The enduring importance of animal modelsin understanding periodontal disease

Porphyromonas gingivalis Manipulates Complement and TLR Signaling to Uncouple Bacterial Clearance from Inflammation and Promote Dysbiosis

(2014) Tomoki Maekawa et al.   Cell Host & Microbe

Community-wide transcriptome of the oral microbiome in subjects with and without periodontitis

(2014) Ana E Duran-Pinedo et al.   ISME Journal

Cytokine gene expression profiles during initiation, progression and resolution of periodontitis

(2014) Jeffrey L. Ebersole et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Genetic and Intervention Studies Implicating Complement C3 as a Major Target for the Treatment of Periodontitis

(2014) T. Maekawa et al.   JOURNAL OF IMMUNOLOGY

Bacterial fight-and-flight responses enhance virulence in a polymicrobial infection

(2014) A. Stacy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defective Neutrophil Recruitment in Leukocyte Adhesion Deficiency Type I Disease Causes Local IL-17-Driven Inflammatory Bone Loss

(2014) N. M. Moutsopoulos et al.   Science Translational Medicine

Metatranscriptomics of the Human Oral Microbiome during Health and Disease

(2014) P. Jorth et al.   mBio

Distinct Lipid A Moieties Contribute to Pathogen-Induced Site-Specific Vascular Inflammation

(2014) Connie Slocum et al.   PLoS Pathogens

Bacterial Infection Increases Periodontal Bone Loss in Diabetic Rats through Enhanced Apoptosis

(2013) Sandra Pacios et al.   AMERICAN JOURNAL OF PATHOLOGY

Induction of Bone Loss by Pathobiont-Mediated Nod1 Signaling in the Oral Cavity

(2013) Yizu Jiao et al.   Cell Host & Microbe

Breaking bad: Manipulation of the host response byPorphyromonas gingivalis

(2013) George Hajishengallis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Myeloperoxidase deficiency induces MIP-2 production via ERK activation in zymosan-stimulated mouse neutrophils

(2013) N. Tateno et al.   FREE RADICAL RESEARCH

Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome

(2013) Dan Knights et al.   GUT

Porphyromonas gingivalis Lipid A Phosphatase Activity Is Critical for Colonization and Increasing the Commensal Load in the Rabbit Ligature Model

(2013) Camille Zenobia et al.   INFECTION AND IMMUNITY

The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation

(2013) Loreto Abusleme et al.   ISME Journal

Optimization of the ligature-induced periodontitis model in mice

(2013) Toshiharu Abe et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases

(2013) Iain L. C. Chapple et al.   JOURNAL OF PERIODONTOLOGY

'Blooming' in the gut: how dysbiosis might contribute to pathogen evolution

(2013) Bärbel Stecher et al.   NATURE REVIEWS MICROBIOLOGY

Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes

(2013) A. J. Glowacki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response

(2013) George Hajishengallis   TRENDS IN IMMUNOLOGY

The Serine Phosphatase SerB of Porphyromonas gingivalis Suppresses IL-8 Production by Dephosphorylation of NF-κB RelA/p65

(2013) Hiroki Takeuchi et al.   PLoS Pathogens

Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD)

(2013) Katarzyna J. Maresz et al.   PLoS Pathogens

The history of matrix metalloproteinases: milestones, myths, and misperceptions

(2012) Rugmani Padmanabhan Iyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Aggregatibacter actinomycetemcomitans Infection Enhances ApoptosisIn Vivothrough a Caspase-3-Dependent Mechanism in Experimental Periodontitis

(2012) Jun Kang et al.   INFECTION AND IMMUNITY

Local Complement-Targeted Intervention in Periodontitis: Proof-of-Concept Using a C5a Receptor (CD88) Antagonist

(2012) T. Abe et al.   JOURNAL OF IMMUNOLOGY

Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology

(2012) G. Hajishengallis et al.   Molecular Oral Microbiology

The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss

(2012) Mehmet A Eskan et al.   NATURE IMMUNOLOGY

The keystone-pathogen hypothesis

(2012) George Hajishengallis et al.   NATURE REVIEWS MICROBIOLOGY

Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and Complement

(2011) George Hajishengallis et al.   Cell Host & Microbe

Diabetes aggravates periodontitis by limiting repair through enhanced inflammation

(2011) Sandra Pacios et al.   FASEB JOURNAL

The Capsule of Porphyromonas gingivalis Leads to a Reduction in the Host Inflammatory Response, Evasion of Phagocytosis, and Increase in Virulence

(2011) Amrita Singh et al.   INFECTION AND IMMUNITY

Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing

(2011) Ann L Griffen et al.   ISME Journal

Diabetes mellitus and periodontitis: a tale of two common interrelated diseases

(2011) Evanthia Lalla et al.   Nature Reviews Endocrinology

EAE: imperfect but useful models of multiple sclerosis

(2011) Bert A. ’t Hart et al.   TRENDS IN MOLECULAR MEDICINE

Metabolite Cross-Feeding Enhances Virulence in a Model Polymicrobial Infection

(2011) Matthew M. Ramsey et al.   PLoS Pathogens

Role of Porphyromonas gingivalis Phosphoserine Phosphatase Enzyme SerB in Inflammation, Immune Response, and Induction of Alveolar Bone Resorption in Rats

(2010) B. Bainbridge et al.   INFECTION AND IMMUNITY

Structural Dissection andIn VivoEffectiveness of a Peptide Inhibitor ofPorphyromonas gingivalisAdherence toStreptococcus gordonii

(2010) Carlo Amorin Daep et al.   INFECTION AND IMMUNITY

The Human Oral Microbiome

(2010) F. E. Dewhirst et al.   JOURNAL OF BACTERIOLOGY

Experimental Periodontitis Induces Gene Expression of Proinflammatory Cytokines in Liver and White Adipose Tissues in Obesity

(2010) Yasumasa Endo et al.   JOURNAL OF PERIODONTOLOGY

Effects of periodontitis on aortic insulin resistance in an obese rat model

(2010) Daisuke Ekuni et al.   LABORATORY INVESTIGATION

The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models

(2010) Sandra Nell et al.   NATURE REVIEWS MICROBIOLOGY

Periodontitis: a polymicrobial disruption of host homeostasis

(2010) Richard P. Darveau   NATURE REVIEWS MICROBIOLOGY

Clinical studies on the management of periodontal diseases utilizing subantimicrobial dose doxycycline (SDD)

(2010) Jack Caton et al.   PHARMACOLOGICAL RESEARCH

Human Toll-like receptor 4 responses toP. gingivalisare regulated by lipid A 1- and 4′-phosphatase activities

(2009) Stephen R. Coats et al.   CELLULAR MICROBIOLOGY

Inhibition of Experimental Periodontitis by a Topical Boron-based Antimicrobial

(2009) Q. Luan et al.   JOURNAL OF DENTAL RESEARCH

Preventive Effects of a Cocoa-Enriched Diet on Gingival Oxidative Stress in Experimental Periodontitis

(2009) Takaaki Tomofuji et al.   JOURNAL OF PERIODONTOLOGY

Cytokines That Promote Periodontal Tissue Destruction

(2008) Dana Graves   JOURNAL OF PERIODONTOLOGY