The Key Regulatory Roles of the PI3K/Akt Signaling Pathway in the Functionalities of Mesenchymal Stem Cells and Applications in Tissue Regeneration
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Title
The Key Regulatory Roles of the PI3K/Akt Signaling Pathway in the Functionalities of Mesenchymal Stem Cells and Applications in Tissue Regeneration
Authors
Keywords
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Journal
TISSUE ENGINEERING PART B-REVIEWS
Volume 19, Issue 6, Pages 516-528
Publisher
Mary Ann Liebert Inc
Online
2013-05-08
DOI
10.1089/ten.teb.2012.0672
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- The potential of human fetal mesenchymal stem cells for off-the-shelf bone tissue engineering application
- (2012) Zhi-Yong Zhang et al. BIOMATERIALS
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- (2012) Juan Hou et al. Biomedical Materials
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- (2012) S. Otsuru et al. BLOOD
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- (2012) Sanjay Kumar et al. BONE
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- (2012) X. Wang et al. CANCER RESEARCH
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- (2012) Jian-Jun Chen et al. Cardiology Journal
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- (2012) P. Sreejit et al. CELL AND TISSUE RESEARCH
- Stromal-cell-derived factor (SDF) 1-alpha in combination with BMP-2 and TGF-β1 induces site-directed cell homing and osteogenic and chondrogenic differentiation for tissue engineering without the requirement for cell seeding
- (2012) Harvey Chim et al. CELL AND TISSUE RESEARCH
- Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease
- (2012) Sudhir H. Ranganath et al. Cell Stem Cell
- Role of IRAK1 on TNF-induced Proliferation and NF-?B Activation in Human Bone Marrow Mesenchymal Stem Cells
- (2012) Jong Myung Kim et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
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- (2012) Jue-Yeon Lee et al. CURRENT PHARMACEUTICAL DESIGN
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- (2012) Hyung Keun Kim et al. JOURNAL OF CELLULAR BIOCHEMISTRY
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- (2012) Min Woo Jang et al. JOURNAL OF CELLULAR PHYSIOLOGY
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- (2012) Stephen Fitter et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
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- (2012) P. Yilgor et al. Journal of Tissue Engineering and Regenerative Medicine
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- (2012) Daisy A. Robinton et al. NATURE
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- (2012) Caroline Szpalski et al. TISSUE ENGINEERING PART B-REVIEWS
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- (2012) Sarah E. Bulman et al. TISSUE ENGINEERING PART B-REVIEWS
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- (2012) Yufang Shi et al. TRENDS IN IMMUNOLOGY
- Mobilization of mesenchymal stem cells by stromal cell-derived factor-1 released from chitosan/tripolyphosphate/fucoidan nanoparticles
- (2011) Yi-Cheng Huang et al. Acta Biomaterialia
- Activation of non-canonical Wnt/JNK pathway by Wnt3a is associated with differentiation fate determination of human bone marrow stromal (mesenchymal) stem cells
- (2011) Weimin Qiu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Osterix is regulated by Erk1/2 during osteoblast differentiation
- (2011) You Hee Choi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- (2011) Jeremy M. Holzwarth et al. BIOMATERIALS
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- (2011) Drew Kuraitis et al. BIOMATERIALS
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- (2011) Chengtie Wu et al. BIOMATERIALS
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- (2011) S. Y. Sokol DEVELOPMENT
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- (2011) Céline Colnot TISSUE ENGINEERING PART B-REVIEWS
- Bone Tissue Engineering Bioreactors: A Role in the Clinic?
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- Bone Tissue Engineering: Current Strategies and Techniques—Part I: Scaffolds
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- Therapeutic Applications of Mesenchymal Stromal Cells: Paracrine Effects and Potential Improvements
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- Mesenchymal stem cells hold promise for regenerative medicine
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- (2010) Wenhua Piao et al. ANGIOGENESIS
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- (2010) Alberto M. Martelli et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
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- (2010) Mingliang You et al. BIOMATERIALS
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- (2010) Seung-Yong Song et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Bioactive mesopore-glass microspheres with controllable protein-delivery properties by biomimetic surface modification
- (2010) Chengtie Wu et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
- Autocrine fibroblast growth factor 18 mediates dexamethasone-induced osteogenic differentiation of murine mesenchymal stem cells
- (2010) Zahia Hamidouche et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Role of mitogen-activated protein kinase in osteoblast differentiation
- (2010) Fu-Hsiung Lin et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Customized Ca-P/PHBV nanocomposite scaffolds for bone tissue engineering: design, fabrication, surface modification and sustained release of growth factor
- (2010) B. Duan et al. Journal of the Royal Society Interface
- Chemokines in mesenchymal stem cell therapy for bone repair: a novel concept of recruiting mesenchymal stem cells and the possible cell sources
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- (2010) Qi Yin et al. MOLECULAR BIOLOGY REPORTS
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- (2010) Louise P. Cramer NATURE CELL BIOLOGY
- Elliptic Flow of Charged Particles in Pb-Pb Collisions atsNN=2.76 TeV
- (2010) K. Aamodt et al. PHYSICAL REVIEW LETTERS
- Challenges in Using Stem Cells for Cardiac Repair
- (2010) C. L. Mummery et al. Science Translational Medicine
- Markers Distinguishing Mesenchymal Stem Cells from Fibroblasts Are Downregulated with Passaging
- (2010) Svetlana Halfon et al. STEM CELLS AND DEVELOPMENT
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- (2010) Françoise Carlotti et al. Islets
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- (2009) Xueli Mao et al. BIOMATERIALS
- The interaction between bone marrow stromal cells and RGD-modified three-dimensional porous polycaprolactone scaffolds
- (2009) Huina Zhang et al. BIOMATERIALS
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- (2009) Zhao-jun Wang et al. CELL BIOLOGY INTERNATIONAL
- The multifaceted role of periostin in tumorigenesis
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- Strontium Promotes Osteogenic Differentiation of Mesenchymal Stem Cells Through the Ras/MAPK Signaling Pathway
- (2009) Songlin Peng et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
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- (2009) Junming Tang et al. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
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- (2009) W.-K. Kim et al. JOURNAL OF CELL SCIENCE
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- (2009) A. Mukherjee et al. JOURNAL OF CELL SCIENCE
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- (2009) Keith R. Shockley et al. JOURNAL OF CELLULAR BIOCHEMISTRY
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- (2009) T. D. Pollard et al. SCIENCE
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- (2009) Manu O. Platt et al. STEM CELLS
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- (2008) Paul R. Crisostomo et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications
- (2008) T Weichhart et al. ANNALS OF THE RHEUMATIC DISEASES
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- (2008) Jie-li Li et al. BONE
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- (2008) P. Jiang et al. CANCER RESEARCH
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