Article
Chemistry, Inorganic & Nuclear
Xuwen Da, Fei-Hu Yu, Chao Zhang, Zhanhua Wang, Yao Jian, Yuanjun Hou, Yong Chen, Xuesong Wang, Qianxiong Zhou
Summary: This work proposes a bioorthogonal assembly based on d(10)MIDLINE HORIZONTAL ELLIPSISd(10) metallophilic interactions for precise cancer cell imaging and photodynamic therapy (PDT). The assembly exhibits luminescence turn-on and singlet oxygen generation upon irradiation, demonstrating the potential of using supramolecular interaction for bioorthogonal chemistry.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Review
Chemistry, Inorganic & Nuclear
Zhiheng Li, Zhenwu Zhou, Yarui Wang, Jie Wang, Liming Zhou, Hong-Bo Cheng, Juyoung Yoon
Summary: Due to deficiencies in specific accumulation at tumors and undesired activation in normal tissues, many photodynamic therapy (PDT) agents show off-target phototoxicity. To address this issue, activatable photodynamic nano-photosensitizers (nanoPSs) that generate reactive oxygen species (ROS) in response to tumor-associated or external stimuli have been developed. These nanoPSs are in an off-state during delivery and are only activated in targeted lesions, enhancing the accuracy and minimizing side effects. This review discusses the design, work principle, and therapeutic performance of PDT using activatable nanoPSs, categorized by different stimuli and composite materials.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Organic
Zilin Zhu, Li Wei, Ashish Kumar Yadav, Zhongxian Fan, Ashish Kumar, Mengzhao Miao, Samya Banerjee, Huaiyi Huang
Summary: Recently, there has been interest in developing photo catalytic anticancer drugs, mainly in the form of metal complexes. In this study, we introduce lysosome/mitochondria targeting cyanine appended bipyridine compounds as potential organic photocatalytic anticancer agents. The organocatalyst (bpyPCN) not only induces light-induced NADH oxidation but also generates intracellular ROS, showcasing its anticancer activity. This is the first example of an organic compound inducing catalytic NADH photo-oxidation in both aqueous solutions and cancer cells.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Lukas Schneider, Martina Kalt, Samuel Koch, Shanmugi Sithamparanathan, Veronika Villiger, Johann Mattiat, Flavia Kradolfer, Ekaterina Slyshkina, Sandra Luber, Mathias Bonmarin, Caroline Maake, Bernhard Spingler
Summary: This article reports six novel and easily accessible BODIPY-based agents for cancer treatment that exhibit both photodynamic and photothermal activities, and do not rely on the generation of reactive oxygen species for cytotoxicity. These agents demonstrate high photocytotoxicity and low dark toxicity in different cancer cell lines. Under hypoxic conditions, they exhibit oxygen-independent photothermal mechanisms, making them potential candidates for overcoming limitations in current cancer therapy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Medicine, Research & Experimental
Tingting Hu, Zhengdi Wang, Weicheng Shen, Ruizheng Liang, Dan Yan, Min Wei
Summary: Photodynamic therapy (PDT) is a non-invasive therapeutic modality that has gained attention for its high selectivity and limited side effects. However, limitations such as inadequate light penetration depth and non-targeting photosensitizers have hindered its full clinical application. Current research focuses on innovative strategies to overcome these limitations and enhance the therapeutic effect of PDT.
Review
Pharmacology & Pharmacy
Sathish Sundar Dhilip Kumar, Heidi Abrahamse
Summary: Nanotechnology plays a crucial role in drug delivery, especially in cancer treatment. Biocompatible nanocarriers are easy to synthesize and can be used for targeted photodynamic therapy effectively.
Article
Chemistry, Multidisciplinary
Shuang Chao, Ziyan Shen, Jiaming Ren, Zhilin Zhang, Xiaolin Chen, Yuxin Pei, Zhichao Pei
Summary: A three-in-one self-assembled metallo-nanophotosensitizer system (NLCD) was constructed by cooperative coordination of amphiphilic l-arginine-modified photosensitizer NBS-l-Arg and DOX in the presence of Cu(2+)via the synergy of coordination, hydrophobic, and pi-pi stacking interactions. The resulting NLCD NPs possessed uniform size, well-defined nanosphere structure, and GSH-responsive ability. In vitro studies exhibited that NLCD NPs integrating photodynamic/chemodynamic/chemo multimodal therapy achieved an enhanced therapeutic effect.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Daniel Obitz, Karmel S. Gkika, Marvin Heller, Tia E. Keyes, Nils Metzler-Nolte
Summary: A lanthanide(iii) complex connected to a light harvesting antenna was synthesized and tested as a potential photosensitizer in photodynamic therapy. The complex showed significant phototoxic activity on cancer cells upon irradiation, with ROS production identified as the compound's phototoxic mode of action. In cell viability assays, a 10-fold decrease in IC50 value was observed compared to the dark control.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Joseph C. Cacaccio, Farukh A. Durrani, Joseph R. Missert, Ravindra K. Pandey
Summary: This study demonstrates the diagnostic potential of a radioactive analog and non-radioactive photosensitizer for various tumors, and shows significantly enhanced therapeutic efficacy when combined with doxorubicin. The toxicity and toxicokinetics of the photosensitizer were evaluated in rats and dogs.
Article
Chemistry, Applied
Toghrul Almammadov, Safacan Kolemen
Summary: The study introduced a H2O2 activatable iodinated resorufin as a redshifted, water soluble and cancer cell selective photosensitizer, exhibiting high singlet oxygen quantum yield and selective photocytotoxicity in colorectal and triple negative breast cancer cells, while showing almost no impact on normal cells.
Review
Chemistry, Multidisciplinary
Wojciech Domka, Dorota Bartusik-Aebisher, Izabela Rudy, Klaudia Dynarowicz, Karolina Pieta, David Aebisher
Summary: Cancer is a leading cause of death and the choice of treatment depends on the type and location of the tumor. Gliomas are the most common malignant brain tumors, but traditional methods like surgery, radiotherapy, and chemotherapy have significant side effects. Photodynamic therapy is gaining attention as a potential treatment option with fewer side effects.
FRONTIERS IN CHEMISTRY
(2023)
Review
Biotechnology & Applied Microbiology
Zijuan Meng, Huiying Xue, Tingting Wang, Biao Chen, Xiyuan Dong, Lili Yang, Jun Dai, Xiaoding Lou, Fan Xia
Summary: Photodynamic therapy (PDT) is a promising non-invasive cancer treatment, but traditional photosensitizers have limitations. Aggregation-induced emission (AIE)-PSs, with their unique structure, exhibit enhanced photosensitivity in the aggregated state. This review discusses the design and preparation of AIE-PSs, their preclinical experiments in treating different types of tumors, and the potential clinical applications. It also presents perspectives on the further development of AIE-PSs.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fen Qi, Hao Yuan, Yuncong Chen, Yan Guo, Shuren Zhang, Zhipeng Liu, Weijiang He, Zijian Guo
Summary: This study designed and synthesized two BODIPY-based monofunctional Pt (II) complexes and studied their PDT effects. The results showed that the complexes exhibited specific phototoxicity to cancer cells under irradiation.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Kun-Xu Teng, Wen-Kai Chen, Li-Ya Niu, Wei-Hai Fang, Ganglong Cui, Qing-Zheng Yang
Summary: Developing Type-I photosensitizers that can generate superoxide radicals under light irradiation has been shown to be an effective approach for improving photodynamic therapy for hypoxic tumors. The reported alpha,beta-linked BODIPY dimers and trimer exclusively generate superoxide radicals through an efficient excited-state relaxation process, demonstrating superior performance in PDT under hypoxic conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Medicine, Research & Experimental
Paromita Sarbadhikary, Blassan P. George, Heidi Abrahamse
Summary: Photodynamic Therapy (PDT) has emerged as a promising alternative in cancer diagnosis and treatment, utilizing light-induced activation of photosensitizers to kill cancer cells. PDT offers advantages such as minimal invasiveness and spatio-temporal control, with proper planning of parameters being crucial for efficacy. The design of PS formulations for imaging-guided PDT has shown promising potential, with recent advances in activatable phototheranostic agents enhancing the specificity of treatment.
Article
Oncology
Phei San Lai, Syed Muhammad Usama, Lik-Voon Kiew, Hong Boon Lee, Lip Yong Chung, Kevin Burgess, Chin Siang Kue
Summary: This study demonstrates the potential of hapten-based pre-immunization combined with cancer receptor labeling to elicit antibody-dependent cellular phagocytosis (ADCP) for improved immunotherapy of cancers expressing TrkC.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Nanoscience & Nanotechnology
Stephanie Sally Fong, Yiing Yee Foo, Wen Shang Saw, Bey Fen Leo, Yin Yin Teo, Ivy Chung, Boon Tong Goh, Misni Misran, Toyoko Imae, Chia-Ching Chang, Lip Yong Chung, Lik Voon Kiew
Summary: This study demonstrates the use of a chitosan-coated-poly(lactic-co-glycolic acid) (C-PLGA) nanocarrier to improve the delivery and efficacy of an antimetastatic agent called Stattic. The Stattic-entrapped C-PLGA nanoparticles showed enhanced anti-cell migration potency in vitro and tumor growth suppression in vivo, suggesting the potential of C-PLGA nanocarrier in improving cancer therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Organic
Rui-Liang Lyu, Shaon Joy, Charles Packianathan, Arthur Laganowsky, Kevin Burgess
Summary: This study identified a set of interface triplet residues as determinant of trypsin binding affinity, which can serve as templates for small molecule mimicry. The researchers used the EKO strategy to evaluate small molecules that mimic the interface triplet regions and found a promising bis-triazole scaffold. The synthesized compounds showed good trypsin inhibitory activity, with the best one having a K-d value of 2.1 μM. X-ray crystallography confirmed the high degree of matching between the mimic's binding mode and the crystal structure. Deviation of the third side chain was attributed to the alleviation of an unfavorable dipole-dipole interaction.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Sopida Thavornpradit, Syed Muhammad Usama, G. Kate Park, Jason Dinh, Hak Soo Choi, Kevin Burgess
Summary: MHI-I-2 and QuatCy-I-2 were compared for their important properties in early-stage photodynamic therapy preclinical candidates. The experiments focused on monitoring dark cytotoxicities, light/dark cytotoxicity ratios, selectivity of localization in tumors over other organs, and clearance from the plasma.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Medicinal
Zhe Gao, Zhen Yang, Zheng Li, Kevin Burgess
Summary: Rucaparib-containing fluorescent probes (1-3) have been found to inhibit PARP1 activity in cell models. One of these probes (1) was tested in a murine model and shown to penetrate into implanted intracranial glioblastoma tumors and persist there for at least 24 hours.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Medicinal
Syed Muhammad Usama, Zhe Gao, Maritess Arancillo, Kevin Burgess
Summary: Conjugating tumor-seeking dyes with fragments can increase selective therapeutic delivery to tumors and drug residence by displacing meso-Cl with free cysteine residues of albumin. The significance of this strategy has recently been elevated as the first tumor-seeking dye-drug conjugate has entered clinical trials. Options for further clinical research include modifying the dye and using preformed albumin adducts instead of dyes alone.
Article
Acoustics
Yean Leng Loke, Adilet Beishenaliev, Pei-Wen Wang, Chung-Yin Lin, Chia -Yu Chang, Yiing Yee Foo, Farid Nazer Faruqu, Bey Fen Leo, Misni Misran, Lip Yong Chung, Dar-Bin Shieh, Lik Voon Kiew, Chia-Ching Chang, Yin Yin Teo
Summary: Gold nanorods coated with alginate (AuNRsALG) are found to be promising nanosonosensitisers for sonodynamic therapy (SDT) due to their enhanced singlet oxygen generation and efficient cancer cell killing effect, primarily through apoptosis.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Tianxiong Mi, Duyen Nguyen, Kevin Burgess
Summary: To design superior synthetic mimics, bioinformatic studies were conducted to better understand Schellman loops, the most common C-caps in proteins. It was discovered that these loops are often stabilized by combinations of three hydrophobic side chains, primarily from Leu, forming hydrophobic triangles. Based on this insight, synthetic mimics called BSMs were designed, where the hydrophobic triumvirate was replaced by 1,3,5-trimethylbenzene. BSMs were shown to be quickly and efficiently made, and more rigid and helix-inducing than current C-cap mimics.
ACS CENTRAL SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Tianxiong Mi, Siriwalee Siriwibool, Kevin Burgess
Summary: This study introduces a new method called Backbone Matching (BM) to efficiently evaluate cyclic peptide libraries for perturbing protein-protein interactions. By prioritizing compounds that correspond to the backbone structures of target protein loops, the study reduces the time and cost required for experimental validation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Cheng Hong Yap, Abdul Qaiyum Ramle, See Khai Lim, Avinash Rames, Sun Tee Tay, Sek Peng Chin, Lik Voon Kiew, Edward R. T. Tiekink, Chin Fei Chee
Summary: Staphylococcus aureus is an adaptable pathogen that can form biofilms and generate persister cells. In this study, a new compound was synthesized and found to have promising antibiofilm activities against S. aureus.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Melbha Starlin Chellathurai, Chung Lip Yong, Zarif Mohamed Sofian, Shariza Sahudin, Najihah Binti Mohd Hasim, Syed Mahmood
Summary: Chitosan is a natural polysaccharide that is biodegradable, bioadhesive, and biocompatible. It has been extensively studied for oral insulin drug delivery systems. Electrostatic interaction between chitosan and insulin leads to the formation of self-assembled nanoparticles, which can protect insulin from degradation and improve intestinal uptake. Functionalized chitosan nanoparticles also offer opportunities for targeted and prolonged delivery. This review provides a comprehensive guide for formulating stable insulin-chitosan nanoparticles using mild ionic interactions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Multidisciplinary
Adilet Beishenaliev, Yean Leng Loke, Sook Jing Goh, Hui Nee Geo, Malar Mugila, Misni Misran, Lip Yong Chung, Lik Voon Kiew, Steve Roffler, Yin Yin Teo
Summary: Monospecific antibodies have limitations in delivering drugs to tumors with multiple epitopes, while bispecific antibodies provide a promising alternative by simultaneously targeting two distinct antigens or epitopes. This review discusses the roles of bispecific antibodies in enhancing the internalization and intracellular trafficking of drug-conjugated antibodies and facilitating the delivery of drug-encapsulating nanoconstructs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Correction
Chemistry, Applied
Theebaa Anasamy, Chin Fei Chee, Yuen Fei Wong, Choon Han Heh, Lik Voon Kiew, Hong Boon Lee, Lip Yong Chung
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
