Hypoxia induces calpain activity and degrades SMAD2 to attenuate TGFβ signaling in macrophages

Genome-wide identification of hypoxia-inducible factor-1 and -2 binding sites in hypoxic human macrophages alternatively activated by IL-10

(2015) Michaela Tausendschön et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Tissue invasion and metastasis: Molecular, biological and clinical perspectives

(2015) W.G. Jiang et al.   SEMINARS IN CANCER BIOLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Sumoylation of Peroxisome Proliferator-Activated Receptor   by Apoptotic Cells Prevents Lipopolysaccharide-Induced NCoR Removal from  B Binding Sites Mediating Transrepression of Proinflammatory Cytokines

(2014) C. Jennewein et al.   JOURNAL OF IMMUNOLOGY

TGF-β1, but Not Bone Morphogenetic Proteins, Activates Smad1/5 Pathway in Primary Human Macrophages and Induces Expression of Proatherogenic Genes

(2014) Dinara Nurgazieva et al.   JOURNAL OF IMMUNOLOGY

Hypoxia-induced and calpain-dependent cleavage of filamin A regulates the hypoxic response

(2014) X. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox Control of Inflammation in Macrophages

(2013) Bernhard Brüne et al.   ANTIOXIDANTS & REDOX SIGNALING

Altered expression of platelet proteins and calpain activity mediate hypoxia-induced prothrombotic phenotype

(2013) T. Tyagi et al.   BLOOD

IL-4 reduces the proangiogenic capacity of macrophages by down-regulating HIF-1  translation

(2013) N. Dehne et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer

(2013) Peter J. Ratcliffe   JOURNAL OF PHYSIOLOGY-LONDON

TGFβ signaling plays a critical role in promoting alternative macrophage activation

(2012) Dapeng Gong et al.   BMC IMMUNOLOGY

TGF-Beta: a Master Switch in Tumor Immunity

(2012) Margherita Gigante et al.   CURRENT PHARMACEUTICAL DESIGN

Hypoxia-inducible factor-1α mediates TGF-β-induced PAI-1 production in alveolar macrophages in pulmonary fibrosis

(2011) Manabu Ueno et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hypoxia and hypoxia inducible factors: Diverse roles in liver diseases

(2011) Bharath Nath et al.   HEPATOLOGY

Different activation forms of MMP-2 oppositely affect the fate of endothelial cells

(2010) Sarah Shapiro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

Opposite functions of HIF-α isoforms in VEGF induction by TGF-β1 under non-hypoxic conditions

(2010) K S Chae et al.   ONCOGENE

The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor-1  in macrophages via sphingosine-1-phosphate and transforming growth factor- 

(2009) B. Herr et al.   BLOOD

Emerging role of nuclear protein 1 (NUPR1) in cancer biology

(2009) Uttio Roy Chowdhury et al.   CANCER AND METASTASIS REVIEWS

Hypoxia-activated Smad3-specific Dephosphorylation by PP2A

(2009) Pekka T. Heikkinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis

(2009) M Petersen et al.   ONCOGENE

Thrombospondin 1 Promotes Tumor Macrophage Recruitment and Enhances Tumor Cell Cytotoxicity of Differentiated U937 Cells

(2008) G. Martin-Manso et al.   CANCER RESEARCH

Chromatin Immunoprecipitation on Microarray Analysis of Smad2/3 Binding Sites Reveals Roles of ETS1 and TFAP2A in Transforming Growth Factor   Signaling

(2008) D. Koinuma et al.   MOLECULAR AND CELLULAR BIOLOGY

Nitric oxide, apoptosis and macrophage polarization during tumor progression

(2008) Andreas Weigert et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

The tumor microenvironment and its role in promoting tumor growth

(2008) T L Whiteside   ONCOGENE