. The procedure provides good yields under mild reaction conditions without the need for excess Lewis Acids. It also presents a preliminary study on the control of the M and P absolute stereochemistry of helicenes 1 using enantiopure sulfur containing Lewis Bases from the natural chiral pool.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Review
Chemistry, Organic
Marcus Muresan, Hariharaputhiran Subramanian, Mukund P. Sibi, James R. Green
Summary: This minireview discusses the increasing importance of propargyl radicals as synthetic intermediates in recent years. It covers the mechanisms of their generation and reactions, as well as their applications in the synthesis of target molecules.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Clement Lemaitre, Stefania Perulli, Ophelie Quinonero, Cyril Bressy, Jean Rodriguez, Thierry Constantieux, Olga Garcia Mancheno, Xavier Bugaut
Summary: Atropisomers are intriguing objects of study for chemists and have various applications in applied chemistry. Obtaining them in enantiopure form is still a challenging task, but there have been significant advancements in recent decades. Among these, oxidative aromatization with central-to-axial conversion of chirality has gained popularity. This review critically analyzes the research field, discussing its historical background, present state of the art, and potential future development directions.
Article
Biochemistry & Molecular Biology
Sara F. Vieira, Joana Araujo, Virginia M. F. Goncalves, Carla Fernandes, Madalena Pinto, Helena Ferreira, Nuno M. Neves, Maria Elizabeth Tiritan
Summary: The relationship between drug chirality and biological activity has gained significant importance in medicinal chemistry in recent years. Chiral derivatives of xanthones (CDXs) exhibit interesting biological activities, such as enantioselective anti-inflammatory effects. This study describes the synthesis of a library of CDXs using a chiral pool strategy, resulting in sixty new derivatives. Several CDXs showed promising anti-inflammatory activity, with the amino ester of L-tyrosine (X1AELT) being the most effective in reducing interleukin 6 (IL-6) production in macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
I-Ting Chen, Ren-You Guan, Jeng-Liang Han
Summary: In this study, a catalytic asymmetric vinylogous Mannich/annulation/acylation reaction was developed for the synthesis of chiral spiro-oxindole piperidine derivatives with polyaromatic scaffolds. The reaction provided the desired products in good yields and high enantioselectivity. DFT computational calculations were used to explain the mechanism and origin of the observed enantioselectivity and O-acetylated products.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Martin Berger, Davide Carboni, Paolo Melchiorre
Summary: The study presents the first catalytic enantioselective conjugate addition of allyl groups to alpha, beta-unsaturated aldehydes, utilizing the visible-light-excitation of chiral iminium ions to activate allyl silanes toward the formation of allylic radicals. This radical mechanism overcomes issues seen in traditional conjugate allylation processes and selectively installs prenyl fragments at the beta-carbon of enals.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Ali Nikbakht, Kamran Amiri, Hormoz Khosravi, Yirong Zhou, Saeed Balalaie, Bernhard Breit
Summary: This novel copper-catalyzed cycloisomerization reaction provides a practical and efficient method for the synthesis of hexahydropyrrolo[3,4-b]azepin-5(4H)-ones by simultaneously forming four new bonds in a single step.
Article
Chemistry, Multidisciplinary
Linlin Ding, Yue Zhao, Hongjian Lu, Zhuangzhi Shi, Minyan Wang
Summary: For the first time, a catalytic enantioselective propargyl-aryl cross-coupling between two electrophiles was achieved in a stereoconvergent manner. The potential utility of this conversion is demonstrated in the facile construction of stereoenriched bioactive molecule derivatives and medicinal compounds based on the diversity of acetylenic chemistry. Detailed experimental studies have revealed the key mechanistic features of this transformation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Everton Machado da Silva, Herika Danielle Almeida Vidal, Marcelo Augusto Pereira Januario, Arlene Goncalves Correa
Summary: BINOL derivatives are significant in terms of their biological activities and functionality as chiral ligands and catalysts, hence attracting considerable interest in their asymmetric synthesis. This paper provides an overview of the most efficient methods for obtaining chiral BINOLs, with emphasis on the utilization of metal complexes and organocatalysts, as well as kinetic resolution. Further derivatizations of BINOLs are also addressed.
Article
Microbiology
Hua-Peng Xue, Zi-Yue Fu, Wei He, Lei Wang, Wen-Jun Li, Ai Hua Zhang, Jian-Ke Huang, Dao-Feng Zhang, Zhe Zhao
Summary: A new species of genus Paracoccus, named Paracoccus marinaquae sp. nov., was isolated from the coastal water of the Yellow Sea, China. This bacterium is Gram-stain-negative, non-motile and coccoid. It grows at a temperature range of 20-37 degrees C, pH range of 5.0-9.0, and NaCl concentration range of 0-7.0%. Based on phylogenetic analysis and phenotypic characteristics, it was determined to be a novel species within the genus Paracoccus.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Hardy Kornfeld, Elizabeth Procter-Gray, Satyavani Kumpatla, Kevin Kane, Wenjun Li, Matthew J. Magee, Subash Babu, Vijay Viswanathan
Summary: This study aimed to investigate the impact of pulmonary TB on glycemic status, as well as the associations of glycemic trends with antidiabetic therapy and TB outcomes. Data from two prospective cohort studies in Chennai, India were analyzed and it was found that baseline A1C levels decreased after TB treatment initiation in all groups. However, in patients with baseline diabetes, rising A1C levels during and after treatment were significantly associated with adverse TB outcomes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Geochemistry & Geophysics
Wenjun Li, Jing Wang, Mengmeng Cui, Xia Liu, Lihui Jia, Kaiyun Chen, Shitou Wu, Bingyu Gao, Dingshuai Xue, Yanhong Liu, Chao Li, Yang Luo, Benxun Su
Summary: Two clinopyroxene megacrysts, DMP-2 and DMP-3, from Cenozoic alkali basalts in Hannuoba region of China were characterized for major and trace element compositions through in situ microanalysis. Both clinopyroxene samples showed homogeneity in element mass fractions based on EPMA and LA-ICP-MS analyses. Bulk analyses using XRF, ICP-OES and solution ICP-MS techniques also revealed consistent major and trace element data. Thus, these samples can serve as potential reference materials for elemental in situ microanalysis, with recommended element mass fractions for thirty-two elements.
GEOSTANDARDS AND GEOANALYTICAL RESEARCH
(2023)
Article
Microbiology
Wenkai Teng, Bin Liao, Mengyun Chen, Wensheng Shu
Summary: GC content is an important factor in microbial ecology and evolution, and the genomic GC of bacteria is characterized by heterogeneity between genomes, homogeneity within genomes, strong phylogenetic inertia, and association with the environment. Current hypotheses regarding direct selection or mutational biases cannot explain these features simultaneously. This study provides evidence that ancient adaptations have transformed the DNA replication and repair system, resulting in mutational biases that contribute to a bimodal distribution of genomic GC. This highlights the importance of indirect effects of natural selection in bacterial evolution.
MICROBIOLOGY SPECTRUM
(2023)
Article
Genetics & Heredity
Wen-Hui Lian, Osama Abdalla Abdelshafy Mohamad, Lei Dong, Ling-Yu Zhang, Dong Wang, Lan Liu, Ming-Xian Han, Shuai Li, Shuang Wang, Andre Antunes, Bao-Zhu Fang, Jian-Yu Jiao, Wen-Jun Li
Summary: This study analyzed the microbial diversity and function of rhizosphere soil samples from Sinai Desert farming systems, revealing a wide range of microbial taxa and differences in composition between sampling sites. However, functional features were similar across different sites. The study highlights the importance of functional microbiomes in rhizosphere microbial communities.
ENVIRONMENTAL MICROBIOME
(2023)
Article
Plant Sciences
Guangzhao Jin, Wenjun Li, Feng Song, Lei Yang, Zhibin Wen, Ying Feng
Summary: This study sequenced and compared the chloroplast genomes of 16 species within the subgenus Seriphidium, revealing genetic consistency and variation in the subgenus. It also identified repetitive sequences and highly variable loci, and found inconsistencies between the molecular phylogeny and traditional taxonomy of subgenus Seriphidium. The whole chloroplast genomes can serve as molecular markers to infer interspecific relationships in this taxon.
Article
Microbiology
Chun-Yan Lu, Lei Dong, Shuai Li, Wen-Hui Lian, Zhi-Liang Lin, Zhuo-Huan Zheng, Lei Gao, Bao-Zhu Fang, Wen-Jun Li
Summary: A new actinobacterium, SYSU T00001(T), was isolated from a tidal flat sediment sample from Guangdong province, China. The isolate exhibited unique characteristics and showed highest similarity to Salinibacterium hongtaonis 194(T) based on phylogenetic analyses. Therefore, a novel species of the genus Salinibacterium, Salinibacterium sedimenticola sp. nov., is proposed, with SYSU T00001(T) as the type strain.
CURRENT MICROBIOLOGY
(2023)
Article
Fisheries
Chong Han, Wenwei Huang, Suhan Peng, Jiangwei Zhou, Huawei Zhan, Wenjun Li, Jian Gong, Qiang Li
Summary: In this study, 11 members of IRFs were identified and their expression patterns in different tissues were analyzed in the zig-zag eel. The results provide valuable information for understanding the antibacterial mechanism of IRFs in teleosts.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Microbiology
Yong-Hong Liu, Osama Abdalla Abdelshafy Mohamad, Lei Gao, Yuan-Guo Xie, Rashidin Abdugheni, Yin Huang, Li Li, Bao-Zhu Fang, Wen-Jun Li
Summary: This study investigated the distribution and potential functions of prokaryotes in different saline lakes in Xinjiang using the cultivation-independent method of amplicon sequencing. The results showed that Proteobacteria was the predominant community in all types of saline lakes, while Desulfobacterota, Firmicutes, Acidobacteriota, and Chloroflexi were mainly distributed in hypersaline, arid saline, and light saltwater lakes respectively. The functional group analysis revealed that fermentation was the main metabolic process of microbes in all saline lakes. Environmental factors such as SO42-, Na+, CO32-, and TN were found to significantly affect the microbial community.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xin-Feng Zhao, Bo-Hui Li, Wen-Sheng Shu, Yi-Qi Hao
Summary: This study found that fluctuating temperature has a positive effect on species diversity in soil bacterial communities compared to constant temperatures, and it also affects bacterial performances. The analysis showed that fluctuating temperature can delay species loss, and temperature-responsive species exhibit performance deviations under fluctuating temperature compared to constant temperatures. Additionally, the effects of fluctuating temperature on species diversity in soil bacterial communities may vary across latitude.
Article
Cell Biology
Yan-Ni Qu, Yang-Zhi Rao, Yan-Ling Qi, Yu-Xian Li, Andrew Li, Marike Palmer, Brian P. Hedlund, Wen-Sheng Shu, Paul N. Evans, Guo-Xing Nie, Zheng-Shuang Huo, Wen-Jun Li
Summary: By reconstructing 10 closely related metagenome-assembled genomes from hot spring habitats, we discovered a new species, Panguiarchaeum symbiosum. Our functional investigations revealed that Panguiarchaeum symbiosum is an anaerobic organism that exclusively grows in thermal habitats by fermenting peptides and producing sulfide and hydrogen. The species likely lives in a symbiotic lifestyle similar to DPANN archaea. Population metagenomics and metatranscriptomic analyses supported the proposed proteolytic catabolism and symbiotic lifestyle of Panguiarchaeum symbiosum. This study provides insights into the metabolism, evolution, and potential symbiotic lifestyle of this unique archaeon within the TACK superphylum.
Article
Microbiology
Kun Zhang, Yanling Zhang, Maocheng Deng, Pengcheng Wang, Xiu Yue, Pandeng Wang, Wenjun Li
Summary: In this study, the dynamics of microbial and viral communities in an expanded granular sludge bed (EGSB) reactor were investigated. The results showed that COD, VSS/TSS ratio, and temperature were the main factors affecting the microbial community structure. The study also identified key genes involved in nitrogen cycling, with the dissimilatory nitrate reduction to ammonia (DNRA) and denitrification pathways dominating in the anaerobic system. The findings provide insights for the optimization of engineered systems.
FRONTIERS IN MICROBIOLOGY
(2023)
Editorial Material
Microbiology
Hongchen Jiang, Wen-Jun Li, Nils-Kare Birkeland, Dilfuza Egamberdieva
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qian Du, Xin Xi, Jie Dong, Tongyan Zhang, Dongxuan Li, Yuzhu Dong, Wenjun Li, Guili Huang, Jun Zhu, Hailong Ran, Jinghui Gou, Cheng Chen, Zhanfeng Bai, Qinglong Liu, Wei Yao, Lei Zhang, Yutian Bi, Songqing Liu
Summary: This study found that early active pharmacy infectious disease consultation can reduce 30-day all-cause mortality and improve clinical outcomes in multidrug-resistant organism patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Cale O. Seymour, Marike Palmer, Eric D. Becraft, Ramunas Stepanauskas, Ariel D. Friel, Frederik Schulz, Tanja Woyke, Emiley Eloe-Fadrosh, Dengxun Lai, Jian-Yu Jiao, Zheng-Shuang Hua, Lan Liu, Zheng-Han Lian, Wen-Jun Li, Maria Chuvochina, Brianna K. Finley, Benjamin J. Koch, Egbert Schwartz, Paul Dijkstra, Duane P. Moser, Bruce A. Hungate, Brian P. Hedlund
Summary: The candidate bacterial phylum Omnitrophota is poorly studied. By analyzing genomes and data from the Earth Microbiome Project, researchers found that Omnitrophota are ultra-small cells mainly found in water, sediments, and soils. These bacteria have reduced genomes but retain key metabolic pathways and symbiotic gene clusters, indicating a host-associated lifestyle. Additionally, stable-isotope probing identified certain Omnitrophota families as potential obligate bacterial predators. Overall, most Omnitrophota inhabit various ecosystems as predators or parasites.
NATURE MICROBIOLOGY
(2023)
