Article
Biochemistry & Molecular Biology
Flavia Carton, Dalila Di Francesco, Luca Fusaro, Emma Zanella, Claudio Apostolo, Francesca Oltolina, Diego Cotella, Maria Prat, Francesca Boccafoschi
Summary: The study evaluated the myogenic potential of dECM substrate derived from decellularized bovine pericardium on murine muscle cells and found that dECM could support and enhance the myogenic potential of muscle cells compared to cells grown on a standard plastic surface. This suggests that extracellular matrix proteins could be a promising therapeutic strategy for skeletal muscle tissue engineering.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Rianne D. W. Vaes, David P. J. van Dijk, Elham Aida Farshadi, Steven W. M. Olde Damink, Sander S. Rensen, Ramon C. Langen
Summary: The study revealed that factors derived from pancreatic tumor organoids alter the kinetics of myogenesis, potentially contributing to impaired muscle mass maintenance in cancer cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Biochemistry & Molecular Biology
Aiping Lu, Ping Guo, Haiying Pan, Chieh Tseng, Krishna M. Sinha, Fan Yang, Alex Scibetta, Yan Cui, Matthieu Huard, Ling Zhong, Sudheer Ravuri, Johnny Huard
Summary: Research shows that pregnant mice demonstrate accelerated muscle healing, superior muscle regeneration, and reduced inflammation and necrosis following muscle injury. Additionally, MPCs from pregnant mice display improved myogenic differentiation capacity in vitro and muscle regeneration in vivo.
Review
Biochemistry & Molecular Biology
Clara Crescioli
Summary: Skeletal muscle cells are finely controlled by vitamin D through genomic and non-genomic mechanisms, constantly undergoing cell remodeling to maintain tissue integrity. Vitamin D insufficiency promotes cell maladaptation, while restoring vitamin D levels can enhance myogenic programming.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Congshan Sun, Suraj Kannan, In Young Choi, HoTae Lim, Hao Zhang, Grace S. Chen, Nancy Zhang, Seong-Hyun Park, Carlo Serra, Shama R. Iyer, Thomas E. Lloyd, Richard M. Lovering, Su Bin Lim, Peter Andersen, Kathryn R. Wagner, Gabsang Lee, Chulan Kwon
Summary: Human pluripotent stem cell (hPSC)-derived myogenic progenitor cell (MPC) transplantation can contribute to muscle fiber regeneration in mice, providing a proof of principle for future hPSC-based cell therapy for muscle disorders.
Review
Engineering, Chemical
Neha Arora, George P. Philippidis
Summary: Aquatic algae provide a rich source of bioproducts for the global market. Microalgae-derived vitamins and their precursors are being extensively studied and used in the cosmeceutical industry due to their therapeutic benefits and ecofriendly nature. This review focuses on the industrial production strategies of vitamins from algae for cosmeceutical applications, emphasizing novel biotechnological interventions to enhance vitamin biosynthesis. The review also summarizes the current market for algae-derived vitamins and presents recent research findings in this area.
Article
Cell Biology
Yajie Hu, Yang Liu, Yuying Yang, Hongming Lv, Shuai Lian, Bin Xu, Shize Li
Summary: The study found that under acute cold exposure conditions, O-GlcNAcylation can enhance the expression of IL-6 in mouse skeletal muscle, promote energy metabolism regulation, and maintain cell survival by enhancing the activity and nuclear translocation of p65.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Cell Biology
Rokas Miksiunas, Siegfried Labeit, Daiva Bironaite
Summary: This study aimed to investigate the myogenic differentiation of CD56-positive and -negative skeletal muscle-derived mesenchymal stem/stromal cells (SM-MSCs) and their response to non-cytotoxic heat stimulus. The results showed that CD56(+) cells were smaller in size, had better proliferation, and expressed higher levels of CD146 and CD318 compared to CD56(-) cells. In addition, the non-cytotoxic heat stimulus significantly stimulated the expression of myogenic markers in CD56(+) cells and correlated with multinucleated cell formation.
Article
Health Care Sciences & Services
Karyn G. Robinson, Adam G. Marsh, Stephanie K. Lee, Jonathan Hicks, Brigette Romero, Mona Batish, Erin L. Crowgey, M. Wade Shrader, Robert E. Akins
Summary: This study examined the DNA methylation differences in myoblasts and myotubes derived from satellite cells in patients with spastic cerebral palsy (CP). The results showed significant DNA methylation differences in these cells, suggesting potential new targets for studying the mechanisms contributing to muscle dysregulation in spastic CP.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Chemistry, Applied
Elayma S. Sanchez-Acevedo, Ricardo Lopez, Vicente Ferreira
Summary: This study investigates the accumulation and degradation of aroma molecules released by acid hydrolysis of aroma precursors in winemaking grapes. The analysis shows that fast hydrolysis at higher temperatures accurately predicts grape aroma potential.
Article
Cell Biology
Paola Fabbrizio, Cassandra Margotta, Jessica D'Agostino, Giuseppe Suanno, Lorenzo Quetti, Caterina Bendotti, Giovanni Nardo
Summary: Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease with a poor prognosis and unmet therapeutic need. Recent research suggests that the modulation of macrophage muscle response and enhancement of satellite cell differentiation can delay muscle atrophy and motor neuron loss in ALS. IL-10 treatment was found to improve motor performance in ALS mice by promoting satellite cells and muscle pro-regenerative activity of macrophages.
Review
Biochemistry & Molecular Biology
Pinshi Ni, Luodan Yang, Fanghui Li
Summary: Exosomes are extracellular membrane vesicles containing RNA and proteins that play a crucial role in physiological and pathological processes. Skeletal muscle-derived exosomes (SkMCs-Exs) carry myokines, regulate receptor cells, and have effects on pathological states such as injury atrophy, aging, and vascular porosis. Exercise also regulates SkMCs-Exs and has physiological significance.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Cell Biology
Qiumei Lu, Ying Gao, Zhimeng Fan, Xing Xiao, Yu Chen, Yuan Si, Deqiang Kong, Shuai Wang, Meijian Liao, Xiaodong Chen, Xusheng Wang, Weiwei Chu
Summary: The study revealed that AREG enhances SKP stemness through the PI3K and MAPK pathways, promoting their proliferation and hair-inducing capacity, suggesting AREG therapy as a potentially promising approach for treating alopecia.
CELL PROLIFERATION
(2021)
Article
Cell Biology
Maria Benavente-Diaz, Glenda Comai, Daniela Di Girolamo, Francina Langa, Shahragim Tajbakhsh
Summary: A knock-in mouse line expressing tdTOMATO fluorescent protein from the endogenous Myogenin locus was reported, allowing tracking and isolation of MYOGENIN(+) cell population. tdTOMATO fluorescence could track differentiating myoblasts both in vitro and in vivo. Live imaging showed that a fraction of the MYOGENIN(+) population could undergo one round of cell division.
Article
Biochemistry & Molecular Biology
Keren Long, Xiaokai Li, Duo Su, Sha Zeng, Hengkuan Li, Yu Zhang, Biwei Zhang, Wenying Yang, Penghao Li, Xuemin Li, Xun Wang, Qianzi Tang, Lu Lu, Long Jin, Jideng Ma, Mingzhou Li
Summary: This study investigates the chromatin interactions of eight myogenic marker genes during myogenesis using 4C-seq. The results reveal dynamic chromatin interactions of these marker genes during differentiation and identify significant interaction sites related to muscle development. Functional genomic screening identifies putative active enhancers and luciferase reporter assays validate the functionality of eight enhancers. Furthermore, epigenome editing and RNA-Seq experiments demonstrate the regulatory role of Myog enhancers in Myog expression and myogenic differentiation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cell Biology
Xiaohua Lei, Yujing Cao, Ying Zhang, Jingjing Qian, Qian Zhao, Fangwu Liu, Tao Zhang, Jiaxi Zhou, Ying Gu, Guoliang Xia, Enkui Duan
CELL PROLIFERATION
(2018)
Review
Clinical Neurology
Xintian Yan, Xinzhi Zhao, Juxue Li, Lin He, Mingqing Xu
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2018)
Article
Dermatology
Jing Liu, Yale Liu, Lingling Peng, Juxue Li, Kunyi Wu, Linlin Xia, Jiawen Wu, Sijia Wang, Xuening Wang, Qilu Liu, Weihui Zeng, Yumin Xia
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Article
Multidisciplinary Sciences
Shaopeng Zhang, Tianzhi Chen, Naixin Chen, Dengfeng Gao, Bingbo Shi, Shuangbo Kong, Rachel Claire West, Ye Yuan, Minglei Zhi, Qingqing Wei, Jinzhu Xiang, Haiyuan Mu, Liang Yue, Xiaohua Lei, Xuepeng Wang, Liang Zhong, Hui Liang, Suying Cao, Juan Carlos Izpisua Belmonte, Haibin Wang, Jianyong Han
NATURE COMMUNICATIONS
(2019)
Article
Neurosciences
Qing Shen, Zhuo Chen, Faming Zhao, Susu Pan, Tingting Zhang, Xueer Cheng, Lei Zhang, Shanshan Zhang, Junxia Qi, Juxue Li, Dongsheng Cai, Guo Zhang
NATURE NEUROSCIENCE
(2020)
Review
Biotechnology & Applied Microbiology
Lei Zhao, Chengyu Bao, Yuxuan Shang, Xinye He, Chiyuan Ma, Xiaohua Lei, Dong Mi, Yeqing Sun
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Biochemistry & Molecular Biology
Rongrong Li, Chiyuan Ma, Yue Xiong, Huashan Zhao, Yali Yang, Li Xue, Baobei Wang, Tianxia Xiao, Jie Chen, Xiaohua Lei, Baohua Ma, Jian Zhang
Summary: The study found that Gpr1 signaling affects the release of reproductive hormones and expression of ovarian genes, revealing a link between depression and reproductive diseases. The antagonistic peptide of Gpr1 may serve as a potential therapeutic application for hormone-modulated depression in women.
Article
Biochemistry & Molecular Biology
Dong Liang, Meng Ning, Hang Xie, Xiaoyan He, Peigen Ren, Xiaohua Lei, Xuepei Zhang
Summary: Cranial radiation therapy is effective for childhood brain cancers, but it can lead to cognitive impairment. This study found that radiation arrested the cell cycle and impacted differentiation of neural stem cells (NSCs). Proteomic analysis revealed that radiation suppressed protein transport and neuron projection development. Additionally, oxidative modifications were observed in proteins of differentiating NSCs. Some of the identified proteins were associated with neurodegenerative diseases. These findings have implications for understanding neurodegeneration and developing preventive strategies.
Article
Biochemistry & Molecular Biology
Yue Xiong, Chiyuan Ma, Qin Li, Wenya Zhang, Huashan Zhao, Peigen Ren, Ke Zhang, Xiaohua Lei
Summary: In this study, the adverse effects of simulated microgravity on hepatocytes were investigated. It was found that microgravity impaired hepatocyte viability, caused cell cycle arrest and apoptosis, triggered lipid accumulation and impaired mitochondria function. Upregulation of genes related to lipid metabolism was also observed. Importantly, these defects could be suppressed by melatonin, suggesting its potential therapeutic intervention.
Article
Cell & Tissue Engineering
Wenya Zhang, Jinhua Zhang, Yan Cui, Yongxiang Zhao, Xiaohua Lei
Summary: An increasing number of astronauts in microgravity environments for long-term space missions has led to serious health problems, including accidental injury and trauma. Skin, as the largest organ and outermost layer of the human body, has the ability to withstand harmful influences. Recent studies have looked into the effects of microgravity on skin cells and wound healing, but there is still limited understanding of the mechanisms and intervention measures. Stem cells and their exosomes have shown potential for improving cutaneous wound healing. This review discusses the effects of microgravity on wound healing and summarizes current research on ground-based treatments using stem cells and exosomes. It also proposes promising therapeutic strategies for wound healing in the microgravity environment using stem cells or exosomes.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Chiyuan Ma, Kaizheng Liu, Qin Li, Yue Xiong, Cuixiang Xu, Wenya Zhang, Changshun Ruan, Xin Li, Xiaohua Lei
Summary: This study demonstrates the use of synthetic hydrogels from polyisocyanides (PIC) to support the growth and maintenance of cells from different germ layers. Schwann cells and hepatocytes formed multicellular spheroids and maintained their properties, while endothelial cells only spread and formed a cell network in hydrogels containing specific adhesive peptides.
BIOENGINEERING-BASEL
(2022)
Article
Endocrinology & Metabolism
Hui-Hui Wang, Cheng-Liang Zhou, Min Lv, Qian Yang, Ju-Xue Li, Min Hou, Jing Lin, Xin-Mei Liu, Yan-Ting Wu, Jian-Zhong Sheng, He-Feng Huang