Somatic Cells with a Heavy Mitochondrial DNA Mutational Load Render Induced Pluripotent Stem Cells with Distinct Differentiation Defects

Genome Instability and Aging

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An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state

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Mitochondrial Regulation in Pluripotent Stem Cells

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Mechanisms that Regulate Stem Cell Aging and Life Span

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Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging

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Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance

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Germline mitochondrial DNA mutations aggravate ageing and can impair brain development

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Tissue- and cell-type-specific manifestations of heteroplasmic mtDNA 3243A>G mutation in human induced pluripotent stem cell-derived disease model

(2013) R. H. Hamalainen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disease-Causing Mitochondrial Heteroplasmy Segregated Within Induced Pluripotent Stem Cell Clones Derived from a Patient with MELAS

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Induced Pluripotent Stem Cells with a Mitochondrial DNA Deletion

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Mesenchymal Stem Cells Transfer Mitochondria to the Cells with Virtually No Mitochondrial Function but Not with Pathogenic mtDNA Mutations

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Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells

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Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming

(2011) Clifford D.L. Folmes et al.   Cell Metabolism

The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming

(2011) Athanasia D Panopoulos et al.   CELL RESEARCH

Accumulating Mitochondrial DNA Mutations Drive Premature Hematopoietic Aging Phenotypes Distinct from Physiological Stem Cell Aging

(2011) Gudmundur L. Norddahl et al.   Cell Stem Cell

A review and appraisal of the DNA damage theory of ageing

(2011) Alex A. Freitas et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Modelling the long QT syndrome with induced pluripotent stem cells

(2011) Ilanit Itzhaki et al.   NATURE

Accumulation of DNA Damage in Hematopoietic Stem and Progenitor Cells during Human Aging

(2011) Claudia E. Rübe et al.   PLoS One

Energy Metabolism in Human Pluripotent Stem Cells and Their Differentiated Counterparts

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The Effects of Nuclear Reprogramming on Mitochondrial DNA Replication

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Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins

(2011) Adam Ameur et al.   PLoS Genetics

Somatic Mitochondrial DNA Mutations in Mammalian Aging

(2010) Nils-Göran Larsson   Annual Review of Biochemistry

Mitochondrial dysfunction as a cause of ageing

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Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients

(2010) Suneet Agarwal et al.   NATURE

Mitochondrial Rejuvenation After Induced Pluripotency

(2010) Steven T. Suhr et al.   PLoS One

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

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The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells

(2010) Alessandro Prigione et al.   STEM CELLS

Human Induced Pluripotent Stem Cell Lines Show Stress Defense Mechanisms and Mitochondrial Regulation Similar to Those of Human Embryonic Stem Cells

(2010) Lyle Armstrong et al.   STEM CELLS

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders

(2009) Z. Ye et al.   BLOOD

Random Point Mutations with Major Effects on Protein-Coding Genes Are the Driving Force behind Premature Aging in mtDNA Mutator Mice

(2009) Daniel Edgar et al.   Cell Metabolism

Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells

(2009) Rosa M. Marion et al.   Cell Stem Cell

Hematopoietic stem cell ageing is uncoupled from p16INK4A-mediated senescence

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Induced Pluripotent Stem Cells at Nanoscale

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Stems Cells and the Pathways to Aging and Cancer

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Induced pluripotent stem cells from a spinal muscular atrophy patient

(2008) Allison D. Ebert et al.   NATURE

A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations

(2008) Weiwei Fan et al.   SCIENCE

Mitochondrial DNA mutations and aging: devils in the details?

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