Article
Biochemistry & Molecular Biology
Jayasimha Rayalu Daddam, Harald M. Hammon, Arnulf Troescher, Laura Vogel, Martina Gnott, Gitit Kra, Yishai Levin, Helga Sauerwein, Maya Zachut
Summary: Phosphoproteomics is a cutting-edge technique used to explore AT metabolism, revealing the effects of CLA supplementation on the phosphoproteome in dairy cows. Changes in phosphorylation of key enzymes related to lipogenesis and metabolism in AT suggest an increase in lipid turnover with CLA supplementation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Pavel Hruska, Jan Kucera, Matej Pekar, Pavol Holeczy, Miloslav Mazur, Marek Buzga, Daniela Kuruczova, Peter Lenart, Jana Fialova Kucerova, David Potesil, Zbynek Zdrahal, Julie Bienertova-Vasku
Summary: The study compared the proteomic profiles of mature adipocytes from different adipose tissue depots, with findings showing that subcutaneous adipocytes are more active in vesicular transport, secretion, and lipid metabolism, while visceral adipocytes have higher protein expression related to mitochondrial energy metabolism and translational or biosynthetic activity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Veronika Paluchova, Tomas Cajka, Thierry Durand, Claire Vigor, Chandra Dodia, Shampa Chatterjee, Aron B. Fisher, Ondrej Kuda
Summary: Peroxiredoxin 6 (Prdx6) is a multifunctional enzyme that plays an important role in antioxidant defense and is linked to the biosynthesis of FAHFAs and various diseases. Deletion or mutation of Prdx6 affects the levels of FAHFAs, with different mutations having varying effects on FAHFA levels.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Lindsay Westbrook, Bradley J. Johnson, Gyoungok Gang, Kentaro Toyonaga, Eun Young Kang, Stephen B. Smith
Summary: This study provides evidence for the presence of functional GPR120 receptors in subcutaneous adipose tissue, which can inhibit lipolysis by reducing cAMP production. However, the role of GPR43 in the accumulation of adipose tissue lipids in growing steers remains unclear.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Nutrition & Dietetics
Maija Vaittinen, Maria A. Lankinen, Pirjo Kakela, Jyrki Agren, Craig E. Wheelock, Markku Laakso, Ursula Schwab, Jussi Pihlajamaki
Summary: The study investigated the role of FADS1 variants in regulating dietary linoleic acid-induced effects on adipose tissue inflammation. The results showed that individuals with the TT genotype had increased inflammation in adipose tissue after a LA-enriched diet, while the CC genotype may play a protective role.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Oscar Osorio-Conles, Arturo Vega-Beyhart, Ainitze Ibarzabal, Jose Maria Balibrea, Josep Vidal, Ana de Hollanda
Summary: The metabolic syndrome is a cluster of dangerous heart attack risk factors. This study compares the dysfunction of obesity-associated white adipose tissue (WAT) between women with severe obesity with or without metabolic syndrome. The results show that women with metabolic syndrome exhibit greater adipocyte hypertrophy, increased fibrosis, and higher expression of macrophage and hypoxia markers in subcutaneous adipose tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Menghua Zhu, Hongyu Li, Yue Yin, Min Ding, Cyriac Abby Philips, Fernando Gomes Romeiro, Xingshun Qi
Summary: Both excessive deficiency and accumulation of subcutaneous adipose tissues negatively influence the outcomes of cirrhotic patients.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Genetics & Heredity
Linghui Wang, Hao Gu, Tianci Liao, Yuhang Lei, Yanhao Qiu, Qiuyang Chen, Lei Chen, Shunhua Zhang, Jinyong Wang, Xiaoxia Hao, Dongmei Jiang, Ye Zhao, Lili Niu, Xuewei Li, Linyuan Shen, Mailin Gan, Li Zhu
Summary: By sequencing, identifying, and analyzing tsRNAs using pigs as animal models, this research reports the characteristics of tsRNAs in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). A total of 474 tsRNAs, with differential expression in endocrine and immune systems, as well as lipid metabolism, were found in white adipose tissue (WAT). The study also discovered a connection between the activity of the host tRNA engaged in translation and the production of tsRNAs. Furthermore, tsRNAs and miRNAs were found to be involved in the regulation of fatty acid metabolism in adipose tissue.
Article
Multidisciplinary Sciences
Tong Mu, Honghong Hu, Yanfen Ma, Huiyu Wen, Chaoyun Yang, Xiaofang Feng, Wan Wen, Juan Zhang, Yaling Gu
Summary: This study used WGCNA to analyze the mRNA expression profile data of bovine mammary epithelial cells and identified several modules and hub genes significantly associated with milk fat rate. The key candidate genes related to lipid metabolism were screened out, and PI4K2A showed the highest expression in the mammary gland and was enriched in GO terms and pathways related to milk fat metabolism. This study provides a theoretical basis for identifying potential pathways and hub genes involved in milk fat synthesis.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Alexander J. Knights, Shanshan Liu, Yingxu Ma, Victoria S. Nudell, Eric Perkey, Matthew J. Sorensen, Robert T. Kennedy, Ivan Maillard, Li Ye, Heejin Jun, Jun Wu
Summary: This study demonstrates that macrophages play a crucial role in regulating thermogenesis by secreting acetylcholine in adipose tissue. The abundance of ChAMs increases in response to acute cold exposure, and their regulation is mediated through adrenergic signaling. Deletion of the enzyme ChAT impairs cold-induced thermogenesis in mice.
Article
Endocrinology & Metabolism
Yutaro Kumagai, Yutaka Saito, Yasuyuki S. Kida
Summary: The study focused on understanding the development of brown adipose tissue (BAT) and its role in regulating energy balance and metabolic diseases. Through transcriptomic and metabolomic analysis of developing mouse BAT, two distinct developmental changes specific to BAT were identified. Key transcription factors involved in BAT development were also discovered. The comparison with other organ development data revealed BAT-specific transcriptome and metabolome patterns. These findings provide an overview of mouse BAT development and have implications for understanding developmental and functional controls of BAT.
Article
Agriculture, Dairy & Animal Science
Lindsay Westbrook, Bradley J. Johnson, Gyoungok Gang, Kentaro Toyonaga, Jinhee Hwang, Kiyong Chung, Stephen B. Smith
Summary: The study conducted 3 experiments to demonstrate G-coupled protein receptors in bovine adipose tissues, showing evidence of functional GPR43 receptors in i.m. adipose tissue and GPR120 receptors in s.c. adipose tissue, both suppressing lipolysis.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Medicine, General & Internal
Oscar Osorio-Conles, Ainitze Ibarzabal, Jose Maria Balibrea, Josep Vidal, Emilio Ortega, Ana de Hollanda
Summary: Hypertriglyceridemia is associated with increased risk of pancreatitis and cardiovascular disease. Fibrosis of subcutaneous adipose tissue is related to changes in triglyceride levels. FABP4 gene may be a potential drug target for the treatment of hypertriglyceridemia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Isis Cortes, Gutemberg Alves, Cesar Claudio-Da-Silva, Leandra Santos Baptista
Summary: This study found that different subpopulations of adipose stem/stromal cells (ASCs) exhibit distinct physiological properties in a 3D spheroid culture. ASC spheroids from superficial subcutaneous adipose tissue (sSAT) showed the highest response to adipogenic induction, while spheroids from deep subcutaneous adipose tissue (dSAT) showed the greatest lipolytic capacity. Spheroids from superficial retinacula cutis (sRC) exhibited a greater secretory capacity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Haidong Zhao, Mingli Wu, Xiaoqin Tang, Qi Li, Xiaohua Yi, Wanxia Zhao, Xiuzhu Sun
Summary: This study reveals the metabolic mechanism of subcutaneous adipose tissue in chicks, demonstrates the crucial role of FFA-induced Ccl2 (chicken CCL26) secretion in lipid transportation, and identifies the significant involvement of macrophages in this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Chong-Su Kim
Summary: The gut microbiota plays a crucial role in brain function through the gut-brain axis. This review highlights the effects of gut microbiota-derived dietary metabolites on cell-to-cell interactions in the central nervous system, particularly microglia, astrocytes, and neuronal cells, affecting cognitive function, mood, and behavior. The review also discusses the potential of diet-induced microbial metabolite-based therapies as novel approaches to mental health treatment.
ADVANCES IN NUTRITION
(2024)