Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 75, Issue 1, Pages 146-151Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2009.09.061
Keywords
Cis-Platinum(II); Pyrimidine derivatives; IR; UV-vis; (1)H NMR; TG; Antimicrobial
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Funding
- Zagazig University [36K12/M3]
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Two complexes were obtained during the reactions of 6-amino-1-methyl-5-nitrosouracil (AMNU) and 6-methylamino-1-benzyl-5-nitrosouracil (MABNU) with cis-diaquadiamineplatinum(II) nitrate complex, cis-[Pt(NH(3))(2)(H(2)O)(2)](NO(3))(2). The complexes were isolated in good yields as powdery precipitates. They were characterized through their elemental analysis, infrared, UV-vis, and (1)H NMR spectroscopies as well as thermal analyses. The obtained results indicated that, pyrimidine bases substitute easily aqua ligands and interact with Pt(II) ions as a monodentate ligand in the neutral and ionic form for the ligands AMNU and MABNU, respectively. The exocyclic oxygen atoms are the most probable binding site. Square planar structures, cis-form, wet e proposed in both cases. The free ligands, and their Pt(H) complexes were screened for their antimicrobial activities. (C) 2009 Elsevier B.V. All rights reserved.
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