A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny

In vivo enrichment of cytidine deaminase gene-modified hematopoietic cells by prolonged cytosine-arabinoside application

(2012) Sebastian Brennig et al.   CYTOTHERAPY

Efficient in vivo regulation of cytidine deaminase expression in the haematopoietic system using a doxycycline-inducible lentiviral vector system

(2012) N Lachmann et al.   GENE THERAPY

Safer, Silencing-Resistant Lentiviral Vectors: Optimization of the Ubiquitous Chromatin-Opening Element through Elimination of Aberrant Splicing

(2012) S. Knight et al.   JOURNAL OF VIROLOGY

Extensive Methylation of Promoter Sequences Silences Lentiviral Transgene Expression During Stem Cell Differentiation In Vivo

(2012) Friederike Herbst et al.   MOLECULAR THERAPY

Oxidase-deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease-mediated safe harbor targeting

(2011) J. Zou et al.   BLOOD

Disease Correction the iPSC Way: Advances in iPSC-Based Therapy

(2011) I Sancho-Martinez et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Site-specific recombinases: from tag-and-target- to tag-and-exchange-based genomic modifications

(2011) Soeren Turan et al.   FASEB JOURNAL

MicroRNA-150-regulated vectors allow lymphocyte-sparing transgene expression in hematopoietic gene therapy

(2011) N Lachmann et al.   GENE THERAPY

Physiological regulation of transgene expression by a lentiviral vector containing the A2UCOE linked to a myeloid promoter

(2011) C Brendel et al.   GENE THERAPY

Recombinase-Mediated Cassette Exchange (RMCE): Traditional Concepts and Current Challenges

(2011) Soeren Turan et al.   JOURNAL OF MOLECULAR BIOLOGY

Harnessing the potential of induced pluripotent stem cells for regenerative medicine

(2011) Sean M. Wu et al.   NATURE CELL BIOLOGY

On target? Tracing zinc-finger-nuclease specificity

(2011) Claudio Mussolino et al.   NATURE METHODS

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

(2011) Tomas Cermak et al.   NUCLEIC ACIDS RESEARCH

Generation of Functional Neutrophils from a Mouse Model of X-Linked Chronic Granulomatous Disorder Using Induced Pluripotent Stem Cells

(2011) Sayandip Mukherjee et al.   PLoS One

Efficient Hematopoietic Redifferentiation of Induced Pluripotent Stem Cells Derived from Primitive Murine Bone Marrow Cells

(2011) Nils Pfaff et al.   STEM CELLS AND DEVELOPMENT

Generation of Healthy Mice from Gene-Corrected Disease-Specific Induced Pluripotent Stem Cells

(2011) Guangming Wu et al.   PLOS BIOLOGY

A Ubiquitous Chromatin Opening Element (UCOE) Confers Resistance to DNA Methylation–mediated Silencing of Lentiviral Vectors

(2010) Fang Zhang et al.   MOLECULAR THERAPY

Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

(2010) Stefan Stein et al.   NATURE MEDICINE

Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells

(2009) Ángel Raya et al.   NATURE

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

(2009) Dirk Hockemeyer et al.   NATURE BIOTECHNOLOGY

Generation of mouse-induced pluripotent stem cells by transient expression of a single nonviral polycistronic vector

(2009) F. Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hematopoietic and Endothelial Differentiation of Human Induced Pluripotent Stem Cells

(2009) Kyung-Dal Choi et al.   STEM CELLS

Reciprocal Relationship between O6-Methylguanine-DNA Methyltransferase P140K Expression Level and Chemoprotection of Hematopoietic Stem Cells

(2008) M. D. Milsom et al.   CANCER RESEARCH

Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis

(2008) F. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA