Review
Pharmacology & Pharmacy
Yang Zhao, Wenling Ye, Yan-Dong Wang, Wei-Dong Chen
Summary: Hepatocyte growth factor (HGF) is a multifunctional cytokine that regulates cell growth, proliferation, and survival by activating the c-Met signaling pathway, and it plays a crucial role in liver regeneration.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Mahdia Benkhoucha, Ngoc Lan Tran, Gautier Breville, Isis Senoner, Paul F. Bradfield, Thalia Papayannopoulou, Doron Merkler, Thomas Korn, Patrice H. Lalive
Summary: CD4(+)c-Met(+) T cells are increased in multiple sclerosis models and exhibit a pro-inflammatory phenotype with enhanced adhesion and migration.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Oncology
Patricia Dias Carvalho, Flavia Martins, Susana Mendonca, Andreia Ribeiro, Ana Luisa Machado, Joana Carvalho, Maria Jose Oliveira, Sergia Velho
Summary: This study reveals the role of mutant KRAS in modulating cell fate through autonomous and nonautonomous signaling mechanisms in colorectal cancer cells. Mutant KRAS autonomously controls processes such as proliferation and cell-cell aggregation, while cancer cell invasion depends on the cooperation between fibroblast-derived HGF and mutant KRAS regulation of C-MET expression.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Oncology
Fatemeh Moosavi, Elisa Giovannetti, Godefridus J. Peters, Omidreza Firuzi
Summary: MET receptor is a promising therapeutic target in various human cancers, with HGF/MET combination therapies showing potential in overcoming drug resistance, targeting tumor microenvironment, and modulating drug metabolism. Further research is needed to fully understand the molecular mechanisms underlying successful pharmacological combinations.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rishav Sharma, Rishabha Malviya
Summary: Pancreatic cancer is highly lethal and difficult to treat, with hypoxia promoting its development and spread. The interaction between cancer cells, stromal cells, and pancreatic stellate cells mediated by the HGF/c-MET pathway plays a crucial role in disease progression. Hypoxia and HGF/c-MET expression are important factors in pancreatic cancer treatment.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Oncology
Jacquelyn T. T. Saunders, Sunil Kumar, Angelica Benavides-Serrato, Brent Holmes, Kennedy E. E. Benavides, Muhammad T. T. Bashir, Robert N. N. Nishimura, Joseph Gera
Summary: A circular RNA encoded HGF protein variant, C-HGF, was discovered to activate c-MET and promote glioblastoma growth and invasion. Inhibition of C-HGF may provide a promising approach for glioblastoma treatment.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Keng-Yu Chiang, Ya-Wen Li, Yen-Hsing Li, Shin-Jie Huang, Chih-Lu Wu, Hong-Yi Gong, Jen-Leih Wu
Summary: The study suggests that progranulin A (GrnA) plays a positive regulatory role in liver regeneration process by promoting hepatocyte proliferation, possibly through enhancing HGF/c-met signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yi Xiang, Bishan Liang, Yu Jiang, Fei Sun, Yang Zhao, Qijing Wu, Xingbin Hu, Yajing Liu, Qiong Huang, Wangjun Liao, Zhiqi Yao, Shaowei Li, Min Shi
Summary: This study identified MACC1 and SPINT1 as key transcription factors with downstream regulatory proteins for predicting patient prognosis in various cancers. The combination of MACC1 and SPINT1 was found to be effective in predicting survival in different cancer types, making it a valuable signature for prognosis prediction.
Article
Oncology
Chiara Modica, Martina Olivero, Francesca Zuppini, Melissa Milan, Cristina Basilico, Elisa Vigna
Summary: This study explores the molecular mechanisms of the MET/HGF signaling pathway in the interaction between pancreatic cancer cells and the tumor microenvironment. Through large-scale gene expression analysis, tenascin C was identified as a key gene involved in sustaining the malignant phenotype. Further research demonstrates the modulation of tenascin C by MET activation, suggesting a role in tumor-stroma interplay during pancreatic tumor progression.
Article
Biology
Debjani Pal, Kuntal De, Carly M. Shanks, Kai Feng, Timothy B. Yates, Jennifer Morrell-Falvey, Russell B. Davidson, Jerry M. Parks, Wellington Muchero
Summary: It was found that the core cysteine residues in the PAN domain of HGF play a crucial role in regulating the c-MET pathway. Mutations in these residues lead to abnormalities in signal transduction and impaired transcriptional activity of cancer-related genes. Targeting the PAN domain of HGF can selectively regulate the c-MET pathway, which is significant for cancer treatment.
COMMUNICATIONS BIOLOGY
(2022)
Review
Cell Biology
Yifan Du, Huimin Sun, Zhiyuan Shi, Xiuyuan Sui, Bin Liu, Zeyuan Zheng, Yankuo Liu, Zuodong Xuan, Min Zhong, Meiling Fu, Yang Bai, Qian Zhang, Chen Shao
Summary: The mutation of MET and the Hedgehog (Hh) pathway both have significant roles in cancer development and tumor stem cell maintenance. Conventional drugs only show moderate efficacy in specific types of cancer, and solely targeting tumor stem cells may overlook the potential for other tumor cells to regain stemness and acquire drug resistance.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Multidisciplinary Sciences
Nayeon Lee, Sunyoung Kim, Junghun Lee
Summary: This study found that nerve regeneration capacity decreases and functional recovery is impaired in the aging PNS. The HGF/c-Met pathway may play a role in the age-related impairment of regenerative capacity.
Article
Parasitology
Samara Alves Santos, Joelma Nascimento de Souza, Flavia Thamiris Figueiredo Pacheco, Mariana Conceicao Santos, Darleide dos Santos Novais, Victoria Nascimento Suzart, Isabela dos Santos Guedes, Maena Honda Neves, Maria Aparecida Gomes, Neci Matos Soares, Marcia Cristina Aquino Teixeira
Summary: The performance of IFAT and WB for detecting Giardia antibodies in human sera was evaluated in this study. The results showed that the specificity and sensitivity of Giardia antibodies in serum varied at different dilutions. Low molecular weight polypeptides were identified as the most frequently recognized antigens with a higher correlation to Giardia infection. Proteins found in intestinal amoebas may cause cross-reactivity in serological diagnosis of giardiasis, but this issue can be partially solved using low molecular weight proteins from Giardia.
ACTA PARASITOLOGICA
(2023)
Article
Oncology
Sunil Singh, Astha Lamichhane, Pouria Rafsanjani Nejad, Jacob Heiss, Hannah Baumann, Ravindra Gudneppanavar, Nic D. Leipzig, Michael Konopka, Gary D. Luker, Hossein Tavana
Summary: Using a three-dimensional organotypic tumor model, we investigated the interactions between patient-derived cancer-associated fibroblasts (CAF) and triple-negative breast cancer (TNBC) cells, identifying the predominant secretion of hepatocyte growth factor (HGF) by CAF and its activation of MET receptor tyrosine kinase in TNBC cells. This interaction promoted invasiveness and oncogenic pathway activities in TNBC cells. We also demonstrated resistance to monotherapy in TNBC cells and identified effective drug combinations to inhibit TNBC cell functions. Additionally, we found that HGF from lung fibroblasts enhanced colony formation by TNBC cells, suggesting a potential target for both primary tumorigenesis and lung metastasis in TNBC.
MOLECULAR CANCER RESEARCH
(2022)
Article
Oncology
Zhibo Shen, Wenhua Xue, Yuanyuan Zheng, Qishun Geng, Le Wang, Zhirui Fan, Wenbin Wang, Ying Yue, Yunkai Zhai, Lifeng Li, Jie Zhao
Summary: The study analyzed immune-related genes and their functions associated with the HGF/c-MET pathway in 11 solid tumors. The HGF/c-MET pathway affects the tumor microenvironment by interfering with the expression levels of other genes, while immune infiltration plays a critical role in changes to the tumor microenvironment. Immune infiltration is significantly linked to cancer development and prognosis.
CANCER CELL INTERNATIONAL
(2021)