Article
Cardiac & Cardiovascular Systems
Chang Liu, Devinder Dhindsa, Zakaria Almuwaqqat, Yi-An Ko, Anurag Mehta, Ayman A. Alkhoder, Zahran Alras, Shivang Rajan Desai, Krishan Jignesh Patel, Ananya Hooda, Mohamad Wehbe, Laurence S. Sperling, Yan Sun, Arshed A. Quyyumi
Summary: This cohort study examined the association between very high HDL-C levels (>80 mg/dL) and mortality in patients with coronary artery disease (CAD). The results demonstrated a U-shaped association, with higher risk of death in individuals with both low and very high HDL-C levels compared to those with midrange values. Specifically, very high HDL-C levels were associated with increased risk of all-cause death and cardiovascular death. These associations were independent of common genetic polymorphisms associated with high HDL-C levels.
Article
Clinical Neurology
Zhirong Yang, Duncan Edwards, Stephen Burgess, Carol Brayne, Jonathan Mant
Summary: This study investigated the potential associations between blood LDL-C, HDL-C, and triglycerides and post-stroke dementia. The results showed that higher LDL-C levels were associated with an increased risk of dementia, while lower triglyceride levels were associated with a decreased risk. There was no association between HDL-C levels and dementia.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Sifan Qian, Shoujiang You, Yaming Sun, Qiuyi Wu, Xianhui Wang, Weiting Tang, Xiaofeng Dong, Chun-feng Liu, Tan Xu, Yongjun Cao, Chongke Zhong
Summary: This study found a significant positive association between elevated fasting remnant cholesterol levels and abnormal cIMT in patients with ischemic stroke, even in patients with optimal LDL cholesterol levels. Future prospective studies are needed to validate these findings and assess the impact of remnant cholesterol-lowering interventions in patients with ischemic stroke.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Behavioral Sciences
Yang Hu, Min Song, Dongmei Wu, Yuqing Zhang, Gongbo Li, Haiyan Luo
Summary: This study aimed to examine the association between different ranges of HDL-C and the risk of total stroke in adults over 40 years old. The results showed that HDL-C below 1.55 mmol/L was inversely associated with stroke risk, while no significant association was found above 1.55 mmol/L. Stratified analyses by sex and race/ethnicity revealed that HDL-C was inversely associated with stroke in men and Whites. Maintaining an appropriate HDL-C range may be beneficial in reducing the incidence of stroke.
BRAIN AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Ilaria Zanotti, Francesco Poti, Marina Cuchel
Summary: HDL plays an antiatherogenic role by accepting cholesterol from cells and promoting reverse cholesterol transport, with cholesterol efflux capacity being associated with cardiovascular risk in various human cohorts. These findings support the protective role of RCT in humans.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Medicine, Research & Experimental
Jianyong Zhong, Hai -Chun Yang, Elaine L. Shelton, Taiji Matsusaka, Amanda J. Clark, Valery Yermalitsky, Zahra Mashhadi, Linda S. May-Zhang, MacRae F. Linton, Agnes B. Fogo, Annet Kirabo, Sean S. Davies, Valentina Kon
Summary: The study found that patients and animals with proteinuric injury have increased IsoLG-apoAI in their urine, which not only serves as a marker of renal injury, but also directly damages renal cells and has a greater impact on renal lymphatic vessels.
Review
Biochemistry & Molecular Biology
Saeed Aslani, Bahman Razi, Danyal Imani, Keyhan Mohammadi, Tannaz Jamialahmadi, Zeljko Reiner, Amirhossein Sahebkar
Summary: A systematic review and meta-analysis showed that statin therapy effectively lowered levels of total cholesterol, LDL-C, and TG, and increased levels of HDL-C in patients with different CVDs.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Leonie Schoch, Lina Badimon, Gemma Vilahur
Summary: Increasing doubt has been raised over the HDL-cholesterol hypothesis, with evidence pointing towards the complexity and molecular changes in HDL particles. Chemical modifications, compositional changes, and miRNA cargo have been identified as factors contributing to the ineffectiveness of HDL particles. Overcoming challenges is crucial to bringing hope to HDL-targeted approaches.
Review
Biochemistry & Molecular Biology
Arianna Bonizzi, Gabriele Piuri, Fabio Corsi, Roberta Cazzola, Serena Mazzucchelli
Summary: HDL is a class of lipoproteins with diverse structure, composition, and biological functions, playing roles in reverse cholesterol transport and various protective functions. However, plasma HDL cholesterol levels do not accurately predict the functionality and composition of HDLs, which can be altered by different disease states, turning them into dysfunctional lipoproteins.
Article
Cardiac & Cardiovascular Systems
Takuma Ishibashi, Hidehiro Kaneko, Satoshi Matsuoka, Yuta Suzuki, Kensuke Ueno, Ryusei Ohno, Akira Okada, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Koichi Node, Hideo Yasunaga, Issei Komuro
Summary: The aim of this study was to investigate the association between fasting plasma glucose, HDL cholesterol levels, and clinical outcomes. The findings suggest that there is a U-shaped association between HDL cholesterol and clinical outcomes, and this association is amplified with worsening glucose tolerance.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Chang Liu, Devinder Dhindsa, Zakaria Almuwaqqat, Yan Sun, Arshed A. Quyyumi
Summary: The study found that very high levels of HDL-C are associated with an increased risk of all-cause death and cardiovascular death among men, but not women, in the general population.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Chemistry, Medicinal
Reyhaneh Yousefi, Maryam Parandoosh, Hoda Khorsandi, Nima Hosseinzadeh, Masoumeh Madani Tonekaboni, Atoosa Saidpour, Hossein Babaei, Arman Ghorbani
Summary: The study found that supplementation with grape seed extract (GSE) can improve blood lipid profile in overweight or obese individuals when accompanied by a restricted-calorie diet. It increases high-density lipoprotein cholesterol levels, decreases low-density lipoprotein cholesterol levels, and reduces visceral adiposity index and atherogenic index of plasma.
PHYTOTHERAPY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Hyun-Gyu Lee, Sang-Don Park, Jang-Whan Bae, SungJoon Moon, Chai Young Jung, Mi-Sook Kim, Tae-Hun Kim, Won Kyung Lee
Summary: This study developed an ensemble model using machine learning and deep learning algorithms to assess obstructive coronary artery disease (ObCAD) using clinical, laboratory, and ECG data. The ensemble model demonstrated good performance and superior prediction compared to traditional pretest probability (PTP) models, providing potential for personalized decisions and reducing overestimation of probability.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Hiroshi Yoshida, Kumie Ito, Daisuke Manita, Ryo Sato, Chika Hiraishi, Sadako Matsui, Yuji Hirowatari
Summary: This study found significant correlations between IDL-C and both F-score and S-score, even in subjects without drug therapy, suggesting that increased IDL-C is an important predictor for 10-year CHD risk >10%.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Genki Kobayashi, Hiroshi Okada, Masahide Hamaguchi, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Michiaki Fukui
Summary: This study investigated the association between LDL cholesterol, HDL cholesterol, and LDL/HDL ratio and the incidence of diabetes, and identified the cut-off values for incident diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Editorial Material
Clinical Neurology
Else Charlotte Sandset, Larry B. Goldstein
Review
Clinical Neurology
Narayanaswamy Venketasubramanian, Craig Anderson, Hakan Ay, Selma Aybek, Waleed Brinjikji, Gabriel R. de Freitas, Oscar H. Del Brutto, Klaus Fassbender, Miki Fujimura, Larry B. Goldstein, Roman L. Haberl, Graeme J. Hankey, Wolf-Dieter Heiss, Isabel Lestro Henriques, Carlos S. Kase, Jong S. Kim, Masatoshi Koga, Yoshihiro Kokubo, Satoshi Kuroda, Kiwon Lee, Tsong-Hai Lee, David S. Liebeskind, Gregory Y. H. Lip, Stephen Meairs, Roman Medvedev, Man Mohan Mehndiratta, Jay P. Mohr, Masao Nagayama, Leonardo Pantoni, Panagiotis Papanagiotou, Guillermo Parrilla, Daniele Pastori, Sarah T. Pendlebury, Luther Creed Pettigrew, Pushpendra N. Renjen, Tatjana Rundek, Ulf Schminke, Yukito Shinohara, Wai Kwong Tang, Kazunori Toyoda, Katja E. Wartenberg, Mohammad Wasay, Michael G. Hennerici
Summary: The COVID-19 pandemic has posed challenges for stroke management, with clinicians facing various etiologies for stroke compounded by unique complications associated with the virus. Strict infection control measures and continuous medical care are essential throughout the patient care journey.
CEREBROVASCULAR DISEASES
(2021)
Article
Clinical Neurology
Greg A. Jicha, Erin L. Abner, Steven E. Arnold, Maria C. Carrillo, Hiroko H. Dodge, Steven D. Edland, Keith N. Fargo, Howard H. Feldman, Larry B. Goldstein, James Hendrix, Ruth Peters, Julie M. Robillard, Lon S. Schneider, Jodi R. Titiner, Christopher J. Weber
Summary: Consensus guidance has been developed for the development and conduct of high-quality Alzheimer's disease clinical trials, covering aspects such as scientific justification, trial registration, conflict of interest disclosure, and defined trial population. This guidance aims to assist in protocol development and may also support the education of potential trial participants and the public on appropriate clinical trial participation decisions.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Else Charlotte Sandset, Larry B. Goldstein
Letter
Clinical Neurology
Zhu Cenjing, Phoebe M. Tran, Rachel P. Dreyer, Larry B. Goldstein, Judith H. Lichtman
Article
Neurosciences
Dana L. Ionel, Fred O. Odago, Andre N. Ene, Jessica D. Lee, William N. O'Connor, Larry B. Goldstein, L. Creed Pettigrew
Summary: In this case report, we describe a patient with Williams-Beuren syndrome who experienced sudden neurological deterioration following a cardiac ablative procedure. Williams-Beuren syndrome is a rare genetic disorder with distinctive clinical features. Chromosomal microdeletion leads to various neurological and cardiac complications.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Article
Clinical Neurology
Tanya N. Turan, Osama O. Zaidat, Gary S. Gronseth, Marc Chimowitz, Antonio Culebras, Anthony J. Furlan, Larry B. Goldstein, Nestor R. Gonzalez, Julius G. Latorre, Steven R. Messe, Thanh N. Nguyen, Rajbeer S. Sangha, Michael J. Schneck, Aneesh B. Singhal, Lawrence R. Wechsler, Alejandro A. Rabinstein, Mary Dolan O'Brien, Heather Silsbee, Jeffrey J. Fletcher
Summary: This study reviewed treatments for reducing the risk of recurrent stroke or death in patients with symptomatic intracranial atherosclerotic arterial stenosis (sICAS). The major recommendations include prescribing aspirin and clopidogrel for long-term prevention of stroke, recommending high-intensity statin therapy, maintaining target blood pressure levels, engaging in regular physical activity, and treating other modifiable vascular risk factors. The study also advises against certain procedures such as angioplasty and stenting for stroke prevention in moderate or severe sICAS patients.
Article
Clinical Neurology
Lynne P. Taylor, Jessica M. Besbris, William D. Graf, Michael A. Rubin, Salvador Cruz-Flores, Leon G. Epstein
Summary: Palliative care, introduced in 1974 by Dr. Balfour Mount, focuses on improving patients' quality of life through symptom control, rather than solely on the end-of-life care like hospice. However, many still confuse palliative care with hospice, leading to missed opportunities for early provision of palliative services.
Article
Clinical Neurology
Daniel Albjerg Rudolph, Stine Munk Hald, Luis Alberto Garcia Rodriguez, Soren Moller, Jesper Hallas, Larry B. Goldstein, David Gaist
Summary: The study demonstrates an association between long-term statin use and a lower risk of intracerebral hemorrhage.
Editorial Material
Clinical Neurology
Larry B. Goldstein
Article
Cardiac & Cardiovascular Systems
Phoebe M. Tran, Lam T. Tran, Cenjing Zhu, Tiffany Chang, Inna P. Powers, Larry B. Goldstein, Judith H. Lichtman
Summary: Poststroke antihypertensive use is comparable in rural and urban stroke survivors with a reported history of hypertension, but there is a trend for increased use among urban residents.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Clinical Neurology
Erica C. Leifheit, Yun Wang, Larry B. Goldstein, Judith H. Lichtman
Summary: Data on trends in recurrent stroke in the US are limited, but this study found an overall decrease in recurrent ischemic strokes from 2001 to 2017. However, there were geographic areas with persistently higher recurrence rates.
Article
Clinical Neurology
Phoebe M. M. Tran, Joshua L. L. Warren, Erica C. C. Leifheit, Larry B. B. Goldstein, Judith H. H. Lichtman
Summary: Long-term exposure to air pollutants is associated with increased risk of hospital readmission within 30 days after stroke, regardless of hospital performance category. The study assessed the relationship between exposure to carbon monoxide, nitrogen dioxide, ozone, particulate matter 2.5, and sulfur dioxide and 30-day all-cause hospital readmission in elderly stroke patients. Despite being below national limits, long-term exposure to air pollutants still increased the risk of readmission.
Article
Biochemistry & Molecular Biology
Deepak Kotiya, Noah Leibold, Nirmal Verma, Gregory A. Jicha, Larry B. Goldstein, Florin Despa
Summary: Amylin-A beta co-aggregation plays a significant role in Alzheimer's disease (AD), but its mechanisms are not fully understood. In this study, a new ELISA method was developed to detect amylin-A beta hetero-oligomers in brain tissue and blood. The results showed that this assay is sensitive to circulating amylin-A beta hetero-oligomers in the blood and may contribute to understanding and treating the development of AD.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Editorial Material
Clinical Neurology
Else Charlotte Sandset, Larry B. Goldstein