Article
Biochemistry & Molecular Biology
Haibin Zhang, Zhiyang Gu, Wenya Li, Lili Guo, Litong Wang, Lan Guo, Saibo Ma, Baoqin Han, Jing Chang
Summary: Oral drug delivery is the most preferred mode of treatment due to its convenience and non-invasiveness. However, delivering protein drugs orally has been a challenge. This study developed a novel OCMC/SA nanohydrogel that solves this problem, with high drug loading capacity and passive drug targeting function.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Polymer Science
Bianca Andrade de Campos, Natalia Cristina Borges da Silva, Lucas Szmgel Moda, Pedro Vidinha, Ligia Passos Maia-Obi
Summary: pH-sensitive degradable hydrogels are smart materials that degrade upon pH variation. This study focused on the development of a hydrogel using HPG and OA, and investigated its formation process, as well as drug release for oral administration.
Article
Biochemistry & Molecular Biology
Min Li, Ling'e Zhang, Yang Xuan, Defu Zhi, Wei Wang, Wenjun Zhang, Yinan Zhao, Shufen Zhang, Shubiao Zhang
Summary: This study developed a pH-responsive tumor prodrug using hyaluronic acid as a targeting carrier. The prodrug micelles demonstrated excellent stability, blood compatibility, and drug release properties. In vivo experiments showed that the prodrug micelles had significant tumor inhibition activity with minimal systemic toxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Luzhi Liu, Qingqing Zhou, Qin He, Wengui Duan, Yan Huang
Summary: This study successfully constructed supramolecular vesicles with pH-triggering effect for drug delivery, which are formed by the complexation between a cationic pillar[5]arene and sodium dodecyl sulfonate. These vesicles efficiently loaded anticancer drug doxorubicin under neutral conditions and could control drug release in the simulated weak acid environment of tumor cells, showing promising potential for various biomedical applications.
FRONTIERS IN CHEMISTRY
(2021)
Article
Biochemical Research Methods
Hongping Li, Ru Zhou, Jinlin He, Mingzu Zhang, Jian Liu, Xingwei Sun, Peihong Ni
Summary: This study successfully constructed biocompatible, biodegradable nanoparticles sensitive to glucose for insulin release in high blood glucose environments. The nanoparticles showed promising potential for diabetes treatment through controlled insulin release.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Applied
Pouya Kasaei, Negin Karami, Jaber Keyvan Rad, Samira Sanjabi, Ali Reza Mahdavian
Summary: In this study, a novel fluorescein mono-acrylate (Flu-Ac) was synthesized and used to produce epoxy-functionalized latex nanoparticles. The obtained fluorescent cellulose paper showed enhanced emission intensity by increasing the pH of the solution. These findings suggest the potential of these fluorescent cellulose substrates for reusable indicators with pH sensing capabilities across a range of acidity or basicity.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Chongyang Zhu, Ning Tang, Jing Gan, Xiaojun Zhang, Yang Li, Xin Jia, Yongqiang Cheng
Summary: A novel pH-sensitive semi-interpenetrating polymer network (semi-IPN) hydrogel was successfully synthesized using konjac glucomannan (KGM) and poly (gamma-glutamic acid) (gamma-PGA) with sodium trimetaphosphate (STMP) as the crosslinking agent. The structure and properties of the hydrogel were characterized through various methods, revealing that the content of cross-linker and gamma-PGA significantly influenced the structure and swelling behavior of the hydrogel, with potential for drug delivery in the intestine.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Qinhai Xu, Kang Li, Peng Wang
Summary: Ag-containing carbon dots (Ag-CDs) were synthesized based on folic acid. The electronic absorption origins of different fluorescent species were assigned by comparing their emission and excitation spectra. The pH-regulating fluorescence mechanism of Ag-CDs was studied, and a particularly strong fluorescence emitter was observed at pH ~12, which could be developed into a fluorescent sensor for extremely basic conditions.
Article
Materials Science, Multidisciplinary
Hengdi Su, Huixian Yan, Xiaolong Zhang, Zheng Zhong
Summary: This paper proposes a field theory for the constrained swelling of pH/temperature sensitive cationic hydrogels. A variational approach is used to obtain a set of governing equations that couple mechanical and chemical equilibrium conditions. The proposed model is validated through comparison with experimental data, and the effects of temperature and pH on solvent concentration and stress distribution in the hydrogel shell are investigated using multiphysics-informed deep learning. The deep learning model is also extended to solve the inverse identification problem of inhomogeneous swelling of core-shell hydrogels.
MECHANICS OF MATERIALS
(2022)
Article
Engineering, Biomedical
Yihalem Abebe Alemayehu, Fasih Bintang Ilhami, Abere Habtamu Manayia, Chih-Chia Cheng
Summary: This study successfully designed and synthesized a new mercury-based supramolecular polymer with multifunctional properties, exhibiting selective cytotoxic effects on cancer cells without harming normal cells. The discovery of this "cytotoxicity-concealing" supramolecular system provides a promising strategy to enhance the safety and efficacy of cancer therapy and bioimaging.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Zi-Peng Chen, Ding Li, Lei Xu, Yu-Fei Jiang, Kai Lin, Yue Zhao, Jing Zhao
Summary: Cationic metal-organic frameworks (MOFs) have recently gained attention for their potential in treating wastewater containing toxic anions. In this study, two novel cationic MOFs were constructed using a neutral imidazole-containing ligand. The structures and properties of the MOFs were analyzed, and it was found that one of the MOFs exhibited high efficiency and recyclability in adsorbing Cr2O72-.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Green & Sustainable Science & Technology
Tuhin Bhattacharjee, Rita Rabha, Devasish Chowdhury, Gitanjali Majumdar
Summary: A cheap green pH sensitive smart paper with in-situ generated carbon dots deposited uniformly on the fibrous surface has been developed. The paper showed high selectivity for the absorptive removal of anionic dye and can recover the adsorbed dye easily.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2022)
Article
Environmental Sciences
Parisa Daraei, Elham Rostami, Farzad Nasirmanesh, Valiollah Nobakht
Summary: In this study, a pH-sensitive polyethersulfone membrane was improved by adding newly synthesized Ag(I)-CP particles, which showed enhanced selectivity towards dyes. It was found that adjusting the feed pH could improve the dye removal efficiency.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Chemistry, Applied
Wheeler R. Lovett, Alaa Al Hamd, Stefanie Casa, Maged Henary
Summary: In this study, four benzothiazole-derived dyes with pyridine moieties were synthesized as prospective pH-responsive probes. These dyes exhibited absorption and emission in the far-red range of the visible spectrum and showed changes in their spectral properties when exposed to hydrochloric acid, indicating their potential as pH probes. Computational studies further confirmed the influence of pyridine on the spectral properties of these dyes.
Article
Materials Science, Biomaterials
Zhongyin Chen, Lihui Wan, Ye Yuan, Ying Kuang, Xiangyu Xu, Tao Liao, Jia Liu, Zi-Qiang Xu, Bingbing Jiang, Cao Li
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Chemistry, Physical
Lihui Wan, Zhongyin Chen, Yan Deng, Tao Liao, Ying Kuang, Jia Liu, Junlin Duan, Ziqiang Xu, Bingbing Jiang, Cao Li
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2020)
Correction
Nanoscience & Nanotechnology
Jia Liu, Xingxin Liu, Ye Yuan, Qilin Li, Bingcheng Chang, Luming Xu, Bo Cai, Chao Qi, Cao Li, Xulin Jiang, Guobin Wang, Zheng Wang, Lin Wang
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Yaoyu Pan, Qiongfang Song, Yalin Zhu, Yun Wang, Zhengguang Sun, Xueqin Chen, Ziqiang Xu, Cao Li, Bingbing Jiang
Summary: A novel and simple strategy was developed to fabricate microporous polymeric film with industrial application potential. By combining self-assembly technology and post-treatment, the film exhibits good CO2 capture capabilities, large-scale feature, and certain improved mechanical properties.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2021)
Article
Engineering, Biomedical
Xiangyu Xu, Junlin Duan, Yun Liu, Ying Kuang, Jingling Duan, Tao Liao, Ziqiang Xu, Bingbing Jiang, Cao Li
Summary: The research focuses on the exploration and application of hollow manganese dioxide nanoparticles (HMDN) for biosensing and biomedicine, particularly in tumor-targeted drug delivery. The prepared DOX@HMDN-PEI-PLL(cit) nanoparticles have shown promising results in vitro and in vivo studies, demonstrating their potential as a drug delivery system for targeted cancer therapy. The nanoparticles exhibit a stealthy property under physiological conditions and enhanced therapeutic effects with minimal side effects, showcasing their potential for future applications in cancer treatment.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Analytical
Hang He, Song Meng, Haimin Li, Qingyuan Yang, Ziqiang Xu, Xueqin Chen, Zhengguang Sun, Bingbing Jiang, Cao Li
Summary: The study developed a mitochondrial-targeted drug delivery system which can release drugs in a GSH-dependent manner and achieve near-infrared fluorescence imaging of mitochondria. This system shows promising activity in anti-tumor therapy.
Article
Chemistry, Analytical
Hang He, Qingyuan Yang, Haimin Li, Song Meng, Ziqiang Xu, Xueqin Chen, Zhengguang Sun, Bingbing Jiang, Cao Li
Summary: The redox-responsive chemodynamic therapy system using H-MnO2, DOX, and FL CDs presents a promising approach for cancer diagnosis and treatment by enhancing cytotoxicity through GSH consumption, releasing DOX, and effectively eliminating cancer cells. Additionally, the system can differentiate cancerous cells from normal ones based on GSH concentrations and restore FL after H-MnO2 degradation.
Article
Chemistry, Applied
Yaoyu Pan, Ruisi Li, Peihang Li, Yun Wang, Yalin Zhu, Ziqiang Xu, Xueqin Chen, Zhengguang Sun, Cao Li, Bingbing Jiang
Summary: A large and flexible nanoporous membrane based on AHCPNPs was fabricated with excellent CO2 capture capacity and oil-water separation efficiency. The membrane exhibits high mechanical strength, large specific surface area, high CO2 capture capacity, and efficient oil-water adsorption and separation.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Tao Liao, Chang Liu, Jun Ren, Hui Chen, Ying Kuang, Bingbing Jiang, Jianli Chen, Zhengguang Sun, Cao Li
Summary: In this study, a dual-pH-sensitive chitosan/mesoporous silica nanoparticle-based anticancer drug delivery system was developed using the tumor-triggered targeting strategy. Both in vitro and in vivo studies demonstrated that the system could induce cancer cell apoptosis, inhibit tumor growth, and reduce the cytotoxicity of the drug against normal cells, showing potential for cancer therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Correction
Chemistry, Physical
Zhongyin Chen, Tao Liao, Lihui Wan, Ying Kuang, Chang Liu, Junlin Duan, Xiangyu Xu, Ziqiang Xu, Bingbing Jiang, Cao Li
Article
Chemistry, Physical
Zhongyin Chen, Tao Liao, Lihui Wan, Ying Kuang, Chang Liu, Junlin Duan, Xiangyu Xu, Ziqiang Xu, Bingbing Jiang, Cao Li
Summary: The use of nanocarriers with dual pH/GSH responsive features for imaging-guided drug delivery can effectively eliminate tumor tissues while reducing side effects, providing a new strategy for cancer therapy.
Article
Pharmacology & Pharmacy
Xiangyu Xu, Junlin Duan, Qian Lan, Ying Kuang, Tao Liao, Yun Liu, Ziqiang Xu, Jianli Chen, Bingbing Jiang, Cao Li
Summary: This article introduces a novel dual-sensitive anticancer drug delivery system that can enhance cancer cell uptake and endocytosis capability through surface charge reversal in the tumor microenvironment. The system utilizes a series of steps involving nanoparticle encapsulation, redox-sensitive disulfide bond for drug release, and rapid charge reversal for better uptake, demonstrating sensitivity to both reducing and weakly acidic environments.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Chemistry, Physical
Zhe Ren, Tao Liao, Cao Li, Ying Kuang
Summary: This review summarizes the stimuli and methods of tumor-triggered targeting or intracellular drug release based on DePEGylation, as well as the targeting and intracellular controlled release behaviors of DDSs.
Article
Chemistry, Multidisciplinary
Xiaoqin Li, Xueqin Chen, Cao Li, Ziqiang Xu, Bingbing Jiang
Summary: In this study, an emulsifier-mediated strategy was introduced into the synthesis of COF for the first time, leading to the successful synthesis of a COF with higher crystallinity and a synthetic yield of 84.7%. The specific surface area and photocatalytic degradation efficacy were significantly improved. This work provides a promising approach for achieving COF with higher surface area, synthetic yield, and photocatalytic efficacy, which could promote the industrial and practical production of COFs.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Physical
Ying Kuang, Qinjian Xiao, Yichen Yang, Menglong Liu, Xiaosa Wang, Pengpeng Deng, Kao Wu, Yi Liu, Bo Peng, Fatang Jiang, Cao Li
Summary: In this study, alkali-treated zein (AZ) and sodium alginate (SA) were combined to prepare AZ/SA composite particles (ZS) for stabilizing Pickering emulsions. The particle size of ZS decreased significantly after alkali treatment, and ZS with different ratios all had sizes smaller than 80 nm. The 3:1 ratio of AZ/SA showed the best stability for Pickering emulsions at a high oil phase fraction of 75%.
Article
Chemistry, Physical
Yiping Yin, Zhe Wang, Hua Zou
Summary: This study presents a novel method for preparing dimpled polymer-silica nanocomposite particles using interfacial swelling-based seeded polymerization. The optimized conditions allow for a relatively high percentage of dimpled particles to be achieved.
Article
Chemistry, Physical
Brenden D. Hoehn, Elizabeth A. Kellstedt, Marc A. Hillmyer
Summary: Porous materials with nanometer-scale pores have important applications as nanoporous membranes. In this study, ABA triblock copolymers were used as precursors to produce nanoporous polymeric membranes (NPMs) in thin film form by degrading the end blocks. Polycyclooctene (PCOE) NPMs with tunable pore sizes were successfully prepared using solvent casting technique. Oxygen plasma etching was employed to improve the surface porosity and hydrophilicity of the membranes. This study provides a straightforward method to produce tough NPMs with high porosity and hydrophilic surface properties.
Article
Chemistry, Physical
Vladislav S. Petrovskii, Stepan I. Zholudev, Igor I. Potemkin
Summary: This article investigates the behavior of linear and ring polypeptide chains in aqueous solution and explores the properties of the complexes formed by these chains with oppositely charged surfactants. The results demonstrate that the complexes of linear supercharged unfolded polypeptides and the corresponding surfactants exhibit impressive adhesive properties.
Article
Chemistry, Physical
Merve Cevik, Serkan Dikici
Summary: Cardiovascular diseases are a leading cause of death globally, and vascular grafts are a promising treatment option. This study focuses on tissue-engineered vascular grafts (TEVGs) using decellularized parsley stems as a potential biomaterial. The decellularized parsley stems showed suitable properties for TEVGs, providing a suitable environment for human endothelial cells to form a pseudo endothelium. This study showcases the potential of using parsley stems for TEVGs.
Article
Chemistry, Physical
Gustavo A. Vasquez-Montoya, Tadej Emersic, Noe Atzin, Antonio Tavera-Vazquez, Ali Mozaffari, Rui Zhang, Orlando Guzman, Alexey Snezhko, Paul F. Nealey, Juan J. de Pablo
Summary: The optical properties of liquid crystals are typically controlled by electric fields. In this study, we investigate the effects of microfluidic flows and acoustic fields on the molecular orientation and optical response of nematic liquid crystals. We identify several previously unknown structures and explain them through calculations and simulations. These findings hold promise for the development of new systems combining sound, flow, and confinement.
Article
Chemistry, Physical
Xinjun Wu, Xin Guan, Shushu Chen, Jiangpeng Jia, Chongyi Chen, Jiawei Zhang, Chuanzhuang Zhao
Summary: This research presents a novel shape memory hydrogel with a remodelable permanent shape and programmable cold-induced shape recovery behavior. The hydrogel is prepared using specific treatment methods to achieve shape fixation by heating and shape recovery by cooling. Additionally, deformable devices can be obtained by assembling hydrogel blocks with different concentrations.
Article
Chemistry, Physical
Rebecca Hengsbach, Gerhard Fink, Ulrich Simon
Summary: This study examines the properties of DNA functionalized pNipmam microgels and pure pNipmam microgels at different concentrations of sodium chloride and in PBS solutions using temperature dependent H-1-NMR measurements. The results show that DNA modification affects the volume phase transition temperature and the addition of salt and PBS further enhances this effect.
Article
Chemistry, Physical
Ningyi Li, Junhong Li, Lijingting Qing, Shicheng Ma, Yao Li, Baohui Li
Summary: This paper investigates the self-assembly behavior of colloids with competing interactions under spherical confinement and finds that different ordered structures can be formed under different sized spherical confinements. Moreover, more perforated structures are formed in smaller spheres.
