Concise Review: A High-Content Screening Approach to Stem Cell Research and Drug Discovery

Identification of Small Molecule Inhibitors of Neurite Loss Induced by Aβ peptide using High Content Screening

(2012) Dimitry Ofengeim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration

(2012) Ting Chen et al.   NATURE

ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4

(2012) Myoung Ok Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Small-Molecule Inhibitors of the Wnt Pathway Potently Promote Cardiomyocytes From Human Embryonic Stem Cell–Derived Mesoderm

(2011) Erik Willems et al.   CIRCULATION RESEARCH

RNAi screening for fat regulatory genes with SRS microscopy

(2011) Meng C Wang et al.   NATURE METHODS

High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules

(2010) Paul D. Andrews et al.   BIOCHEMICAL JOURNAL

Imaging-based chemical screens using normal and glioma-derived neural stem cells

(2010) Davide Danovi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Image-Based Chemical Screening Identifies Drug Efflux Inhibitors in Lung Cancer Cells

(2010) X. Xia et al.   CANCER RESEARCH

Cellular Heterogeneity: Do Differences Make a Difference?

(2010) Steven J. Altschuler et al.   CELL

Lab-on-a-chip devices as an emerging platform for stem cell biology

(2010) Kshitiz Gupta et al.   LAB ON A CHIP

Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities

(2010) Dinesh Kumar Singh et al.   Molecular Systems Biology

A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity

(2010) Na-Yu Chia et al.   NATURE

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes

(2010) Beate Neumann et al.   NATURE

CellCognition: time-resolved phenotype annotation in high-throughput live cell imaging

(2010) Michael Held et al.   NATURE METHODS

Three-dimensional tissue culture based on magnetic cell levitation

(2010) Glauco R. Souza et al.   Nature Nanotechnology

Human stem cells and drug screening: opportunities and challenges

(2010) Allison D. Ebert et al.   NATURE REVIEWS DRUG DISCOVERY

Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency

(2010) Rodolfo Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel regulators of stem cell fates identified by a multivariate phenotype screen of small compounds on human embryonic stem cell colonies

(2010) Ivana Barbaric et al.   Stem Cell Research

High content screening: seeing is believing

(2010) Fabian Zanella et al.   TRENDS IN BIOTECHNOLOGY

A Small-Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog

(2009) Justin K. Ichida et al.   Cell Stem Cell

A Small Molecule Primes Embryonic Stem Cells for Differentiation

(2009) Shoutian Zhu et al.   Cell Stem Cell

A Genome-Scale RNAi Screen for Oct4 Modulators Defines a Role of the Paf1 Complex for Embryonic Stem Cell Identity

(2009) Li Ding et al.   Cell Stem Cell

Small Molecules Efficiently Direct Endodermal Differentiation of Mouse and Human Embryonic Stem Cells

(2009) Malgorzata Borowiak et al.   Cell Stem Cell

Human stem cells as a model for cardiac differentiation and disease

(2009) A. Beqqali et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Novel trends in high-throughput screening

(2009) Lorenz M Mayr et al.   CURRENT OPINION IN PHARMACOLOGY

A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal

(2009) G. Hu et al.   GENES & DEVELOPMENT

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs

(2009) Gabsang Lee et al.   NATURE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

A small molecule that directs differentiation of human ESCs into the pancreatic lineage

(2009) Shuibing Chen et al.   Nature Chemical Biology

An approach for extensibly profiling the molecular states of cellular subpopulations

(2009) Lit-Hsin Loo et al.   NATURE METHODS

High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research

(2009) Tiago G. Fernandes et al.   TRENDS IN BIOTECHNOLOGY

Disease-Specific Induced Pluripotent Stem Cells

(2008) In-Hyun Park et al.   CELL

Genetic Modification of Human Embryonic Stem Cells for Derivation of Target Cells

(2008) Antonietta Giudice et al.   Cell Stem Cell

High-Throughput Screening Assay for the Identification of Compounds Regulating Self-Renewal and Differentiation in Human Embryonic Stem Cells

(2008) Sabrina C. Desbordes et al.   Cell Stem Cell

Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Oct4 and Klf4 with Small-Molecule Compounds

(2008) Yan Shi et al.   Cell Stem Cell

The Use of Immortalized Cell Lines in GPCR Screening: The Good, Bad and Ugly.

(2008) Richard Eglen et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

A confident scale-space shape representation framework for cell migration detection

(2008) K. ZHANG et al.   JOURNAL OF MICROSCOPY

Small-Molecule Fluorophores To Detect Cell-State Switching in the Context of High-Throughput Screening

(2008) Bridget K. Wagner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Induced pluripotent stem cells from a spinal muscular atrophy patient

(2008) Allison D. Ebert et al.   NATURE

Characterizing heterogeneous cellular responses to perturbations

(2008) M. D. Slack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

(2008) J. T. Dimos et al.   SCIENCE

Integrated Chemical Genomics Reveals Modifiers of Survival in Human Embryonic Stem Cells

(2008) Robert Damoiseaux et al.   STEM CELLS