Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 83, Issue 1, Pages 570-574Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2011.09.005
Keywords
Chloramphenicol; Heptakis (2,6-di-O-methyl)-beta-cyclodextrin; Inclusion complex; Phase solubility; Spectroscopic method
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The inclusion interaction between chloramphenicol and heptakis (2,6-di-O-methyl)-beta-cyclodextrin (DMBCD) had been investigated by phase solubility and spectroscopic methods such as UV-vis spectroscopy, circular dichroism, Fourier transform infrared (FT-IR) spectroscopy, proton nuclear magnetic resonance spectroscopy (H-1 NMR) as well as 2D-ROESY spectra. Phase solubility analysis showed A(L)-type diagram with DMBCD, which suggested the formation of 1:1 inclusion complex of DMBCD with chloramphenicol. The estimated stability constant (K-s) of the inclusion complex of chloramphenicol with DMBCD is 493 M-1 at 293 K. The solubility enhancement of chloramphenicol in the presence of DMBCD is stronger than that in the presence of beta-CD, HP-beta-CD and M-beta-CD. The results obtained by spectroscopic methods showed that the nitrophenyl moiety of chloramphenicol is deeply inserted into inner cavity of DMBCD from the narrow rim of DMBCD, which the inclusion model of chloramphenicol with DMBCD differs from that with beta-CD. (C) 2011 Elsevier B.V. All rights reserved.
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