Article
Health Care Sciences & Services
Ariana M. Kelly, Mariana Bezamat, Adriana Modesto, Alexandre R. Vieira
Summary: The study found that genetic variations in certain genes may be associated with an increased likelihood of individuals maintaining a caries-free status, particularly the TFIP11, MMP20, and ENAM genes. However, no associations were found in patients missing both mandibular first molars and second molars.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Pedro Henrique Felix Silva, Luiz Fernando Ferreira Oliveira, Renata Silva Cardoso, Sandro Isaias Santana, Renato Correa Casarin, Edilson Ervolino, Sergio Luiz Salvador, Daniela Bazan Palioto, Flavia Aparecida Chaves Furlaneto, Michel Reis Messora
Summary: This study evaluated the effects of Bdellovibrio bacteriovorus HD100 on experimental periodontitis in rats. The results showed that the topical use of Bdellovibrio bacteriovorus HD100 reduces alveolar bone loss and modulates the cytokines levels in periodontal tissues.
MOLECULAR ORAL MICROBIOLOGY
(2023)
Review
Microbiology
Carla Cugini, Narayanan Ramasubbu, Vincent K. Tsiagbe, Daniel H. Fine
Summary: Microbiology and immunology have gained significant attention in the study of caries and periodontal disease over the past 60 years, with experiments showing the relevance of bacteria in oral infections. Research has shifted from downplaying the role of bacteria in oral disease to recognizing them as true pathogens, and now proposes that bacteria play a key role in training the immune system and defending against foreign invaders. Advanced omics technologies are being used to better understand changes in the host and microbiome in oral disease, shaping the detection of quantifiable biomarkers to define human physiology and pathologies.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Nikolaos Donos, Luis Andre Mezzomo, Nikolaos Mardas, Matteo Goldoni, Elena Calciolari
Summary: The study compared tooth-supported and implant-supported removable prostheses in patients with stage IV periodontitis, showing that implant-supported prostheses have higher implant and prosthesis survival rates.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Editorial Material
Dentistry, Oral Surgery & Medicine
A. P. Colombo, B. Wu
Summary: With the increase in life expectancy and aging population globally, promoting healthy longevity has become more important. Oral health, as a fundamental contributor to overall health and well-being, is an integral part of the sustainable development goals set by the World Health Organization. Aging significantly increases the risk of oral disorders and other noncommunicable diseases. This special issue focuses on recent advances in the behavioral and social implications of age-related oral diseases and tooth loss on the quality of life of adults, as well as the molecular mechanisms associated with cellular aging and their implications for oral tissue health and regeneration.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Sawita Khimsuksri, Jarin Paphangkorakit, Waranuch Pitiphat, Susan Elaine Coldwell
Summary: This study identified the TAS2R38 genotypes among Thais and explored their association with oral diseases. The AVI/AVI genotype was found to be associated with a decreased prevalence of periodontal disease, while no significant association was found between TAS2R38 genotype and tooth decay in this patient population.
Article
Medicine, General & Internal
Michihiko Usui, Masanori Iwasaki, Wataru Ariyoshi, Kaoru Kobayashi, Shingo Kasai, Rieko Yamanaka, Keisuke Nakashima, Tatsuji Nishihara
Summary: This study investigated the relationship between the detection of TLPs using a novel TLP-AA, AD-CHECK and the detection of red-complex pathogens using real-time PCR. The results showed that AD-CHECK is an effective tool for detecting red-complex pathogens.
Review
Dentistry, Oral Surgery & Medicine
Stefano Gennai, Rossana Izzetti, Maria C. Pioli, Larisa Music, Filippo Graziani
Summary: The study investigates the effect of rehabilitation on oral-health-related quality of life and systemic health in edentulous patients with stage IV periodontitis. The results show that oral rehabilitation can significantly improve OHRQoL in patients with periodontal diseases, with potential effects on systemic health. However, further research is needed to determine if these findings apply to patients with severe periodontitis.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Eduardo Montero, Ana Molina, David Palombo, Belen Moron, Guillermo Pradies, Ignacio Sanz-Sanchez
Summary: The study aimed to evaluate the efficacy and effectiveness of tooth-supported fixed prostheses in partially edentulous patients with stage IV periodontitis. Results showed that tooth-supported fixed prostheses appeared to be a valid treatment approach for restoring masticatory function in patients with severe periodontitis. However, the comparative efficacy of this treatment between periodontitis and non-periodontitis patients remains unclear due to the lack of clinical trials.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Review
Multidisciplinary Sciences
Thinni Nurul Rochmah, Aulia Ramadhani, Taufan Bramantoro, Lucindari Gea Permata, Tin Zar Tun
Summary: This study aims to assess the variance of the cost-effectiveness ratio of the school-based oral health promotion and prevention program for elementary school children. Five articles that matched the search criteria were included in a systematic review. The fluoride programs and the comprehensive program with glass ionomer cement have the lowest cost-effectiveness ratio.
Article
Nutrition & Dietetics
Lorena Lucia Costa Ladeira, Gustavo Giacomelli Nascimento, Fabio Renato Manzolli Leite, Silas Alves-Costa, Janaina Maiana Abreu Barbosa, Claudia Maria Coelho Alves, Erika Barbara Abreu Fonseca Thomaz, Rosangela Fernandes Lucena Batista, Cecilia Claudia Costa Ribeiro
Summary: This study investigated the relationship between obesity and insulin resistance with caries and periodontitis, and found that obesity and insulin resistance were associated with chronic oral disease burden. Behavioral risk factors were also found to be associated with increased chronic oral disease burden.
Article
Medicine, General & Internal
Theresa Meusburger, Annika Wuelk, Andreas Kessler, Katrin Heck, Reinhard Hickel, Helena Dujic, Jan Kuehnisch
Summary: The purpose of this study was to compare the reliability for the detection of caries, periapical lesions, periodontal bone loss (PBL), and endo-perio lesions on periapical radiographs. The study found significant differences in dentists' ability to detect these pathologies, with periapical lesions and PBL being less reliably identified compared to caries and endo-perio lesions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
An Li, Yuntao Chen, Anita Visser, Luc A. M. Marks, Geerten-Has E. Tjakkes
Summary: The study aimed to investigate the association between cognitive impairment and oral health status with mortality. Data from the National Health and Nutrition Examination Survey (1999-2002) showed that cognitive impairment, periodontitis, and edentulism were significant predictors of all-cause mortality.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Medicine, General & Internal
Gathani Dash, Lora Mishra, Naomi Ranjan Singh, Rini Behera, Satya Ranjan Misra, Manoj Kumar, Krzysztof Sokolowski, Kunal Agarwal, Suresh Kumar Behera, Sunil Mishra, Barbara Lapinska
Summary: This study evaluates the prevalence and quality of endodontic treatment in patients with cardiovascular disease and cardiovascular risk factors. The results show a higher prevalence of endodontically treated teeth in these patients, suggesting a potential link between endodontic pathologies and cardiovascular diseases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Otofumi Chigasaki, Norio Aoyama, Yoshiyuki Sasaki, Yasuo Takeuchi, Koji Mizutani, Yuichi Ikeda, Misa Gokyu, Makoto Umeda, Yuichi Izumi, Takanori Iwata, Akira Aoki
Summary: The study in a Japanese population found that the amount of P. gingivalis is strongly associated with the severity of periodontal condition, and the co-occurrence of P. gingivalis with other bacteria can exacerbate the progression of periodontitis.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Microbiology
Christopher E. Bagwell, Peter A. Noble, Charles E. Milliken, Dien Li, Daniel I. Kaplan
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Biotechnology & Applied Microbiology
Peter A. Noble, Alexander E. Pozhitkov
Article
Nutrition & Dietetics
Johanna W. Lampe, Eunji Kim, Lisa Levy, Laurie A. Davidson, Jennifer S. Goldsby, Fayth L. Miles, Sandi L. Navarro, Timothy W. Randolph, Ni Zhao, Ivan Ivanov, Andrew M. Kaz, Christopher Damman, David M. Hockenbery, Meredith A. J. Hullar, Robert S. Chapkin
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2019)
Article
Nutrition & Dietetics
Gertraud Maskarinec, Meredith A. J. Hullar, Kristine R. Monroe, John A. Shepherd, Jeani Hunt, Timothy W. Randolph, Lynne R. Wilkens, Carol J. Boushey, Loic Le Marchand, Unhee Lim, Johanna W. Lampe
JOURNAL OF NUTRITION
(2019)
Article
Nutrition & Dietetics
Sandi L. Navarro, Aliasghar Tarkhan, Ali Shojaie, Timothy W. Randolph, Haiwei Gu, Danijel Djukovic, Katie J. Osterbauer, Meredith A. Hullar, Mario Kratz, Marian L. Neuhouser, Paul D. Lampe, Daniel Raftery, Johanna W. Lampe
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2019)
Article
Nutrition & Dietetics
Benjamin C. Fu, Meredith A. J. Hullar, Timothy W. Randolph, Adrian A. Franke, Kristine R. Monroe, Iona Cheng, Lynne R. Wilkens, John A. Shepherd, Margaret M. Madeleine, Loic Le Marchand, Unhee Lim, Johanna W. Lampe
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2020)
Article
Oncology
Alexander Pozhitkov, Michael Rosenzweig, Flavia Pichiorri, Emine G. Gunes, Ralf Buettner, Jonathan J. Keats, Steven T. Rosen
LEUKEMIA & LYMPHOMA
(2020)
Article
Nutrition & Dietetics
Destiny A. Mullens, Ivan Ivanov, Meredith A. J. Hullar, Timothy W. Randolph, Johanna W. Lampe, Robert S. Chapkin
Summary: This study investigated the impact of the metabolic phenotype of flaxseed lignan on host gene expression. The findings suggest that a higher conversion of flaxseed lignan to enterolactone (ENL) is associated with a suppressed inflammatory status.
Article
Medicine, Research & Experimental
Sandi L. Navarro, Zihan Zheng, Timothy W. Randolph, Ryotaro Nakamura, Brenda M. Sandmaier, David Hockenbery, Jeannine S. McCune
Summary: Biomarker-guided dosing could potentially improve the effectiveness and safety of cyclophosphamide (CY), but evaluating its association with CY plasma concentration-time curve (AUC) is time-consuming. This study aimed to identify lipidomic biomarkers associated with 4-hydroxycyclophosphamide (4HCY) formation clearance in hematopoietic cell transplant patients receiving CY. The results showed the feasibility of lipidomics but further studies are needed to optimize CY dosing in larger samples.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Jeannine S. McCune, Sandi L. Navarro, K. Scott Baker, Linda J. Risler, Brian R. Phillips, Timothy W. Randolph, Laura Shireman, H. Gary Schoch, H. Joachim Deeg, Yuzheng Zhang, Alex Men, Loes Maton, Alwin D. R. Huitema
Summary: A linear regression model of 13 endogenous metabolomic compounds (EMCs) can be used to predict an individual's busulfan clearance (BuCL) before administration. This pharmacometabolomics method is more effective than using a busulfan test dose or pharmacogenomics to guide dosing.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Cell Biology
Kristin J. Lastwika, Andrew Kunihiro, Joell L. Solan, Yuzheng Zhang, Lydia R. Taverne, David Shelley, Jung-Hyun Rho, Timothy W. Randolph, Christopher I. Li, Eric L. Grogan, Pierre P. Massion, Annette L. Fitzpatrick, David MacPherson, A. McGarry Houghton, Paul D. Lampe
Summary: Small cell lung cancer (SCLC) triggers the generation of autoantibodies, causing unique paraneoplastic neurological syndromes. We developed a technique to detect autoantibodies directly from patient plasma and found that SCLC patients have significantly higher disease-specific autoantibody signals compared to patients with other cancers. We identified previously unknown autoantibodies produced in response to both intracellular and extracellular tumor antigens in multiple SCLC cohorts and discovered disease-specific posttranslational modifications within targeted extracellular proteins. These findings have implications for the early detection and clinical utility of SCLC.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Huajia Zhang, Xiaodong Zhu, Travis J. Friesen, Jeff W. Kwak, Tatyana Pisarenko, Surapat Mekvanich, Mark A. Velasco, Timothy W. Randolph, Julia Kargl, A. McGarry Houghton
Summary: This study reveals the expression of ARG1 in neutrophil lineage cells in non-small cell lung cancer and the active transcription of ARG7 mRNA in tumor-associated neutrophils (TANs). ANXA2 is identified as the major driver of ARG7 mRNA expression in TANs through signaling via the TLR2/MYD88 axis. This study uncovers a novel mechanism in regulating ARG7 mRNA expression in neutrophils and emphasizes the crucial role of neutrophil lineage cells in suppressing tumor-infiltrating lymphocytes.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Gastroenterology & Hepatology
Meredith A. J. Hullar, Isaac C. Jenkins, Timothy W. Randolph, Keith R. Curtis, Kristine R. Monroe, Thomas Ernst, John A. Shepherd, Daniel O. Stram, Iona Cheng, Bruce S. Kristal, Lynne R. Wilkens, Adrian Franke, Loic Le Marchand, Unhee Lim, Johanna W. Lampe
Summary: This study investigated the association of gut microbiome with hepatic adiposity among different ethnicities. The research found that NAFLD patients from various ethnic groups exhibited differences in bacterial composition and metabolism, but shared similar bacterial metabolic pathways.
Article
Endocrinology & Metabolism
Fayth L. Miles, Sandi L. Navarro, Carly B. Garrison, Timothy W. Randolph, Yuzheng Zhang, Ali Shojaie, Mario Kratz, Meredith A. J. Hullar, Daniel Raftery, Marian L. Neuhouser, Paul D. Lampe, Johanna W. Lampe
Summary: Urinary excretion of the microbial metabolite ENL of dietary lignans is associated with plasma protein abundance, potentially linking to cancer prevention. Over-representation analysis indicates associations of ENL excretion with estrogen and TNF signaling pathways.
HUMAN NUTRITION & METABOLISM
(2021)
Article
Nutrition & Dietetics
Maggie S. Burhans, Niranjan Balu, Kelsey A. Schmidt, Gail Cromer, Kristina M. Utzschneider, Ellen A. Schur, Sarah E. Holte, Timothy W. Randolph, Mario Kratz
CURRENT DEVELOPMENTS IN NUTRITION
(2020)