Article
Clinical Neurology
Shang-Ying Tsai, Chian-Jue Kuo, Martha Sajatovic, Yu-Jui Huang, Pao-Huan Chen, Kuo-Hsuan Chung
Summary: This study explored the association between carotid intima-media thickness (CIMT), psycho-pharmacotherapy, and inflammatory markers in bipolar disorder (BD). The results showed that lithium exposure may be a protective factor for atherosclerosis progression in BD-I, while chronic inflammation may contribute to atherosclerosis development.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Environmental Sciences
Yue Leon Guo, Rosario D. Ampon, Ivan C. Hanigan, Luke D. Knibbs, Christy Geromboux, Ta-Chen Su, Kazuaki Negishi, Leanne Poulos, Geoffrey G. Morgan, Guy B. Marks, Bin Jalaludin
Summary: The study found that long-term exposure to low levels of PM2.5 in children may have measurable adverse impacts on cardiovascular risk marker, carotid intima-media thickness (CIMT), by age 11-12 years.
ENVIRONMENTAL POLLUTION
(2021)
Article
Medicine, General & Internal
Ettore Dinoto, Domenico Mirabella, Francesca Ferlito, Graziella Tortomasi, Davide Turchino, Salvatore Evola, Massimiliano Zingales, Emanuela Bologna, Felice Pecoraro
Summary: The intima-media thickness (IMT) and its irregularities or ulcerations in the common carotid artery (CCA) can serve as biomarkers for cardiovascular system integrity. Total homocysteine and lipoprotein levels are commonly used for cardiovascular risk stratification. Duplex ultrasound (DUS) combined with serum biomarkers can assess atherosclerotic disease and cardiovascular risk effectively.
Article
Nutrition & Dietetics
Athanasia Tragomalou, George Paltoglou, Maria Manou, Ioannis V. Kostopoulos, Sofia Loukopoulou, Maria Binou, Ourania E. Tsitsilonis, Flora Bacopoulou, Penio Kassari, Marina Papadopoulou, George Mastorakos, Evangelia Charmandari
Summary: Obesity in adolescence is linked to cardiovascular disease. Non-traditional risk factors can be used as biomarkers to predict future CVD. Lifestyle intervention programs can improve these risk factors.
Article
Biochemistry & Molecular Biology
Victor Lazarenko, Mikhail Churilin, Iuliia Azarova, Elena Klyosova, Marina Bykanova, Natalia Ob'edkova, Mikhail Churnosov, Olga Bushueva, Galina Mal, Sergey Povetkin, Stanislav Kononov, Yulia Luneva, Sergey Zhabin, Anna Polonikova, Alina Gavrilenko, Igor Saraev, Maria Solodilova, Alexey Polonikov
Summary: The study investigated the role of lipid-associated loci identified by GWAS in the molecular pathogenesis of CAD. Specific gene polymorphisms were found to be significantly associated with CAD risk, independent of demographic factors. Bioinformatics analysis revealed that these loci might act as allele-specific binding sites for transcription factors controlling atherosclerosis mechanisms.
Article
Biochemistry & Molecular Biology
Vaishali Narendra Naik, R. S. Gamad, P. P. Bansod
Summary: This study investigates the effects of three despeckle filters on the segmentation of carotid IMT in ultrasound images. The results show that the median filter performs better than the hybrid median and IACDF filters.
BIOMEDICAL JOURNAL
(2022)
Article
Environmental Sciences
Johan Nilsson Sommar, Margareta Norberg, Christer Gronlund, David Segersson, Ulf Naslund, Bertil Forsberg
Summary: This study estimated the association between long-term exposure to particulate air pollution and sub-clinical atherosclerosis, finding that particle concentrations were related to plaque presence but not associated with plaque progression or carotid intima-media thickness.
ENVIRONMENTAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Mengyuan Miao, Guo Zhou, Anran Bao, Yaming Sun, Huaping Du, Liyan Song, Yongjun Cao, Shoujiang You, Chongke Zhong
Summary: This study found an association between TyG index and carotid atherosclerosis in patients with ischemic stroke, suggesting that TyG could be a promising marker for atherosclerosis.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Medicine, Research & Experimental
Mira Merashli, Tommaso Bucci, Alessia Arcaro, Fabrizio Gentile, Paul R. J. Ames
Summary: This study aimed to evaluate the intima media thickness of carotid arteries (IMT) and its correlates in Behcet's disease (BD). A meta-analysis of case control studies found that IMT was greater in BD patients compared to controls. The analysis also showed a higher prevalence of carotid plaques in BD patients. The results suggest that subclinical carotid artery atherosclerosis is a vascular feature of BD. The inverse correlations between IMT, age, and azathioprine use indicate that thicker carotid arteries at disease onset may regress with immune suppressive treatment but further research is needed.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Biology
Eva Anna Piros, Akos Szabo, Fanni Rencz, Valentin Brodszky, Klara Szalai, Noemi Galajda, Balint Szilveszter, Edit Dosa, Bela Merkely, Peter Hollo
Summary: In this study, IL-17 inhibitor therapy was found to significantly improve the condition of severe psoriatic patients, reducing both physical and psychological burden. Furthermore, the arterial intima-media thickness showed significant improvement during the treatment process, suggesting a potential protective effect on cardiovascular complications.
Article
Multidisciplinary Sciences
Gisoo Darban Hosseini Amirkhiz, Mohammad Reza Babaei, Nahid Hashemi Madani, Mohammad Ebrahim Khamseh
Summary: In patients with type 2 diabetes, TBI is significantly correlated with right carotid intima-media thickness and can be used as a predictor for subclinical carotid atherosclerosis, while there is no significant association between ABI and increased CIMT.
Article
Cardiac & Cardiovascular Systems
Matthew K. Armstrong, Brooklyn J. Fraser, Olli Hartiala, Marie-Jeanne Buscot, Markus Juonala, Feitong Wu, Juha Koskinen, Nina Hutri-Kahonen, Mika Kahonen, Tomi P. Laitinen, Terho Lehtimaki, Jorma S. A. Viikari, Olli T. Raitakari, Costan G. Magnussen
Summary: The study shows that elevated non-HDL-C levels at different life stages are associated with coronary atherosclerosis in mid-adulthood, with adolescent non-HDL-C levels showing the strongest association.
Article
Cardiac & Cardiovascular Systems
Joseph F. Polak, Jye-Yu C. Backlund, Matt Budoff, Philip Raskin, Ionut Bebu, John M. Lachin
Summary: In individuals with type 1 diabetes, common carotid artery IMT is weakly associated with subsequent coronary artery events, but this association disappears after adjusting for traditional cardiovascular risk factors. There is no significant association between internal carotid artery IMT and coronary artery disease events.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Health Care Sciences & Services
Anna Maria Rychter, Dariusz Naskret, Agnieszka Zawada, Alicja Ewa Ratajczak, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: Atherosclerosis is strongly associated with obesity, with carotid intima-media thickness (cIMT) serving as a predictor of cardiovascular events and subclinical atherosclerosis. Behavioral interventions can directly impact cIMT values, influencing cardiovascular disease risk.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Maria Pina Dore, Sandro Mereu, Pier Sergio Saba, Michele Portoghese, Giovanni Mario Pes
Summary: This study aims to investigate the relationship between celiac disease (CD) and premature atherosclerosis, including cardiovascular disease (CVD). The study found that patients with CD have a reduced risk of CVD, especially those on long-term gluten-free diet (GFD) treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Betul Toprak, Stephanie Brandt, Jan Brederecke, Francesco Gianfagna, Julie K. K. Vishram-Nielsen, Francisco M. Ojeda, Simona Costanzo, Christin S. Borschel, Stefan Soderberg, Ioannis Katsoularis, Stephan Camen, Erkki Vartiainen, Maria Benedetta Donati, Jukka Kontto, Martin Bobak, Ellisiv B. Mathiesen, Allan Linneberg, Wolfgang Koenig, Maja-Lisa Lochen, Augusto Di Castelnuovo, Stefan Blankenberg, Giovanni de Gaetano, Kari Kuulasmaa, Veikko Salomaa, Licia Iacoviello, Teemu Niiranen, Tanja Zeller, Renate B. Schnabel
Summary: The study aims to find reliable circulating predictors for incident atrial fibrillation (AF) using classical regressions and machine learning techniques. Fourteen routinely available biomarkers reflecting different pathophysiological pathways were examined in relation to incident AF. NT-proBNP was identified as the strongest blood-based predictor of incident AF.
Article
Cardiac & Cardiovascular Systems
Jonas Persson, Jacinth Yan, Oskar Angeras, Dimitrios Venetsanos, Anders Jeppsson, Iwar Sjogren, Rikard Linder, David Erlinge, Torbjorn Ivert, Elmir Omerovic
Summary: This observational study aimed to analyze outcomes after coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) in patients with unprotected left main coronary artery (LMCA) disease. The study found that CABG was associated with lower mortality and fewer major adverse cardiovascular and cerebrovascular events (MACCE) compared to PCI in LMCA disease patients.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Kerstin Welen Schef, Per Tornvall, Joakim Alfredsson, Emil Hagstrom, Annica Ravn-Fischer, Stefan Soderberg, Troels Yndigegn, Tomas Jernberg
Summary: The objective of this study was to assess the prevalence of angina pectoris symptoms and investigate their relationship with coronary atherosclerosis in a middle-aged general population. The results showed that angina symptoms were common among the general population of Sweden, but were not strongly associated with obstructive coronary atherosclerosis. Sociodemographic and psychological factors were found to be highly associated with angina symptoms, regardless of the degree of coronary atherosclerosis.
Article
Medicine, Research & Experimental
Marja Lisa Byhamre, Mats Eliasson, Stefan Soederberg, Patrik Wennberg, Viktor Oskarsson
Summary: Snus, a common tobacco product in Sweden, has been found to be associated with higher levels of HDL cholesterol and triglycerides compared to non-tobacco use, and higher levels of HDL cholesterol and lower levels of triglycerides compared to cigarette smoking. However, there was no association between snus use and non-HDL cholesterol levels. Further studies are needed to validate these findings.
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2023)
Article
Hematology
Marta Brambilla, Paola Canzano, Patrizia Della Valle, Alessia Becchetti, Maria Conti, Mariangela Alberti, Arianna Galotta, Maria Luisa Biondi, Paola Adele Lonati, Fabrizio Veglia, Alice Bonomi, Nicola Cosentino, Pier Luigi Meroni, Gian Vincenzo Zuccotti, Armando D'Angelo, Marina Camera
Summary: This study evaluated the impact of four COVID-19 vaccines on platelet activation, coagulation, and inflammation. It found that vaccination did not induce platelet activation and microvesicle release. Although there were minor changes in clotting activation and endothelial function, these could potentially explain the rare venous thromboembolic complications of COVID-19 vaccination at a population level.
THROMBOSIS RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Lena Tschiderer, Lisa Seekircher, Raffaele Izzo, Costantino V. Mancusi, Maria Manzi, Damiano Baldassarre, Mauro Amato, Elena Tremoli, Fabrizio Veglia, Tomi-Pekka Tuomainen, Jussi Kauhanen, Ari Voutilainen, Bernhard Iglseder, Lars Lind, Tatjana Rundek, Moise Desvarieux, Akihiko Kato, Eric de Groot, Guelay Asci, Ercan Ok, Stefan Agewall, Joline W. J. D. Beulens, Christopher C. Byrne, Philip C. Calder, Hertzel Gerstein, Paolo Gresele, Gerhard Klingenschmid, Michiaki H. Nagai, Michael Olsen, Grace S. Parraga, Maya Safarova, Naveed Sattar, Michael Skilton, Coen D. A. Stehouwer, Heiko A. Uthoff, Michiel A. van Agtmael, Amber A. van der Heijden, Dorota Zozulinska-Ziolkiewicz, Hyun-Woong Park, Moo-Sik Lee, Jang-Ho Bae, Oscar F. Beloqui, Manuel Landecho, Matthieu Plichart, Pierre Ducimetiere, Jean Philippe Empana, Lena Bokemark, Goeran Bergstroem, Caroline Schmidt, Samuela Castelnuovo, Laura D. Calabresi, Giuseppe Norata, Liliana Grigore, Alberico Catapano, Dong Zhao, Miao Wang, Jing Liu, M. Arfan Ikram, Maryam L. Kavousi, Michiel J. Bots, Michael W. Sweeting, Matthias Lorenz, Peter Willeit
Summary: This study conducted a meta-analysis of individual participant data from 20 prospective studies and found that common carotid artery intima-media thickness (CCA-IMT) is associated with the risk of developing carotid plaque, independent of traditional cardiovascular risk factors.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Christina Ekenbaeck, Jannike Nickander, Fadi Jokhaji, Per Tornvall, Henrik Engblom, Jonas Spaak, Jonas Persson
Summary: This study evaluated and compared levels of CMD in patients with TTS and patients with INOCA, and investigated the associations between CMD and clinical parameters, left ventricular function, and coronary atherosclerosis in TTS. It was found that CMD is common in TTS patients, more severe in the apical phenotype of the syndrome, and unrelated to coronary atherosclerosis.
Article
Cardiac & Cardiovascular Systems
Buamina Maitusong, Federica J. Laguzzi, Rona Strawbridge, Damiano Baldassarre, Fabrizio E. Veglia, Steve Humphries, Kai Savonen, Sudhir Kurl, Matteo J. Pirro, Andries Smit, Philippe Giral, Angela Silveira, Elena Tremoli, Anders Hamsten, Ulf de Faire, Bruna Gigante, Karin Leander, IMPROVE Study Grp
Summary: The study found that certain genetic variants may modify the effect of smoking on carotid intima-media thickness, increasing the risk of atherosclerosis.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Cecilia Vitali, Chiara Pavanello, Marta Turri, Sissel Lund-Katz, Michael C. Phillips, Alberico Luigi Catapano, Andrea Baragetti, Giuseppe Danilo Norata, Fabrizio Veglia, Laura Calabresi
Summary: The present study investigated the ability of different isoforms of apoE to promote LCAT-mediated cholesterol esterification, and found that apoE2 isoform is associated with a higher LCAT-mediated cholesterol esterification.
Article
Cardiac & Cardiovascular Systems
Qiao Sen Chen, Otto Bergman, Louise Ziegler, Damiano Baldassarre, Fabrizio Veglia, Elena Tremoli, Rona J. Strawbridge, Antonio Gallo, Matteo Pirro, Andries J. Smit, Sudhir Kurl, Kai Savonen, Lars Lind, Per Eriksson, Bruna Gigante, IMPROVE Study Grp
Summary: This study aimed to define the endotypes of carotid subclinical atherosclerosis using demographic, clinical, and molecular data. Four endotypes were identified, and they were associated with the progression of atherosclerosis and the risk of atherosclerotic cardiovascular disease (ASCVD) in two different populations.
CARDIOVASCULAR RESEARCH
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Jonas Persson, Torbjorn Ivert, Elmir Omerovic
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Damiano Baldassarre, Licia Iacoviello, Roberta Baetta, Maria Carla Roncaglioni, Gianluigi Condorelli, Giuseppe Remuzzi, Gianfranco Gensini, Luigi Frati, Walter Ricciardi, Pier Giulio Conaldi, Antonio Uccelli, Fabio Blandini, Silvano Bosari, Giovanni Scambia, Massimo Fini, Antonio Di Malta, Mauro Amato, Fabrizio Veglia, Alice Bonomi, Catherine Klersy, Francesca Colazzo, Martino Pengo, Francesca Gorini, Luciana Auteri, Giuseppe Ferrante, Marta Baviera, Giuseppe Ambrosio, Alberico Catapano, Alessandro Gialluisi, Alexis Elias Malavazos, Serenella Castelvecchio, Massimiliano Marco Corsi-Romanelli, Rosanna Cardani, Maria Teresa La Rovere, Valentina Agnese, Bianca Pane, Daniele Prati, Laura Spinardi, Giovanna Liuzzo, Eloisa Arbustini, Maurizio Volterrani, Marco Visconti, Jose Pablo Werba, Stefano Genovese, Grzegorz Bilo, Cecilia Invitti, Anna Di Blasio, Carolina Lombardi, Andrea Faini, Debora Rosa, Luisa Ojeda-Fernandez, Andreana Foresta, Amalia De Curtis, Augusto Di Castelnuovo, Simonetta Scalvini, Antonia Pierobon, Alessandra Gorini, Luca Valenti, Livio Luzi, Annarosa Racca, Manuela Bandi, Elena Tremoli, Lorenzo Menicanti, Gianfranco Parati, Giulio Pompilio
Summary: The CV-PREVITAL study is a multicentre, prospective, randomised, controlled, open-label interventional trial aiming to compare the effectiveness of an educational and motivational mobile health intervention with usual care in reducing cardiovascular risk. The trial plans to enrol approximately 80,000 subjects without overt cardiovascular diseases and evaluate the short-term endpoints, as well as conduct a long-term follow-up to assess the incidence of major adverse cardiovascular events.
Article
Rheumatology
Erik Hulander, Tatiana Zverkova Sandstrom, Jeannette Beckman Rehnman, Lucy Law, Stefan Soderberg, Helena Forsblad-d'Elia
Summary: This study assessed the dietary nutrient intake in patients with r-axSpA and compared it to persons without r-axSpA. The results showed that the patients had impaired dietary intake, particularly in nutrients with anti-inflammatory properties. Therefore, it is suggested to incorporate nutrition screening into the management of r-axSpA patients.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Hina Taki, Jaakko Tuomilehto, Paul Zimmet, Abdonas Tamosiunas, Sudhir Kowlessur, Dianna J. Magliano, Jonathan E. Shaw, Stefan Soederberg, Ulf Nilsson
Summary: LVH is more common in individuals with hypertension, African ancestry, and/or low education level. These individuals are usually older, more likely to have hypertension, diabetes, known cardiovascular disease, and elevated levels of cholesterol and creatinine. Creole ethnicity, low education level, hypertension, known CVD, and elevated creatinine are associated with LVH. Individuals with untreated or uncontrolled hypertension are at a higher risk for LVH than those with well-controlled hypertension or normotension.
Article
Cardiac & Cardiovascular Systems
Therese Andersson, Lars Nilsson, Flemming Larsen, Bo Carlberg, Stefan Soderberg
Summary: This study aimed to follow a cohort of patients with pulmonary embolism (PE) to generate information about long-term symptoms and investigate the prevalence of chronic thromboembolic pulmonary hypertension (CTEPH). The study found that the overall prevalence of CTEPH in Sweden in 2005 was 0.4%, while the prevalence among survivors was higher at 0.7%. The cumulative incidence of CTEPH in patients who underwent a V/Q scan was 1.1%.
PULMONARY CIRCULATION
(2023)