Complete re-sequencing of a 2Mb topological domain encompassing the FTO/IRXB genes identifies a novel obesity-associated region upstream of IRX5

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypomorphism for RPGRIP1L, a Ciliary Gene Vicinal to the FTO Locus, Causes Increased Adiposity in Mice

(2014) George Stratigopoulos et al.   Cell Metabolism

Obesity and FTO: Changing Focus at a Complex Locus

(2014) Y.C. Loraine Tung et al.   Cell Metabolism

The role of the FTO (Fat Mass and Obesity Related) locus in regulating body size and composition

(2014) Giles S.H. Yeo   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

CTCF: an architectural protein bridging genome topology and function

(2014) Chin-Tong Ong et al.   NATURE REVIEWS GENETICS

Systematic Fine-Mapping of Association with BMI and Type 2 Diabetes at the FTO Locus by Integrating Results from Multiple Ethnic Groups

(2014) Koichi Akiyama et al.   PLoS One

The Influence of Obesity-Related Single Nucleotide Polymorphisms on BMI Across the Life Course: The PAGE Study

(2013) M. Graff et al.   DIABETES

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

(2013) Sonja I Berndt et al.   NATURE GENETICS

Ensembl 2014

(2013) Paul Flicek et al.   NUCLEIC ACIDS RESEARCH

Extensive Promoter-Centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation

(2012) Guoliang Li et al.   CELL

Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology

(2012) N. Gaborit et al.   DEVELOPMENT

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Topological domains in mammalian genomes identified by analysis of chromatin interactions

(2012) Jesse R. Dixon et al.   NATURE

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Basic statistical analysis in genetic case-control studies

(2011) Geraldine M Clarke et al.   Nature Protocols

Influences of the Common FTO rs9939609 Variant on Inflammatory Markers Throughout a Broad Range of Body Mass Index

(2011) Esther Zimmermann et al.   PLoS One

Genome-Wide Population-Based Association Study of Extremely Overweight Young Adults – The GOYA Study

(2011) Lavinia Paternoster et al.   PLoS One

An evolutionarily conserved three-dimensional structure in the vertebrate Irx clusters facilitates enhancer sharing and coregulation

(2011) Juan J. Tena et al.   Nature Communications

Variant rs9939609 in the FTO gene is associated with body mass index among Chinese children

(2010) Hongyun Fang et al.   BMC Medical Genetics

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

Cut-like Homeobox 1 (CUX1) Regulates Expression of the Fat Mass and Obesity-associated and Retinitis Pigmentosa GTPase Regulator-interacting Protein-1-like (RPGRIP1L) Genes and Coordinates Leptin Receptor Signaling

(2010) George Stratigopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

FTOgene variation and measures of body mass in an African population

(2009) Branwen J Hennig et al.   BMC Medical Genetics

Regulation and Function of FTO mRNA Expression in Human Skeletal Muscle and Subcutaneous Adipose Tissue

(2009) L. G. Grunnet et al.   DIABETES

Life course variations in the associations between FTO and MC4R gene variants and body size

(2009) R. Hardy et al.   HUMAN MOLECULAR GENETICS

FTO Genotype Is Associated with Body Mass Index after the Age of Seven Years But Not with Energy Intake or Leisure-Time Physical Activity

(2009) Maarit Hakanen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Inactivation of the Fto gene protects from obesity

(2009) Julia Fischer et al.   NATURE

Fatness-Associated FTO Gene Variant Increases Mortality Independent of Fatness – in Cohorts of Danish Men

(2009) Esther Zimmermann et al.   PLoS One

Severe Obesity in Young Women and Reproductive Health: The Danish National Birth Cohort

(2009) Ellen A. Nohr et al.   PLoS One

Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3

(2009) A. Ragvin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene

(2009) Chris Church et al.   PLoS Genetics

Enrichment of sequencing targets from the human genome by solution hybridization

(2009) Ryan Tewhey et al.   GENOME BIOLOGY

Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans

(2008) N. Klöting et al.   DIABETOLOGIA

Impact on weight dynamics and general growth of the common FTO rs9939609: a longitudinal Danish cohort study

(2008) T Jess et al.   INTERNATIONAL JOURNAL OF OBESITY

Lack of Association of Fatness-Related FTO Gene Variants with Energy Expenditure or Physical Activity

(2008) T. Berentzen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Variations in the FTO gene are associated with severe obesity in the Japanese

(2008) Kikuko Hotta et al.   JOURNAL OF HUMAN GENETICS

TheFTOGene Is Associated With Adulthood Obesity in the Mexican Population

(2008) Marisela Villalobos-Comparán et al.   Obesity

FTO Gene Associated Fatness in Relation to Body Fat Distribution and Metabolic Traits throughout a Broad Range of Fatness

(2008) Sofia I. I. Kring et al.   PLoS One