Pkb/Akt1 Mediates Wnt/GSK3β/β-Catenin Signaling-Induced Apoptosis in Human Cord Blood Stem Cells Exposed to Organophosphate Pesticide Monocrotophos

The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Is a Potent Inhibitor of ATM- and DNA-PKCs-Mediated DNA Damage Responses

(2015) Bipasha Mukherjee et al.   NEOPLASIA

Pharmacophore, QSAR, and ADME based semisynthesis and in vitro evaluation of ursolic acid analogs for anticancer activity

(2012) Komal Kalani et al.   JOURNAL OF MOLECULAR MODELING

N-cadherin regulates mammary tumor cell migration through Akt3 suppression

(2012) S Chung et al.   ONCOGENE

Mechanism of Inhibition of the ATPase Domain of Human Topoisomerase IIα by 1,4-Benzoquinone, 1,2-Naphthoquinone, 1,4-Naphthoquinone, and 9,10-Phenanthroquinone

(2012) Deepak Gurbani et al.   TOXICOLOGICAL SCIENCES

Synthesis of GSK3β mimetic inhibitors of Akt featuring a novel extended dipeptide surrogate

(2011) Sujeewa Ranatunga et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Successful mobilization and engraftment of PBSCs derived from donor cord blood cells after a previous allogeneic RIC single unrelated cord blood transplantation

(2011) F. Larosa et al.   BLOOD

Human umbilical cord blood mesenchymal stem cells protect mice brain after trauma*

(2011) Elisa R. Zanier et al.   CRITICAL CARE MEDICINE

Pesticide induced alterations in marrow physiology and depletion of stem and stromal progenitor population: An experimental model to study the toxic effects of pesticide

(2011) Sumanta Chatterjee et al.   ENVIRONMENTAL TOXICOLOGY

Monocrotophos Induced Apoptosis in PC12 Cells: Role of Xenobiotic Metabolizing Cytochrome P450s

(2011) Mahendra Pratap Kashyap et al.   PLoS One

Differential Estrogenic Effects of the Persistent Organochlorine Pesticides Dieldrin, Endosulfan, and Lindane in Primary Neuronal Cultures

(2011) Víctor Briz et al.   TOXICOLOGICAL SCIENCES

Current development of the second generation of mTOR inhibitors as anticancer agents

(2011) Hong-Yu Zhou et al.   Chinese Journal of Cancer

β-Adrenoceptor stimulation potentiates insulin-stimulated PKB phosphorylation in rat cardiomyocytes via cAMP and PKA

(2010) Jorid T Stuenaes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Diallyl Trisulfide Inhibits Phorbol Ester-Induced Tumor Promotion, Activation of AP-1, and Expression of COX-2 in Mouse Skin by Blocking JNK and Akt Signaling

(2010) S. Shrotriya et al.   CANCER RESEARCH

Caspase Cascade Regulated Mitochondria Mediated Apoptosis in Monocrotophos Exposed PC12 Cells

(2010) M. P. Kashyap et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Performance and haematological indices in rats exposed to monocrotophos contamination

(2010) TO Sunmonu et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Paraquat-induced Oxidative Stress Represses Phosphatidylinositol 3-Kinase Activities Leading to Impaired Glucose Uptake in 3T3-L1 Adipocytes

(2010) Michihiro Shibata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Akt Requires Glucose Metabolism to Suppress Puma Expression and Prevent Apoptosis of Leukemic T Cells

(2010) Jonathan L. Coloff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design of Selective, ATP-Competitive Inhibitors of Akt

(2010) Kevin D. Freeman-Cook et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

(2010) Wen-I Wu et al.   PLoS One

Induction of Macrophage Apoptosis by an Organochlorine Insecticide Acetofenate

(2009) Meirong Zhao et al.   CHEMICAL RESEARCH IN TOXICOLOGY

CoMFA and molecular docking studies of benzoxazoles and benzothiazoles as CYP450 1A1 inhibitors

(2009) Jie Pan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial membrane permeabilization in neuronal injury

(2009) Lorenzo Galluzzi et al.   NATURE REVIEWS NEUROSCIENCE

Synthesis and structure based optimization of novel Akt inhibitors

(2008) Blaise Lippa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Prediction of the receptor conformation for iGluR2 agonist binding: QM/MM docking to an extensive conformational ensemble generated using normal mode analysis

(2007) Tommy Sander et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING