An integrative systems genetics approach reveals potential causal genes and pathways related to obesity

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

Gene expression analysis identifies global gene dosage sensitivity in cancer

(2015) Rudolf S N Fehrmann et al.   NATURE GENETICS

From genome to function by studying eQTLs

(2014) Harm-Jan Westra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Identification of co-expression gene networks, regulatory genes and pathways for obesity based on adipose tissue RNA Sequencing in a porcine model

(2014) Lisette J A Kogelman et al.   BMC Medical Genomics

Genomics to systems biology in animal and veterinary sciences: Progress, lessons and opportunities

(2014) Haja N. Kadarmideen   Livestock Science

Brown Fat Determination and Development from Muscle Precursor Cells by Novel Action of Bone Morphogenetic Protein 6

(2014) Ankur Sharma et al.   PLoS One

Effects of mutations and deletions in the human optineurin gene

(2014) Sanja Turturro et al.   SpringerPlus

The role of protein interaction networks in systems biomedicine

(2014) Tuba Sevimoglu et al.   Computational and Structural Biotechnology Journal

Expression studies of six human obesity-related genes in seven tissues from divergent pig breeds

(2013) S. Cirera et al.   ANIMAL GENETICS

CIDEC/FSP27 and PLIN1 gene expression run in parallel to mitochondrial genes in human adipose tissue, both increasing after weight loss

(2013) J M Moreno-Navarrete et al.   INTERNATIONAL JOURNAL OF OBESITY

Abnormal expression of chondroitin sulphate N-acetylgalactosaminyltransferase 1 and Hapln-1 in cartilage with Kashin–Beck disease and primary osteoarthritis

(2013) Jingjing Zheng et al.   INTERNATIONAL ORTHOPAEDICS

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

Systems genetics approaches to understand complex traits

(2013) Mete Civelek et al.   NATURE REVIEWS GENETICS

p11 and its role in depression and therapeutic responses to antidepressants

(2013) Per Svenningsson et al.   NATURE REVIEWS NEUROSCIENCE

Artemin–GFRα3 interactions partially contribute to acute inflammatory hypersensitivity

(2013) Peter Thornton et al.   NEUROSCIENCE LETTERS

The MIntAct project—IntAct as a common curation platform for 11 molecular interaction databases

(2013) Sandra Orchard et al.   NUCLEIC ACIDS RESEARCH

Genome-Wide Association Study Reveals Genetic Architecture of Eating Behavior in Pigs and Its Implications for Humans Obesity by Comparative Mapping

(2013) Duy Ngoc Do et al.   PLoS One

ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC

(2013) Jacqueline L. Blankman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Elucidating Molecular Networks That Either Affect or Respond to Plasma Cortisol Concentration in Target Tissues of Liver and Muscle

(2012) S. Ponsuksili et al.   GENETICS

miRNA and Protein Expression Profiles of Visceral Adipose Tissue Reveal miR-141/YWHAG and miR-520e/RAB11A as Two Potential miRNA/Protein Target Pairs Associated with Severe Obesity

(2012) Valentina Capobianco et al.   JOURNAL OF PROTEOME RESEARCH

From genome-wide association studies to disease mechanisms: celiac disease as a model for autoimmune diseases

(2012) Vinod Kumar et al.   Seminars in Immunopathology

Characterization and improvement of RNA-Seq precision in quantitative transcript expression profiling

(2011) Paweł P. Łabaj et al.   BIOINFORMATICS

Genetic and genomic analysis of hyperlipidemia, obesity and diabetes using (C57BL/6J × TALLYHO/JngJ) F2 mice

(2011) Taryn P Stewart et al.   BMC GENOMICS

Gene expression profiling of subcutaneous adipose tissue in morbid obesity using a focused microarray: Distinct expression of cell-cycle- and differentiation-related genes

(2011) Sara Rodríguez-Acebes et al.   BMC Medical Genomics

Differential regulation of CIDEA and CIDEC expression by insulin via Akt1/2- and JNK2-dependent pathways in human adipocytes

(2011) Minoru Ito et al.   JOURNAL OF LIPID RESEARCH

Integrating expression profiling and whole-genome association for dissection of fat traits in a porcine model

(2011) S. Ponsuksili et al.   JOURNAL OF LIPID RESEARCH

Genetics of eating behavior: established and emerging concepts

(2011) Eleanor R Grimm et al.   NUTRITION REVIEWS

Systems genetics of susceptibility to obesity-induced diabetes in mice

(2011) Richard C. Davis et al.   PHYSIOLOGICAL GENOMICS

Disease Risk Links to Gene Regulation

(2011) E. Pennisi   SCIENCE

Effects of obesity on bone metabolism

(2011) Jay J Cao   Journal of Orthopaedic Surgery and Research

Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the HLA

(2011) Rudolf S. N. Fehrmann et al.   PLoS Genetics

From RNA-seq reads to differential expression results

(2011) Alicia Oshlack et al.   GENOME BIOLOGY

GLay: community structure analysis of biological networks

(2010) G. Su et al.   BIOINFORMATICS

Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor

(2010) William McLaren et al.   BIOINFORMATICS

A genome-wide association study for diabetic nephropathy genes in African Americans

(2010) Caitrin W. McDonough et al.   KIDNEY INTERNATIONAL

Systems biology of ovine intestinal parasite resistance: disease gene modules and biomarkers

(2010) Haja N. Kadarmideen et al.   Molecular BioSystems

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Gene ontology analysis for RNA-seq: accounting for selection bias

(2010) Matthew D Young et al.   GENOME BIOLOGY

Mapping complex disease traits with global gene expression

(2009) William Cookson et al.   NATURE REVIEWS GENETICS

BioMart Central Portal—unified access to biological data

(2009) Syed Haider et al.   NUCLEIC ACIDS RESEARCH

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Osteoclasts—the innate immune cells of the bone

(2008) Yalei Wu et al.   AUTOIMMUNITY

Lysophosphatidylserine regulates blood glucose by enhancing glucose transport in myotubes and adipocytes

(2008) Kyungmoo Yea et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

Selective Transcriptional Profiling and Data Analysis Strategies for Expression Quantitative Trait Loci Mapping in Outbred F 2 Populations

(2008) Fernando F. Cardoso et al.   GENETICS

RNA-seq: An assessment of technical reproducibility and comparison with gene expression arrays

(2008) J. C. Marioni et al.   GENOME RESEARCH

Heritability in the genomics era — concepts and misconceptions

(2008) Peter M. Visscher et al.   NATURE REVIEWS GENETICS

RNA-Seq: a revolutionary tool for transcriptomics

(2008) Zhong Wang et al.   NATURE REVIEWS GENETICS

Gene-environment Association of an ITGB2 Sequence Variant With Obesity in Ethnic Japanese

(2008) Tomokazu Awaya et al.   Obesity

Up-Regulation of Mitochondrial Activity and Acquirement of Brown Adipose Tissue-Like Property in the White Adipose Tissue of Fsp27 Deficient Mice

(2008) Shen Yon Toh et al.   PLoS One