Design of Glycosyltransferase Inhibitors: Serine Analogues as Pyrophosphate Surrogates?

Synthesis and biological evaluation of nonionic substrate mimics of UDP-Galp as candidate inhibitors of UDP galactopyranose mutase (UGM)

(2015) Ramakrishna Kuppala et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of 5′-glycyl derivatives of uridine as inhibitors of 1,4-β-galactosyltransferase

(2015) Jadwiga Paszkowska et al.   BIOORGANIC CHEMISTRY

Beyond substrate analogues: new inhibitor chemotypes for glycosyltransferases

(2014) Lauren Tedaldi et al.   MedChemComm

Sialyltransferase inhibitors: consideration of molecular shape and charge/hydrophobic interactions

(2013) Rishi Kumar et al.   CARBOHYDRATE RESEARCH

Design of Glycosyltransferase Inhibitors: Pyridine as a Pyrophosphate Surrogate

(2013) Shuai Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Glycosyltransferase Inhibitor from a Molecular Fragment Library Simultaneously Interferes with Metal Ion and Substrate Binding

(2012) Rene Jørgensen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A New Concept for Glycosyltransferase Inhibitors: Nonionic Mimics of the Nucleotide Donor of the Human Blood Group B Galactosyltransferase

(2012) Katrin Schaefer et al.   CHEMBIOCHEM

Recent structures, evolution and mechanisms of glycosyltransferases

(2012) Christelle Breton et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase

(2011) Jiaoyang Jiang et al.   Nature Chemical Biology

The first C-glycosidic analogue of a novel galactosyltransferase inhibitor

(2011) Karine Descroix et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Substrate and product analogues as human O-GlcNAc transferase inhibitors

(2010) Helge C. Dorfmueller et al.   AMINO ACIDS

Mechanistic Insight into Enzymatic Glycosyl Transfer with Retention of Configuration through Analysis of Glycomimetic Inhibitors

(2010) James C. Errey et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of sugar–amino acid–nucleosides as potential glycosyltransferase inhibitors

(2010) Kannan Vembaiyan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Chemoenzymatic Synthesis, Inhibition Studies, and X-ray Crystallographic Analysis of the Phosphono Analog of UDP-Galp as an Inhibitor and Mechanistic Probe for UDP-Galactopyranose Mutase

(2010) Sarathy Karunan Partha et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural and mechanistic basis for a new mode of glycosyltransferase inhibition

(2010) Thomas Pesnot et al.   Nature Chemical Biology

Synthesis and Evaluation of the Analogues for Galactosyl Donors as Inhibitors of β-1,4-Galactosyltransferase

(2010) Yanxia Zhang et al.   SYNTHETIC COMMUNICATIONS

Probing replacement of pyrophosphate via click chemistry; synthesis of UDP-sugar analogues as potential glycosyl transferase inhibitors

(2009) Kar Kheng Yeoh et al.   CARBOHYDRATE RESEARCH

Synthesis of ThreeC-Glycoside Analogues of UDP-Galactopyranose as Conformational Probes for the Mutase-Catalyzed Furanose/Pyranose Interconversion

(2009) Audrey Caravano et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Glycomimetic Inhibitors of Mycobacterial Glycosyltransferases: Targeting the TB Cell Wall

(2008) Ricardo Lucas et al.   CHEMBIOCHEM

Enzyme-catalyzed synthesis of isosteric phosphono-analogues of sugar nucleotides

(2008) Stephen A. Beaton et al.   CHEMICAL COMMUNICATIONS

ABO(H) Blood Group A and B Glycosyltransferases Recognize Substrate via Specific Conformational Changes

(2008) Javier A. Alfaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycosyltransferases: Structures, Functions, and Mechanisms

(2007) L.L. Lairson et al.   Annual Review of Biochemistry

A convenient synthesis of the C-1-phosphonate analogue of UDP-GlcNAc and its evaluation as an inhibitor of O-linked GlcNAc transferase (OGT)

(2007) Jan Hajduch et al.   CARBOHYDRATE RESEARCH