Hypoxia and TGF-β1 lead to endostatin resistance by cooperatively increasing cancer stem cells in A549 transplantation tumors

Endostar attenuates melanoma tumor growth via its interruption of b-FGF mediated angiogenesis

(2015) Lijia Xiao et al.   CANCER LETTERS

TGF-β Promotes Heterogeneity and Drug Resistance in Squamous Cell Carcinoma

(2015) Naoki Oshimori et al.   CELL

Curcumin inhibits cobalt chloride-induced epithelial-to-mesenchymal transition associated with interference with TGF-β/Smad signaling in hepatocytes

(2015) Desong Kong et al.   LABORATORY INVESTIGATION

Hypoxia-induced cell stemness leads to drug resistance and poor prognosis in lung adenocarcinoma

(2015) Mingchuan Zhao et al.   LUNG CANCER

Endostatin: A novel inhibitor of androgen receptor function in prostate cancer

(2015) Joo Hyoung Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p21-activated kinase 1 determines stem-like phenotype and sunitinib resistance via NF-κB/IL-6 activation in renal cell carcinoma

(2015) Y Zhu et al.   Cell Death & Disease

IL-8 confers resistance to EGFR inhibitors by inducing stem cell properties in lung cancer

(2015) Yi-Nan Liu et al.   Oncotarget

Blocking the NOTCH pathway can inhibit the growth of CD133-positive A549 cells and sensitize to chemotherapy

(2014) Juntao Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial–mesenchymal transition in hepatocellular carcinoma

(2014) Qing-Min Fan et al.   CANCER LETTERS

HIF-1 Signaling in Drug Resistance to Chemotherapy

(2014) N.A. Warfel et al.   CURRENT MEDICINAL CHEMISTRY

Cancer stem cell: A rogue responsible for tumor development and metastasis

(2014) Sudhir Kumar et al.   INDIAN JOURNAL OF CANCER

Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF- 1

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

Hypoxia Increases Gefitinib-Resistant Lung Cancer Stem Cells through the Activation of Insulin-Like Growth Factor 1 Receptor

(2014) Akiko Murakami et al.   PLoS One

Convergence of Hypoxia and TGFβ Pathways on Cell Cycle Regulation in Human Hematopoietic Stem/Progenitor Cells

(2014) Albertus T. J. Wierenga et al.   PLoS One

TNFR1 mediates TNF-α-induced tumour lymphangiogenesis and metastasis by modulating VEGF-C-VEGFR3 signalling

(2014) Hong Ji et al.   Nature Communications

Cancer statistics, 2013

(2013) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Role of the Hypoxia-inducible factor-1 alpha induced autophagy in the conversion of non-stem pancreatic cancer cells into CD133+ pancreatic cancer stem-like cells

(2013) Haitao Zhu et al.   Cancer Cell International

Hypoxia-Induced Secretion of TGF-β1 in Mesenchymal Stem Cell Promotes Breast Cancer Cell Progression

(2013) Shun-Pei Hung et al.   CELL TRANSPLANTATION

HtrA1 Downregulation Induces Cisplatin Resistance in Lung Adenocarcinoma by Promoting Cancer Stem Cell-Like Properties

(2013) Yongqing Xu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

IL-17 mediates resistance to anti-VEGF therapy

(2013) Eleni Maniati et al.   NATURE MEDICINE

Fibulin-3-mediated inhibition of epithelial-to-mesenchymal transition and self-renewal of ALDH+ lung cancer stem cells through IGF1R signaling

(2013) I G Kim et al.   ONCOGENE

Intratumor Hypoxia Promotes Immune Tolerance by Inducing Regulatory T Cells via TGF-β1 in Gastric Cancer

(2013) Bin Deng et al.   PLoS One

Hypoxia Stimulates the EMT of Gastric Cancer Cells through Autocrine TGFβ Signaling

(2013) Junko Matsuoka et al.   PLoS One

TGF-β1 exposure induces epithelial to mesenchymal transition both in CSCs and non-CSCs of the A549 cell line, leading to an increase of migration ability in the CD133+ A549 cell fraction

(2013) V Tirino et al.   Cell Death & Disease

Anti-angiogenesis therapy in cancer: Current challenges and future perspectives

(2012) Farbod Shojaei   CANCER LETTERS

Targeting the Cancer Initiating Cell: The Ultimate Target for Cancer Therapy

(2012) James A. McCubrey et al.   CURRENT PHARMACEUTICAL DESIGN

Resistance to Hypoxia-Induced, BNIP3-Mediated Cell Death Contributes to an Increase in a CD133-Positive Cell Population in Human Glioblastomas In Vitro

(2012) Ulf Dietrich Kahlert et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Effect of 5-FU and MTX on the Expression of Drug-resistance Related Cancer Stem Cell Markers in Non-small Cell Lung Cancer Cells

(2012) Hee Yi et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity

(2012) S Akunuru et al.   Cell Death & Disease

Upregulated IL-19 in Breast Cancer Promotes Tumor Progression and Affects Clinical Outcome

(2011) C.-H. Hsing et al.   CLINICAL CANCER RESEARCH

Expression of cancer stem cell markers ALDH1, CD44 and CD133 in primary tumor and lymph node metastasis of gastric cancer

(2011) Yuta Wakamatsu et al.   PATHOLOGY INTERNATIONAL

Impact of the hypoxic tumor microenvironment on the regulation of cancer stem cell characteristics

(2010) Qun Lin et al.   CANCER BIOLOGY & THERAPY

Tumor-Associated Fibroblasts as “Trojan Horse” Mediators of Resistance to Anti-VEGF Therapy

(2009) Giulio Francia et al.   CANCER CELL

Hypoxia-Regulated Delta-like 1 Homologue Enhances Cancer Cell Stemness and Tumorigenicity

(2009) Y. Kim et al.   CANCER RESEARCH

Ovarian cancer tumor infiltrating T-regulatory (Treg) cells are associated with a metastatic phenotype

(2009) Jason C. Barnett et al.   GYNECOLOGIC ONCOLOGY

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α

(2009) A Soeda et al.   ONCOGENE

Hypoxia and TGF-β Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Cells and the Bone Microenvironment

(2009) Lauren K. Dunn et al.   PLoS One

Stem cells are dispensable for lung homeostasis but restore airways after injury

(2009) A. Giangreco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment

(2009) G. Bertolini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial cell differentiation of human breast tumour stem/progenitor cells

(2008) Benedetta Bussolati et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE