Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 92, Issue -, Pages 234-237Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2012.02.039
Keywords
Kaempferol; Galangin; Human serum albumin; Surface enhanced Raman scattering (SERS); Interaction
Categories
Funding
- State Science and Technology Support Program [2011BAI03B01-6, 2012BAI29B05]
- Ministry of Science and Technology [2010ZX09401-305-02, 2010ZX09401-305-09, 2010ZX09401-305-10]
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Raman and surface-enhanced Raman scattering (SERS) spectroscopy were employed to probe the interaction of the flavonol drugs, kaempferol and galangin, with human serum albumin (HSA). SERS spectra of both flavonol derivatives were obtained from a colloidal silver surface in physiological condition, based on the high performance of the enhanced substrate, the most enhanced modes of kaempferol and galangin were those with certain motions perpendicular to the metal surface. The SERS spectra were allowed to predict similar orientation geometry for both of the drugs on the colloidal surface with minor difference. In addition, both flavonols-HSA complexes were prepared in different concentration ratios and the orientated differences between kaempferol and galangin were investigated by SERS. (C) 2012 Elsevier B.V. All rights reserved.
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