Journal
ADVANCED HEALTHCARE MATERIALS
Volume 4, Issue 16, Pages 2375-2387Publisher
WILEY
DOI: 10.1002/adhm.201500192
Keywords
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Funding
- Natural Sciences and Engineering Research Council (NSERC)
- Ontario Research Foundation
- Province of Ontario
- University of Toronto
- NSERC CREATE in Manufacturing Materials and Mimetics (M3) training program
- Canadian Institutes of Health Research (CIHR)
- CIHR Training Program in Regenerative Medicine
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In diabetic patients the development of chronic non-healing wounds is a common complication. A methacrylic acid-based biomaterial is a vascular regenerative material that enhances diabetic healing without the use of cells or growth factors. The bioactive nature of this material is thought to be associated with its anionic charge or surface chemistry. Contact between the methacrylic acid-based biomaterial and tissue begins with protein (including complement) adsorption and is followed by interaction of the biomaterial with resident and infi ltrating cells in the wound bed (e.g., macrophages and endothelial cells). This results in changes to their surface receptors to activate phosphorylation cascades that lead to differential activation of signalling pathways such as those involving osteopontin and sonic hedgehog. These changes modulate the phenotype of the cells in the wound bed, eventually improving vessel formation and wound healing. Understanding the molecular and cellular mechanisms will have broad implications for biomaterials, not just the methacrylic acid-based material, and will facilitate the advancement of regenerative biomaterials for diverse applications.
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