Differential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer’s disease

BACE1 Activity in Cerebrospinal Fluid and Its Relation to Markers of AD Pathology

(2017) Sandra D. Mulder et al.   JOURNAL OF ALZHEIMERS DISEASE

Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer’s Disease

(2015) Wioletta Rozpedek et al.   CURRENT MEDICINAL CHEMISTRY

Sex modifies theAPOE-related risk of developing Alzheimer disease

(2014) Andre Altmann et al.   ANNALS OF NEUROLOGY

Overexpression of JAZF1 protected ApoE-deficient mice from atherosclerosis by inhibiting hepatic cholesterol synthesis via CREB-dependent mechanisms

(2014) Xiaoqiang Li et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Disability and Care Needs Among Older Americans

(2014) VICKI A. FREEDMAN et al.   MILBANK QUARTERLY

Contribution of Alzheimer disease to mortality in the United States

(2014) B. D. James et al.   NEUROLOGY

The effect of chicken extract on ERK/CREB signaling is ApoE isoform-dependent

(2014) Shan-May Yong et al.   Food & Function

Apolipoprotein E, gender, and Alzheimer’s disease: an overlooked, but potent and promising interaction

(2013) Leo Ungar et al.   Brain Imaging and Behavior

BACE1 Levels by APOE Genotype in Non-Demented and Alzheimer’s Post-Mortem Brains

(2013) Boris Decourt et al.   Current Alzheimer Research

Cognitive Deficits and Disruption of Neurogenesis in a Mouse Model of Apolipoprotein E4 Domain Interaction

(2013) Samuel O. Adeosun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blocking the apolipoprotein E/Amyloid β interaction in triple transgenic mice ameliorates Alzheimer's disease related amyloid β and tau pathology

(2013) Shan Liu et al.   JOURNAL OF NEUROCHEMISTRY

Genetics of dementia

(2013) Clement T Loy et al.   LANCET

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

APOE-related biomarker profiles in non-pathological aging and early phases of Alzheimer's disease

(2013) Ivar Reinvang et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Monetary Costs of Dementia in the United States

(2013) Michael D. Hurd et al.   NEW ENGLAND JOURNAL OF MEDICINE

Animal Models of Alzheimer Disease

(2013) F. M. LaFerla et al.   Cold Spring Harbor Perspectives in Medicine

Minireview: Translational Animal Models of Human Menopause: Challenges and Emerging Opportunities

(2012) Roberta Diaz Brinton   ENDOCRINOLOGY

Behavioral phenotype and BDNF differences related to apoE isoforms and sex in young transgenic mice

(2012) Ingrid Reverte et al.   EXPERIMENTAL NEUROLOGY

Gender Modulates the APOE  4 Effect in Healthy Older Adults: Convergent Evidence from Functional Brain Connectivity and Spinal Fluid Tau Levels

(2012) J. S. Damoiseaux et al.   JOURNAL OF NEUROSCIENCE

Allopregnanolone Reinstates Tyrosine Hydroxylase Immunoreactive Neurons and Motor Performance in an MPTP-Lesioned Mouse Model of Parkinson's Disease

(2012) Samuel O. Adeosun et al.   PLoS One

Sex and gonadal hormones in mouse models of Alzheimer’s disease: what is relevant to the human condition?

(2012) Dena B Dubal et al.   Biology of Sex Differences

Performing Vaginal Lavage, Crystal Violet Staining, and Vaginal Cytological Evaluation for Mouse Estrous Cycle Staging Identification

(2012) Ashleigh C. McLean et al.   Jove-Journal of Visualized Experiments

BACE1 Elevation is Involved in Amyloid Plaque Development in the Triple Transgenic Model of Alzheimer’s Disease: Differential Aβ Antibody Labeling of Early-Onset Axon Terminal Pathology

(2011) Yan Cai et al.   NEUROTOXICITY RESEARCH

Sex differences in β-amyloid accumulation in 3xTg-AD mice: Role of neonatal sex steroid hormone exposure

(2010) Jenna C. Carroll et al.   BRAIN RESEARCH

Analysis of Oestrogen Regulation of Alpha-, Beta- and Gamma-Secretase Gene and Protein Expression in Cultured Human Neuronal and Glial Cells

(2010) Linda Csöregh Nord et al.   Neurodegenerative Diseases

Oestrogen Downregulates BACE Protein in Human Cell Culture: What Does This Teach Us about Alzheimer’s Disease?

(2010) Hans-Gert Bernstein et al.   Neurodegenerative Diseases

Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer's disease

(2010) Z. Amtul et al.   NEUROSCIENCE

Apolipoprotein E4 Domain Interaction Induces Endoplasmic Reticulum Stress and Impairs Astrocyte Function

(2009) Ning Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease

(2009) Emily R. Rosario et al.   NEUROBIOLOGY OF AGING

Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan

(2009) R. W. Halford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks

(2008) Alexandra Bour et al.   BEHAVIOURAL BRAIN RESEARCH

APOE ε4 lowers age at onset and is a high risk factor for Alzheimer's disease; A case control study from central Norway

(2008) Sigrid B Sando et al.   BMC Neurology

Increased CSF-BACE 1 activity is associated with ApoE-ε4 genotype in subjects with mild cognitive impairment and Alzheimer's disease

(2008) Michael Ewers et al.   BRAIN

Genetically Altering Aβ Distribution from the Brain to the Vasculature Ameliorates Tau Pathology

(2008) Salvatore Oddo et al.   BRAIN PATHOLOGY

BACE1 Structure and Function in Health and Alzheimers Disease

(2008) Sarah Cole et al.   Current Alzheimer Research

APOE  4 allele predicts faster cognitive decline in mild Alzheimer disease

(2008) S. Cosentino et al.   NEUROLOGY