Synthesis, characterization and biological study on Cr3+, ZrO2+, HfO2+ and UO22+ complexes of oxalohydrazide and bis(3-hydroxyimino)butan-2-ylidene)-oxalohydrazide

Cr3+, ZrO2+, HfO2+ and UO22+ complexes of oxalohydrazide (H2L1) and oxalyl bis(diacetylmonoxime hydrazone) [its IUPAC name is oxalyl bis(3-hydroxyimino)butan-2-ylidene)oxalohydrazide] (H4L2) have been synthesized and characterized by partial elemental analysis, spectral (IR; electronic), thermal and magnetic measurements. [Cr(L-1)(H2O)(3)(CI).H2O, [ZrO(HL1)(2)].C2H5OH, [UO2(L-1)(H2O)(2)] [ZrO(H3L2)(CI)](2).2H(2)O, [HfO(H3L2)(Cl)](2).2H(2)O and [UO2(H2L2)].2H(2)O have been suggested. H2L1 behaves as a monobasic or dibasic bidentate ligand while H4L2 acts as a tetrabasic octadentate with the two metal centers. The molecular modeling of the two ligands have been drawn and their molecular parameters were calculated. Examination of the DNA degradation of H2L1 and H4L2 as well as their complexes revealed that direct contact of [ZrO(H3L2)(Cl)](2).2H(2)O or [HfO(H3L2)(Cl)](2).2H(2)O degrading the DNA of Eukaryotic subject. The ligands and their metal complexes were tested against Gram's positive Bacillus thuringiensis (BT) and Gram's negative (Escherichia coli) bacteria. All compounds have small inhibitory effects. (C) 2010 Elsevier B.V. All rights reserved.