Article
Clinical Neurology
Radoslav Raychev, Stanimir Sirakov, Alexander Sirakov, Hamidreza Saber, Fernando Vinuela, Reza Jahan, May Nour, Viktor Szeder, Geoffrey Colby, Gary Duckwiler, Satoshi Tateshima
Summary: This study aimed to investigate the hemodynamic changes in intracranial aneurysms and parent vessels after flow diversion (FD) treatment, as well as the occurrence of silent emboli. The results showed that the early and sustained visibility of the eclipse sign was the most reliable predictor of permanent aneurysm occlusion at 12 months. Additionally, none of the patients experienced silent emboli.
FRONTIERS IN NEUROLOGY
(2022)
Article
Nanoscience & Nanotechnology
Zhikang Zhao, Hancheng Qiu, Xiaowen Song, Xiaobo Xu, Yiying Dong
Summary: The study aims to investigate the effects of a novel stereoscopic flow-diverting stent on the hemodynamics and pathophysiology of intracranial aneurysms. Clinical data including 3D digital subtraction angiography (3D-DSA), transcranial Doppler ultrasound (TCD) findings, and blood examination-related parameters were collected. A model of aneurysm with its bearing artery was established, and a novel stereoscopic flow-diverting stent model was constructed. The results showed that the novel stent effectively reduced blood flow into the aneurysm, decreased blood flow velocity, and attenuated wall shear stress in the aneurysm.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mirte Schaafsma, Gerard J. Glade, Paul J. Keller, Arjen Schaafsma
Summary: A study on patients undergoing carotid endarterectomy showed changes in certain hemodynamic parameters on postoperative day 3, with an increase in Z-scores for Sys1 and Sys2, and a decrease in the Z-score for Dias@560. This suggests a return to normal arteriolar vascular resistance.
JOURNAL OF CARDIOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Rachel J. Skow, R. Matthew Brothers, Jurgen A. H. R. Claassen, Trevor A. Day, Caroline A. Rickards, Jonathan D. Smirl, Patrice Brassard
Summary: This article presents recommended terminology for reporting cerebral hemodynamic data and discusses the current use and misuse of terminology in the field. It provides guidelines for researchers in the study of cerebral hemodynamics.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Simin Mahinrad, Can Ozan Tan, Yue Ma, Maria Aristova, Andrew L. Milstead, Donald Lloyd-Jones, Susanne Schnell, Michael Markl, Farzaneh A. Sorond
Summary: The study aimed to compare cerebral blood flow velocity measures derived from dual-venc 4D flow MRI and TCD. The results showed excellent interobserver agreement in dual-venc 4D flow MRI-based measurements of peak velocity, with a slight underestimation compared to TCD.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Review
Clinical Neurology
Yang Chen, Pengyu Chen, Guosheng Duan, Ren Li, Ziao Li, Geng Guo
Summary: This systematic review examines the safety of extracranial-intracranial (EC-IC) bypass in the management of anterior circulation intracranial aneurysms (IAs). The study found that EC-IC therapy has a high safety profile, but more high-level evidence is needed to support clinical decision-making.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Navpreet Reehal, Stephanie Cummings, Michael T. Mullen, Wesley B. Baker, David Kung, William Tackett, Christopher G. Favilla
Summary: This study compared cerebral autoregulation in all major cerebral vessels and found that while the time course of autoregulation was similar in all vessels, the magnitude of hemodynamic regulation was lower in the posterior cerebral artery. However, after adjusting for baseline flow differences, normalized gain was similar in all vessels.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Haogeng Sun, Rui Tian, Zhiyuan Yu, Anqi Xiao, Chao You, Yi Liu
Summary: This study found that patients with MMD with IAs have different clinical and hemodynamic features compared to patients with MMD without IAs. CoW aneurysms and peripheral aneurysms may occur at different stages of MMD, leading to differences in anatomical location, type of hemorrhage, and treatment strategy.
WORLD NEUROSURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Jie Zhang, Shouchun Wang, Ying Chen, Cong Li, Lijuan Wang
Summary: This study aimed to evaluate patients with MCA disease with different morphologies using ultrasound. The findings suggest that the bilateral VMCA ratio can be used to predict long stenosis and focal occlusion, while the bilateral VICA ratio can be used to predict long stenosis. There were no significant changes in the focal lesion group. Endovascular treatment might not be recommended when the bilateral VICA ratio is <0.84.
Article
Clinical Neurology
Camilla Gelormini, Eleonora Ioannoni, Angela Scavone, Luca Pisapia, Francesco Signorelli, Nicola Montano, Marco Piastra, Anselmo Caricato
Summary: This study found that an increase in velocity in the middle cerebral artery (MCA) was associated with intracranial hypertension in traumatic brain injury (TBI) patients. Transcranial EcoDoppler (TCD) monitoring could be a useful method to detect and guide the therapy for this condition. It may serve as a tool for cause-oriented therapy of intracranial hypertension.
FRONTIERS IN NEUROLOGY
(2023)
Article
Biology
Palak Patel, Seyyed Mostafa Mousavi Janbeh Sarayi, Danyang Chen, Adam L. Hammond, Robert J. Damiano, Jason M. Davies, Jinhui Xu, Hui Meng
Summary: The study introduces a fast virtual coiling algorithm called P3, which accurately predicts and improves the treatment outcome of endovascular coiling of intracranial aneurysms by simulating patient-specific coil deployment.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Clinical Neurology
Qingyuan Liu, Xinyi Leng, Junhua Yang, Yi Yang, Pengjun Jiang, Maogui Li, Shaohua Mo, Shuzhe Yang, Jun Wu, Hongwei He, Shuo Wang
Summary: The study developed multidimensional predictive models for the stability of unruptured intracranial aneurysms and found that hemodynamic features are related to aneurysm stability. Nomograms incorporating clinical, morphological, and hemodynamic features had significantly higher predictive accuracies than conventional risk prediction scores.
JOURNAL OF NEUROSURGERY
(2021)
Article
Endocrinology & Metabolism
Ai'nan Guo, Peng Fu, Yue'e Wu, Haijun Dan
Summary: This study investigated the most efficient method to diagnose intracranial atherosclerotic stenosis (ICAS) in patients with diabetes mellitus. The study found that transcranial color -code Doppler (TCCD) examination was effective in evaluating the positivity rate of ICAS, which frequently affected the middle cerebral artery.
MINERVA ENDOCRINOLOGY
(2022)
Review
Anesthesiology
Sameh M. Hakim, Ayman A. Abdellatif, Mohammad Ali, Mona A. Ammar
Summary: Transcranial sonography is a reliable alternative to computed tomography for evaluating brain midline shift in adult neurocritical patients, showing strong concordance and narrow limits of agreement between the two methods.
MINERVA ANESTESIOLOGICA
(2021)
Article
Medicine, General & Internal
Bhakti Gajjar, Sanjay Sharma, Erum Khan, Pranita Sharma, Pawan Jain, Vikas Goel, Arvind Neral, Jyotish Patel, Mamta Parmar, Kanika Sharma, Vijay K. Sharma, Arvind K. Sharma
Summary: This study aimed to assess cerebral hemodynamics among Indian children with sickle cell disease (SCD) and explore their association with clinical and hematological parameters. The results showed that stroke and cerebral hemodynamic alterations are common among Indian children with SCD. Further larger studies are needed for better understanding and optimizing treatment approaches.
Article
Clinical Neurology
Michal J. Stasiowski, Anna Dulawa, Seweryn Krol, Radoslaw Marciniak, Wojciech Kaspera, Ewa Niewiadomska, Lech Krawczyk, Piotr Ladzinski, Beniamin O. Grabarek, Przemyslaw Jalowiecki
Summary: This study aimed to investigate whether raw EEG signals can accurately reflect the depth of general anesthesia during induction. The results showed that certain types of epileptiform discharges can cause false awakening, misleading anesthesiologists and leading to potentially toxic levels of sevoflurane.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Article
Genetics & Heredity
Adria-Jaume Roura, Bartlomiej Gielniewski, Paulina Pilanc, Paulina Szadkowska, Marta Maleszewska, Sylwia K. Krol, Ryszard Czepko, Wojciech Kaspera, Bartosz Wojtas, Bozena Kaminska
Summary: Most somatic mutations found in primary HGGs were not present in recurrent tumors, suggesting subclone substitution during tumor progression. Transcriptomic changes and immune-related signatures distinguish recurrent HGGs, showing a prominent infiltration of immature dendritic cells and M2 macrophages.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Oncology
Liang-Bo Wang, Alla Karpova, Marina A. Gritsenko, Jennifer E. Kyle, Song Cao, Yize Li, Dmitry Rykunov, Antonio Colaprico, Joseph H. Rothstein, Runyu Hong, Vasileios Stathias, MacIntosh Cornwell, Francesca Petralia, Yige Wu, Boris Reva, Karsten Krug, Pietro Pugliese, Emily Kawaler, Lindsey K. Olsen, Wen-Wei Liang, Xiaoyu Song, Yongchao Dou, Michael C. Wendl, Wagma Caravan, Wenke Liu, Daniel Cui Zhou, Jiayi Ji, Chia-Feng Tsai, Vladislav A. Petyuk, Jamie Moon, Weiping Ma, Rosalie K. Chu, Karl K. Weitz, Ronald J. Moore, Matthew E. Monroe, Rui Zhao, Xiaolu Yang, Seungyeul Yoo, Azra Krek, Alexis Demopoulos, Houxiang Zhu, Matthew A. Wyczalkowski, Joshua F. McMichael, Brittany L. Henderson, Caleb M. Lindgren, Hannah Boekweg, Shuangjia Lu, Jessika Baral, Lijun Yao, Kelly G. Stratton, Lisa M. Bramer, Erika Zink, Sneha P. Couvillion, Kent J. Bloodsworth, Shankha Satpathy, Weiva Sieh, Simina M. Boca, Stephan Schurer, Feng Chen, Maciej Wiznerowicz, Karen A. Ketchum, Emily S. Boja, Christopher R. Kinsinger, Ana Robles, Tara Hiltke, Mathangi Thiagarajan, Alexey Nesvizhskii, Bing Zhang, D. R. Mani, Michele Ceccarelli, Xi S. Chen, Sandra L. Cottingham, Qing Kay Li, Albert H. Kim, David Fenyo, Kelly Ruggles, Henry Rodriguez, Mehdi Mesri, Samuel H. Payne, Adam C. Resnick, Pei Wang, Richard D. Smith, Antonio Iavarone, Milan G. Chheda, Jill S. Barnholtz-Sloan, Karin D. Rodland, Tao Liu, Li Ding
Summary: Understanding the molecular pathogenesis of glioblastoma is crucial for improving diagnosis and treatment. Integrated analysis of genomic, proteomic, and metabolomic data on treatment-naive glioblastomas has identified key phosphorylation events and potential targets for specific tumor alterations. Immune subtypes with distinct immune cell types were discovered, and specific histone acetylation patterns were correlated with these subtypes, providing insights for stratification of patients for more effective treatment.
Article
Clinical Neurology
Mikolaj Zimny, Edyta Kawlewska, Anna Hebda, Wojciech Wolanski, Piotr Ladzinski, Wojciech Kaspera
Summary: This study analyzed the combination of high wall shear stress (WSS) and positive wall shear stress gradient (WSSG) in intracranial aneurysm formation. Positive WSSG was identified as a significant independent prognosticator for aneurysm formation, with logistic regression showing it as a co-predictor along with WSS. A higher proportion of patients in the case group had regions of high WSS combined with positive WSSG near the bifurcation apex, indicating the influence of these hemodynamic factors on aneurysm development.
Article
Medicine, General & Internal
Justyna Maczynska, Florian Raes, Chiara Da Pieve, Stephen Turnock, Jessica K. R. Boult, Julia Hoebart, Marcin Niedbala, Simon P. Robinson, Kevin J. Harrington, Wojciech Kaspera, Gabriela Kramer-Marek
Summary: The study demonstrates that targeted photoimmunotherapy can accurately visualize EGFR-positive brain tumors and destroy tumor cells after conjugate irradiation, turning an immunosuppressive tumor environment into an immune-vulnerable one. In vitro and in vivo experiments show that the photodynamic treatment promotes immunogenic cell death and activates T cell response, leading to reduced cell proliferation and tumor necrosis. These findings highlight the potential of photoimmunotherapy as a multimodal treatment approach for glioblastoma.
Article
Clinical Neurology
K. Cmiel-Smorzyk, E. Kawlewska, W. Wolanski, A. Hebda, P. Ladzinski, W. Kaspera
Summary: The study found that the dimensions of arteries forming the circle of Willis do not follow the principle of minimum work. Deviations from the energetically optimum geometry, such as larger parent artery radius and wider total bifurcation angle, may lead to the formation of intracranial aneurysms. Further investigation is needed to explore the significance of vessel dimensions and bifurcation angle on shear stress in arterial bifurcations.
Article
Dentistry, Oral Surgery & Medicine
Leila Galiay, Quentin Hennocq, Connor Cross, Eric Arnaud, Dawid Larysz, Lars Kolby, Giovanna Paternoster, Roman H. Khonsari, Mehran Moazen
Summary: The aim of this study was to compare the morphological outcomes of 8 techniques used for the management of sagittal synostosis with a control group. The study found no significant difference in morphological outcomes between the techniques, but most techniques showed a tendency for relapse. Additionally, more invasive procedures at older ages seemed to result in larger intracranial volume.
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2022)
Correction
Medicine, General & Internal
Justyna Maczynska, Florian Raes, Chiara Da Pieve, Stephen Turnock, Jessica K. R. Boult, Julia Hoebart, Marcin Niedbala, Simon P. Robinson, Kevin J. Harrington, Wojciech Kaspera, Gabriela Kramer-Marek
Review
Biotechnology & Applied Microbiology
Marcin Niedbala, Katarzyna Malarz, Gitanjali Sharma, Gabriela Kramer-Marek, Wojciech Kaspera
Summary: Glioblastoma multiforme (GBM) is the most common and aggressive primary central nervous system tumour in adults. The current standard of care for GBM, including surgery and chemoradiotherapy, is not effective in providing a durable response due to the heterogeneous and immune-escaping nature of GBM. Therefore, there is an urgent need to develop more effective therapeutic approaches, such as immunotherapy.
ONCOTARGETS AND THERAPY
(2022)
Article
Oncology
Natalia Kurowska, Barbara Strzalka-Mrozik, Marcel Madej, Klaudia Pajak, Celina Kruszniewska-Rajs, Wojciech Kaspera, Joanna Magdalena Gola
Summary: The genes associated with TGF beta isoforms have a significant impact on the progression of different cancers, including brain tumors. In this study, the expression patterns of these genes in astrocytic brain tumor sections were assessed using an oligonucleotide microarray method. The results showed that the TGF beta 1 and TGF beta 2 isoforms were significantly upregulated in advanced stages of the disease. Further analysis revealed that these genes form an interaction network involved in carcinogenesis. The quantitative assessment of TGF beta 2 mRNA may serve as a valuable diagnostic tool in the future.
Article
Oncology
Paulina Szadkowska, Adria-Jaume Roura, Bartosz Wojtas, Kamil Wojnicki, Sabina Licholai, Tomasz Waller, Tomasz Gubala, Kacper Zukowski, Michal Karpeta, Kinga Wilkus, Wojciech Kaspera, Sergiusz Nawrocki, Bozena Kaminska
Summary: Malignant brain tumors, due to their genetic heterogeneity and difficult accessibility, pose a major challenge for precise diagnosis. This study explored the use of liquid biopsy from a patient's plasma as a less invasive method for diagnosis and personalized therapy selection. The researchers performed targeted next-generation sequencing of tumors and circulating cell-free DNA (ccfDNA) from brain tumor patients and detected tumor-specific genetic alterations in ccfDNA, showing potential for noninvasive diagnosis and revolutionizing personalized therapy.
Article
Oncology
Agata Gozdz, Bartosz Wojtas, Patrycja Szpak, Paulina Szadkowska, Tomasz Czernicki, Andrzej Marchel, Katarzyna Wojtowicz, Wojciech Kaspera, Piotr Ladzinski, Wojciech Szopa, Marcin Niedbala, Sergiusz Nawrocki, Bozena Kaminska, Ilona Kalaszczynska
Summary: This study investigates the impact of lowering oxygen tension on the transcriptome of patient-derived GBM cells, revealing that cells cultured under reduced oxygen tension express more genes related to hypoxia, metabolic adaptation, stemness, and tumor progression compared to those cultured under standard oxygen conditions. Lowering oxygen tension to 5% does not affect cell proliferation rate but increases the expression of stemness markers, providing a better model to mimic the GBM tumor microenvironment.
Article
Biochemistry & Molecular Biology
Bartlomiej Goc, Agata Roch-Zniszczol, Dawid Larysz, Lukasz Zarudzki, Malgorzata Stapor-Fudzinska, Agnieszka Rozek, Grzegorz Wozniak, Magdalena Boczarska-Jedynak, Leszek Miszczyk, Aleksandra Napieralska
Summary: This study evaluated the safety and efficacy of frameless stereotactic radiosurgery (SRS) in the treatment of tremor in patients with Parkinson's disease (PD). Results showed that frameless SRS had a high efficacy in improving tremor control in the majority of patients, with a low complication rate.
Article
Oncology
Bartlomiej Gielniewski, Katarzyna Poleszak, Adria-Jaume Roura, Paulina Szadkowska, Karol Jacek, Sylwia K. Krol, Rafal Guzik, Paulina Wiechecka, Marta Maleszewska, Beata Kaza, Andrzej Marchel, Tomasz Czernicki, Andrzej Koziarski, Grzegorz Zielinski, Andrzej Styk, Maciej Kawecki, Cezary Szczylik, Ryszard Czepko, Mariusz Banach, Wojciech Kaspera, Wojciech Szopa, Mateusz Bujko, Bartosz Czapski, Miroslaw Zabek, Ewa Izycka-Swieszewska, Wojciech Kloc, Pawel Nauman, Joanna Cieslewicz, Wieslawa Grajkowska, Natalia Morosini, Houtan Noushmehr, Bartosz Wojtas, Bozena Kaminska
Summary: High-grade gliomas are aggressive and deadly brain tumors with poor prognosis. In this study, genomic alterations and transcriptomic patterns in high-grade gliomas were analyzed. A recurrent mutation in the TOP2A gene was found in four GBMs, leading to altered DNA binding and relaxation activities. GBM patients carrying this mutation had shorter overall survival and transcriptomic alterations consistent with splicing dysregulation, suggesting its contribution to disease pathology.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Gitanjali Sharma, Marta C. Braga, Chiara Da Pieve, Wojciech Szopa, Tatjana Starzetz, Karl H. Plate, Wojciech Kaspera, Gabriela Kramer-Marek
Summary: Almost all GBM patients relapse due to adaptive and acquired resistance from tumour heterogeneity and immune-depleted microenvironment. High PD-L1 levels are associated with GBM invasiveness and immuno-resistance. We investigated the ability of a radiolabelled Z(PD-L1) affibody molecule to measure PD-L1 expression in GBM xenograft models.