Protein kinase D enzymes: novel kinase targets in pancreatic cancer

Effective Targeting of Estrogen Receptor-Negative Breast Cancers with the Protein Kinase D Inhibitor CRT0066101

(2015) S. Borges et al.   MOLECULAR CANCER THERAPEUTICS

Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia

(2015) Geou-Yarh Liou et al.   Nature Communications

Protein Kinase D as a Potential Chemotherapeutic Target for Colorectal Cancer

(2014) N. Wei et al.   MOLECULAR CANCER THERAPEUTICS

Mutant KRAS–Induced Expression of ICAM-1 in Pancreatic Acinar Cells Causes Attraction of Macrophages to Expedite the Formation of Precancerous Lesions

(2014) Geou-Yarh Liou et al.   Cancer Discovery

Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs

(2013) Geou-Yarh Liou et al.   JOURNAL OF CELL BIOLOGY

Protein kinase D2 induces invasion of pancreatic cancer cells by regulating matrix metalloproteinases

(2013) Christoph Wille et al.   MOLECULAR BIOLOGY OF THE CELL

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

(2012) Christine M. Ardito et al.   CANCER CELL

In vitro cytotoxicity, pharmacokinetics, tissue distribution, and metabolism of small-molecule protein kinase D inhibitors, kb-NB142-70 and kb-NB165-09, in mice bearing human cancer xenografts

(2012) Jianxia Guo et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Protein Kinase D Regulates Cell Death Pathways in Experimental Pancreatitis

(2012) Jingzhen Yuan et al.   Frontiers in Physiology

Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence

(2011) Carmen Guerra et al.   CANCER CELL

Design, Synthesis, and Biological Evaluation of PKD Inhibitors

(2011) Kara M. George et al.   Pharmaceutics

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

(2010) Ian M. Evans et al.   BIOCHEMICAL JOURNAL

Protein kinase D1 promotes anchorage-independent growth, invasion, and angiogenesis by human pancreatic cancer cells

(2010) Nobuo Ochi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In vitro and In vivo

(2010) K. B. Harikumar et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose Homeostasis

(2009) Grzegorz Sumara et al.   CELL

PKD3 Is the Predominant Protein Kinase D Isoform in Mouse Exocrine Pancreas and Promotes Hormone-induced Amylase Secretion

(2008) L. Andy Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potent and Selective Disruption of Protein Kinase D Functionality by a Benzoxoloazepinolone

(2008) Elizabeth R. Sharlow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY