Article
Chemistry, Physical
Gyeongseok Yang, Sangpil Kim, Jun Yong Oh, Dohyun Kim, Seongeon Jin, Eunshil Choi, Ja-Hyoung Ryu
Summary: In this paper, a strategy for targeted delivery and controlled drug release using disulfide-incorporated mesoporous organosilica nanoparticles (MONs) was presented. The MONs were loaded with the chemodrug doxorubicin (DOX) and conjugated with a cell-specific affibody (Afb) fused with glutathione-S-transferase (GST). The particles exhibited prompt responsivity to the SS bond-dissociating glutathione (GSH), resulting in significant degradation of the particles and release of DOX, thereby enhancing cancer-therapeutic outcomes.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Montserrat Colilla, Maria Vallet-Regi
Summary: Bacterial antimicrobial resistance is a major threat to global health, and the stalled antibiotic research pipeline has worsened the situation. Nanotechnology offers a potential solution by using nanocarriers to transport and deliver antimicrobials to overcome bacterial resistant barriers. Mesoporous silica nanoparticles (MSNs) have attracted attention due to their unique features. This perspective article outlines recent research in the design and development of organically modified MSNs to fight bacterial infections, addressing the current challenges and future perspectives.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Steffi Tiburcius, Kannan Krishnan, Linta Jose, Vaishwik Patel, Arnab Ghosh, C. Sathish, Judith Weidenhofer, Jae-Hun Yang, Nicole M. Verrills, Ajay Karakoti, Ajayan Vinu
Summary: This study reports a direct single-step synthesis of mesoporous silica-based nanoparticles (MSNs) with a unique egg-yolk core-shell morphology. The nanoparticles have excellent textural properties and surface functionalization, making them an effective drug delivery system. The morphology and structure of the nanoparticles can be tuned by changing the pH of the synthesis medium.
Review
Chemistry, Physical
Sara Hooshmand, Sahar Mollazadeh, Negar Akrami, Mehrnoosh Ghanad, Ahmed El-Fiqi, Francesco Baino, Simin Nazarnezhad, Saeid Kargozar
Summary: Both MSNs and MBGs show promise in managing skin wounds, with the ability to treat acute, chronic, and malignant wounds. Their main advantages lie in strong biocompatibility and the capability to load and release a wide range of bioactive molecules and chemicals.
Article
Chemistry, Multidisciplinary
Ju Hyang Park, Kyung Eun Sung, Ki Hak Kim, Jong Ryeol Kim, Jongbok Kim, Geon Dae Moon, Dong Choon Hyun
Summary: This work presents the fabrication of AuNR@MSNs with independent sensitivities to pH and NIR light for reversible drug release. The inclusion of thermosensitive and pH-sensitive gatekeepers allows controlled drug release under specific conditions.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Review
Chemistry, Physical
Arezoo Sodagar Taleghani, Ali Taghvaie Nakhjiri, Mohammad Javad Khakzad, Seyed Mahdi Rezayat, Pedram Ebrahimnejad, Amir Heydarinasab, Azim Akbarzadeh, Azam Marjani
Summary: In recent decades, significant progress has been made in cancer treatment, but finding more effective therapies is crucial. The application of drug delivery nanovehicles, particularly mesoporous silica nanoparticles (MSNPs), shows promise in reducing side effects. MSNPs possess excellent characteristics that make them suitable for targeted and stimuli responsive drug delivery in cancer treatment.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Pharmacology & Pharmacy
Ruma Rani, Parth Malik, Sunena Dhania, Tapan Kumar Mukherjee
Summary: Breast cancer ranks second in cancer-related global female deaths. Late diagnosis and drug resistance limit the effectiveness of chemotherapeutic drugs, leading to relapse and metastasis. Core-shell mesoporous silica nanoparticles (MSNPs) have emerged as potential drug carriers for breast cancer treatment due to their high surface area, drug loading capacity, and stealth drug delivery capabilities. This article discusses the preparation methods, drug delivery mechanisms, and emerging utility of MSNPs in breast cancer treatment.
Article
Materials Science, Ceramics
Yao Hu, Song Bai, Xiaozan Wu, Songwen Tan, Yongju He
Summary: Understanding and controlling the biodegradability of mesoporous silica nanoparticles (MSN) is crucial for enhancing their bioapplications. Research has shown that physicochemical properties such as specific surface area, morphology, and pore size play a role in MSN biodegradation. Strategies including doping with metal ions and organic species have been introduced to improve the biodegradability of MSN.
CERAMICS INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Cristina Carucci, Nicola Scalas, Andrea Porcheddu, Marco Piludu, Maura Monduzzi, Andrea Salis
Summary: Mesoporous silica nanoparticles (MSN) functionalized with triethylenetetramine (MSN-TETA) showed higher adsorption capacity and slower release rate for the antimicrobial drug sulphamethizole (SMZ), indicating the importance of intermolecular interactions in drug delivery systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biophysics
Riyasudheen Nechikkattu, Jungwon Kong, Young-Shin Lee, Hyun-Jung Moon, Jae-Ho Bae, Sun-Hee Kim, Sung Soo Park, Chang-Sik Ha
Summary: Tunable multi-responsive mesoporous silica nanoparticles were prepared through post-condensation/surface modification of MCM-41 nanoparticles. These nanoparticles exhibited excellent drug-loading capacity and dual responsive behavior, showing potential for cancer therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Materials Science, Ceramics
Mehdi Talaei, S. A. Hassanzadeh-Tabrizi, Ali Saffar-Teluri
Summary: Magnetic CuFe2O4 nanoparticles were synthesized via a sol-gel combustion and coated with mesoporous SiO2. The CuFe2O4@SiO2 nanocomposite showed high ibuprofen loading and controlled drug release, with potential applications in biomedicine. Coating CuFe2O4 nanoparticles with mesoporous silica reduced cytotoxicity and improved drug release properties, although it decreased hyperthermia ability.
CERAMICS INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Noyel Ghosh, Mousumi Kundu, Sumit Ghosh, Abhishek Kumar Das, Samhita De, Joydeep Das, Parames C. Sil
Summary: Cancer is a global disease and the use of phytochemicals with inherent anticancer efficacy is important. Nanotechnology is essential to enhance the bioavailability and therapeutic efficacy of these phytochemicals. In this study, folic acid conjugated polyacrylic acid capped mesoporous silica nanoparticles were used for targeted delivery of chrysin to breast cancer cells. Chrysin loaded nanoparticles showed increased cytotoxicity and induced apoptosis in the cancer cells. Furthermore, in tumor-bearing mice, the nanoparticles enhanced the anti-neoplastic effects of chrysin. This study highlights the potential of chrysin and the importance of nanotechnology in biomedical research.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Engineering, Environmental
Shuaipeng Feng, Junya Lu, Kaili Wang, Donghua Di, Zhenning Shi, Qinfu Zhao, Siling Wang
Summary: Mesoporous carbon nanoparticles and their derivatives have been extensively studied in photothermal therapy for cancer treatment due to their unique structure and excellent photothermal conversion efficiency. The current research focuses on the application of these nanoparticles in multimodal therapies and the development of low-power efficient photothermal therapy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Biotechnology & Applied Microbiology
Ying Li, Guoxing Deng, Xianlong Hu, Chenyang Li, Xiaodong Wang, Qinchang Zhu, Kai Zheng, Wei Xiong, Haiqiang Wu
Summary: Mesoporous silica nanoparticles (MSNs) have been extensively studied and applied in targeted drug-delivery systems for tumor therapy. They possess outstanding features, such as high surface area, large pore volume, tunable pore size, easy surface modification, and stable framework. This review covers the advances, challenges, and prospects of MSN-based targeted drug-delivery systems for anticancer treatment, providing new insights for researchers in this field.
Review
Pharmacology & Pharmacy
Fatemeh Ahmadi, Arezoo Sodagar-Taleghani, Pedram Ebrahimnejad, Seyyed Pouya Hadipour Moghaddam, Farzam Ebrahimnejad, Kofi Asare-Addo, Ali Nokhodchi
Summary: Cancer, the second leading cause of death worldwide, poses challenges for conventional therapies. Nanomaterials, particularly mesoporous silica nanoparticles (MSNs), have been developed to overcome the limitations of conventional cancer treatments. This review highlights the latest progress in using MSNs for cancer diagnosis and treatment, including stimuli-responsive drug delivery, surface modification for targeting, multifunctional MSNs in drug delivery systems, and their potential as imaging platforms. The physicochemical attributes of MSNs and their impact on cancer therapy, as well as challenges and safety concerns, are discussed.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Xinyue Dai, Yu Chen
Summary: With the development of material simulation methods, computing technologies, and high-performance computing equipment, computational simulation tools have been widely used to predict the physicochemical properties and biological effects of biomaterials. This article introduces the concept of computational biomaterials and summarizes the computational methods used in the biomedical field. It discusses the theoretical calculation of the properties and biological performance of biomaterials in disease diagnosis, drug delivery, and biomimetic biomaterials, and presents the biosafety evaluation applications of theoretical simulations. The challenges and future prospects of computational simulations for biomaterials development are also clarified.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jiahuan Xu, Liang Chen, Sujun Ding, Xinyue Dai, Yanfei Dai, Yu Chen, Xuejun Ni
Summary: Through theoretical calculation, Nb2C MXenes are engineered as high-performance sonocatalysts/sonosensitizers through mild in-situ self-oxidation. The formation of efficient Schottky barriers after mild hydrothermal oxidation accelerates the separation of sono-triggered electron-hole pairs, enhancing the reactive oxygen species (ROS) generation efficiency of Nb2C-Ox under ultrasound irradiation.
Review
Chemistry, Multidisciplinary
Yinying Pu, Wencheng Wu, Huijing Xiang, Yu Chen, Huixiong Xu
Summary: The CRISPR/Cas9 gene editing technology has the potential to cure cancer by precisely manipulating cancer-related targets. By combining gene therapy with other therapeutic modalities, this approach can achieve optimal curative effects against cancer and lay the foundation for the development of CRISPR/Cas9-based synergistic cancer therapy.
Article
Chemistry, Multidisciplinary
Ke Xu, Meiqi Chang, Zeyu Wang, Haitang Yang, Yunxuan Jia, Weijiao Xu, Baicheng Zhao, Yu Chen, Feng Yao
Summary: In this study, LaCoO3 (LCO) lanthanide-based nanocrystals were designed to trigger lung cancer cell pyroptosis by generating cytotoxic reactive oxygen species (ROS) and releasing lanthanum ions. The LCO nanoenzyme exhibited peroxidase- and oxidase-mimicking activities, producing ROS in the tumor microenvironment. It also reversed the hypoxic environment, destroying the antioxidant system of tumor cells and increasing their sensitivity to ROS. LCO-induced pyroptotic cell death effectively restrained lung cancer growth and metastasis.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Fan Zhuang, Huijing Xiang, Beijian Huang, Yu Chen
Summary: Ultrasound-triggered cascade amplification of nanotherapies is an effective strategy for cancer treatment, as it maximizes antitumor efficacy and minimizes detrimental effects. This review comprehensively summarizes the recent advances in intelligent nanosystems based on ultrasound-triggered cascade amplification, which provide superior controllability and overcome the challenges of precision medicine.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Xinran Song, Qin Zhang, Meiqi Chang, Li Ding, Hui Huang, Wei Feng, Tianming Xu, Yu Chen
Summary: This review provides a comprehensive overview of the applications and advancements of nanomedicine in the field of ultrasound medicine, including the role of sonosensitive nanomaterials in ultrasound therapy and the concept and development of other acoustic therapies. It offers an updated analysis of the field of nanoultrasonic biomedicine, discussing current treatments and future prospects.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yanling You, Ya-Xuan Zhu, Junjie Jiang, Zhixin Chen, Chenyao Wu, Zhimin Zhang, Han Lin, Jianlin Shi
Summary: In this study, a new two-dimensional iodine nanomaterial called iodinene was proposed for the treatment of infectious diseases in vivo. Iodinene demonstrated enhanced antibacterial efficacy against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa by in situ production of active HIO and I2 molecules via allotropic transformation. The in vivo results further confirmed the desirable antibacterial efficacy of iodinene in treating bacterial wound infection and pneumonia.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Guiying Feng, Hui Huang, Min Zhang, Zhuole Wu, Dandan Sun, Qiqing Chen, Dayan Yang, Yuanyi Zheng, Yu Chen, Xiangxiang Jing
Summary: Sonodynamic therapy (SDT) is a non-invasive therapeutic modality that uses reactive oxygen species (ROS) to treat tumors. However, the lack of high-performance sonosensitizers has limited the clinical translation of SDT. In this study, single atom iron (Fe)-doped graphitic-phase carbon nitride (C3N4) nanosheets were designed as chemoreactive sonosensitizers to generate ROS for melanoma treatment. The Fe doping not only improves the efficiency of ROS generation, but also acts as a peroxidase mimetic enzyme to catalyze the Fenton reaction for generating hydroxyl radicals, enhancing the therapeutic effect of SDT. This work demonstrates a unique single atom doping strategy for improving sonosensitizers and expands the application of semiconductor-based inorganic sonosensitizers in cancer therapy.
Article
Chemistry, Multidisciplinary
Xinran Song, Hui Huang, Lili Xia, Wencong Jia, Shaoling Yang, Chenglong Wang, Yu Chen
Summary: Overcoming apoptosis resistance is crucial for effective cancer treatment, but it is difficult to achieve currently. This study introduces 2D NiCoOx nanosheets as inducers of harmful reactive oxygen species (ROS) to promote intense cell pyroptosis for cancer therapy. These nanosheets possess multiple enzyme-mimicking activities and induce hypoxic microenvironment reversal, glutathione depletion, and continuous ROS production. The ROS-induced pyroptosis is enhanced by ultrasound (US) activation, which further induces mitochondrial dysfunction. The experimental results support the effectiveness of NiCoOx nanosheet-induced pyroptosis in anti-cancer treatment. This work expands the biomedical applications of engineered 2D materials in US-augmented catalytic breast cancer nanotherapy and enhances the understanding of nanomaterials' multienzyme activities.
Article
Chemistry, Multidisciplinary
Ying Fang, Yang Yu, Xiaoyan Jiang, Peilai Liu, Yu Chen, Wei Feng
Summary: A self-adaptive functional tissue engineering scaffold is developed by integrating MoO(3-)x subnanometric wires onto 3D printing bioactive glass scaffolds to address the challenges of residual tumor cells and bone tissue defects in clinical osteosarcoma treatment. The scaffold can aggregate in an acidic tumor microenvironment and react with hydrogen peroxide to provide specific chemodynamic therapy, while also enhancing tumor-targeting photothermal therapy. Furthermore, it promotes bone mesenchymal stem cell differentiation and proliferation, as well as osteogenesis in bone defects.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Inorganic & Nuclear
Weiyi Wang, Weijie Yu, Guangru Li, Hui Huang, Xinran Song, Luodan Yu, Yu Chen
Summary: With the advancement of bacteriotherapy and functional nanoplatforms, nano-bacteria hybrids have emerged as distinct theranostic platforms for enhanced tumor therapy. These hybrids combine the unique characteristics of specialty bacteria with the versatile properties of nanoparticles, enabling efficient anti-cancer therapy. This review comprehensively discusses the current progress, fabrication methods, and applications of anticancer nano-bacteria hybrids in different therapeutic modalities. The biosafety evaluation, challenges, and future prospects of these hybrids are also addressed, highlighting their potential for precise and personalized cancer therapy.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Ruirui Zhou, Meiqi Chang, Mengjun Shen, Yang Cong, Yu Chen, Yin Wang
Summary: Recent technological advances in ultrasound-based treatment modality offer great potential for conquering diseases with remarkable tissue penetration and non-invasive, non-thermal characteristics. Titanium (Ti)-based sonosensitizers, with unique physicochemical properties and exceptional sonodynamic efficiency, have been extensively used in nanomedical applications. Various methods have been developed to optimize the sonodynamic performance of Ti-based nanomedicine, including defect engineering, plasmon resonance modulation, heterojunction, tumor microenvironment modulation, and synergistic therapeutic modalities. This comprehensive review summarizes and highlights state-of-the-art Ti-based nanoplatforms, from preparation process to wide medical applications, aiming to present future research prospects and bench-to-beside translation of these sonocatalytic optimization tactics. Furthermore, the difficulties and future direction of sonocatalytic optimization of Ti-based therapeutic nanomedicine are proposed to stimulate further technological advancements.
Review
Chemistry, Inorganic & Nuclear
Luping Qiu, Zhining Zhu, Jing Liang, Xiaohui Qiao, Huning Xu, Huijing Xiang, Hong Ding, Yu Chen
Summary: This article reviews recent advances in the use of ultrasound and micro/nanoparticles for the treatment of brain diseases, elaborating on the composition and function of ultrasound-sensitive nanoplatforms based on different therapeutic principles, as well as validating their in vitro and in vivo therapeutic effects. The article also discusses the biosafety issues related to future clinical translation and potential challenges and prospects.
COORDINATION CHEMISTRY REVIEWS
(2024)
Article
Chemistry, Multidisciplinary
Xinran Song, Jiefu Liu, Wenrong Wang, Li Ding, Wei Feng, Tingting Zhang, Yu Chen, Xuejun Ni
Summary: The researchers propose a nanomedicine strategy to induce immunogenic tumor-cell ferroptosis, which can improve the effectiveness of immunotherapy. Experimental results demonstrate the efficacy of this strategy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Keyi Wang, Weipu Mao, Xinran Song, Ming Chen, Wei Feng, Bo Peng, Yu Chen
Summary: Reactive oxygen, nitrogen, sulfur, carbonyl, chlorine, bromine, and iodine species (RXS) play important roles in normal physiological processes by governing cell signaling, immune balance, and tissue homeostasis. However, an imbalance in RXS production and consumption can lead to the occurrence and development of various diseases. The advancements in nanomedicine have allowed for the design of nanosystems that can regulate RXS and restore balance, thus halting the pathological processes of different diseases.
CHEMICAL SOCIETY REVIEWS
(2023)