Review
Cell Biology
Terese A. Garcia, Carrie R. Jonak, Devin K. Binder
Summary: Edema formation following traumatic spinal cord injury (SCI) worsens secondary injury and is correlated with worse neurological outcome. The aquaporin-4 (AQP4) water channel plays an important role in water homeostasis and has the potential to modulate edema resolution and functional recovery after SCI. Further research is needed to understand the expression and subcellular localization of AQP4 during specific phases after SCI for therapeutic optimization.
Review
Cell Biology
Chao-Hua Yang, Zheng-Xue Quan, Gao-Ju Wang, Tao He, Zhi-Yu Chen, Qiao-Chu Li, Jin Yang, Qing Wang
Summary: The current recommended management for acute traumatic spinal cord injury aims to reduce secondary injury incidence and promote functional recovery. Elevated ISP, mainly caused by hemorrhage, edema, and blood-spinal cord barrier destruction, peaks at 3 days after traumatic spinal cord injury. Promising treatments for reducing ISP within this time window include duraplasty and hypertonic saline.
NEURAL REGENERATION RESEARCH
(2022)
Article
Immunology
Chenxi Zhao, Tiangang Zhou, Xiaoqing Zhao, Yilin Pang, Wenxiang Li, Baoyou Fan, Ming Li, Xinjie Liu, Lei Ma, Jiawei Zhang, Chao Sun, Wenyuan Shen, Xiaohong Kong, Xue Yao, Shiqing Feng
Summary: This study provides preclinical information on the administration time window of 2-12 h post-injury for nafamostat in contusive SCI. It reveals that nafamostat functions by inhibiting thrombin-mediated BSCB breakdown and subsequent infiltration of peripheral immune cells.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Olaia Baylo-Marin, Africa Flores, Guillermo Garcia-Alias
Summary: Voluntary sensorimotor rehabilitation can decrease task error variability and drive the recovery of movement gestures, but the achieved plasticity is insufficient for full functional recovery. Additional interventional therapies are necessary to promote repair.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Medicine, General & Internal
Redwan Jabbar, Bartosz Szmyd, Jakub Jankowski, Weronika Lusa, Agnieszka Pawelczyk, Grzegorz Wysiadecki, R. Shane Tubbs, Joe Iwanaga, Maciej Radek
Summary: Intramedullary spinal cord abscess is a rare clinical pathology that often coexists with other diseases. Prompt diagnosis and improved treatment strategies have led to better outcomes. We present a case of a patient who underwent surgery and achieved partial improvement.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Erliang Li, Rongbao Yan, Kang Yan, Ruqin Huang, Rui Zhang, Yanhua Wen, Shuang Li, Peng Li, Qiong Ma, Bo Liao
Summary: Through network pharmacology and molecular docking analysis, it was revealed that Erxian Decoction (EXD) inhibits apoptosis by activating Akt1, reducing spinal cord edema and restoring motor function in spinal cord injury (SCI) rats.
Article
Biochemistry & Molecular Biology
Alexandra Alves-Sampaio, Patricia Del-Cerro, Jorge E. Collazos-Castro
Summary: Biomaterials have the potential to enhance neural repair after spinal cord injury, and testing in large animals is crucial for clinical translation. A porcine SCI model was developed to investigate the effects of myelotomy and implantation of MF/fibrin gel scaffolds. While myelotomy and lesion debridement did not further damage neural tissue, they had limited positive effects on neural regrowth. The MF/fibrin gel implant facilitated axonal sprouting and elongation, but also increased lesion volume and did not prevent fibrosis, thus limiting functional neural regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Siyu Wu, Concepcion Garcia-Rama, Lorenzo Romero-Ramirez, Johannes P. J. M. de Munter, Erik Ch Wolters, Boris W. Kramer, Jorg Mey
Summary: The study revealed that TUDCA did not have an additional effect in the treatment of spinal cord injury (SCI) and failed to improve treatment outcomes. Despite showing positive effects in promoting recovery of motor functions and improving autonomic bladder control, the benefits of TUDCA were only temporary.
Article
Neurosciences
Jiajun Cai, Jundong Kong, Song Ma, Yaozu Ban, Jian Li, Zhongkai Fan
Summary: This study investigates the effects and mechanisms of inhibiting TRPC6 downregulation and reducing AQP4 expression on astrocyte activation and proliferation following spinal cord injury. The results suggest that TRPC6 agonists and AQP4 inhibitors significantly suppress astrocyte activation, promote neuronal survival, and contribute to the recovery of motor function after spinal cord injury.
BRAIN RESEARCH BULLETIN
(2022)
Article
Neurosciences
Jian Li, Zhiqiang Jia, Qiangqiang Zhang, Junyu Dai, Jundong Kong, Zhongkai Fan, Gang Li
Summary: Blocking p-ERK1/2 effectively inhibits astrocyte proliferation and proinflammatory cytokine release, preserves surviving ventral horn neurons, and improves locomotor function in rats after SCI.
BRAIN RESEARCH BULLETIN
(2021)
Article
Neurosciences
Wu Jiang, Fan He, Guoming Ding, Junsong Wu
Summary: This study aimed to investigate the protective effect of the novel mitochondria-targeted peptide EPT in spinal cord injury (SCI). The results showed that EPT improved locomotor functional recovery and reduced neuronal loss. EPT also inhibited NLRP3 inflammasome activation and elevated levels of pro-inflammatory cytokines. Furthermore, EPT alleviated mitochondrial dysfunction and reduced mitochondrial reactive oxygen species level. Therefore, EPT may protect against SCI by inhibiting pyroptosis.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Multidisciplinary Sciences
Fengshou Chen, Jie Han, Xiaoqian Li, Zaili Zhang, Dan Wang
Summary: Overexpression of miR-9 improves neurological outcomes after spinal cord ischemia-reperfusion injury and may inhibit blood-spinal cord barrier disruption, neuroinflammation, and apoptosis through MAP2K3- or Notch2-mediated signaling pathways.
Article
Neurosciences
Zaili Zhang, Xiaoqian Li, Fengshou Chen, Zhe Li, Dan Wang, Xiaoyan Ren, Hong Ma
Summary: Spinal cord ischemia-reperfusion injury (SCII) affects nerve function through complex mechanisms, with long noncoding RNAs (lncRNAs) playing an important role. Research on lncRNA Gas5 in SCII suggests its downregulation can inhibit MMP-7, reducing apoptosis and inflammation to improve nerve function.
BRAIN RESEARCH BULLETIN
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yi Liu, Changbin Liu, Chuan Qin, Xin Zhang, Hao Feng, Zhanjing Wang, Jianjun Li
Summary: The study utilized DTI parameters obtained through MRI to observe significant decreases in FA values in both the SCI and Mye groups. Nissl staining revealed a higher number of neurons and better morphology in the Mye group, indicating the efficacy of myelotomy. This suggests that DTI parameters, especially ADC values, can quantitatively evaluate the therapeutic effect of myelotomy on rats with SCI in a non-invasive manner.
Article
Immunology
Xuankang Wang, Xin Li, Xiaoshuang Zuo, Zhuowen Liang, Tan Ding, Kun Li, Yangguang Ma, Penghui Li, Zhijie Zhu, Cheng Ju, Zhihao Zhang, Zhiwen Song, Huilin Quan, Jiawei Zhang, Xueyu Hu, Zhe Wang
Summary: This study found that PBM can promote motor function recovery, inhibit the activation of neurotoxic microglia and astrocytes, alleviate neuroinflammation and tissue apoptosis, and increase the number of neurons retained after SCI. It was also observed that PBM can suppress the Lcn2/JAK2-STAT3 crosstalk involved in the activation of neurotoxic microglia and astrocytes after SCI.
JOURNAL OF NEUROINFLAMMATION
(2021)