Review
Surgery
Ramin Shekouhi, Harvey Chim
Summary: The study aimed to investigate the clinicopathological characteristics and outcome of patients with primary tumors of the brachial plexus who underwent surgical treatment. The results showed that complete surgical resection is the ideal management strategy, but in some cases, such as neurofibromas, subtotal resection may be preferable to preserve maximal neurological function.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Clinical Neurology
Mariano Socolovsky, Karina Barillaro, Gonzalo Bonilla, Gilda Di Masi, Martijn Malessy
Summary: This study investigates the levels of disconnection and reconnection in nerve transfers for brachial plexus injuries. A novel plasticity grading scale was developed and used to assess the volitional control achieved. The study found that only approximately 20% of patients achieved complete control over the reinnervated muscle.
JOURNAL OF NEUROSURGERY
(2023)
Article
Neurosciences
Fan Su, Guobao Wang, Tie Li, Su Jiang, Aiping Yu, Xiaomin Wang, Wendong Xu
Summary: Patients with cerebral injury undergoing contralateral C7 transfer showed faster C7 nerve regeneration, possibly due to altered systemic inflammation leading to macrophage polarization. Serum amyloid protein A1 (SAA1) was found to promote C7 regeneration and interfere with macrophage polarization.
NEUROSCIENCE BULLETIN
(2021)
Article
Health Care Sciences & Services
Andreas Gohritz, Gregor Laengle, Anna Boesendorfer, Bernhard Gesslbauer, Clemens Gstoettner, Olga Politikou, Agnes Sturma, Oskar C. C. Aszmann
Summary: We present a series of patients aged over 60 who underwent nerve reconstruction using nerve transfers, and show that this method is effective in restoring muscle strength and arm function in older patients, contradicting previous literature.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Matthias E. Sporer, Peter C. Brugger, Martin Aman, Christoph F. Fuchssteiner, Christopher Festin, Clemens Gstoettner, Oskar C. Aszmann
Summary: The fascicular shift procedure is a new technique that allows for nerve regeneration in peripheral nerve reconstruction. It involves harvesting a fascicular group distal to a nerve injury and shifting it to bridge the defect. This study evaluated the clinical applicability of this technique in brachial plexus reconstruction, finding that the ulnar and median nerves were suitable for fascicular shifting.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Daniel Lubelski, James Feghali, Andrew Hersh, Srujan Kopparapu, Abdel-Hameed Al-Mistarehi, Allan J. Belzberg
Summary: This study aims to survey peripheral nerve surgeons on their management of brachial plexus injuries (BPI) and reveals substantial disagreement among surgeons regarding the optimal timing and treatment methods. The study also highlights the differences in operative approaches and nerve transfer choices for adult and pediatric BPI cases.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Review
Clinical Neurology
Haijun Li, Jinxiu Chen, Juehan Wang, Tianfang Zhang, Zuobing Chen
Summary: Brachial plexus injury (BPI) is a serious peripheral nerve injury that leads to severe and persistent impairments of the upper limb. The demand for rehabilitation treatment after BPI is increasing due to the relatively mature early diagnosis and surgical technique. Rehabilitation intervention can benefit different stages of recovery, but the treatment methods vary due to the complexity of the brachial plexus. This article explores the potential contributions of various methods to BPI rehabilitation and provides a concise overview of beneficial interventions, forming clear rehabilitation processes based on different periods and populations.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Robert B. B. Kim, Michael Bounajem, Forrest Hamrick, Mark A. A. Mahan
Summary: Neurotization of partial or total brachial plexus injuries through intercostal or phrenic nerve transfers may result in better functional recovery than using contralateral C7. Ulnar, median, or double fascicle nerve transfers show similarly excellent functional recovery in patients with upper trunk injuries.
Article
Anatomy & Morphology
Amgad S. Hanna, Daniel J. Hellenbrand, Dominic T. Schomberg, Shahriar M. Salamat, Megan Loh, Lea Wheeler, Barbara Hanna, Burak Ozaydin, Jennifer Meudt, Dhanansayan Shanmuganayagam
Summary: The study compared the brachial plexus between humans and Wisconsin Miniature Swine and found differences in nerve development, with pigs showing a less developed separation into trunks and cords. Despite this, pigs were deemed a suitable model for studying BPI mechanisms, with differences in nerve trunk diameters and myelinated axon numbers observed. Pigs had fewer myelinated axons in certain nerves compared to humans, likely due to differences in hand motor and sensory demands.
JOURNAL OF ANATOMY
(2022)
Article
Acoustics
Shihui Gu, Qian Zhao, Jing Yao, Li Zhang, Lei Xu, Weiming Chen, Yudong Gu, Jianguang Xu
Summary: This study aimed to quantify the diagnostic accuracy of ultrasonography in brachial plexus root injury at different stages post-trauma. The results showed that ultrasonography had high accuracy in diagnosing brachial plexus root injury, with high detection rates for cervical and thoracic nerve roots. There were no significant differences in sensitivity or specificity across different time stages. Ultrasonography can be used as an optional method for early diagnosis of complete brachial plexus root injury.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Clinical Neurology
Christopher S. Crowe, Nicholas Pulos, Robert J. Spinner, Allen T. Bishop, Dennis A. Wigle, Alexander Y. Shin
Summary: This study aimed to determine the diagnostic value of inspiratory-expiratory chest radiography compared to intraoperative stimulation of the phrenic nerve for assessing phrenic nerve injury associated with brachial plexus injury. The results showed that while inspiratory-expiratory chest radiography has good specificity for detecting phrenic nerve injuries, a high number of false negatives suggest that it should not be relied upon for routine screening of dysfunction after traumatic brachial plexus injury.
ACTA NEUROCHIRURGICA
(2023)
Review
Clinical Neurology
Ruhui Xiao, Jiao Chen, Chen Zeng, Xu Feng, Tao Li, Sushant-kumar Das, Bing Li, Chuan Zhang, Hanfeng Yang
Summary: This paper systematically elaborates on brachial plexus neuropathy, morphological and functional imaging, and post-processing. As the incidence of peripheral neurological diseases increases, the precise display of nerves becomes important in imaging examinations.
NEUROLOGICAL SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Emily J. J. Davidson, Ek T. T. Tan, Emily G. G. Pedrick, Darryl B. B. Sneag
Summary: Magnetic resonance neurography of the brachial plexus is challenging but can be improved through optimization of imaging techniques, resulting in better image quality and diagnostic confidence for guiding nonoperative and operative management.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Veterinary Sciences
Marilena Bolcato, Mariana Roccaro, Joana G. P. Jacinto, Angelo Peli, Arcangelo Gentile, Ezio Bianchi
Summary: This case report presents a long-term electrodiagnostic follow-up of a Holstein calf with brachial plexus syndrome. Motor NCS was used to evaluate the condition, which showed improvement over the course of 12 months. This demonstrates the usefulness of electrodiagnostics in bovine medicine.
VETERINARY SCIENCES
(2022)
Article
Clinical Neurology
Nutdanai Neti, Panai Laohaprasitiporn, Yuwarat Monteerarat, Roongsak Limthongthang, Torpon Vathana
Summary: This study aimed to identify strong predictive factors and develop a prediction model for unsuccessful functional elbow flexion recovery after nerve transfer surgery in patients with brachial plexus injury. By reviewing the medical records of 987 patients, the researchers identified factors such as BMI, smoking, type of injury, donor nerve, and associated injuries that could predict the success of the surgery. They developed a model with good predictive value and internal validity.
JOURNAL OF NEUROSURGERY
(2023)
Review
Clinical Neurology
Ryan D. Schubert, Michael R. Wilson
CURRENT OPINION IN NEUROLOGY
(2015)
Article
Oncology
Jay K. Nathan, Amanda L. Brezzell, Michelle M. Kim, Denise Leung, D. Andrew Wilkinson, Shawn L. Hervey-Jumper
JOURNAL OF NEURO-ONCOLOGY
(2017)
Editorial Material
Clinical Neurology
Ryan D. Schubert, Megan B. Richie
Article
Computer Science, Information Systems
Jay K. Nathan, Jenevra Foley, Tiffany Hoang, Jim Hiner, Stephanie Brooks, Julian L. Gendreau, William J. Meurer, Aditya S. Pandey, Eric E. Adelman
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2018)
Article
Clinical Neurology
Jay K. Nathan, Bridger M. Rodoni, Jacob R. Joseph, Brandon W. Smith, Paul Park
OPERATIVE NEUROSURGERY
(2020)
Article
Clinical Neurology
Timothy J. Yee, Brandon W. Smith, Jacob R. Joseph, Yamaan S. Saadeh, Jay K. Nathan, Elyne N. Kahn, Siri S. Khalsa, Kelsey J. Fearer, Michael J. Kirsch, David R. Nerenz, Victor Chang, Jason M. Schwalb, Muwaffak M. Abdulhak, Paul Park
JOURNAL OF NEUROSURGERY-SPINE
(2019)
Article
Biochemistry & Molecular Biology
Ryan D. Schubert, Isobel A. Hawes, Prashanth S. Ramachandran, Akshaya Ramesh, Emily D. Crawford, John E. Pak, Wesley Wu, Carly K. Cheung, Brian D. O'Donovan, Cristina M. Tato, Amy Lyden, Michelle Tan, Rene Sit, Gavin A. Sowa, Hannah A. Sample, Kelsey C. Zorn, Debarko Banerji, Lillian M. Khan, Riley Bove, Stephen L. Hauser, Amy A. Gelfand, Bethany L. Johnson-Kerner, Kendall Nash, Kalpathy S. Krishnamoorthy, Tanuja Chitnis, Joy Z. Ding, Hugh J. McMillan, Charles Y. Chiu, Benjamin Briggs, Carol A. Glaser, Cynthia Yen, Victoria Chu, Debra A. Wadford, Samuel R. Dominguez, Terry Fei Fan Ng, Rachel L. Marine, Adriana S. Lopez, W. Allan Nix, Ariane Soldatos, Mark P. Gorman, Leslie Benson, Kevin Messacar, Jennifer L. Konopka-Anstadt, M. Steven Oberste, Joseph L. DeRisi, Michael R. Wilson
Article
Clinical Neurology
Kristen M. Krysko, Sara C. LaHue, Annika Anderson, Alice Rutatangwa, William Rowles, Ryan D. Schubert, Jacqueline Marcus, Claire S. Riley, Carolyn Bevan, Thomas W. Hale, Riley Bove
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2020)
Article
Clinical Neurology
Kristoffer E. Leon, Ryan D. Schubert, Didac Casas-Alba, Isobel A. Hawes, Prashanth S. Ramachandran, Akshaya Ramesh, John E. Pak, Wesley Wu, Carly K. Cheung, Emily D. Crawford, Lillian M. Khan, Cristian Launes, Hannah A. Sample, Kelsey C. Zorn, Maria Cabrerizo, Ana Valero-Rello, Charles Langelier, Carmen Munoz-Almagro, Joseph L. DeRisi, Michael R. Wilson
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2020)
Article
Multidisciplinary Sciences
Akshaya Ramesh, Ryan D. Schubert, Ariele L. Greenfield, Ravi Dandekar, Rita Loudermilk, Joseph J. Sabatino, Matthew T. Koelzer, Edwina B. Tran, Kanishka Koshal, Kicheol Kim, Anne-Katrin Probstel, Debarko Banerji, Chu-Yueh Guo, Ari J. Green, Riley M. Bove, Joseph L. DeRisi, Jeffrey M. Gelfand, Bruce A. C. Cree, Scott S. Zamvil, Sergio E. Baranzini, Stephen L. Hauser, Michael R. Wilson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Correction
Biochemistry & Molecular Biology
Ryan D. Schubert, Isobel A. Hawes, Prashanth S. Ramachandran, Akshaya Ramesh, Emily D. Crawford, John E. Pak, Wesley Wu, Carly K. Cheung, Brian D. O'Donovan, Cristina M. Tato, Amy Lyden, Michelle Tan, Rene Sit, Gavin M. Sowa, Hannah A. Sample, Kelsey C. Zorn, Debarko Banerji, Lillian M. Khan, Riley Bove, Stephen L. Hauser, Amy A. Gelfand, Bethany L. Johnson-Kerner, Kendall Nash, Kalpathy S. Krishnamoorthy, Tanuja Chitnis, Joy Z. Ding, Hugh J. McMillan, Charles Y. Chiu, Benjamin Briggs, Carol A. Glaser, Cynthia Yen, Victoria Chu, Debra A. Wadford, Samuel R. Dominguez, Terry Fei Fan Ng, Rachel L. Marine, Adriana S. Lopez, W. Allan Nix, Ariane Soldatos, Mark P. Gorman, Leslie Benson, Kevin Messacar, Jennifer L. Konopka-Anstadt, M. Steven Oberste, Joseph L. DeRisi, Michael R. Wilson
Article
Clinical Neurology
Harsh Wadhwa, Jigyasa Sharma, Kunal Varshneya, Parastou Fatemi, Jay Nathan, Zachary A. Medress, Martin N. Stienen, John K. Ratliff, Anand Veeravagu
Summary: This retrospective study reviewed readmission and reoperation rates for patients who had undergone ACDF or laminoplasty for multilevel CSM from a national administrative claims database. Results showed higher postoperative complication rates, longer length of stay, and higher readmission rates in the laminoplasty group, as well as higher hospital and total payments.
WORLD NEUROSURGERY
(2021)
Article
Medicine, Research & Experimental
Andres Cruz-Herranz, Frederike C. Oertel, Kicheol Kim, Ester Canto, Garrett Timmons, Jung H. Sin, Michael Devereux, Nicholas Baker, Brady Michel, Ryan D. Schubert, Lakshmisahithi Rani, Christian Cordano, Sergio E. Baranzini, Ari J. Green
Summary: This study revealed the dynamic evolution of innate immune cells in experimental autoimmune encephalitis, showing distinct waves of inflammatory phagocytic and regulatory antiinflammatory functions. The magnitude of the first wave was associated with neuronal loss, and potential targets for enhancing microglial protective effects in the chronic phase were identified as GAS6 and SOCS3.
Article
Clinical Neurology
Kunal Varshneya, Zachary A. Medress, Martin N. Stienen, Jay Nathan, Allen Ho, Arjun V. Pendharkar, Sheri Loo, Jessica Aikin, Gordon Li, Atman Desai, John K. Ratliff, Anand Veeravagu
Summary: This retrospective cohort study analyzed postoperative complications, quality outcomes, and costs of surgical approaches for adult cervical deformity (ACD). The study found that posterior fusion surgery for ACD had higher complication rates, readmission rates, and higher costs compared to anterior fusion, but was associated with a lower rate of reoperation.
GLOBAL SPINE JOURNAL
(2021)
Article
Clinical Neurology
Michael R. Wilson, Dan Suan, Andrew Duggins, Ryan D. Schubert, Lillian M. Khan, Hannah A. Sample, Kelsey C. Zorn, Aline Rodrigues Hoffman, Anna Blick, Meena Shingde, Joseph L. DeRisi
ANNALS OF NEUROLOGY
(2017)