Review
Physiology
Paul J. Davis, Shaker A. Mousa, Hung-Yun Lin
Summary: The integrin alpha v beta 3 receptor for thyroid hormone plays a crucial role in cancer and endothelial cells by regulating cell division, tumor defense mechanisms, angiogenesis, and supporting metastasis, radioresistance, and chemoresistance. T4 and tetrac are the main regulators, involved in signaling pathways and gene expression related to these cell processes.
PHYSIOLOGICAL REVIEWS
(2021)
Article
Agriculture, Dairy & Animal Science
Yun Hu, Xuelian Ma, Lin Lu, Liyang Zhang, Xiudong Liao, Xugang Luo
Summary: The present study aimed to evaluate the effects of different sources and levels of iron on the concentration of iron and the expression of iron-containing enzymes or proteins in primary cultured hepatocytes of broiler embryos. The results showed that all supplemented iron treatments significantly increased the iron concentration and mRNA levels of specific genes compared to the control group. The Fe-Pro ES, which had an extremely strong chelation strength, had a negative impact on the iron concentration and gene expression in hepatocytes compared to Fe sulfate and other organic iron chelates.
Article
Fisheries
Xuan lihui, Guo Jinming, Guan Yalin, Wang Hemeng, Wu Hao, Chang Ying
Summary: Profenofos (PFF) as an environmental pollutant can induce oxidative stress in hepatocytes, inhibit AKT phosphorylation, and activate mitochondrial apoptosis. Albicanol can significantly reduce the effects of PFF on grass carp hepatocytes by regulating the ROS/PTEN/PI3K/AKT pathway.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Cell Biology
Xueyi Chen, Ping Liu, Wei Zhang, Xiaofang Li, Caihua Wang, Feifei Han, Wenxuan Liu, Yaoyao Huang, Man Li, Yujia Li, Xiaomin Sun, Xiaobin Fan, Wenqing Li, Yuyan Xiong, Lu Qian
Summary: Hyperinsulinemia is a critical risk factor for insulin resistance (IR) in metabolic tissues. ETNPPL, a metabolic enzyme abundantly expressed in liver tissue, was found to mediate hyperinsulinemia-induced IR through the inactivation of the PI3K/AKT signaling pathway via SIK1/ROS.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Reproductive Biology
Leticia Pereira Alcaraz, Lucia Prellwitz, Gutemberg Alves, Joanna Maria Gonsalves Souza-Fabjan, Angelo Jose Burla Dias
Summary: Modulation of the PI3K/AKT/PTEN pathway has the potential to improve overall efficiency of in vitro embryo production, but its effects on meiosis resumption are still uncertain.
Review
Physiology
D. Gnocchi, K. R. Steffensen, G. Bruscalupi, P. Parini
Article
Gastroenterology & Hepatology
Meng Li, Ewa Ellis, Helene Johansson, Greg Nowak, Bengt Isaksson, Davide Gnocchi, Paolo Parini, Jonas Axelsson
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Lee Roth, Swati Srivastava, Moshit Lindzen, Aldema Sas-Chen, Michal Sheffer, Mattia Lauriola, Yehoshua Enuka, Ashish Noronha, Maicol Mancini, Sara Lavi, Gabi Tarcic, Gur Pines, Nava Nevo, Ori Heyman, Tamar Ziv, Oscar M. Rueda, Davide Gnocchi, Eli Pikarski, Arie Admon, Carlos Caldas, Yosef Yarden
Article
Biochemistry & Molecular Biology
Lee Roth, Swati Srivastava, Moshit Lindzen, Aldema Sas-Chen, Michal Sheffer, Mattia Lauriola, Yehoshua Enuka, Ashish Noronha, Maicol Mancini, Sara Lavi, Gabi Tarcic, Gur Pines, Nava Nevo, Ori Heyman, Tamar Ziv, Oscar M. Rueda, Davide Gnocchi, Eli Pikarski, Arie Admon, Carlos Caldas, Yosef Yarden
Article
Endocrinology & Metabolism
D. Gnocchi, M. Massimi, A. Alisi, S. Incerpi, G. Bruscalupi
HORMONE AND METABOLIC RESEARCH
(2014)
Article
Biochemistry & Molecular Biology
Sergio Scapin, Silvia Leoni, Silvana Spagnuolo, Davide Gnocchi, Paolo De Vito, Paolo Luly, Jens Z. Pedersen, Sandra Incerpi
Review
Genetics & Heredity
Davide Gnocchi, Carlo Custodero, Carlo Sabba, Antonio Mazzocca
JOURNAL OF MOLECULAR MEDICINE-JMM
(2019)
Article
Plant Sciences
Davide Gnocchi, Gianluigi Cesari, Generosa Jenny Calabrese, Roberto Capone, Carlo Sabba, Antonio Mazzocca
PLANT FOODS FOR HUMAN NUTRITION
(2020)
Article
Genetics & Heredity
Davide Gnocchi, Saketh Kapoor, Patrizia Nitti, Maria Maddalena Cavalluzzi, Giovanni Lentini, Nunzio Denora, Carlo Sabba, Antonio Mazzocca
JOURNAL OF MOLECULAR MEDICINE-JMM
(2020)
Article
Cell Biology
Davide Gnocchi, Ewa C. S. Ellis, Helene Johansson, Mats Eriksson, Giovannella Bruscalupi, Knut R. Steffensen, Paolo Parini
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Rosa Lippolis, Davide Gnocchi, Luigi Santacroce, Rosa Anna Siciliano, Maria Fiorella Mazzeo, Salvatore Scacco, Carlo Sabba, Antonio Mazzocca
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Davide Gnocchi, Laura Del Coco, Chiara Roberta Girelli, Francesca Castellaneta, Gianluigi Cesari, Carlo Sabba, Francesco Paolo Fanizzi, Antonio Mazzocca
Summary: Studies have shown that the extract of Crithmum maritimum has an inhibitory effect on liver cancer cells by altering cellular metabolic processes to achieve cytostasis. This finding provides hope for Crithmum maritimum as a new treatment for hepatocellular carcinoma and other types of tumors.
SCIENTIFIC REPORTS
(2021)
Review
Hematology
Alessandro Ciavarella, Davide Gnocchi, Carlo Custodero, Gennaro Mariano Lenato, Giorgio Fiore, Carlo Sabba, Antonio Mazzocca
Summary: Non-alcoholic fatty liver disease (NAFLD) is a pathological condition that ranges from fatty liver (FL) to chronic steatohepatitis (NASH), liver cirrhosis, and eventually to hepatocellular carcinoma (HCC). Patients with NAFLD have a higher risk of cardiovascular events and thromboembolism, which is independent of metabolic diseases commonly associated with NAFLD.
THROMBOSIS RESEARCH
(2021)
Review
Biology
Davide Gnocchi, Giovannella Bruscalupi
Article
Biochemistry & Molecular Biology
Olexander M. Semenenko, Victoria V. Lipson, Alina O. Sadchenko, Olga V. Vashchenko, Natalia A. Kasian, Liliia Sviechnikova, Longin M. Lisetski, Mykola L. Babak, Volodymyr M. Vakula, Oleksandr Borysov, Yuliia Holota, Sergey O. Zozulya, Petro O. Borysko, Olexander Mazepa
Summary: An efficient protocol for the synthesis of novel methotrexate-betulonic acid hybrids has been developed and their structures and properties have been fully established. The hybrids showed inferior interactions with artificial lipid membranes, possibly due to their increasing lipophilicity.
Article
Biochemistry & Molecular Biology
Mohadese Yaghoobi Anzabi, Piotr Cmoch, Roman Luboradzki, Zbigniew Pakulski
Summary: Friedelin and 3-acetoxyfriedel-3-en-2-one, known as friedelane triterpenoids, have been isolated from cork smoker wash solids and used as starting materials for the synthesis of new friedelane derivatives. Reduction reactions result in the formation of friedelinol and epi-cerin derivatives.
Article
Biochemistry & Molecular Biology
Detlef Thieme, Aniko Krumbholz, Martin Bidlingmaier, Christoph Geffert, Annika Hameder, Andreas Stoever, Matthias Graw, Annekathrin M. Keiler
Summary: Ethanol can affect testosterone metabolism and potentially influence steroid biosynthesis and blood steroid profiles. The study emphasizes the importance of sufficient time interval from food and ethanol intake during blood sampling, particularly for diagnostics in doping control.
Article
Biochemistry & Molecular Biology
Masanobu Murao, Tetsuo Imano, Yoshinobu Sato, Masaaki Nakajima
Article
Biochemistry & Molecular Biology
Jingyuan Wang, Ye Feng, Brian Liu, Wen Xie
Summary: Sulfation and desulfation of steroids are opposing processes that regulate steroid homeostasis and are involved in steroid-related diseases. Cytosolic sulfotransferase and steroid sulfatase modify and regulate steroids to affect hormonal dysregulation, metabolic diseases, and cancer.
Article
Biochemistry & Molecular Biology
Noah K. Babel, Brian J. Feldman
Summary: Our research identified a previously unrecognized ADAMTS1-PTN-Wnt pathway in regulating adipose precursor cell behavior. The non-muscle myosin protein MYH9 was found to be a key target of this pathway for modulating adipogenesis. These findings offer potential for developing novel therapeutics for obesity and related metabolic disorders.
Article
Biochemistry & Molecular Biology
Martiniano Bello
Summary: This study explores the structural and thermodynamic basis of molecular recognition between ERβ and DPN and its derivatives using molecular dynamics simulations and end-point methods. The results show that the MMGBSA approach is able to reproduce experimental trends and identify eight residues that strongly interact with the ligands.