Article
Engineering, Environmental
Huixin Wang, Wenshen Wang, Chengpan Li, Ao Xu, Bensheng Qiu, Fenfen Li, Weiping Ding
Summary: This study presented a novel microneedle system loaded with the multipurpose small molecule Flav7 for high-efficiency light-activated drug release for chemotherapy and high-performance light-controlled thermotherapy of tumors, as well as remarkable NIR-II fluorescence imaging to guide chemo-thermal therapy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Chin-Hao Su, Andree Soendoro, Shinya Okayama, Fitriani Jati Rahmania, Takashi Nagai, Toyoko Imae, Kaname Tsutsumiuchi, Noriyasu Kawai
Summary: In this study, magnetite nanoparticles were hybridized with carbon dots and chemically bound on an acid-treated carbon nanohom, resulting in composite materials with magnetism and drug release capabilities. Under laser light emission, these composites exhibited photodynamic/photothermal effects that influenced drug release. Complete drug release was achieved under hyperthermia procedure conducted with a magnet. Therefore, these composites hold potential for simultaneous usage in phototherapy, thermotherapy, and chemotherapy.
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
(2022)
Article
Chemistry, Multidisciplinary
P. Tiago Ribeiro, J. Agostinho Moreira, J. Fernando Monterio, S. Marta Laranjeira
Summary: Nanoparticle mediated hyperthermia is a method of increasing cancer treatment efficacy by heating tumors from the inside out. This method utilizes nanoparticles that respond to external stimuli and convert energy into heat, causing damage to tumor cells. Combining hyperthermia with chemotherapy has been shown to be more effective, with the high temperature and drug effects working synergistically and allowing for remote controlled drug release.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Maximilian Regenold, Kan Kaneko, Xuehan Wang, H. Benson Peng, James C. Evans, Pauric Bannigan, Christine Allen
Summary: Triggered drug delivery strategies, such as thermosensitive liposomes, have shown improved targetability for chemotherapeutics. However, most studies have focused on doxorubicin encapsulation, while other drugs could also benefit from this targeted delivery approach.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Lingna Wang, Yingjie Yu, Dengshuai Wei, Lingpu Zhang, Xiaoyan Zhang, Guanxin Zhang, Dan Ding, Haihua Xiao, Deqing Zhang
Summary: A systematic combination strategy utilizing near-infrared light-triggered hyperthermia, combined with cisplatin, was proposed to overcome drug resistance. The strategy showed significant efficacy in inhibiting the growth of multidrug-resistant lung cancer in both in vitro and in vivo studies.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Nisha Chander, Johannes Morstein, Jan S. Bolten, Andrej Shemet, Pieter R. Cullis, Dirk Trauner, Dominik Witzigmann
Summary: Incorporation of photoswitchable-phosphatidylcholine analogs in conventional lipid nanoparticles can generate photoactivatable LNPs, allowing light-induced drug release at specific sites, which shows promising potential for clinical development.
Article
Chemistry, Physical
Jiuyu Cui, Jun Huang, Yonggan Yan, Wenqian Chen, Jie Wen, Xunwei Wu, Jikai Liu, Hanlian Liu, Chuanzhen Huang
Summary: A Fe3O4-loaded photothermal microneedle patch (Fe3O4@MN) has been developed for controlled drug delivery, achieving enhanced drug release efficiency. The Fe3O4@MN has sufficient mechanical strength to penetrate the skin, and its temperature can rapidly increase under NIR irradiation. In vitro experiments showed high drug release rates and increased penetration depth compared to a patch without Fe3O4 nanoparticles, indicating the potential application of the synthesized microneedle patch for transdermal drug delivery.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Zishuo Hou, Zizhen Wang, Peiwen Wang, Fan Chen, Xianglin Luo
Summary: In this study, carboxylated and aminated nanodiamonds were synthesized as photothermal agents with stable properties and good biocompatibility for mild-temperature photothermal therapy. The nanodiamonds demonstrated efficient photothermal conversion and excellent antibacterial and cancer ablation effects under near-infrared light triggering.
DIAMOND AND RELATED MATERIALS
(2022)
Article
Chemistry, Physical
Dina S. Salem, Salem F. Hegazy, Salah S. A. Obayya
Summary: This study utilized a ternary system consisting of optimally prepared chitosan nanoparticles (ChNPs) efficiently encapsulating 5-Fluorouracil (5-FU) and loaded by gold nanoparticles (AuNPs) for synergistic chemophotothermal therapy. The synthesized nanocomposites exhibited excellent biocompatibility, stability, and killing efficiency of tumor cells, with a strong absorbance in the visible region promoting rapid drug release under laser exposure. The synergistic effect of the combined chemo-photothermal therapy was demonstrated through cytotoxicity experiments towards hepatocellular carcinoma cells (HepG2), highlighting the high potential of the 5-FU-ChNPs@Au nanocomposites as a therapeutic platform.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2021)
Article
Biophysics
Huan Zheng, Huanhuan Li, Hongxian Deng, Wenlan Fang, Xiting Huang, Jiuquan Qiao, Yan Tong
Summary: In this study, black phosphorus nanosheets were prepared and loaded with antimicrobial agents to achieve excellent bactericidal effect through photothermal conversion and synergistic effect.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Biotechnology & Applied Microbiology
Runcong Liu, Yongjun Peng, Ligong Lu, Shaojun Peng, Tianfeng Chen, Meixiao Zhan
Summary: Gas therapy as a new cancer treatment method has gained increasing attention in recent years. By using near-infrared light as a stimulus to trigger the release of gas molecules, it has achieved improved therapeutic efficacy and reduced side effects.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Kaiqi Long, Yang Yang, Wen Lv, Kuan Jiang, Yafei Li, Amy Cheuk Yin Lo, Wai Ching Lam, Changyou Zhan, Weiping Wang
Summary: Retinoblastoma is a severe ocular disease that is typically treated with repetitive intravitreal injections of chemotherapeutics. However, a new study has introduced a photoresponsive drug release system that can potentially enhance drug accumulation in the eye through light-triggered intravenous injections of drug-loaded nanocarriers. This proof-of-concept study may pave the way for the development of improved treatment options for eye diseases using light-triggered drug release systems.
Article
Materials Science, Multidisciplinary
Zhuoting Deng, Yaling He, Muhammad Rizwan Younis, Shan Lei, Chao Jiang, Yanyan Yuan, Peng Huang, Jing Lin
Summary: The development of a light-triggered nanoplatform for cancer synergistic therapy combining photothermal and starvation treatment effectively eradicated tumors with enhanced glucose oxidase activity, demonstrating superior anti-tumor therapeutic effects without apparent systemic side effects.
SCIENCE CHINA-MATERIALS
(2021)
Article
Polymer Science
Shenglong Gan, Jiao Dong, Xian Li, Juan Wang, Longbin Chen, Yao Wang, Shiting Feng, Hao Li, Guofu Zhou
Summary: By using nonionic poly(acrylamide-co-acrylonitrile) with an upper critical solution temperature (UCST) and inverse emulsification, self-localizing microcages were created. These microcages exhibited phase transition at approximately 40 degrees C and underwent expansion-fusion-fission cycles under mild temperature hyperthermia. With the ability for simultaneous release of drugs, these smart microcages can be utilized for tumor starving therapy, tumor chemotherapy, and imaging.
Article
Chemistry, Physical
Saeid Choopannezhad, S. A. Hassanzadeh-Tabrizi
Summary: In this research, CoFe2O4 nanostructures were synthesized using a sol-gel auto-combustion method, and a novel approach was used to synthesize CoFe2O4-CaCO3 nanocomposites. Characterization of the samples showed that they had particle sizes ranging from 30 to 60 nm, with spherical and irregular shapes. The MTT assay revealed that increasing the CaCO3 content in the nanocomposites increased the cell viability. The samples also exhibited appropriate drug loading and controlled drug delivery capability, making them suitable for hyperthermia treatment.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Materials Science, Multidisciplinary
Anil Kumar, Alfons R. Weig, Seema Agarwal
Summary: The study found that blends of poly(l,l-lactide) degrade faster than homopolymers, but still result in persistent microplastics in compost. Further research on the degradation of polylactide in different environmental conditions is recommended to find better solutions.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Qiang Gao, Tobias Lauster, Bernd A. F. Kopera, Markus Retsch, Seema Agarwal, Andreas Greiner
Summary: The nonwoven fabric combines high porosity, high IR reflectance, and low IR emittance, and can be adjustable from reflective to emissive when turned inside out, simultaneously reducing heat losses by radiation. Low sheet resistance and superior flexibility make it possible to use them in flexible electronics and wearable devices. It can also be further equipped with a porous Joule heating layer for active control of personal thermal comfort.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Renee L. Timmins, Anil Kumar, Maximilian Roehrl, Karel Havlicek, Seema Agarwal, Josef Breu
Summary: Conventional biodegradable polymer PLA is an attractive alternative to nondegradable food packaging films, but has shown to be non-degradable in certain environmental conditions. Compositing with clay can improve barrier properties and result in a unique self-assembled nanostructure.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Article
Polymer Science
Pin Hu, Anil Kumar, Reza Gharibi, Seema Agarwal
Summary: The study developed fast-degrading polyurethanes by introducing degradable ester units through a polyaddition reaction, showing high mechanical strength and almost complete degradation in 3 months at 45 degrees Celsius, significantly faster than known compostable polymers.
Article
Nanoscience & Nanotechnology
Qiang Gao, Thomas Tran, Xiaojian Liao, Sabine Rosenfeldt, Chao Gao, Haoqing Hou, Markus Retsch, Seema Agarwal, Andreas Greiner
Summary: This article introduces a method for preparing ultralight conductive sponge and its properties, including low thermal conductivity, mechanical flexibility, piezoresistivity, and adjustable heating behavior. The sponge can be used in sensor devices, including thermal management, and has potential applications in smart sportswear, human-machine interfaces, and wearable healthcare devices.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Abhilash Venkateshaiah, Renee L. Timmins, Elmar Sehl, Stanislaw Waclawek, Miroslav Cernik, Vinod V. T. Padil, Seema Agarwal
Summary: Recently, environmentally friendly packaging materials with biodegradability, flexibility, and high barrier properties have been in high demand as a substitute for conventional plastic packaging materials. This study successfully fabricated a mechanically stable, biodegradable film of tree gum kondagogu with remarkable barrier properties by introducing a spray-coated, waterborne, large-aspect ratio sodium-hectorite dispersion. The clay-coated nanocomposite films outperformed various commercial polymers and exhibited promising oxygen barrier properties, making them a potential packaging material in the field of sustainable packaging.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Article
Polymer Science
Benjamin R. Kordes, Laura Ascherl, Christoph Ruedinger, Timo Melchin, Seema Agarwal
Summary: A major challenge in modern society is the reduction of microplastics. The chemistry of radical ring-opening copolymerization shows promise in introducing degradable ester units into polymers. However, the hydrolytic instability of cyclic ketene acetals (CKAs) is a bottleneck. This study investigates the hydrolysis kinetics of CKAs and provides guidelines for future emulsion copolymerizations.
Article
Chemistry, Physical
Sivaraj Pazhaniswamy, Sagar A. Joshi, Haoqing Hou, Abhilash Karuthedath Parameswaran, Seema Agarwal
Summary: This paper develops a unique strategy to reduce interfacial resistance in Li7La3Zr2O12 (LLZO)-based solid-state batteries by designing an interface-based core-shell structure. The results show that the rational design outperforms the conventional assembly in specific capacity, internal resistance, and rate performance. The proposed strategy is simple, cost-effective, robust, and scalable, which is essential for the practical applicability of solid-state batteries.
ADVANCED ENERGY MATERIALS
(2023)
Article
Polymer Science
Nikola Majstorovic, Mohamed Zahedtalaban, Seema Agarwal
Summary: Printable synthetic polymer formulations are needed to control the mechanical and functional characteristics of biological scaffolds. In this study, nanocomposite hydrogels were prepared using the upper critical solution (UCST)-type polymer ink poly(N-acryloyl glycinamide) (PNAGA) and carbon nanotubes (CNTs). The hydrogel scaffolds showed increased bioactivities with the addition of CNTs. Different printing methods were compared, and their rheologies were determined. The printed constructs exhibited high mechanical strength, great elasticity, and electrical conductivity, making them suitable for biological and tissue engineering applications.
Article
Materials Science, Multidisciplinary
Eva M. M. Eger, Seema Agarwal
Summary: This study focuses on the characterization and reprocessing ability of PLGA in the form of dynamic covalent networks. The synthesized networks with dynamic bonding and debonding have enhanced thermomechanical properties and maintain the potential for thermal reprocessing and recycling like thermoplastics.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Chenhui Ding, Yingying Du, Seema Agarwal
Summary: A simple and scalable method of making a robust, highly compressible 3D porous sponge made of interconnected crystalline organic frameworks (COF) nanowires is demonstrated. The sponge exhibits high compressive strength and can withstand multiple compression-release cycles and a load of 2800 times its weight without collapsing. As a filter, the sponge shows a high water flux and maintains its performance for many cycles.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Polymer Science
Benjamin R. Kordes, Seema Agarwal
Summary: This study presents two new cyclic vinyl acetal (CVA) monomers that are investigated for their synthesis and homo- and copolymerization behavior with vinyl acetate (VAc) in emulsion polymerization, providing a new pathway for degradable polymers.
Article
Materials Science, Multidisciplinary
Hendrik K. -H. Volz, Seema Agarwal
Summary: The synthesis of polyesters by radical ring-opening polymerization offers advantages such as a variety of reaction conditions, simple initiators, and the possibility of copolymerization. This study explores a comonomer system consisting of 2-methylene-4-phenyl-1,3-dioxolane and syringyl methacrylate and investigates the homogeneous distribution and degradation of ester units in the copolymer.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Physical
Qiang Huang, Guojun Zha, Zhaoyu Hu, Hangzhong Liu, Seema Agarwal, Haoqing Hou
Summary: A lithium sulfur composite electrode (SCPV) is prepared by in situ permeation of PEDOT:PSS onto the surface of a SC (sulfur and carbon nanotubes) electrode. The SCPV electrode exhibits higher discharge capacities compared to the SC electrode at different rates, attributed to the storage of electrolytes and excellent conductivities of PEDOT:PSS. Moreover, the SCPV cathode shows superior cycling stability due to the in situ fixation of PEDOT:PSS, inhibiting shuttle effect and volume change.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Environmental Sciences
Azora Konig Kardgar, Dipannita Ghosh, Joachim Sturve, Seema Agarwal, Bethanie Carney Almroth
Summary: Juvenile perch were exposed to poly(L-lactide) (PLA) microplastic particles or kaolin particles, and their effects on behavior and gene expression were studied. Ingestion of PLA microplastics altered the social behavior of perch, while ingestion of kaolin particles affected gene expression related to oxidative stress and androgenesis. This study highlights the importance of including natural particles in toxicity studies of biobased and biodegradable polymers.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
